The network for 'myotube differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

myotube differentiation

The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.

Mus musculus
Name Description Probability Func Analog Organism
Foxc1 forkhead box C1 0.994
Bcl2 B-cell leukemia/lymphoma 2 0.993
Pitx2 paired-like homeodomain transcription factor 2 0.988
Vegfa vascular endothelial growth factor A 0.988
Rarg retinoic acid receptor, gamma 0.978
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.975
Pax3 paired box gene 3 0.966
Mef2d myocyte enhancer factor 2D 0.958
Nf1 neurofibromatosis 1 0.937
Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.936
Tcfap2a transcription factor AP-2, alpha 0.930
Pitx1 paired-like homeodomain transcription factor 1 0.913
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.908
En1 engrailed 1 0.890
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.885
Actc1 actin, alpha, cardiac muscle 1 0.875
Fgf8 fibroblast growth factor 8 0.859
Gdnf glial cell line derived neurotrophic factor 0.850
Cacna1s calcium channel, voltage-dependent, L type, alpha 1S subunit 0.848
Grb10 growth factor receptor bound protein 10 0.841
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.831
Tbx1 T-box 1 0.831
Lepr leptin receptor 0.821
Fgfr2 fibroblast growth factor receptor 2 0.810
Pax2 paired box gene 2 0.801
Axl AXL receptor tyrosine kinase 0.801
Nos1 nitric oxide synthase 1, neuronal 0.798
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.793
Smo smoothened homolog (Drosophila) 0.790
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.778
Otx2 orthodenticle homolog 2 (Drosophila) 0.773
Prkce protein kinase C, epsilon 0.756
Ccl2 chemokine (C-C motif) ligand 2 0.753
Shh sonic hedgehog 0.752
Sox2 SRY-box containing gene 2 0.722
Nog noggin 0.718
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.707
Ttn titin 0.707
Ldb3 LIM domain binding 3 0.687
Eya1 eyes absent 1 homolog (Drosophila) 0.687
Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) 0.684
Hdac7 histone deacetylase 7 0.683
Nfatc4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 0.681
Igf2 insulin-like growth factor 2 0.678
Hand1 heart and neural crest derivatives expressed transcript 1 0.673
Efnb2 ephrin B2 0.657
Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 0.647
Ifng interferon gamma 0.644
Des desmin 0.644
Foxg1 forkhead box G1 0.617
Hand2 heart and neural crest derivatives expressed transcript 2 0.611
Emx2 empty spiracles homolog 2 (Drosophila) 0.607
Selp selectin, platelet 0.605
Ptk2 PTK2 protein tyrosine kinase 2 0.605
Hrc histidine rich calcium binding protein 0.602
Il10 interleukin 10 0.602
Csf1 colony stimulating factor 1 (macrophage) 0.597
Insr insulin receptor 0.584
Pax8 paired box gene 8 0.582
Ncor2 nuclear receptor co-repressor 2 0.579
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.575
Actn2 actinin alpha 2 0.572
Pax7 paired box gene 7 0.561
Wt1 Wilms tumor 1 homolog 0.556
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.551
Gab1 growth factor receptor bound protein 2-associated protein 1 0.532
Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 0.530
Ccl7 chemokine (C-C motif) ligand 7 0.530
Tbx3 T-box 3 0.525
Inpp5d inositol polyphosphate-5-phosphatase D 0.518
Isl1 ISL1 transcription factor, LIM/homeodomain 0.514
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.511
Pten phosphatase and tensin homolog 0.510
Nos3 nitric oxide synthase 3, endothelial cell 0.507
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.507
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.505
Id3 inhibitor of DNA binding 3 0.497
Hoxa1 homeobox A1 0.495
Src Rous sarcoma oncogene 0.494
Acvr1 activin A receptor, type 1 0.491
Ptgs2 prostaglandin-endoperoxide synthase 2 0.491
Ncoa1 nuclear receptor coactivator 1 0.485
Nphs2 nephrosis 2 homolog, podocin (human) 0.475
Lama5 laminin, alpha 5 0.470
Tbx2 T-box 2 0.469
Otx1 orthodenticle homolog 1 (Drosophila) 0.468
Mapk14 mitogen-activated protein kinase 14 0.465
Myl3 myosin, light polypeptide 3 0.456
Id1 inhibitor of DNA binding 1 0.453
Rxra retinoid X receptor alpha 0.453
Socs1 suppressor of cytokine signaling 1 0.452
Lhx1 LIM homeobox protein 1 0.450
Hspb2 heat shock protein 2 0.448
Ccr1 chemokine (C-C motif) receptor 1 0.444
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.444
Esr1 estrogen receptor 1 (alpha) 0.441
Ncoa2 nuclear receptor coactivator 2 0.434
Foxc2 forkhead box C2 0.433
Atp2a1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 0.431
Tbx5 T-box 5 0.431
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
cdh2 cadherin 2, neuronal 0.936
myog myogenin 0.835
myhz2 myosin, heavy polypeptide 2, fast muscle specific 0.826
mylz2 myosin, light polypeptide 2, skeletal muscle 0.788
myod1 myogenic differentiation 1 0.775
myf5 myogenic factor 5 0.765
mbnl2 muscleblind-like 2 (Drosophila) 0.733
bmp2b bone morphogenetic protein 2b 0.692
ryr1b ryanodine receptor 1b (skeletal) 0.679
mef2d myocyte enhancer factor 2d 0.668
ptch2 patched 2 0.662
actn2 actinin, alpha 2 0.649
six1b sine oculis homeobox homolog 1b 0.619
robo3 roundabout homolog 3 0.597
ptch1 patched 1 0.556
gli1 GLI-Kruppel family member 1 0.543
lgals9l1 lectin, galactoside-binding, soluble, 9 (galectin 9)-like 1 0.529
ambra1 autophagy/beclin-1 regulator 1 0.511
sox9a SRY-box containing gene 9a 0.508
gapdh glyceraldehyde-3-phosphate dehydrogenase 0.486
tnni1al troponin I, skeletal, slow like 0.481
smyhc2 slow myosin heavy chain 2 0.475
actn3a actinin alpha 3a 0.438
gdf6b growth differentiation factor 6b 0.437
wt1b wilms tumor 1b 0.407
xirp1 xin actin-binding repeat containing 1 0.406
kirrel3l kin of IRRE like 3 like 0.391
tbx18 T-box 18 0.351
ckma creatine kinase, muscle a 0.348
pitx3 paired-like homeodomain transcription factor 3 0.347
sox9b SRY-box containing gene 9b 0.338
got2b glutamic-oxaloacetic transaminase 2b, mitochondrial (aspartate aminotransferase 2) 0.333
stac3 SH3 and cysteine rich domain 3 0.310
akt2 v-akt murine thymoma viral oncogene homolog 2 0.302
wnt10a wingless-type MMTV integration site family, member 10a 0.302
col2a1a collagen type II, alpha-1a 0.300
vmhc ventricular myosin heavy chain 0.297
sgcd sarcoglycan, delta (dystrophin-associated glycoprotein) 0.293
rerea arginine-glutamic acid dipeptide (RE) repeats a 0.266
smyd1b SET and MYND domain containing 1b 0.266
jam2a junctional adhesion molecule 2a 0.260
spata2 spermatogenesis associated 2 0.251
tcf12 transcription factor 12 0.247
igf1rb insulin-like growth factor 1b receptor 0.239
rx3 retinal homeobox gene 3 0.235
unc45b unc-45 homolog B (C. elegans) 0.233
lama2 laminin, alpha 2 0.232
mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.222
lgi1b leucine-rich, glioma inactivated 1b 0.221
tbx1 T-box 1 0.219
dcc deleted in colorectal carcinoma 0.218
dkk1b dickkopf 1b 0.211
atp1a2a ATPase, Na+/K+ transporting, alpha 2a polypeptide 0.210
smyd1a SET and MYND domain containing 1a 0.209
zgc:92715 zgc:92715 0.203
tbx24 T-box 24 0.202
dmd dystrophin 0.199
myf6 myogenic factor 6 0.193
runx2b runt-related transcription factor 2b 0.187
efnb2a ephrin B2a 0.187
ldb3a LIM-domain binding factor 3a 0.186
tbx20 T-box 20 0.176
antxr1 anthrax toxin receptor 1 0.172
srf serum response factor 0.168
mtm1 myotubularin 1 0.167
apobec2a apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2a 0.166
rad21 RAD21 homolog (S. pombe) 0.164
sema3aa semaphorin 3aa 0.163
hoxa13b homeo box A13b 0.163
scinla scinderin like a 0.158
hoxa11a homeo box A11a 0.157
smad1 MAD homolog 1 (Drosophila) 0.156
ryr1a ryanodine receptor 1a (skeletal) 0.153
lbx2 ladybird homeobox homolog 2 (Drosophila) 0.150
pdlim7 PDZ and LIM domain 7 0.148
vasp vasodilator-stimulated phosphoprotein 0.146
tpm3 tropomyosin 3 0.145
dock5 dedicator of cytokinesis 5 0.140
fgf10a fibroblast growth factor 10a 0.140
tp73 tumor protein p73 0.139
pcdh8 protocadherin 8 0.138
desma desmin a 0.136
hgfa hepatocyte growth factor a 0.135
gmfg glia maturation factor, gamma 0.134
robo2 roundabout homolog 2 0.130
cdh1 cadherin 1, epithelial 0.130
zgc:66326 zgc:66326 0.124
jam3b junctional adhesion molecule 3b 0.123
pitx2 paired-like homeodomain transcription factor 2 0.123
p2rx3a purinergic receptor P2X, ligand-gated ion channel, 3a 0.122
adipor1b adiponectin receptor 1b 0.120
ptprf protein tyrosine phosphatase, receptor type, F 0.119
pbx1a pre-B-cell leukemia transcription factor 1a 0.118
cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit 0.117
ryr3 ryanodine receptor 3 0.115
lum lumican 0.115
twist1a twist1a 0.114
pth2 parathyroid hormone 2 0.114
mnx1 motor neuron and pancreas homeobox 1 0.114
vgll2b vestigial like 2b 0.112
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Vrp1 Verprolin 1 0.996
InR Insulin-like receptor 0.979
Pax Paxillin 0.977
rols rolling pebbles 0.959
hbs hibris 0.956
Mp20 Muscle protein 20 0.956
mbc myoblast city 0.954
S6k RPS6-p70-protein kinase 0.951
sns sticks and stones 0.950
Rac2 CG8556 gene product from transcript CG8556-RA 0.944
wg wingless 0.934
Arp66B Actin-related protein 66B 0.932
blow blown fuse 0.924
Pglym78 Phosphoglyceromutase 0.918
pfk piefke 0.914
sls sallimus 0.855
foxo forkhead box, sub-group O 0.836
pan pangolin 0.835
rst roughest 0.804
Thor CG8846 gene product from transcript CG8846-RA 0.796
Tm2 Tropomyosin 2 0.792
Act57B Actin 57B 0.706
siz schizo 0.663
CanB2 Calcineurin B2 0.647
egh egghead 0.606
LamC Lamin C 0.587
kirre kin of irre 0.579
PyK Pyruvate kinase 0.551
slou slouch 0.550
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.538
ptc patched 0.530
Tpi Triose phosphate isomerase 0.505
drk downstream of receptor kinase 0.488
Rya-r44F Ryanodine receptor 44F 0.442
WASp CG1520 gene product from transcript CG1520-RA 0.433
Pgk Phosphoglycerate kinase 0.405
so sine oculis 0.404
zfh1 Zn finger homeodomain 1 0.380
eve even skipped 0.375
nej nejire 0.375
p120ctn Adherens junction protein p120 0.374
Mlp84B Muscle LIM protein at 84B 0.374
myoglianin CG1838 gene product from transcript CG1838-RD 0.359
Rala Ras-related protein 0.339
stck steamer duck 0.322
pnt pointed 0.314
nau nautilus 0.310
HLH54F CG5005 gene product from transcript CG5005-RA 0.293
hth homothorax 0.289
Mef2 Myocyte enhancer factor 2 0.275
arm armadillo 0.266
CG9090 CG9090 gene product from transcript CG9090-RA 0.260
pcs parcas 0.257
Nrg Neuroglian 0.238
ara araucan 0.236
G-oalpha47A G protein oalpha 47A 0.235
CG5177 CG5177 gene product from transcript CG5177-RA 0.233
Pp2B-14D Protein phosphatase 2B at 14D 0.228
babo baboon 0.228
lbe ladybird early 0.217
Hem HEM-protein 0.216
bin biniou 0.210
CaMKII Calcium/calmodulin-dependent protein kinase II 0.205
ttk tramtrack 0.198
mib2 mind bomb 2 0.192
htl heartless 0.166
bib big brain 0.165
Antp Antennapedia 0.163
Mlc1 Myosin alkali light chain 1 0.160
Poxm Pox meso 0.150
en engrailed 0.147
imd immune deficiency 0.143
Cul-3 Cullin-3 0.141
Pak3 CG14895 gene product from transcript CG14895-RA 0.139
kn knot 0.138
Sdc Syndecan 0.138
Argk Arginine kinase 0.137
norpA no receptor potential A 0.137
Ric Ras which interacts with Calmodulin 0.136
kon kon-tiki 0.134
lmd lame duck 0.134
Mf Myofilin 0.131
CG7998 CG7998 gene product from transcript CG7998-RA 0.131
pb proboscipedia 0.122
Ras85D Ras oncogene at 85D 0.119
Rho1 CG8416 gene product from transcript CG8416-RB 0.118
gro groucho 0.115
Abi Abelson interacting protein 0.115
Arf51F ADP ribosylation factor 51F 0.110
alpha-Adaptin CG4260 gene product from transcript CG4260-RA 0.107
inv invected 0.106
sim single-minded 0.105
dac dachshund 0.104
Cdc42 CG12530 gene product from transcript CG12530-RA 0.103
cno canoe 0.101
GLaz Glial Lazarillo 0.099
shn schnurri 0.097
Dad Daughters against dpp 0.093
Mad Mothers against dpp 0.093
p38b CG7393 gene product from transcript CG7393-RA 0.092
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Homo sapiens
Name Description Probability Func Analog Organism
EGFR epidermal growth factor receptor 0.994
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.992
GRB2 growth factor receptor-bound protein 2 0.983
HDAC4 histone deacetylase 4 0.755
IQGAP1 IQ motif containing GTPase activating protein 1 0.608
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.604
NOTCH1 notch 1 0.551
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.550
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.386
JAG1 jagged 1 0.362
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.334
AR androgen receptor 0.301
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.297
CAV1 caveolin 1, caveolae protein, 22kDa 0.294
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.242
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.240
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.221
PSG9 pregnancy specific beta-1-glycoprotein 9 0.210
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.197
NCK1 NCK adaptor protein 1 0.192
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.184
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.157
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.157
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.149
NCOR2 nuclear receptor corepressor 2 0.149
TTN titin 0.146
ATXN1 ataxin 1 0.140
DOCK1 dedicator of cytokinesis 1 0.130
ESR1 estrogen receptor 1 0.117
TBX5 T-box 5 0.117
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.117
MEF2C myocyte enhancer factor 2C 0.117
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.116
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.108
KAT2B K(lysine) acetyltransferase 2B 0.092
CREBBP CREB binding protein 0.090
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.086
PTK2 PTK2 protein tyrosine kinase 2 0.085
FSTL1 follistatin-like 1 0.074
BMPR1A bone morphogenetic protein receptor, type IA 0.074
IGF2R insulin-like growth factor 2 receptor 0.073
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.064
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.064
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.063
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 0.060
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.059
ITSN1 intersectin 1 (SH3 domain protein) 0.059
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.058
MET met proto-oncogene (hepatocyte growth factor receptor) 0.057
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.056
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 0.055
NCOR1 nuclear receptor corepressor 1 0.053
PTRF polymerase I and transcript release factor 0.053
IRS1 insulin receptor substrate 1 0.049
ALDOA aldolase A, fructose-bisphosphate 0.047
LDHA lactate dehydrogenase A 0.046
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.042
SH3BP2 SH3-domain binding protein 2 0.040
LAT linker for activation of T cells 0.039
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.037
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.037
RABEP1 rabaptin, RAB GTPase binding effector protein 1 0.037
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.036
PSG6 pregnancy specific beta-1-glycoprotein 6 0.036
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa 0.036
TRIM63 tripartite motif containing 63 0.036
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.035
WIPF1 WAS/WASL interacting protein family, member 1 0.035
LTA lymphotoxin alpha (TNF superfamily, member 1) 0.035
PRKD2 protein kinase D2 0.034
JUN jun proto-oncogene 0.034
FLNA filamin A, alpha 0.034
MYL9 myosin, light chain 9, regulatory 0.034
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.034
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.033
BCL6 B-cell CLL/lymphoma 6 0.033
PSG4 pregnancy specific beta-1-glycoprotein 4 0.033
IGF1R insulin-like growth factor 1 receptor 0.033
IGF2 insulin-like growth factor 2 (somatomedin A) 0.032
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.032
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.032
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.032
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.032
ATF3 activating transcription factor 3 0.031
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.031
UTRN utrophin 0.031
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.031
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.030
VAV1 vav 1 guanine nucleotide exchange factor 0.030
DTNA dystrobrevin, alpha 0.030
SMAD3 SMAD family member 3 0.029
GAB1 GRB2-associated binding protein 1 0.029
SYNRG synergin, gamma 0.029
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.028
SMAD1 SMAD family member 1 0.028
TESK1 testis-specific kinase 1 0.028
FYN FYN oncogene related to SRC, FGR, YES 0.027
ELMO1 engulfment and cell motility 1 0.027
FBLN1 fibulin 1 0.027
JUND jun D proto-oncogene 0.026
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Rattus norvegicus
Name Description Probability Func Analog Organism
Actc1 actin, alpha, cardiac muscle 1 0.013
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism