The network for 'response to hyperoxia' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to hyperoxia

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension.

Homo sapiens
Name Description Probability Func Analog Organism
CAV1 caveolin 1, caveolae protein, 22kDa 0.996
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.994
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.975
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.931
ATG3 ATG3 autophagy related 3 homolog (S. cerevisiae) 0.916
FADD Fas (TNFRSF6)-associated via death domain 0.887
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.851
ACTN2 actinin, alpha 2 0.804
AR androgen receptor 0.746
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.726
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.677
PLAU plasminogen activator, urokinase 0.623
NOSTRIN nitric oxide synthase trafficker 0.592
FAS Fas (TNF receptor superfamily, member 6) 0.509
HDAC2 histone deacetylase 2 0.474
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.463
COTL1 coactosin-like 1 (Dictyostelium) 0.452
PLAUR plasminogen activator, urokinase receptor 0.443
CFLAR CASP8 and FADD-like apoptosis regulator 0.421
KAT2B K(lysine) acetyltransferase 2B 0.412
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 0.408
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.385
CREBBP CREB binding protein 0.380
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.363
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.352
CCL5 chemokine (C-C motif) ligand 5 0.346
TRADD TNFRSF1A-associated via death domain 0.345
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.344
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.327
UHRF1 ubiquitin-like with PHD and ring finger domains 1 0.326
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.301
PTEN phosphatase and tensin homolog 0.293
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.268
PLAT plasminogen activator, tissue 0.263
NCF4 neutrophil cytosolic factor 4, 40kDa 0.262
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.253
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.249
NCOA1 nuclear receptor coactivator 1 0.248
TIMP2 TIMP metallopeptidase inhibitor 2 0.197
COL1A2 collagen, type I, alpha 2 0.192
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.178
S100B S100 calcium binding protein B 0.172
ESR1 estrogen receptor 1 0.169
THBS1 thrombospondin 1 0.168
PDGFC platelet derived growth factor C 0.161
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.160
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 0.148
CAV2 caveolin 2 0.139
PDGFA platelet-derived growth factor alpha polypeptide 0.137
COL6A1 collagen, type VI, alpha 1 0.117
NCOA2 nuclear receptor coactivator 2 0.116
NCF1 neutrophil cytosolic factor 1 0.114
BID BH3 interacting domain death agonist 0.112
CXCR4 chemokine (C-X-C motif) receptor 4 0.109
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.105
NCOA6 nuclear receptor coactivator 6 0.103
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.101
COL3A1 collagen, type III, alpha 1 0.100
PTPRF protein tyrosine phosphatase, receptor type, F 0.095
THBS2 thrombospondin 2 0.094
PRDX1 peroxiredoxin 1 0.093
FOXO1 forkhead box O1 0.092
GJA1 gap junction protein, alpha 1, 43kDa 0.091
COL4A1 collagen, type IV, alpha 1 0.086
FHL2 four and a half LIM domains 2 0.085
F2R coagulation factor II (thrombin) receptor 0.084
SNAI1 snail homolog 1 (Drosophila) 0.076
SIRT1 sirtuin 1 0.071
EP300 E1A binding protein p300 0.071
IGFBP3 insulin-like growth factor binding protein 3 0.070
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.070
ALOX5AP arachidonate 5-lipoxygenase-activating protein 0.068
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.057
EGR3 early growth response 3 0.056
TGFB1 transforming growth factor, beta 1 0.055
EGFR epidermal growth factor receptor 0.055
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.054
DAXX death-domain associated protein 0.053
TTR transthyretin 0.052
EGR2 early growth response 2 0.052
ORM1 orosomucoid 1 0.052
PRKCDBP protein kinase C, delta binding protein 0.051
CYBA cytochrome b-245, alpha polypeptide 0.050
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 0.050
FOXO3 forkhead box O3 0.049
RUNX1 runt-related transcription factor 1 0.047
EZH2 enhancer of zeste homolog 2 (Drosophila) 0.046
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.044
MYOZ1 myozenin 1 0.044
LOX lysyl oxidase 0.043
ADAM12 ADAM metallopeptidase domain 12 0.042
TNF tumor necrosis factor 0.041
COL7A1 collagen, type VII, alpha 1 0.040
FGFR1 fibroblast growth factor receptor 1 0.037
CXCR6 chemokine (C-X-C motif) receptor 6 0.037
HTT huntingtin 0.037
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.036
SFTPD surfactant protein D 0.035
IL1B interleukin 1, beta 0.035
SLA Src-like-adaptor 0.035
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
kst karst 0.069
CG14686 CG14686 gene product from transcript CG14686-RA 0.054
Rel Relish 0.051
sev sevenless 0.051
Gyc-89Db Guanylyl cyclase at 89Db 0.048
king-tubby king tubby 0.028
Cng Cyclic-nucleotide-gated ion channel protein 0.028
Pvf2 PDGF- and VEGF-related factor 2 0.026
InR Insulin-like receptor 0.026
Gyc-89Da Guanylyl cyclase at 89Da 0.025
Tpi Triose phosphate isomerase 0.024
drd drop dead 0.021
repo reversed polarity 0.020
hbs hibris 0.019
Thor CG8846 gene product from transcript CG8846-RA 0.018
kon kon-tiki 0.018
l(3)82Fd CG32464 gene product from transcript CG32464-RR 0.017
slou slouch 0.017
dnr1 defense repressor 1 0.017
Glut1 Glucose transporter 1 0.016
bnl branchless 0.016
stumps CG31317 gene product from transcript CG31317-RC 0.015
ImpL2 Ecdysone-inducible gene L2 0.015
dpr defective proboscis extension response 0.015
mRpS33 mitochondrial ribosomal protein S33 0.014
kuz kuzbanian 0.014
scb scab 0.014
Cat Catalase 0.013
l(3)03670 lethal (3) 03670 0.012
sty sprouty 0.012
GLaz Glial Lazarillo 0.012
Gr33a Gustatory receptor 33a 0.011
lbe ladybird early 0.011
CG14483 CG14483 gene product from transcript CG14483-RA 0.011
CG3683 CG3683 gene product from transcript CG3683-RC 0.011
mas masquerade 0.011
sns sticks and stones 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Lepr leptin receptor 0.990
Mmp9 matrix metallopeptidase 9 0.989
Nos3 nitric oxide synthase 3, endothelial cell 0.962
Trp53 transformation related protein 53 0.951
Apoe apolipoprotein E 0.920
Csf1 colony stimulating factor 1 (macrophage) 0.882
Ptgs2 prostaglandin-endoperoxide synthase 2 0.824
Col1a1 collagen, type I, alpha 1 0.641
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.519
Pten phosphatase and tensin homolog 0.476
Selp selectin, platelet 0.444
Fbn1 fibrillin 1 0.417
Lep leptin 0.371
Ccr2 chemokine (C-C motif) receptor 2 0.371
Lmna lamin A 0.369
Lyz2 lysozyme 2 0.354
Tlr4 toll-like receptor 4 0.348
Nos2 nitric oxide synthase 2, inducible 0.340
Nos1 nitric oxide synthase 1, neuronal 0.330
Plat plasminogen activator, tissue 0.305
Ldlr low density lipoprotein receptor 0.298
Vdr vitamin D receptor 0.277
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.271
Vegfa vascular endothelial growth factor A 0.250
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.239
Tgfbr2 transforming growth factor, beta receptor II 0.235
Cav1 caveolin 1, caveolae protein 0.223
Notch2 Notch gene homolog 2 (Drosophila) 0.155
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.130
Hif1a hypoxia inducible factor 1, alpha subunit 0.127
Ccl2 chemokine (C-C motif) ligand 2 0.124
Agtr2 angiotensin II receptor, type 2 0.119
Pparg peroxisome proliferator activated receptor gamma 0.115
Pkd1 polycystic kidney disease 1 homolog 0.113
Foxp3 forkhead box P3 0.093
Tgfb1 transforming growth factor, beta 1 0.085
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.084
Ptges prostaglandin E synthase 0.083
Ifng interferon gamma 0.083
Kcne1 potassium voltage-gated channel, Isk-related subfamily, member 1 0.081
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.080
Egfr epidermal growth factor receptor 0.077
Il6 interleukin 6 0.074
Esr1 estrogen receptor 1 (alpha) 0.072
Nfe2l2 nuclear factor, erythroid derived 2, like 2 0.071
Alox5ap arachidonate 5-lipoxygenase activating protein 0.070
Fas Fas (TNF receptor superfamily member 6) 0.070
Lox lysyl oxidase 0.063
Crebbp CREB binding protein 0.062
Vhl von Hippel-Lindau tumor suppressor 0.061
Il10 interleukin 10 0.058
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.056
Icam1 intercellular adhesion molecule 1 0.053
Efemp2 epidermal growth factor-containing fibulin-like extracellular matrix protein 2 0.052
Sele selectin, endothelial cell 0.049
Mmp2 matrix metallopeptidase 2 0.048
Ppia peptidylprolyl isomerase A 0.047
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.047
Spp1 secreted phosphoprotein 1 0.046
Prkch protein kinase C, eta 0.044
Lpin1 lipin 1 0.043
Nab2 Ngfi-A binding protein 2 0.043
Agtr1a angiotensin II receptor, type 1a 0.043
Fos FBJ osteosarcoma oncogene 0.042
Lrp1 low density lipoprotein receptor-related protein 1 0.041
Cyr61 cysteine rich protein 61 0.041
Ar androgen receptor 0.039
Itgb3 integrin beta 3 0.039
Ctnnb1 catenin (cadherin associated protein), beta 1 0.037
Egr2 early growth response 2 0.036
Wdfy2 WD repeat and FYVE domain containing 2 0.036
Ahr aryl-hydrocarbon receptor 0.035
Col1a2 collagen, type I, alpha 2 0.034
Col4a3 collagen, type IV, alpha 3 0.034
Kit kit oncogene 0.033
Ctsk cathepsin K 0.033
Orai1 ORAI calcium release-activated calcium modulator 1 0.032
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.032
Insr insulin receptor 0.032
Pnpla2 patatin-like phospholipase domain containing 2 0.032
Adrb3 adrenergic receptor, beta 3 0.031
Ltbp3 latent transforming growth factor beta binding protein 3 0.031
Slfn4 schlafen 4 0.031
Adipoq adiponectin, C1Q and collagen domain containing 0.031
Cd151 CD151 antigen 0.031
Timp4 tissue inhibitor of metalloproteinase 4 0.030
Card11 caspase recruitment domain family, member 11 0.030
Tal1 T-cell acute lymphocytic leukemia 1 0.029
Tmprss11e transmembrane protease, serine 11e 0.028
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.028
Cd44 CD44 antigen 0.027
Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 0.027
Npc1 Niemann Pick type C1 0.027
Prdx1 peroxiredoxin 1 0.026
Tlr2 toll-like receptor 2 0.026
Csf2 colony stimulating factor 2 (granulocyte-macrophage) 0.026
Sirt3 sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae) 0.026
Tenc1 tensin like C1 domain-containing phosphatase 0.026
Rag1 recombination activating gene 1 0.026
Thbs3 thrombospondin 3 0.026
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Rattus norvegicus
Name Description Probability Func Analog Organism
Col1a1 collagen, type I, alpha 1 0.837
Col3a1 collagen, type III, alpha 1 0.534
Col1a2 collagen, type I, alpha 2 0.401
Col5a1 collagen, type V, alpha 1 0.390
Egr2 early growth response 2 0.251
ND1 NADH dehydrogenase subunit 1 0.238
COX2 COXII 0.205
COX3 cytochrome c oxidase subunit 3 0.192
Bgn biglycan 0.175
Col12a1 collagen, type XII, alpha 1 0.129
COX1 cytochrome c oxidase subunit 1 0.125
Cpa3 carboxypeptidase A3, mast cell 0.112
Col14a1 collagen, type XIV, alpha 1 0.111
Fndc1 fibronectin type III domain containing 1 0.106
Plau plasminogen activator, urokinase 0.103
Selp selectin P 0.101
Gna15 guanine nucleotide binding protein, alpha 15 0.092
Col5a2 collagen, type V, alpha 2 0.087
Tpo thyroid peroxidase 0.085
Col15a1 collagen, type XV, alpha 1 0.081
Chrm1 cholinergic receptor, muscarinic 1 0.076
Ubb ubiquitin B 0.076
Loxl1 lysyl oxidase-like 1 0.076
RT1-M5 RT1 class Ib, locus M5 0.068
Adra2b adrenergic, alpha-2B-, receptor 0.067
Plcb2 phospholipase C, beta 2 0.067
Arpp21 cAMP-regulated phosphoprotein 21 0.065
Postn periostin, osteoblast specific factor 0.064
Gpr20 G protein-coupled receptor 20 0.062
Ccl4 chemokine (C-C motif) ligand 4 0.059
Fos FBJ osteosarcoma oncogene 0.059
ND4 NADH dehydrogenase subunit 4 0.058
S1pr2 sphingosine-1-phosphate receptor 2 0.058
Col10a1 collagen, type X, alpha 1 0.058
Ccl2 chemokine (C-C motif) ligand 2 0.057
LOC100361445 mCG7602-like 0.057
Eln elastin 0.057
Fosl1 fos-like antigen 1 0.056
Adrb1 adrenergic, beta-1-, receptor 0.054
LOC305103 cell surface glycoprotein gp42 0.053
Lum lumican 0.051
Adam2 ADAM metallopeptidase domain 2 0.051
Egr1 early growth response 1 0.051
Kcnk13 potassium channel, subfamily K, member 13 0.051
Nr4a3 nuclear receptor subfamily 4, group A, member 3 0.050
Col4a1 collagen, type IV, alpha 1 0.050
Hrh4 histamine receptor H4 0.049
Olr1496 olfactory receptor 1496 0.049
Gckr glucokinase (hexokinase 4) regulator 0.048
Tbxa2r thromboxane A2 receptor 0.048
Tas2r107 taste receptor, type 2, member 107 0.048
Serpina5 serine (or cysteine) peptidase inhibitor, clade A, member 5 0.047
Mas1 MAS1 oncogene 0.047
Il8rb interleukin 8 receptor, beta 0.046
Irx4 iroquois homeobox 4 0.046
Nid2 nidogen 2 0.044
Pcolce procollagen C-endopeptidase enhancer 0.044
Sctr secretin receptor 0.044
Igfals insulin-like growth factor binding protein, acid labile subunit 0.043
ND2 NADH dehydrogenase subunit 2 0.043
Adam6 a disintegrin and metallopeptidase domain 6 0.042
Sgp158 proline-rich glycoprotein (sgp158) 0.041
Csf3 colony stimulating factor 3 (granulocyte) 0.041
Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 0.040
PVR poliovirus receptor 0.040
Ube2i ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.039
Aqp8 aquaporin 8 0.039
Rps29 ribosomal protein S29 0.039
Ptgis prostaglandin I2 (prostacyclin) synthase 0.039
Gpr182 G protein-coupled receptor 182 0.039
Il1a interleukin 1 alpha 0.038
Ces2c carboxylesterase 2C 0.038
Ypel5 yippee-like 5 (Drosophila) 0.038
Ptgdr prostaglandin D receptor 0.038
Foxe1 forkhead box E1 (thyroid transcription factor 2) 0.037
Ccr5 chemokine (C-C motif) receptor 5 0.037
Vcsa2 variable coding sequence A2 0.037
Ankrd1 ankyrin repeat domain 1 (cardiac muscle) 0.037
Nppb natriuretic peptide precursor B 0.037
Lef1 lymphoid enhancer binding factor 1 0.037
Cela1 chymotrypsin-like elastase family, member 1 0.036
Csf3r colony stimulating factor 3 receptor (granulocyte) 0.036
Ncf1 neutrophil cytosolic factor 1 0.036
Ptprh protein tyrosine phosphatase, receptor type, H 0.035
Dbc1 deleted in bladder cancer 1 (human) 0.035
Cfp complement factor properdin 0.035
Fap fibroblast activation protein, alpha 0.035
Cebpe CCAAT/enhancer binding protein (C/EBP), epsilon 0.035
Nr4a1 nuclear receptor subfamily 4, group A, member 1 0.033
Dnase1l3 deoxyribonuclease 1-like 3 0.033
Serpina3m serine (or cysteine) proteinase inhibitor, clade A, member 3M 0.033
Fgf16 fibroblast growth factor 16 0.033
Icam1 intercellular adhesion molecule 1 0.032
LOC100364212 heterogeneous nuclear ribonucleoprotein K-like 0.032
LOC686539 similar to immunoglobulin superfamily containing leucine-rich repeat 0.032
Bglap bone gamma-carboxyglutamate (gla) protein 0.032
Iapp islet amyloid polypeptide 0.032
Mmp23 matrix metallopeptidase 23 0.032
Lalba lactalbumin, alpha 0.031
Cpxm1 carboxypeptidase X (M14 family), member 1 0.031
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism