The network for 'regulation of striated muscle cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of striated muscle cell differentiation

Any process that modulates the frequency, rate or extent of striated muscle cell differentiation.

Mus musculus
Name Description Probability Func Analog Organism
Pitx2 paired-like homeodomain transcription factor 2 0.996
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.971
Pax3 paired box gene 3 0.970
Mef2d myocyte enhancer factor 2D 0.954
Vegfa vascular endothelial growth factor A 0.950
Jarid2 jumonji, AT rich interactive domain 2 0.903
Bcl2 B-cell leukemia/lymphoma 2 0.897
Ifng interferon gamma 0.887
Rarg retinoic acid receptor, gamma 0.873
Tcfap2a transcription factor AP-2, alpha 0.832
Hand2 heart and neural crest derivatives expressed transcript 2 0.824
Shh sonic hedgehog 0.816
Prrx1 paired related homeobox 1 0.804
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.787
Tbx3 T-box 3 0.784
Meox2 mesenchyme homeobox 2 0.779
Foxc2 forkhead box C2 0.779
Pitx1 paired-like homeodomain transcription factor 1 0.770
Pten phosphatase and tensin homolog 0.759
Fgfr2 fibroblast growth factor receptor 2 0.758
Tbx5 T-box 5 0.715
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.711
Tcf21 transcription factor 21 0.678
Gata4 GATA binding protein 4 0.674
Sox2 SRY-box containing gene 2 0.652
Sox4 SRY-box containing gene 4 0.626
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.617
Tbx1 T-box 1 0.606
Nog noggin 0.581
Bmp4 bone morphogenetic protein 4 0.579
Bax BCL2-associated X protein 0.574
Ikzf1 IKAROS family zinc finger 1 0.564
Psen1 presenilin 1 0.562
Ccl2 chemokine (C-C motif) ligand 2 0.539
Hes1 hairy and enhancer of split 1 (Drosophila) 0.535
Gja1 gap junction protein, alpha 1 0.534
Dll4 delta-like 4 (Drosophila) 0.524
Rxra retinoid X receptor alpha 0.515
Trp53 transformation related protein 53 0.508
Gli3 GLI-Kruppel family member GLI3 0.506
Foxc1 forkhead box C1 0.499
Nrp1 neuropilin 1 0.498
Hand1 heart and neural crest derivatives expressed transcript 1 0.497
Smad6 MAD homolog 6 (Drosophila) 0.493
Socs1 suppressor of cytokine signaling 1 0.493
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.491
Gata6 GATA binding protein 6 0.488
Tnf tumor necrosis factor 0.465
Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) 0.455
Zeb1 zinc finger E-box binding homeobox 1 0.446
Rag1 recombination activating gene 1 0.442
Nfatc2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.440
Hoxa1 homeobox A1 0.432
Acvr1 activin A receptor, type 1 0.431
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.425
Otx2 orthodenticle homolog 2 (Drosophila) 0.421
Chrd chordin 0.416
Ephb2 Eph receptor B2 0.412
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.402
Id3 inhibitor of DNA binding 3 0.401
Ccl12 chemokine (C-C motif) ligand 12 0.396
Cxcl1 chemokine (C-X-C motif) ligand 1 0.385
Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 0.383
Myod1 myogenic differentiation 1 0.381
Mapk14 mitogen-activated protein kinase 14 0.381
Nos2 nitric oxide synthase 2, inducible 0.365
Fgf8 fibroblast growth factor 8 0.365
Il4 interleukin 4 0.363
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.361
Tcf3 transcription factor 3 0.358
Id1 inhibitor of DNA binding 1 0.353
Hoxa3 homeobox A3 0.352
Wt1 Wilms tumor 1 homolog 0.348
Nfatc4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 0.340
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.332
Foxg1 forkhead box G1 0.332
Pbx1 pre B-cell leukemia transcription factor 1 0.327
Nodal nodal 0.325
Lif leukemia inhibitory factor 0.325
Irx5 Iroquois related homeobox 5 (Drosophila) 0.322
Ednra endothelin receptor type A 0.310
Cd40 CD40 antigen 0.307
Sox7 SRY-box containing gene 7 0.306
Cxcl2 chemokine (C-X-C motif) ligand 2 0.303
Prrx2 paired related homeobox 2 0.302
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.298
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.295
Cxcl13 chemokine (C-X-C motif) ligand 13 0.292
Csf1 colony stimulating factor 1 (macrophage) 0.287
Sox11 SRY-box containing gene 11 0.282
Foxf1a forkhead box F1a 0.282
Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.279
Ctnnb1 catenin (cadherin associated protein), beta 1 0.278
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.275
Igh immunoglobulin heavy chain complex 0.274
Tbx2 T-box 2 0.274
Isl1 ISL1 transcription factor, LIM/homeodomain 0.273
Nf1 neurofibromatosis 1 0.272
Bmp7 bone morphogenetic protein 7 0.267
Ptrf polymerase I and transcript release factor 0.265
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
smyd1b SET and MYND domain containing 1b 0.413
myod1 myogenic differentiation 1 0.399
bmp2b bone morphogenetic protein 2b 0.261
hspb1 heat shock protein, alpha-crystallin-related, 1 0.194
ptch2 patched 2 0.187
myhz2 myosin, heavy polypeptide 2, fast muscle specific 0.142
myog myogenin 0.140
fabp11a fatty acid binding protein 11a 0.080
myf5 myogenic factor 5 0.070
mef2cb myocyte enhancer factor 2cb 0.067
tbx2b T-box 2b 0.067
sox9a SRY-box containing gene 9a 0.062
myhc4 myosin heavy chain 4 0.051
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.044
mef2d myocyte enhancer factor 2d 0.042
stac3 SH3 and cysteine rich domain 3 0.041
smyd1a SET and MYND domain containing 1a 0.037
bmp4 bone morphogenetic protein 4 0.035
wnt11r wingless-type MMTV integration site family, member 11, related 0.033
osr1 odd-skipped related 1 (Drosophila) 0.032
mef2ca myocyte enhancer factor 2ca 0.031
tgfb3 transforming growth factor, beta 3 0.028
calcrla calcitonin receptor-like a 0.027
myf6 myogenic factor 6 0.025
twist1b twist1b 0.025
ryr1b ryanodine receptor 1b (skeletal) 0.024
kdrl kinase insert domain receptor like 0.024
hoxa9a homeo box A9a 0.024
cdh2 cadherin 2, neuronal 0.023
chrna1 cholinergic receptor, nicotinic, alpha polypeptide 1 0.021
pdlim7 PDZ and LIM domain 7 0.020
epha4a eph receptor A4a 0.019
rarab retinoic acid receptor, alpha b 0.019
musk muscle, skeletal, receptor tyrosine kinase 0.019
adrb2a adrenergic receptor, beta 2a 0.018
pitx3 paired-like homeodomain transcription factor 3 0.018
tbx2a T-box gene 2a 0.018
smyhc1 slow myosin heavy chain 1 0.016
nrg2a neuregulin 2a 0.015
myhz1.1 myosin, heavy polypeptide 1.1, skeletal muscle 0.015
hsp90a.1 heat shock protein 90-alpha 1 0.015
si:ch211-173o4.2 si:ch211-173o4.2 0.015
wnt5b wingless-type MMTV integration site family, member 5b 0.015
tfe3a transcription factor binding to IGHM enhancer 3a 0.015
has2 hyaluronan synthase 2 0.015
dmrt2b doublesex and mab-3 related transcription factor 2b 0.015
rbfox1l RNA binding protein, fox-1 homolog (C. elegans) 1-like 0.014
vegfaa vascular endothelial growth factor Aa 0.014
cdh5 cadherin 5 0.014
dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.013
jam3b junctional adhesion molecule 3b 0.013
jam2a junctional adhesion molecule 2a 0.013
hoxa11a homeo box A11a 0.013
grifin galectin related inter-fiber protein 0.013
igf1rb insulin-like growth factor 1b receptor 0.013
smyd2b SET and MYND domain containing 2b 0.012
pparg peroxisome proliferator activated receptor gamma 0.012
tbx20 T-box 20 0.011
thrab thyroid hormone receptor alpha b 0.011
tpm3 tropomyosin 3 0.011
efnb2a ephrin B2a 0.011
tomm40l translocase of outer mitochondrial membrane 40 homolog, like 0.011
dusp6 dual specificity phosphatase 6 0.011
wnt9a wingless-type MMTV integration site family, member 9A 0.010
dkk1b dickkopf 1b 0.010
fsta follistatin a 0.010
gng8 guanine nucleotide binding protein (G protein), gamma 8 0.010
tpm4 tropomyosin 4 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
wg wingless 0.754
kirre kin of irre 0.531
sls sallimus 0.255
sns sticks and stones 0.095
LamC Lamin C 0.052
slou slouch 0.048
CG12558 CG12558 gene product from transcript CG12558-RA 0.047
rst roughest 0.036
kn knot 0.036
dpp decapentaplegic 0.034
Pax Paxillin 0.031
Egfr Epidermal growth factor receptor 0.030
ap apterous 0.028
Pde8 Phosphodiesterase 8 0.026
ci cubitus interruptus 0.024
eve even skipped 0.022
nau nautilus 0.022
en engrailed 0.021
CG4168 CG4168 gene product from transcript CG4168-RA 0.020
hbs hibris 0.019
rols rolling pebbles 0.018
blow blown fuse 0.016
sens senseless 0.016
mew multiple edematous wings 0.016
Act57B Actin 57B 0.015
so sine oculis 0.015
Ubx Ultrabithorax 0.015
Vrp1 Verprolin 1 0.015
lbe ladybird early 0.015
pan pangolin 0.014
hth homothorax 0.014
Rac1 CG2248 gene product from transcript CG2248-RA 0.014
sd scalloped 0.013
CG17658 CG17658 gene product from transcript CG17658-RA 0.012
myoglianin CG1838 gene product from transcript CG1838-RD 0.012
Fas2 Fasciclin 2 0.012
CG13838 CG13838 gene product from transcript CG13838-RA 0.011
JIL-1 CG6297 gene product from transcript CG6297-RA 0.011
CG31226 CG31226 gene product from transcript CG31226-RB 0.011
Gyc76C Guanylyl cyclase at 76C 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.999
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.998
JAG1 jagged 1 0.994
NOTCH1 notch 1 0.991
HDAC4 histone deacetylase 4 0.959
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.896
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.831
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.802
PSG9 pregnancy specific beta-1-glycoprotein 9 0.783
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.696
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 0.684
CREBBP CREB binding protein 0.604
TBX5 T-box 5 0.581
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.571
MEF2C myocyte enhancer factor 2C 0.495
LIMS1 LIM and senescent cell antigen-like domains 1 0.489
BMPR1A bone morphogenetic protein receptor, type IA 0.473
TTN titin 0.451
PSG6 pregnancy specific beta-1-glycoprotein 6 0.434
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.382
PTRF polymerase I and transcript release factor 0.368
FSTL1 follistatin-like 1 0.359
MYOD1 myogenic differentiation 1 0.349
AR androgen receptor 0.323
NCOR2 nuclear receptor corepressor 2 0.322
MEF2A myocyte enhancer factor 2A 0.315
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.309
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.286
FNBP1L formin binding protein 1-like 0.246
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.239
JUN jun proto-oncogene 0.238
EP300 E1A binding protein p300 0.226
NOTCH3 notch 3 0.224
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7 0.220
SMAD7 SMAD family member 7 0.194
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.187
ENG endoglin 0.186
ATXN1 ataxin 1 0.175
PSG5 pregnancy specific beta-1-glycoprotein 5 0.167
TP53 tumor protein p53 0.161
DCN decorin 0.154
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma 0.147
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.147
PSG4 pregnancy specific beta-1-glycoprotein 4 0.145
IGF2 insulin-like growth factor 2 (somatomedin A) 0.144
LRP6 low density lipoprotein receptor-related protein 6 0.144
DPP4 dipeptidyl-peptidase 4 0.128
CXCL11 chemokine (C-X-C motif) ligand 11 0.125
BMPR1B bone morphogenetic protein receptor, type IB 0.119
ATF3 activating transcription factor 3 0.117
NOG noggin 0.114
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.107
DLL1 delta-like 1 (Drosophila) 0.106
PRKD2 protein kinase D2 0.101
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.098
CBLB Cas-Br-M (murine) ecotropic retroviral transforming sequence b 0.097
PNRC1 proline-rich nuclear receptor coactivator 1 0.094
HDAC1 histone deacetylase 1 0.086
TGFB3 transforming growth factor, beta 3 0.085
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.084
PTK2 PTK2 protein tyrosine kinase 2 0.084
PSG1 pregnancy specific beta-1-glycoprotein 1 0.083
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.077
PDLIM7 PDZ and LIM domain 7 (enigma) 0.077
PARVA parvin, alpha 0.076
MYOG myogenin (myogenic factor 4) 0.074
KAT2B K(lysine) acetyltransferase 2B 0.069
MYL9 myosin, light chain 9, regulatory 0.068
FZD1 frizzled homolog 1 (Drosophila) 0.067
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 0.067
IL2RG interleukin 2 receptor, gamma 0.066
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.065
BCL6 B-cell CLL/lymphoma 6 0.064
ADAM12 ADAM metallopeptidase domain 12 0.063
PAX8 paired box 8 0.059
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.058
ESR1 estrogen receptor 1 0.057
ATF4 activating transcription factor 4 (tax-responsive enhancer element B67) 0.057
SMAD1 SMAD family member 1 0.056
GATA4 GATA binding protein 4 0.055
DBP D site of albumin promoter (albumin D-box) binding protein 0.053
CNOT8 CCR4-NOT transcription complex, subunit 8 0.053
NOTCH2NL notch 2 N-terminal like 0.052
INO80B INO80 complex subunit B 0.051
WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 0.048
MAML1 mastermind-like 1 (Drosophila) 0.048
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.047
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.047
BCL2L1 BCL2-like 1 0.045
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.043
IGFBP4 insulin-like growth factor binding protein 4 0.043
HNF4A hepatocyte nuclear factor 4, alpha 0.043
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.043
PPARA peroxisome proliferator-activated receptor alpha 0.042
HDAC9 histone deacetylase 9 0.040
PSG3 pregnancy specific beta-1-glycoprotein 3 0.040
NOTCH2 notch 2 0.039
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.038
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 0.038
FHL2 four and a half LIM domains 2 0.035
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism