The network for 'response to axon injury' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to axon injury

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus.

Homo sapiens
Name Description Probability Func Analog Organism
JUN jun proto-oncogene 0.996
EGFR epidermal growth factor receptor 0.975
DHX30 DEAH (Asp-Glu-Ala-His) box polypeptide 30 0.953
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.894
DUSP1 dual specificity phosphatase 1 0.889
FOS FBJ murine osteosarcoma viral oncogene homolog 0.854
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.815
CAV1 caveolin 1, caveolae protein, 22kDa 0.796
MAPK8 mitogen-activated protein kinase 8 0.745
ATF2 activating transcription factor 2 0.739
IGF1R insulin-like growth factor 1 receptor 0.733
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 0.691
GSTM2 glutathione S-transferase mu 2 (muscle) 0.687
PPP1R9B protein phosphatase 1, regulatory (inhibitor) subunit 9B 0.653
JUNB jun B proto-oncogene 0.652
BCL2 B-cell CLL/lymphoma 2 0.588
MAPK14 mitogen-activated protein kinase 14 0.498
INSR insulin receptor 0.477
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 0.428
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.381
FGFR1 fibroblast growth factor receptor 1 0.374
MOBKL3 MOB1, Mps One Binder kinase activator-like 3 (yeast) 0.368
STRN3 striatin, calmodulin binding protein 3 0.356
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.348
NOSTRIN nitric oxide synthase trafficker 0.333
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 0.326
MAPK1 mitogen-activated protein kinase 1 0.303
THBS1 thrombospondin 1 0.294
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.289
ATF3 activating transcription factor 3 0.285
ADORA2A adenosine A2a receptor 0.281
RARA retinoic acid receptor, alpha 0.260
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.258
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 0.257
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.247
ARRB1 arrestin, beta 1 0.233
SOCS3 suppressor of cytokine signaling 3 0.232
GSTM4 glutathione S-transferase mu 4 0.229
MAPK10 mitogen-activated protein kinase 10 0.225
SH3RF1 SH3 domain containing ring finger 1 0.219
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.216
TIMP2 TIMP metallopeptidase inhibitor 2 0.212
JAK2 Janus kinase 2 0.210
ATF4 activating transcription factor 4 (tax-responsive enhancer element B67) 0.185
MAP2K4 mitogen-activated protein kinase kinase 4 0.178
BAK1 BCL2-antagonist/killer 1 0.170
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.163
SLMAP sarcolemma associated protein 0.156
CDK9 cyclin-dependent kinase 9 0.155
CAV2 caveolin 2 0.154
FAM40A family with sequence similarity 40, member A 0.153
NCOA1 nuclear receptor coactivator 1 0.151
PDCD10 programmed cell death 10 0.150
JUND jun D proto-oncogene 0.137
IRF2BP1 interferon regulatory factor 2 binding protein 1 0.136
FAT1 FAT tumor suppressor homolog 1 (Drosophila) 0.133
SNIP1 Smad nuclear interacting protein 1 0.133
NGF nerve growth factor (beta polypeptide) 0.129
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.128
EPOR erythropoietin receptor 0.128
CTTNBP2NL CTTNBP2 N-terminal like 0.127
HMGA2 high mobility group AT-hook 2 0.122
SLC6A3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.122
FAM40B family with sequence similarity 40, member B 0.118
PGR progesterone receptor 0.116
STK24 serine/threonine kinase 24 0.111
IRS1 insulin receptor substrate 1 0.109
TSC22D1 TSC22 domain family, member 1 0.108
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.107
LIF leukemia inhibitory factor (cholinergic differentiation factor) 0.105
BID BH3 interacting domain death agonist 0.104
MAPK9 mitogen-activated protein kinase 9 0.103
MED25 mediator complex subunit 25 0.103
PSAP prosaposin 0.102
STAT5A signal transducer and activator of transcription 5A 0.101
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 0.100
STRN striatin, calmodulin binding protein 0.100
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.096
MYCN v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.095
EGR1 early growth response 1 0.095
FGFR1OP2 FGFR1 oncogene partner 2 0.094
NCF1 neutrophil cytosolic factor 1 0.094
FGF1 fibroblast growth factor 1 (acidic) 0.093
ZNF512B zinc finger protein 512B 0.093
SH2B1 SH2B adaptor protein 1 0.091
PFN1 profilin 1 0.090
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.089
DDIT3 DNA-damage-inducible transcript 3 0.087
MAPK3 mitogen-activated protein kinase 3 0.087
FOSL1 FOS-like antigen 1 0.086
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.086
PARD3 par-3 partitioning defective 3 homolog (C. elegans) 0.085
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.085
FBXW7 F-box and WD repeat domain containing 7 0.084
GSTM3 glutathione S-transferase mu 3 (brain) 0.084
BCL2L1 BCL2-like 1 0.083
ETS2 v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) 0.081
STAT1 signal transducer and activator of transcription 1, 91kDa 0.080
APLP2 amyloid beta (A4) precursor-like protein 2 0.078
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.078
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
scn8aa sodium channel, voltage-gated, type VIII, alpha a 0.745
mmp9 matrix metalloproteinase 9 0.636
atoh1a atonal homolog 1a 0.469
myf5 myogenic factor 5 0.276
atoh1b atonal homolog 1b 0.266
boc brother of CDO 0.241
junb jun B proto-oncogene 0.212
efna5b ephrin A5b 0.208
gad2 glutamate decarboxylase 2 0.201
arnt2 aryl hydrocarbon receptor nuclear translocator 2 0.185
ptf1a pancreas specific transcription factor, 1a 0.163
dpysl3 dihydropyrimidinase-like 3 0.161
efnb1 ephrin B1 0.143
alcama activated leukocyte cell adhesion molecule a 0.134
LOC100000687 signal peptide, CUB and EGF-like domain-containing protein 3-like 0.131
ret1 receptor tyrosine kinase 0.131
slc17a6b solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6b 0.125
slc17a7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 0.114
slc1a2b solute carrier family 1 (glial high affinity glutamate transporter), member 2b 0.112
tnc tenascin C 0.110
neurog1 neurogenin 1 0.109
neurod4 neurogenic differentiation 4 0.105
socs3a suppressor of cytokine signaling 3a 0.089
tbx18 T-box 18 0.089
dlg2 discs, large (Drosophila) homolog 2 0.088
atp2b2 ATPase, Ca++ transporting, plasma membrane 2 0.086
otx2 orthodenticle homolog 2 0.084
lamc1 laminin, gamma 1 0.079
tbx2b T-box 2b 0.078
appa amyloid beta (A4) precursor protein a 0.078
c1qtnf4 C1q and tumor necrosis factor related protein 4 0.076
drd2b dopamine receptor D2b 0.075
dpysl4 dihydropyrimidinase-like 4 0.073
gro1 groucho 1 0.071
chrna7 cholinergic receptor, nicotinic, alpha polypeptide 7 0.071
atf3 activating transcription factor 3 0.067
tcf7l1a transcription factor 7-like 1a (T-cell specific, HMG-box) 0.066
cntn2 contactin 2 0.065
olig3 oligodendrocyte transcription factor 3 0.057
jak1 Janus kinase 1 0.056
cacnb1 calcium channel, voltage-dependent, beta 1 subunit 0.055
zgc:92851 zgc:92851 0.054
socs3b suppressor of cytokine signaling 3b 0.053
gadd45bb growth arrest and DNA-damage-inducible, beta b 0.053
aldoca aldolase C, fructose-bisphosphate, a 0.052
crx cone-rod homeobox 0.052
sema3d semaphorin 3d 0.051
dag1 dystroglycan 1 0.047
dpysl5a dihydropyrimidinase-like 5a 0.045
gata2a GATA-binding protein 2a 0.045
jam2a junctional adhesion molecule 2a 0.045
otx5 orthodenticle homolog 5 0.043
esrrga estrogen-related receptor gamma a 0.043
id:ibd2050 id:ibd2050 0.042
cpn1 carboxypeptidase N, polypeptide 1 0.042
runx1 runt-related transcription factor 1 0.041
drl draculin 0.041
top2b topoisomerase (DNA) II beta 0.041
dusp2 dual specificity phosphatase 2 0.040
pcp4a Purkinje cell protein 4a 0.039
junbl jun B proto-oncogene, like 0.039
fosl2 fos-like antigen 2 0.037
lama2 laminin, alpha 2 0.037
matn4 matrilin 4 0.036
m17 IL-6 subfamily cytokine M17 0.036
copeb core promoter element binding protein 0.035
irx4b iroquois homeobox protein 4b 0.034
spry1 sprouty homolog 1 (Drosophila) 0.034
gro2 groucho 2 0.034
wu:fj52c07 wu:fj52c07 0.034
igfbp3 insulin-like growth factor binding protein 3 0.034
chst11 carbohydrate (chondroitin 4) sulfotransferase 11 0.033
myod1 myogenic differentiation 1 0.033
cntn1a contactin 1a 0.033
kif5aa kinesin family member 5A, a 0.032
tgif1 TGFB-induced factor homeobox 1 0.032
insm1a insulinoma-associated 1a 0.032
sh3gl1b SH3-domain GRB2-like 1b 0.032
pou3f2 POU class 3 homeobox 2 0.032
cx39.9 connexin 39.9 0.032
gpm6ba glycoprotein M6Ba 0.031
zgc:110340 zgc:110340 0.031
egr2b early growth response 2b 0.031
olfm2 olfactomedin 2 0.030
foxg1a forkhead box G1a 0.029
dmd dystrophin 0.029
lmo1 LIM domain only 1 0.028
dpysl2b dihydropyrimidinase-like 2b 0.028
tada3l transcriptional adaptor 3 (NGG1 homolog, yeast)-like 0.028
six1b sine oculis homeobox homolog 1b 0.027
cacna1ab calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b 0.027
gabra1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 0.027
lbx2 ladybird homeobox homolog 2 (Drosophila) 0.027
stc1l stanniocalcin 1, like 0.026
lhx1b LIM homeobox 1b 0.026
zgc:162213 zgc:162213 0.026
smad1 MAD homolog 1 (Drosophila) 0.026
evx1 even-skipped homeobox 1 0.026
ephb4b eph receptor B4b 0.025
nxph1 neurexophilin 1 0.025
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Drosophila melanogaster
Name Description Probability Func Analog Organism
CaMKII Calcium/calmodulin-dependent protein kinase II 0.661
mav maverick 0.515
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.403
kay kayak 0.345
bsk basket 0.325
Ras85D Ras oncogene at 85D 0.190
rl rolled 0.180
Nrg Neuroglian 0.135
Trx-2 thioredoxin-2 0.116
Rho1 CG8416 gene product from transcript CG8416-RB 0.097
dap dacapo 0.089
p38b CG7393 gene product from transcript CG7393-RA 0.089
CdsA CDP diglyceride synthetase 0.084
Pten CG5671 gene product from transcript CG5671-RB 0.073
Lectin-galC1 Galactose-specific C-type lectin 0.070
spas spastin 0.056
retn retained 0.054
aop anterior open 0.053
Gr28b Gustatory receptor 28b 0.047
Nrx-IV Neurexin IV 0.045
foxo forkhead box, sub-group O 0.045
cta concertina 0.043
Dscam Down syndrome cell adhesion molecule 0.041
srp serpent 0.040
Aplip1 APP-like protein interacting protein 1 0.038
Unc-76 CG3981 gene product from transcript CG3981-RB 0.036
M6 CG7540 gene product from transcript CG7540-RA 0.033
chico CG5686 gene product from transcript CG5686-RB 0.033
Ptp69D Protein tyrosine phosphatase 69D 0.032
scb scab 0.032
ewg erect wing 0.030
Fkbp13 CG9847 gene product from transcript CG9847-RC 0.030
CG10641 CG10641 gene product from transcript CG10641-RA 0.029
drd drop dead 0.029
jim CG11352 gene product from transcript CG11352-RB 0.028
AnnX Annexin X 0.028
sinu sinuous 0.027
Abl Abl tyrosine kinase 0.026
LanB1 CG7123 gene product from transcript CG7123-RA 0.025
Spf45 CG17540 gene product from transcript CG17540-RB 0.025
al aristaless 0.024
arm armadillo 0.024
Mtl Mig-2-like 0.024
cnc cap-n-collar 0.023
chinmo Chronologically inappropriate morphogenesis 0.022
Ephrin CG1862 gene product from transcript CG1862-RA 0.021
S6k RPS6-p70-protein kinase 0.021
btl breathless 0.021
pgant5 polypeptide GalNAc transferase 5 0.021
gek genghis khan 0.021
HLHm5 E(spl) region transcript m5 0.020
unc-104 CG8566 gene product from transcript CG8566-RB 0.019
Mekk1 CG7717 gene product from transcript CG7717-RB 0.019
fru fruitless 0.019
CG6429 CG6429 gene product from transcript CG6429-RA 0.019
bsh brain-specific homeobox 0.018
C15 CG7937 gene product from transcript CG7937-RA 0.018
sr stripe 0.018
Pvr PDGF- and VEGF-receptor related 0.018
myoglianin CG1838 gene product from transcript CG1838-RD 0.017
eIF4G eukaryotic translation initiation factor 4G 0.017
Amph Amphiphysin 0.017
wkd whacked 0.016
zfh1 Zn finger homeodomain 1 0.016
mRpL24 mitochondrial ribosomal protein L24 0.016
Sara Smad anchor for receptor activation 0.016
Klp68D Kinesin-like protein at 68D 0.015
Hml Hemolectin 0.015
Hsf Heat shock factor 0.015
IFa IFamide 0.015
loqs loquacious 0.014
DAAM Dishevelled Associated Activator of Morphogenesis 0.014
Cdk5alpha Cdk5 activator-like protein 0.014
nrv1 nervana 1 0.014
sqz squeeze 0.013
scny scrawny 0.013
Pdi Protein disulfide isomerase 0.013
Trh Tryptophan hydroxylase 0.013
Mcr Macroglobulin complement-related 0.012
Dad Daughters against dpp 0.012
ken ken and barbie 0.012
futsch CG34387 gene product from transcript CG34387-RC 0.012
NPFR1 neuropeptide F receptor 0.012
wit wishful thinking 0.012
Tsp96F Tetraspanin 96F 0.012
Dab Disabled 0.012
Actbeta Activin-beta 0.012
cwo clockwork orange 0.012
Lgr3 CG31096 gene product from transcript CG31096-RA 0.012
wnd wallenda 0.012
Itp-r83A Inositol 1,4,5,-tris-phosphate receptor 0.012
unc-119 CG1659 gene product from transcript CG1659-RA 0.012
Crk CG1587 gene product from transcript CG1587-RC 0.012
fog folded gastrulation 0.011
sty sprouty 0.011
EcR Ecdysone receptor 0.011
mtt mangetout 0.011
Cpr97Eb Cuticular protein 97Eb 0.011
Su(dx) Suppressor of deltex 0.011
Ppn Papilin 0.011
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Gstm1 glutathione S-transferase mu 1 0.565
Jun Jun oncogene 0.499
Lgals9 lectin, galactoside-binding, soluble, 9 0.209
Ephx1 epoxide hydrolase 1, microsomal 0.154
Cox8a cytochrome c oxidase subunit VIIIa 0.152
Egr2 early growth response 2 0.147
Anxa2 annexin A2 0.134
Gadd45a growth arrest and DNA-damage-inducible, alpha 0.127
Plaur plasminogen activator, urokinase receptor 0.121
Grm6 glutamate receptor, metabotropic 6 0.115
Itgb1 integrin, beta 1 0.114
Ucn urocortin 0.113
Sncb synuclein, beta 0.113
S100a6 S100 calcium binding protein A6 0.111
S100a10 S100 calcium binding protein A10 0.105
Lgals5 lectin, galactose binding, soluble 5 0.103
Pstpip1 proline-serine-threonine phosphatase-interacting protein 1 0.101
Gjd2 gap junction protein, delta 2 0.100
Foxa3 forkhead box A3 0.100
Arf3 ADP-ribosylation factor 3 0.098
Cd44 Cd44 molecule 0.097
Lgals3 lectin, galactoside-binding, soluble, 3 0.094
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.083
Nmnat2 nicotinamide nucleotide adenylyltransferase 2 0.082
C1qb complement component 1, q subcomponent, B chain 0.082
Myc myelocytomatosis oncogene 0.078
Sstr2 somatostatin receptor 2 0.078
Slc18a3 solute carrier family 18 (vesicular acetylcholine), member 3 0.077
Tagln3 transgelin 3 0.077
Zp3 zona pellucida glycoprotein 3 (sperm receptor) 0.076
Grb2 growth factor receptor bound protein 2 0.076
Shox2 short stature homeobox 2 0.072
Nr2f6 nuclear receptor subfamily 2, group F, member 6 0.071
Gabrg3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 0.071
Myl6l myosin, light polypeptide 6, alkali, smooth muscle and non-muscle-like 0.069
Cd4 Cd4 molecule 0.068
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.068
Morf4l2 mortality factor 4 like 2 0.068
Fis1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 0.067
Cd151 CD151 molecule (Raph blood group) 0.066
Atf3 activating transcription factor 3 0.066
Msx2 msh homeobox 2 0.065
Gstp1 glutathione S-transferase pi 1 0.065
Foxd3 forkhead box D3 0.064
Sst somatostatin 0.064
Klf6 Kruppel-like factor 6 0.064
Mmp3 matrix metallopeptidase 3 0.062
Ctsc cathepsin C 0.062
Stat6 signal transducer and activator of transcription 6 0.061
RT1-DMa RT1 class II, locus DMa 0.061
Lgals4 lectin, galactoside-binding, soluble, 4 0.061
Bcat1 branched chain aminotransferase 1, cytosolic 0.059
Sgp158 proline-rich glycoprotein (sgp158) 0.059
Gria2 glutamate receptor, ionotropic, AMPA 2 0.059
Th tyrosine hydroxylase 0.057
Tspo translocator protein 0.056
Pla2g2a phospholipase A2, group IIA (platelets, synovial fluid) 0.056
Spp1 secreted phosphoprotein 1 0.056
Ctnna1 catenin (cadherin associated protein), alpha 1 0.056
Haao 3-hydroxyanthranilate 3,4-dioxygenase 0.056
Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 0.055
Dnase1l3 deoxyribonuclease 1-like 3 0.054
Prl3d4 prolactin family 3, subfamily d, member 4 0.054
Gpam glycerol-3-phosphate acyltransferase, mitochondrial 0.053
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.053
Tst thiosulfate sulfurtransferase 0.053
Cck cholecystokinin 0.052
Marcks myristoylated alanine rich protein kinase C substrate 0.051
Arl11 ADP-ribosylation factor-like 11 0.051
Dpysl3 dihydropyrimidinase-like 3 0.051
Avp arginine vasopressin 0.051
Acads acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain 0.050
Itgb7 integrin, beta 7 0.050
Socs3 suppressor of cytokine signaling 3 0.050
Tgfbr2 transforming growth factor, beta receptor II 0.050
G6pc glucose-6-phosphatase, catalytic subunit 0.049
Slc29a2 solute carrier family 29 (nucleoside transporters), member 2 0.049
Tnnt2 troponin T type 2 (cardiac) 0.049
Htr1d 5-hydroxytryptamine (serotonin) receptor 1D 0.049
Esr2 estrogen receptor 2 (ER beta) 0.049
Mmp9 matrix metallopeptidase 9 0.048
Timp2 TIMP metallopeptidase inhibitor 2 0.048
Timp1 TIMP metallopeptidase inhibitor 1 0.048
Hcrt hypocretin 0.047
Prdx2 peroxiredoxin 2 0.047
Ctss cathepsin S 0.047
Il6 interleukin 6 0.047
Lyz2 lysozyme 2 0.047
Vav1 vav 1 guanine nucleotide exchange factor 0.047
Btg2 BTG family, member 2 0.046
Prkar1a protein kinase, cAMP-dependent, regulatory, type I, alpha 0.046
Shc3 SHC (Src homology 2 domain containing) transforming protein 3 0.046
Il18 interleukin 18 0.046
Gja5 gap junction protein, alpha 5 0.046
Lin7b lin-7 homolog b (C. elegans) 0.046
S100a4 S100 calcium-binding protein A4 0.045
Csf1 colony stimulating factor 1 (macrophage) 0.045
Crmp1 collapsin response mediator protein 1 0.045
Nefm neurofilament, medium polypeptide 0.045
Gal galanin prepropeptide 0.044
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism