The network for 'regulation of tyrosine phosphorylation of stat3 protein' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of tyrosine phosphorylation of stat3 protein

Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat3 protein.

Homo sapiens
Name Description Probability Func Analog Organism
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 1.000
GHR growth hormone receptor 0.999
EGFR epidermal growth factor receptor 0.999
JAK2 Janus kinase 2 0.999
FGF1 fibroblast growth factor 1 (acidic) 0.998
SOCS3 suppressor of cytokine signaling 3 0.996
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.992
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.992
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.991
IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) 0.990
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.947
LAT linker for activation of T cells 0.914
GH1 growth hormone 1 0.884
JAK1 Janus kinase 1 0.864
PTPRB protein tyrosine phosphatase, receptor type, B 0.847
INSR insulin receptor 0.831
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.819
HDAC2 histone deacetylase 2 0.751
VEGFA vascular endothelial growth factor A 0.734
IL23A interleukin 23, alpha subunit p19 0.688
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.658
IL6R interleukin 6 receptor 0.615
CD44 CD44 molecule (Indian blood group) 0.571
GAB1 GRB2-associated binding protein 1 0.552
IL6 interleukin 6 (interferon, beta 2) 0.538
IRS1 insulin receptor substrate 1 0.507
CSH2 chorionic somatomammotropin hormone 2 0.437
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.407
SOCS1 suppressor of cytokine signaling 1 0.403
STAT1 signal transducer and activator of transcription 1, 91kDa 0.376
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.336
CSHL1 chorionic somatomammotropin hormone-like 1 0.308
NRP1 neuropilin 1 0.291
IGF1R insulin-like growth factor 1 receptor 0.286
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.284
GH2 growth hormone 2 0.282
GRB2 growth factor receptor-bound protein 2 0.280
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.240
IL22 interleukin 22 0.239
SCHIP1 schwannomin interacting protein 1 0.229
PLCG1 phospholipase C, gamma 1 0.210
TBC1D10A TBC1 domain family, member 10A 0.199
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.188
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.187
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.164
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.147
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.126
CNTF ciliary neurotrophic factor 0.111
EPOR erythropoietin receptor 0.087
CAV1 caveolin 1, caveolae protein, 22kDa 0.082
PTPRJ protein tyrosine phosphatase, receptor type, J 0.082
SH2B1 SH2B adaptor protein 1 0.081
PGF placental growth factor 0.078
STAT4 signal transducer and activator of transcription 4 0.075
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.073
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.073
FRS2 fibroblast growth factor receptor substrate 2 0.069
CAPN1 calpain 1, (mu/I) large subunit 0.062
CDH5 cadherin 5, type 2 (vascular endothelium) 0.060
EZR ezrin 0.058
GRB7 growth factor receptor-bound protein 7 0.057
JAK3 Janus kinase 3 0.056
KITLG KIT ligand 0.052
CD33 CD33 molecule 0.051
MED28 mediator complex subunit 28 0.049
SOCS2 suppressor of cytokine signaling 2 0.048
GAB2 GRB2-associated binding protein 2 0.048
ICAM1 intercellular adhesion molecule 1 0.048
IFNGR1 interferon gamma receptor 1 0.048
PTK2 PTK2 protein tyrosine kinase 2 0.047
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.047
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.046
FGF10 fibroblast growth factor 10 0.046
MET met proto-oncogene (hepatocyte growth factor receptor) 0.046
STAT5A signal transducer and activator of transcription 5A 0.044
BCAR1 breast cancer anti-estrogen resistance 1 0.042
PDGFA platelet-derived growth factor alpha polypeptide 0.042
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 0.041
SYK spleen tyrosine kinase 0.041
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.040
ICA1 islet cell autoantigen 1, 69kDa 0.039
IL12A interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) 0.038
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.036
SNAI1 snail homolog 1 (Drosophila) 0.033
FGFR1 fibroblast growth factor receptor 1 0.033
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.033
LIFR leukemia inhibitory factor receptor alpha 0.032
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.031
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 0.031
PTPN3 protein tyrosine phosphatase, non-receptor type 3 0.030
SOS2 son of sevenless homolog 2 (Drosophila) 0.029
EXT1 exostosin 1 0.028
TLR3 toll-like receptor 3 0.027
SLA Src-like-adaptor 0.026
STC1 stanniocalcin 1 0.026
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.024
GRB10 growth factor receptor-bound protein 10 0.024
CMIP c-Maf-inducing protein 0.023
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.022
PDGFC platelet derived growth factor C 0.022
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
stm starmaker 0.393
il6st interleukin 6 signal transducer 0.385
mitfa microphthalmia-associated transcription factor a 0.303
il6r interleukin 6 receptor 0.296
prox1 prospero-related homeobox gene 1 0.249
sema6dl sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, like 0.229
ednrb1 endothelin receptor B 0.219
neurod neurogenic differentiation 0.214
insm1a insulinoma-associated 1a 0.188
scn1bb sodium channel, voltage-gated, type I, beta b 0.169
aox3 aldehyde oxidase 3 0.129
sb:cb429 sb:cb429 0.112
ltk leukocyte tyrosine kinase 0.098
kita kit receptor a 0.087
fezf2 FEZ family zinc finger 2 0.086
pcdh17 protocadherin 17 0.080
her4.2 hairy-related 4.2 0.072
dlb deltaB 0.062
scn1ba sodium channel, voltage-gated, type I, beta a 0.058
ntrk3b neurotrophic tyrosine kinase, receptor, type 3b 0.055
prom1a prominin 1a 0.051
pcsk5a proprotein convertase subtilisin/kexin type 5a 0.051
cmyb transcription factor cmyb 0.050
smox spermine oxidase 0.050
emx2 empty spiracles homeobox 2 0.049
LOC100149863 hairy-related 4.1-like 0.048
scrt2 scratch homolog 2, zinc finger protein (Drosophila) 0.046
spry1 sprouty homolog 1 (Drosophila) 0.046
mmp9 matrix metalloproteinase 9 0.046
sulf2 sulfatase 2 0.045
nrp2b neuropilin 2b 0.045
tagln3b transgelin 3b 0.045
cacna1da calcium channel, voltage-dependent, L type, alpha 1D subunit, a 0.041
irf3 interferon regulatory factor 3 0.041
insm1b insulinoma-associated 1b 0.040
arhgef7b Rho guanine nucleotide exchange factor (GEF) 7b 0.039
zbtb10 zinc finger and BTB domain containing 10 0.037
ighm immunoglobulin heavy constant mu and immunoglobulin heavy constant mu 0.037
rhcgb Rhesus blood group, C glycoprotein b 0.037
elovl4a elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4a 0.036
abca12 ATP-binding cassette, sub-family A (ABC1), member 12 0.036
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.036
pax7b paired box gene 7b 0.035
fcho2 FCH domain only 2 0.035
ctbp2l C-terminal binding protein 2, like 0.035
emx3 empty spiracles homeobox 3 0.034
mtmr8 myotubularin related protein 8 0.034
etv5a ets variant 5a 0.034
kcnj13 potassium inwardly-rectifying channel, subfamily J, member 13 0.033
ikbkg inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.033
sc:d0319 sc:d0319 0.032
tlr3 toll-like receptor 3 0.032
notch3 notch homolog 3 0.030
il7r interleukin 7 receptor 0.030
elovl6 ELOVL family member 6, elongation of long chain fatty acids (yeast) 0.029
LOC566020 Gig2-like protein DreO 0.028
wasb Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b 0.028
neurog1 neurogenin 1 0.028
jag2 jagged 2 0.027
ahcyl2 S-adenosylhomocysteine hydrolase-like 2 0.026
chrna6 cholinergic receptor, nicotinic, alpha 6 0.026
stat3 signal transduction and activation of transcription 3 0.025
zgc:66441 zgc:66441 0.024
msi1 musashi homolog 1 (Drosophila) 0.024
adcyap1r1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I 0.023
atp6v1al ATPase, H+ transporting, lysosomal V1 subunit A, like 0.023
barhl1.1 BarH-like 1.1 0.023
csf1ra colony stimulating factor 1 receptor, a 0.022
sox4a SRY-box containing gene 4a 0.021
otpb orthopedia homolog b 0.021
cav1 caveolin 1 0.021
fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.021
socs3a suppressor of cytokine signaling 3a 0.021
emx1 empty spiracles homeobox 1 0.021
fcer1gl Fc receptor, IgE, high affinity I, gamma polypeptide like 0.020
s100t S100 calcium binding protein T 0.020
hoxb8a homeo box B8a 0.020
clic4 chloride intracellular channel 4 0.020
cited3 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 3 0.020
six1b sine oculis homeobox homolog 1b 0.019
crfb7 cytokine receptor family member b7 0.019
sc:d812 sc:d812 0.019
gadd45g growth arrest and DNA-damage-inducible, gamma 0.019
grn2 granulin 2 0.019
amotl2a angiomotin like 2a 0.019
grn1 granulin 1 0.019
prom1b prominin 1 b 0.019
iclp1 invariant chain-like protein 1 0.018
atl1 atlastin GTPase 1 0.018
dntt deoxynucleotidyltransferase, terminal 0.018
runx3 runt-related transcription factor 3 0.018
ildr1b immunoglobulin-like domain containing receptor 1b 0.017
nr3c2 nuclear receptor subfamily 3, group C, member 2 0.017
c21orf59l c21orf59 homolog (H. sapiens), like 0.017
scn8ab sodium channel, voltage-gated, type VIII, alpha b 0.017
LOC100003330 melanocortin-2 receptor accessory protein 2-like 0.017
bmp3 bone morphogenetic protein 3 0.017
tac1 tachykinin 1 0.017
atp1b1a ATPase, Na+/K+ transporting, beta 1a polypeptide 0.017
nr2f6b nuclear receptor subfamily 2, group F, member 6b 0.017
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Lepr leptin receptor 0.952
Il6st interleukin 6 signal transducer 0.859
Stat3 signal transducer and activator of transcription 3 0.824
Otx2 orthodenticle homolog 2 (Drosophila) 0.650
Emx2 empty spiracles homolog 2 (Drosophila) 0.558
Jak2 Janus kinase 2 0.536
Lhx3 LIM homeobox protein 3 0.448
Emx1 empty spiracles homolog 1 (Drosophila) 0.277
Vegfa vascular endothelial growth factor A 0.253
Ctnnb1 catenin (cadherin associated protein), beta 1 0.251
Sox2 SRY-box containing gene 2 0.224
Apc adenomatosis polyposis coli 0.215
Tgfb1 transforming growth factor, beta 1 0.195
Gli3 GLI-Kruppel family member GLI3 0.184
Kdr kinase insert domain protein receptor 0.177
Smad3 MAD homolog 3 (Drosophila) 0.157
Prf1 perforin 1 (pore forming protein) 0.128
Pitx2 paired-like homeodomain transcription factor 2 0.127
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.119
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.102
Nos2 nitric oxide synthase 2, inducible 0.096
Lyz2 lysozyme 2 0.086
Tnf tumor necrosis factor 0.079
Hes5 hairy and enhancer of split 5 (Drosophila) 0.078
Socs3 suppressor of cytokine signaling 3 0.070
Stat5a signal transducer and activator of transcription 5A 0.067
Il6 interleukin 6 0.062
Kitl kit ligand 0.060
Trp53 transformation related protein 53 0.060
Tcra T-cell receptor alpha chain 0.059
Phospho1 phosphatase, orphan 1 0.058
Pax6 paired box gene 6 0.055
Foxc2 forkhead box C2 0.052
Sox9 SRY-box containing gene 9 0.052
Meox2 mesenchyme homeobox 2 0.043
Il10 interleukin 10 0.040
Bmpr1a bone morphogenetic protein receptor, type 1A 0.039
Ptpn2 protein tyrosine phosphatase, non-receptor type 2 0.038
Col1a1 collagen, type I, alpha 1 0.036
Prop1 paired like homeodomain factor 1 0.036
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.034
Cdh5 cadherin 5 0.030
Pkd1 polycystic kidney disease 1 homolog 0.030
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.029
Foxp3 forkhead box P3 0.028
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.027
Socs1 suppressor of cytokine signaling 1 0.027
Plcg1 phospholipase C, gamma 1 0.027
Ldlr low density lipoprotein receptor 0.026
Flt4 FMS-like tyrosine kinase 4 0.026
Kit kit oncogene 0.026
Nr2e1 nuclear receptor subfamily 2, group E, member 1 0.025
Shh sonic hedgehog 0.025
Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.023
Elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.022
Hes3 hairy and enhancer of split 3 (Drosophila) 0.022
Esr1 estrogen receptor 1 (alpha) 0.022
Smpd3 sphingomyelin phosphodiesterase 3, neutral 0.022
Nog noggin 0.021
Insm1 insulinoma-associated 1 0.021
Cyld cylindromatosis (turban tumor syndrome) 0.021
Fgf8 fibroblast growth factor 8 0.020
Nos3 nitric oxide synthase 3, endothelial cell 0.020
Inpp5d inositol polyphosphate-5-phosphatase D 0.020
Prkar1a protein kinase, cAMP dependent regulatory, type I, alpha 0.019
Chd7 chromodomain helicase DNA binding protein 7 0.019
Tsc1 tuberous sclerosis 1 0.018
Pax3 paired box gene 3 0.018
Ifng interferon gamma 0.017
Fgfr3 fibroblast growth factor receptor 3 0.017
Tsc2 tuberous sclerosis 2 0.017
Rag1 recombination activating gene 1 0.017
Gsc goosecoid homeobox 0.017
Sh2b1 SH2B adaptor protein 1 0.017
Stat5b signal transducer and activator of transcription 5B 0.017
Ptch1 patched homolog 1 0.017
Socs2 suppressor of cytokine signaling 2 0.017
Gdnf glial cell line derived neurotrophic factor 0.017
Ptprb protein tyrosine phosphatase, receptor type, B 0.016
Adam17 a disintegrin and metallopeptidase domain 17 0.016
Csf1 colony stimulating factor 1 (macrophage) 0.016
Cbl Casitas B-lineage lymphoma 0.015
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.015
Nlrp3 NLR family, pyrin domain containing 3 0.014
Il1r1 interleukin 1 receptor, type I 0.014
Ldb2 LIM domain binding 2 0.014
Foxh1 forkhead box H1 0.014
Vegfc vascular endothelial growth factor C 0.014
Ednrb endothelin receptor type B 0.014
Foxn1 forkhead box N1 0.013
Nodal nodal 0.013
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.013
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.013
Acvr1 activin A receptor, type 1 0.013
Flt1 FMS-like tyrosine kinase 1 0.012
Sox17 SRY-box containing gene 17 0.011
Fyn Fyn proto-oncogene 0.011
Wt1 Wilms tumor 1 homolog 0.011
Cd44 CD44 antigen 0.011
Hesx1 homeobox gene expressed in ES cells 0.011
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Rattus norvegicus
Name Description Probability Func Analog Organism
Rps26 ribosomal protein S26 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism