The network for 'negative regulation of developmental growth' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of developmental growth

Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth.

Homo sapiens
Name Description Probability Func Analog Organism
FYN FYN oncogene related to SRC, FGR, YES 0.898
CREBBP CREB binding protein 0.755
AR androgen receptor 0.562
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.362
TSC2 tuberous sclerosis 2 0.353
FGF1 fibroblast growth factor 1 (acidic) 0.334
SNX9 sorting nexin 9 0.315
TTR transthyretin 0.305
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.290
STK3 serine/threonine kinase 3 0.207
WIPF1 WAS/WASL interacting protein family, member 1 0.206
BMPR1A bone morphogenetic protein receptor, type IA 0.157
SPTAN1 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) 0.118
SMAD1 SMAD family member 1 0.104
ATG13 ATG13 autophagy related 13 homolog (S. cerevisiae) 0.103
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 0.092
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.085
VEGFA vascular endothelial growth factor A 0.070
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.068
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.068
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.067
PTN pleiotrophin 0.067
STK4 serine/threonine kinase 4 0.061
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.056
SPRR2A small proline-rich protein 2A 0.056
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.055
MED28 mediator complex subunit 28 0.053
NCOA6 nuclear receptor coactivator 6 0.052
SCHIP1 schwannomin interacting protein 1 0.049
NCOA2 nuclear receptor coactivator 2 0.048
FSTL1 follistatin-like 1 0.047
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.047
NXF1 nuclear RNA export factor 1 0.047
FGFR2 fibroblast growth factor receptor 2 0.046
SIRT1 sirtuin 1 0.044
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.043
YAP1 Yes-associated protein 1 0.042
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) 0.041
TSC1 tuberous sclerosis 1 0.041
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.037
CABLES1 Cdk5 and Abl enzyme substrate 1 0.037
TGFB3 transforming growth factor, beta 3 0.037
PDCD6IP programmed cell death 6 interacting protein 0.037
BAIAP2 BAI1-associated protein 2 0.037
MLL myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.036
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.036
CLASP1 cytoplasmic linker associated protein 1 0.036
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.032
SPG20 spastic paraplegia 20 (Troyer syndrome) 0.031
GAS7 growth arrest-specific 7 0.030
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.029
RASSF3 Ras association (RalGDS/AF-6) domain family member 3 0.029
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.027
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.022
PTEN phosphatase and tensin homolog 0.021
KAT2B K(lysine) acetyltransferase 2B 0.020
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein 0.020
GRB2 growth factor receptor-bound protein 2 0.020
GRB7 growth factor receptor-bound protein 7 0.019
BTK Bruton agammaglobulinemia tyrosine kinase 0.019
MOBKL1B MOB1, Mps One Binder kinase activator-like 1B (yeast) 0.019
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 0.019
CYFIP2 cytoplasmic FMR1 interacting protein 2 0.019
SATB2 SATB homeobox 2 0.019
BMP7 bone morphogenetic protein 7 0.019
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.018
BTRC beta-transducin repeat containing 0.018
PXN paxillin 0.017
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.017
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.017
SMAD2 SMAD family member 2 0.017
FASLG Fas ligand (TNF superfamily, member 6) 0.016
PTK2 PTK2 protein tyrosine kinase 2 0.016
PTPRC protein tyrosine phosphatase, receptor type, C 0.016
INO80B INO80 complex subunit B 0.016
RNF11 ring finger protein 11 0.015
RB1CC1 RB1-inducible coiled-coil 1 0.015
NCOA1 nuclear receptor coactivator 1 0.015
FHL2 four and a half LIM domains 2 0.015
SMAD7 SMAD family member 7 0.015
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.015
PRKCZ protein kinase C, zeta 0.015
FOXO1 forkhead box O1 0.015
CTTN cortactin 0.014
LCK lymphocyte-specific protein tyrosine kinase 0.014
DCC deleted in colorectal carcinoma 0.014
PIAS4 protein inhibitor of activated STAT, 4 0.014
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.014
CREB1 cAMP responsive element binding protein 1 0.014
AXIN1 axin 1 0.014
FGF10 fibroblast growth factor 10 0.013
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.013
WWOX WW domain containing oxidoreductase 0.013
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.013
ENG endoglin 0.013
RB1 retinoblastoma 1 0.013
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.012
KRT5 keratin 5 0.012
NCK1 NCK adaptor protein 1 0.012
FAT1 FAT tumor suppressor homolog 1 (Drosophila) 0.012
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
cst-1 Protein CST-1 0.022
ttyh-1 Protein TTYH-1 0.021
cst-2 Protein CST-2 0.016
ain-1 Protein AIN-1 0.014
unc-68 Protein UNC-68 0.013
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Danio rerio
Name Description Probability Func Analog Organism
efnb2a ephrin B2a 0.466
lhx2b LIM homeobox 2b 0.383
boc brother of CDO 0.312
robo2 roundabout homolog 2 0.258
slit3 slit (Drosophila) homolog 3 0.189
nf1a neurofibromin 1a 0.174
foxa1 forkhead box A1 0.129
bmp2b bone morphogenetic protein 2b 0.115
fgfr3 fibroblast growth factor receptor 3 0.112
twist3 twist3 0.107
nog1 noggin 1 0.105
ptpra protein tyrosine phosphatase, receptor type, A 0.104
wnt11r wingless-type MMTV integration site family, member 11, related 0.103
cdh2 cadherin 2, neuronal 0.102
fzd7a frizzled homolog 7a 0.081
fzd2 frizzled homolog 2 0.080
notch2 notch homolog 2 0.075
col7a1l collagen type VII alpha 1-like 0.074
nrp2b neuropilin 2b 0.073
efnb3b ephrin B3b 0.063
fgfr4 fibroblast growth factor receptor 4 0.063
pea3 ETS-domain transcription factor pea3 0.060
sh3gl1b SH3-domain GRB2-like 1b 0.056
nkd1 naked cuticle homolog 1 (Drosophila) 0.054
ptprsa protein tyrosine phosphatase, receptor type, s, a 0.054
ascl1a achaete-scute complex-like 1a (Drosophila) 0.048
rbfox1l RNA binding protein, fox-1 homolog (C. elegans) 1-like 0.047
crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.046
cdkn1a cyclin-dependent kinase inhibitor 1A 0.045
slit2 slit (Drosophila) homolog 2 0.043
adrb2a adrenergic receptor, beta 2a 0.043
fstl1b follistatin-like 1b 0.041
ets1a v-ets erythroblastosis virus E26 oncogene homolog 1a 0.040
sdc2 syndecan 2 0.039
zbtb4 zinc finger and BTB domain containing 4 0.037
bambia BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a 0.036
fgfrl1a fibroblast growth factor receptor-like 1a 0.036
ntn2 netrin 2 0.035
msxb muscle segment homeobox B 0.034
igf2b insulin-like growth factor 2b 0.034
fmr1 fragile X mental retardation 1 0.033
sulf1 sulfatase 1 0.033
mycbp2 MYC binding protein 2 0.033
llgl2 lethal giant larvae homolog 2 (Drosophila) 0.033
gli3 GLI-Kruppel family member GLI3 0.031
arnt2 aryl hydrocarbon receptor nuclear translocator 2 0.031
atp6v1ba ATPase, H+ transporting, lysosomal, V1 subunit B, member a 0.030
mapk1 mitogen-activated protein kinase 1 0.028
itgb1b.1 integrin, beta 1b.1 0.028
gap43 growth associated protein 43 0.028
pcdh8 protocadherin 8 0.027
ntn1a netrin 1a 0.027
adipoql adiponectin, C1Q and collagen domain containing, like 0.027
has2 hyaluronan synthase 2 0.026
ptprk protein tyrosine phosphatase, receptor type, K 0.026
fzd7b frizzled homolog 7b 0.026
sfrp1a secreted frizzled-related protein 1a 0.025
ldb2a LIM-domain binding factor 2a 0.025
pou1f1 POU domain, class 1, transcription factor 1 0.025
ptk2.1 protein tyrosine kinase 2a 0.025
notch3 notch homolog 3 0.024
nav3 neuron navigator 3 0.024
sema3fb semaphorin 3fb 0.024
neo1 neogenin 1 0.024
col5a2l collagen, type V, alpha 2-like 0.023
csf3r colony stimulating factor 3 receptor (granulocyte) 0.023
traf4a tnf receptor-associated factor 4a 0.022
ctsl1b cathepsin L, 1 b 0.022
sgk1 serum/glucocorticoid regulated kinase 1 0.022
zdhhc8b zinc finger, DHHC-type containing 8b 0.022
sema3d semaphorin 3d 0.020
nrg2a neuregulin 2a 0.020
acvr1b activin A receptor, type IB 0.020
nrg1 neuregulin 1 0.020
im:7137555 im:7137555 0.020
notum3 notum 3 0.019
sox2 SRY-box containing gene 2 0.019
tbx1 T-box 1 0.019
fgfr1b fibroblast growth factor receptor 1b 0.019
olfm2 olfactomedin 2 0.019
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.019
grnb granulin b 0.018
gli1 GLI-Kruppel family member 1 0.018
ntrk2a neurotrophic tyrosine kinase, receptor, type 2a 0.018
mecom MDS1 and EVI1 complex locus 0.018
nrarpa notch-regulated ankyrin repeat protein a 0.018
grem2 gremlin 2, cysteine knot superfamily 0.018
tnc tenascin C 0.017
ephb4b eph receptor B4b 0.017
plxnb2a plexin b2a 0.017
ebf3 early B-cell factor 3 0.016
chat choline acetyltransferase 0.016
npc1 Niemann-Pick disease, type C1 0.016
kif5bb kinesin family member 5B, b 0.016
tnfsf10l tumor necrosis factor (ligand) superfamily, member 10 like 0.016
cacnb1 calcium channel, voltage-dependent, beta 1 subunit 0.016
eomesb eomesodermin homolog b 0.016
axin1 axin 1 0.015
ucn3l urocortin 3, like 0.015
bmp2a bone morphogenetic protein 2a 0.015
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Rac1 CG2248 gene product from transcript CG2248-RA 0.847
Fak56D Focal Adhesion Kinase 0.829
smo smoothened 0.823
Mob2 CG11711 gene product from transcript CG11711-RC 0.805
jeb jelly belly 0.794
lea leak 0.782
gig gigas 0.770
Pten CG5671 gene product from transcript CG5671-RB 0.767
ago archipelago 0.750
brp bruchpilot 0.700
hpo hippo 0.684
wit wishful thinking 0.620
neuroligin CG13772 gene product from transcript CG13772-RA 0.618
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.610
babo baboon 0.605
Nrg Neuroglian 0.576
Pk61C Protein kinase 61C 0.570
vri vrille 0.562
wg wingless 0.559
kibra kibra ortholog 0.558
dnc dunce 0.552
caz cabeza 0.551
ena enabled 0.529
crb crumbs 0.452
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.440
cdm cadmus 0.437
Mad Mothers against dpp 0.429
S6k RPS6-p70-protein kinase 0.406
CG14869 CG14869 gene product from transcript CG14869-RB 0.406
ptc patched 0.359
Pak PAK-kinase 0.348
wb wing blister 0.346
trio CG18214 gene product from transcript CG18214-RA 0.338
Dad Daughters against dpp 0.310
Dap160 Dynamin associated protein 160 0.288
Wnt5 Wnt oncogene analog 5 0.280
CycD Cyclin D 0.277
ds dachsous 0.270
HGTX CG13475 gene product from transcript CG13475-RB 0.268
Liprin-alpha CG11199 gene product from transcript CG11199-RB 0.262
os outstretched 0.253
nwk nervous wreck 0.253
shot short stop 0.248
CadN Cadherin-N 0.244
tin tinman 0.241
CG13253 CG13253 gene product from transcript CG13253-RB 0.237
simj simjang 0.230
sr stripe 0.220
drk downstream of receptor kinase 0.218
Tsc1 CG6147 gene product from transcript CG6147-RA 0.210
CkIIalpha Casein kinase II alpha subunit 0.207
AdoR Adenosine receptor 0.202
LanA Laminin A 0.196
mew multiple edematous wings 0.196
S6kII RPS6-protein kinase-II 0.187
not non-stop 0.187
Hem HEM-protein 0.181
unc-104 CG8566 gene product from transcript CG8566-RB 0.179
unc-5 CG8166 gene product from transcript CG8166-RA 0.178
Mst57Db Male-specific RNA 57Db 0.174
Nf1 Neurofibromin 1 0.172
Zyx102EF CG32018 gene product from transcript CG32018-RA 0.171
plu plutonium 0.170
ci cubitus interruptus 0.168
htt huntingtin 0.168
Rbsn-5 Rabenosyn-5 0.163
Tbh Tyramine beta hydroxylase 0.162
Trim9 CG31721 gene product from transcript CG31721-RB 0.158
fz2 frizzled 2 0.154
RanBPM Ran-binding protein M 0.154
mnb minibrain 0.149
Cdk4 Cyclin-dependent kinase 4 0.148
Ten-a Tenascin accessory 0.147
chico CG5686 gene product from transcript CG5686-RB 0.146
LanB2 Laminin B2 0.146
chb chromosome bows 0.145
X11L CG5675 gene product from transcript CG5675-RB 0.144
Alk CG8250 gene product from transcript CG8250-RA 0.144
rg rugose 0.144
Ras85D Ras oncogene at 85D 0.140
Fsn CG4643 gene product from transcript CG4643-RA 0.137
Akt1 CG4006 gene product from transcript CG4006-RA 0.137
sra sarah 0.134
stnB stoned B 0.134
vav CG7893 gene product from transcript CG7893-RB 0.127
RagA CG11968 gene product from transcript CG11968-RA 0.126
baz bazooka 0.124
Octbeta2R CG33976 gene product from transcript CG33976-RA 0.123
lap like-AP180 0.121
nmo nemo 0.120
Aplip1 APP-like protein interacting protein 1 0.119
hkb huckebein 0.117
dco discs overgrown 0.116
stumps CG31317 gene product from transcript CG31317-RC 0.116
milt milton 0.113
path pathetic 0.113
arr arrow 0.113
Fmr1 CG6203 gene product from transcript CG6203-RC 0.112
spict spichthyin 0.112
Ephrin CG1862 gene product from transcript CG1862-RA 0.110
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Cav1 caveolin 1, caveolae protein 0.195
Cd37 CD37 molecule 0.151
Smad7 SMAD family member 7 0.088
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.077
LOC100362824 caveolin 2-like 0.071
Usf2 upstream transcription factor 2, c-fos interacting 0.058
Cish cytokine inducible SH2-containing protein 0.054
Itgam integrin, alpha M 0.048
Tgfbr2 transforming growth factor, beta receptor II 0.045
Nos3 nitric oxide synthase 3, endothelial cell 0.043
Inpp5d inositol polyphosphate-5-phosphatase D 0.037
Fgfr1 Fibroblast growth factor receptor 1 0.030
Gnb2 guanine nucleotide binding protein (G protein), beta polypeptide 2 0.030
Hk1 hexokinase 1 0.029
A3galt2 alpha 1,3-galactosyltransferase 2 0.028
Pld2 phospholipase D2 0.024
Pkn2 protein kinase N2 0.024
Fgfr2 fibroblast growth factor receptor 2 0.023
Ubtf upstream binding transcription factor, RNA polymerase I 0.022
Ptafr platelet-activating factor receptor 0.022
Mprip myosin phosphatase Rho interacting protein 0.021
Olfml2b olfactomedin-like 2B 0.021
Sod3 superoxide dismutase 3, extracellular 0.021
Gna15 guanine nucleotide binding protein, alpha 15 0.020
Mcam melanoma cell adhesion molecule 0.020
Adrb2 adrenergic, beta-2-, receptor, surface 0.020
Cav2 caveolin 2 0.019
Grin2a glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.019
Fmnl1 formin-like 1 0.018
Rab1b RAB1B, member RAS oncogene family 0.018
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.018
Ptprc protein tyrosine phosphatase, receptor type, C 0.017
Timp3 TIMP metallopeptidase inhibitor 3 0.017
Bcl2 B-cell CLL/lymphoma 2 0.017
Tcof1 Treacher Collins-Franceschetti syndrome 1 homolog (human) 0.017
RGD1559896 similar to RIKEN cDNA 2310022B05 0.016
Pgr progesterone receptor 0.016
Cpxm2 carboxypeptidase X (M14 family), member 2 0.016
Il2rg interleukin 2 receptor, gamma 0.015
Tub tubby homolog (mouse) 0.015
Acvr1 activin A receptor, type I 0.015
Cyfip1 cytoplasmic FMR1 interacting protein 1 0.015
Pld1 phospholipase D1 0.015
Sox2 SRY (sex determining region Y)-box 2 0.014
Sema6b sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B 0.014
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.014
Gabbr2 gamma-aminobutyric acid (GABA) B receptor 2 0.014
Nfia nuclear factor I/A 0.014
Nos1 nitric oxide synthase 1, neuronal 0.013
Alox5 arachidonate 5-lipoxygenase 0.013
Fzd2 frizzled homolog 2 (Drosophila) 0.013
Sept8 septin 8 0.013
Nfib nuclear factor I/B 0.013
B4galt1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.013
Gcn1l1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast) 0.013
Shank1 SH3 and multiple ankyrin repeat domains 1 0.013
Prkca protein kinase C, alpha 0.013
Cd38 CD38 molecule 0.013
Irf2 interferon regulatory factor 2 0.013
Ptprs protein tyrosine phosphatase, receptor type, S 0.012
Rara retinoic acid receptor, alpha 0.012
Epn2 epsin 2 0.012
Fgf17 fibroblast growth factor 17 0.012
Glg1 golgi apparatus protein 1 0.012
Vcan versican 0.012
Sirpa signal-regulatory protein alpha 0.012
Adrbk1 adrenergic, beta, receptor kinase 1 0.012
Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 0.012
Serpine2 serine (or cysteine) peptidase inhibitor, clade E, member 2 0.012
Prkch protein kinase C, eta 0.012
Gja1 gap junction protein, alpha 1 0.012
Cyp2s1 cytochrome P450, family 2, subfamily s, polypeptide 1 0.011
Camk2a calcium/calmodulin-dependent protein kinase II alpha 0.011
Prkcd protein kinase C, delta 0.011
Gna12 guanine nucleotide binding protein (G protein) alpha 12 0.011
Nr2f6 nuclear receptor subfamily 2, group F, member 6 0.011
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.011
Socs3 suppressor of cytokine signaling 3 0.011
Nlgn2 neuroligin 2 0.011
Fnbp1 formin binding protein 1 0.011
Jak1 Janus kinase 1 0.011
Hspb2 heat shock protein beta 2 0.011
Rab27a RAB27A, member RAS oncogene family 0.011
Tcf4 transcription factor 4 0.011
Plcg2 phospholipase C, gamma 2 0.011
Ager advanced glycosylation end product-specific receptor 0.011
Vav1 vav 1 guanine nucleotide exchange factor 0.010
Msn moesin 0.010
Smurf2 SMAD specific E3 ubiquitin protein ligase 2 0.010
Casp1 caspase 1 0.010
Musk muscle, skeletal, receptor tyrosine kinase 0.010
Rab3il1 RAB3A interacting protein (rabin3)-like 1 0.010
Rock2 Rho-associated coiled-coil containing protein kinase 2 0.010
Prkar2a protein kinase, cAMP dependent regulatory, type II alpha 0.010
Olr857 olfactory receptor 857 0.010
Cops7a COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis) 0.010
Fam65a family with sequence similarity 65, member A 0.010
Pecam1 platelet/endothelial cell adhesion molecule 1 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism