The network for 'response to ph' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to ph

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution.

Mus musculus
Name Description Probability Func Analog Organism
Grb10 growth factor receptor bound protein 10 0.405
Thra thyroid hormone receptor alpha 0.356
Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 0.209
Cldn16 claudin 16 0.209
Kl klotho 0.202
Cav1 caveolin 1, caveolae protein 0.190
Igf2 insulin-like growth factor 2 0.175
Igf2r insulin-like growth factor 2 receptor 0.153
Gab1 growth factor receptor bound protein 2-associated protein 1 0.151
Pkd1 polycystic kidney disease 1 homolog 0.132
Cys1 cystin 1 0.125
Ostm1 osteopetrosis associated transmembrane protein 1 0.121
Duox2 dual oxidase 2 0.107
Pax8 paired box gene 8 0.098
Pcp2 Purkinje cell protein 2 (L7) 0.092
Tshr thyroid stimulating hormone receptor 0.087
Thrb thyroid hormone receptor beta 0.082
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.081
Shc3 src homology 2 domain-containing transforming protein C3 0.074
Atp6v1b2 ATPase, H+ transporting, lysosomal V1 subunit B2 0.073
Adam9 a disintegrin and metallopeptidase domain 9 (meltrin gamma) 0.068
Bicc1 bicaudal C homolog 1 (Drosophila) 0.067
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.066
Ghr growth hormone receptor 0.065
Pparg peroxisome proliferator activated receptor gamma 0.061
Vdr vitamin D receptor 0.059
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.058
Mb myoglobin 0.054
Prkce protein kinase C, epsilon 0.050
Tgfb1 transforming growth factor, beta 1 0.049
Pkd2 polycystic kidney disease 2 0.047
Tjp1 tight junction protein 1 0.046
Slc4a4 solute carrier family 4 (anion exchanger), member 4 0.041
Pten phosphatase and tensin homolog 0.036
Meox2 mesenchyme homeobox 2 0.035
Cbl Casitas B-lineage lymphoma 0.035
Igf1r insulin-like growth factor I receptor 0.034
Adora3 adenosine A3 receptor 0.033
Pxn paxillin 0.033
Fgfr1 fibroblast growth factor receptor 1 0.033
Mks1 Meckel syndrome, type 1 0.032
Kcna1 potassium voltage-gated channel, shaker-related subfamily, member 1 0.032
Neurog3 neurogenin 3 0.032
Akt1 thymoma viral proto-oncogene 1 0.032
Sstr3 somatostatin receptor 3 0.030
Psap prosaposin 0.029
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.029
Insr insulin receptor 0.028
Ar androgen receptor 0.028
Ins2 insulin II 0.028
Hif1a hypoxia inducible factor 1, alpha subunit 0.027
Atp6v1h ATPase, H+ transporting, lysosomal V1 subunit H 0.027
Ppard peroxisome proliferator activator receptor delta 0.026
Srcin1 SRC kinase signaling inhibitor 1 0.025
Ski ski sarcoma viral oncogene homolog (avian) 0.025
Htr3a 5-hydroxytryptamine (serotonin) receptor 3A 0.025
Cacna1d calcium channel, voltage-dependent, L type, alpha 1D subunit 0.024
Atp2b1 ATPase, Ca++ transporting, plasma membrane 1 0.023
Notch2 Notch gene homolog 2 (Drosophila) 0.023
Mpl myeloproliferative leukemia virus oncogene 0.022
Sh3gl2 SH3-domain GRB2-like 2 0.022
Sik3 SIK family kinase 3 0.022
Mapk14 mitogen-activated protein kinase 14 0.021
Il6st interleukin 6 signal transducer 0.020
Agap2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 0.020
Grb2 growth factor receptor bound protein 2 0.019
Runx2 runt related transcription factor 2 0.018
Ryr2 ryanodine receptor 2, cardiac 0.018
Slc2a5 solute carrier family 2 (facilitated glucose transporter), member 5 0.018
Invs inversin 0.018
Tpo thyroid peroxidase 0.018
Ncoa3 nuclear receptor coactivator 3 0.017
Aatk apoptosis-associated tyrosine kinase 0.017
Irs2 insulin receptor substrate 2 0.017
Hrh2 histamine receptor H2 0.017
Stat3 signal transducer and activator of transcription 3 0.016
Kcnh1 potassium voltage-gated channel, subfamily H (eag-related), member 1 0.016
Drd2 dopamine receptor D2 0.016
Nek8 NIMA (never in mitosis gene a)-related expressed kinase 8 0.016
Bmpr2 bone morphogenic protein receptor, type II (serine/threonine kinase) 0.016
Gab2 growth factor receptor bound protein 2-associated protein 2 0.016
Nos1 nitric oxide synthase 1, neuronal 0.015
Megf8 multiple EGF-like-domains 8 0.015
Scpep1 serine carboxypeptidase 1 0.015
Pomc pro-opiomelanocortin-alpha 0.015
Upk3a uroplakin 3A 0.015
Mdm2 transformed mouse 3T3 cell double minute 2 0.015
Sh3gl1 SH3-domain GRB2-like 1 0.014
Bcl2 B-cell leukemia/lymphoma 2 0.014
Rps6ka4 ribosomal protein S6 kinase, polypeptide 4 0.014
Sla src-like adaptor 0.014
Cd2ap CD2-associated protein 0.014
Mypop Myb-related transcription factor, partner of profilin 0.014
Atp6v1c1 ATPase, H+ transporting, lysosomal V1 subunit C1 0.014
Dctn1 dynactin 1 0.014
Arrb1 arrestin, beta 1 0.014
Pkhd1 polycystic kidney and hepatic disease 1 0.014
Ina internexin neuronal intermediate filament protein, alpha 0.014
Cuzd1 CUB and zona pellucida-like domains 1 0.014
Gpr132 G protein-coupled receptor 132 0.014
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
ca15a carbonic anhydrase XV a 0.392
ca2 carbonic anhydrase II 0.271
sgk1 serum/glucocorticoid regulated kinase 1 0.094
ctsc cathepsin C 0.041
slc4a1b solute carrier family 4, anion exchanger, member 1b 0.035
atp6v1h ATPase, H+ transporting, lysosomal, V1 subunit H 0.026
rhcgb Rhesus blood group, C glycoprotein b 0.024
slc12a10.2 solute carrier family 12 (sodium/potassium/chloride transporters), member 10.2 0.021
cyp3c1 cytochrome P450, family 3, subfamily c, polypeptide 1 0.019
jak1 Janus kinase 1 0.019
sb:cb247 sb:cb247 0.019
igfbp1a insulin-like growth factor binding protein 1a 0.019
trpv6 transient receptor potential cation channel, subfamily V, member 6 0.019
igfbp1b insulin-like growth factor binding protein 1b 0.016
ctsz cathepsin Z 0.015
cldn7b claudin 7b 0.014
pglyrp6 peptidoglycan recognition protein 6 0.013
atp6v1al ATPase, H+ transporting, lysosomal V1 subunit A, like 0.013
fundc1 FUN14 domain containing 1 0.013
lamp2 lysosomal membrane glycoprotein 2 0.012
fuca2 fucosidase, alpha-L- 2, plasma 0.012
spns1 spinster homolog 1 (Drosophila) 0.011
cyp1a cytochrome P450, family 1, subfamily A 0.011
aqp7 aquaporin 7 0.011
zgc:77775 zgc:77775 0.010
cdkn1a cyclin-dependent kinase inhibitor 1A 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
EGFR epidermal growth factor receptor 0.911
IGF1R insulin-like growth factor 1 receptor 0.851
INSR insulin receptor 0.421
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.399
IRS1 insulin receptor substrate 1 0.345
BCAR1 breast cancer anti-estrogen resistance 1 0.217
GRB10 growth factor receptor-bound protein 10 0.203
GRB2 growth factor receptor-bound protein 2 0.124
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.124
RAB11A RAB11A, member RAS oncogene family 0.108
IRS2 insulin receptor substrate 2 0.074
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 0.061
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.055
GHR growth hormone receptor 0.053
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.051
JAK2 Janus kinase 2 0.047
STAT5B signal transducer and activator of transcription 5B 0.041
PDCD6 programmed cell death 6 0.032
EPOR erythropoietin receptor 0.030
CAV1 caveolin 1, caveolae protein, 22kDa 0.029
SRCIN1 SRC kinase signaling inhibitor 1 0.024
TSG101 tumor susceptibility gene 101 0.023
LAT linker for activation of T cells 0.022
SLC4A1 solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) 0.020
SH2B1 SH2B adaptor protein 1 0.019
PICK1 protein interacting with PRKCA 1 0.019
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.019
STAT5A signal transducer and activator of transcription 5A 0.018
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 0.017
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.016
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.015
CD2AP CD2-associated protein 0.014
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 0.013
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.012
YES1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 0.012
KCNJ11 potassium inwardly-rectifying channel, subfamily J, member 11 0.012
CTTN cortactin 0.011
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Rattus norvegicus
Name Description Probability Func Analog Organism
Fgfr2 fibroblast growth factor receptor 2 0.045
Kcnt1 potassium channel, subfamily T, member 1 0.040
Slc4a1 solute carrier family 4 (anion exchanger), member 1 0.035
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.034
RGD1562344 similar to Gm566 protein 0.030
Lim2 lens intrinsic membrane protein 2 0.027
Slc22a6 solute carrier family 22 (organic anion transporter), member 6 0.024
Sirpa signal-regulatory protein alpha 0.024
Pla2g10 phospholipase A2, group X 0.024
Cp ceruloplasmin 0.023
Ngb neuroglobin 0.023
Tmie transmembrane inner ear 0.023
Kcnj9 potassium inwardly-rectifying channel, subfamily J, member 9 0.022
Scrg1 stimulator of chondrogenesis 1 0.022
Lrp3 low density lipoprotein receptor-related protein 3 0.022
Folh1 folate hydrolase 1 0.021
Adam2 ADAM metallopeptidase domain 2 0.021
Rln1 relaxin 1 0.020
Cryaa crystallin, alpha A 0.019
Kcnj16 potassium inwardly-rectifying channel, subfamily J, member 16 0.019
Gfra1 GDNF family receptor alpha 1 0.018
Degs2 degenerative spermatocyte homolog 2, lipid desaturase (Drosophila) 0.018
Adra2c adrenergic, alpha-2C-, receptor 0.017
Serpine2 serine (or cysteine) peptidase inhibitor, clade E, member 2 0.017
Crygc crystallin, gamma C 0.017
Chp2 calcineurin B homologous protein 2 0.017
Arsb arylsulfatase B 0.017
Amph amphiphysin 0.017
Pnlip pancreatic lipase 0.016
Ocm oncomodulin 0.016
Nppc natriuretic peptide precursor C 0.016
Prlh prolactin releasing hormone 0.016
Fbp2 fructose-1,6-bisphosphatase 2 0.016
Shank1 SH3 and multiple ankyrin repeat domains 1 0.016
Icam1 intercellular adhesion molecule 1 0.016
Aqp4 aquaporin 4 0.016
Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 0.015
Kcnq2 potassium voltage-gated channel, KQT-like subfamily, member 2 0.015
Clec11a C-type lectin domain family 11, member a 0.015
Neu2 sialidase 2 (cytosolic sialidase) 0.015
Umod uromodulin 0.015
Neu3 sialidase 3 (membrane sialidase) 0.015
Phka1 phosphorylase kinase, alpha 1 0.015
Gabra5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 0.015
Ush1c Usher syndrome 1C homolog (human) 0.014
Dmd dystrophin 0.014
RGD1560871 similar to plexin 1 0.014
Ntsr2 neurotensin receptor 2 0.014
Slc6a17 solute carrier family 6 (neurotransmitter transporter), member 17 0.014
Neurl2 neuralized homolog 2 (Drosophila) 0.014
Vav1 vav 1 guanine nucleotide exchange factor 0.014
LOC360479 similar to hypothetical protein 0.014
Slc10a2 solute carrier family 10 (sodium/bile acid cotransporter family), member 2 0.013
Prg2 proteoglycan 2, bone marrow 0.013
Htr2a 5-hydroxytryptamine (serotonin) receptor 2A 0.013
Ocln occludin 0.013
Nucb1 nucleobindin 1 0.013
Crhr1 corticotropin releasing hormone receptor 1 0.013
Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 0.013
Prkca protein kinase C, alpha 0.013
Scn11a sodium channel, voltage-gated, type XI, alpha 0.013
Mobp myelin-associated oligodendrocyte basic protein 0.013
Rab3b RAB3B, member RAS oncogene family 0.013
RGD1562618 similar to RIKEN cDNA 6030419C18 gene 0.013
Tgfbr2 transforming growth factor, beta receptor II 0.013
Kcnj15 potassium inwardly-rectifying channel, subfamily J, member 15 0.013
Pim1 pim-1 oncogene 0.013
Acsbg1 acyl-CoA synthetase bubblegum family member 1 0.012
Mag myelin-associated glycoprotein 0.012
Freq frequenin homolog (Drosophila) 0.012
Hpcal1 hippocalcin-like 1 0.012
Gfap glial fibrillary acidic protein 0.012
Pcdhgc3 protocadherin gamma subfamily C, 3 0.012
Ucp3 uncoupling protein 3 (mitochondrial, proton carrier) 0.012
App amyloid beta (A4) precursor protein 0.012
Kcne3 potassium voltage-gated channel, Isk-related family, member 3 0.012
Mybph myosin binding protein H 0.012
Rasgrp1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 0.012
Padi3 peptidyl arginine deiminase, type III 0.012
Mk1 Mk1 protein 0.012
Lbp lipopolysaccharide binding protein 0.012
Pla2g2c phospholipase A2, group IIC 0.012
Cd40 CD40 molecule, TNF receptor superfamily member 5 0.011
Phkg1 phosphorylase kinase, gamma 1 0.011
Rhcg Rh family, C glycoprotein 0.011
Ecel1 endothelin converting enzyme-like 1 0.011
RT1-M4 RT1 class Ib, locus M4 0.011
Ereg epiregulin 0.011
Agtr2 angiotensin II receptor, type 2 0.011
C3 complement component 3 0.011
Msx2 msh homeobox 2 0.011
Gja1 gap junction protein, alpha 1 0.011
Spta1 spectrin, alpha, erythrocytic 1 (elliptocytosis 2) 0.011
Gm2a GM2 ganglioside activator 0.011
Ctla4 cytotoxic T-lymphocyte-associated protein 4 0.011
Glud1 glutamate dehydrogenase 1 0.011
Atp1b2 ATPase, Na+/K+ transporting, beta 2 polypeptide 0.011
Gulo gulonolactone (L-) oxidase 0.011
LOC100364212 heterogeneous nuclear ribonucleoprotein K-like 0.011
Mstn myostatin 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
ENA5 Ena5p 0.193
YOL057W hypothetical protein 0.125
ENA2 Ena2p 0.089
ZAP1 Zap1p 0.084
CRZ1 Crz1p 0.078
SLT2 Slt2p 0.078
PMR1 Pmr1p 0.072
VHS1 Vhs1p 0.071
GLN3 Gln3p 0.070
MIG2 Mig2p 0.062
SLG1 Slg1p 0.062
SPF1 Spf1p 0.060
BDH2 Bdh2p 0.054
CSR2 Csr2p 0.048
RIM13 Rim13p 0.048
VPS27 Vps27p 0.042
STE5 Ste5p 0.040
PDR12 Pdr12p 0.039
LYS5 Lys5p 0.039
HAL5 Hal5p 0.039
YEL073C hypothetical protein 0.037
URA8 Ura8p 0.037
YKR075C hypothetical protein 0.037
HXT3 Hxt3p 0.037
NCR1 Ncr1p 0.034
SAC7 Sac7p 0.033
CBK1 Cbk1p 0.032
MIG3 Mig3p 0.032
MSG5 Msg5p 0.031
BAP2 Bap2p 0.031
BEM3 Bem3p 0.031
PSK2 Psk2p 0.030
POG1 Pog1p 0.030
DFG16 Dfg16p 0.029
RHO1 Rho1p 0.029
YPL014W hypothetical protein 0.028
ROX1 Rox1p 0.026
EAR1 Ear1p 0.026
NHX1 Nhx1p 0.026
MUK1 Muk1p 0.026
MET4 Met4p 0.026
DIG1 Dig1p 0.025
LDB19 Ldb19p 0.025
DBF2 Dbf2p 0.025
MGA2 Mga2p 0.025
AKR2 Akr2p 0.025
ARR3 Arr3p 0.023
YRO2 Yro2p 0.023
YNL194C hypothetical protein 0.023
SWI5 Swi5p 0.022
GFA1 Gfa1p 0.022
ENA1 Ena1p 0.022
RIM8 Rim8p 0.022
FRT1 Frt1p 0.022
DSE3 Dse3p 0.022
MOT3 Mot3p 0.022
YMR102C hypothetical protein 0.021
SPT20 Spt20p 0.021
STB6 Stb6p 0.021
SSP1 Ssp1p 0.021
SPO1 Spo1p 0.021
DCS2 Dcs2p 0.021
MGA1 Mga1p 0.021
SIN3 Sin3p 0.020
GPD1 Gpd1p 0.020
RGS2 Rgs2p 0.020
CHA4 Cha4p 0.020
PUT1 Put1p 0.020
AFI1 Afi1p 0.019
MBR1 Mbr1p 0.019
CAR2 Car2p 0.019
MHP1 Mhp1p 0.019
VAC7 Vac7p 0.019
TYE7 Tye7p 0.018
SFL1 Sfl1p 0.018
PHO12 Pho12p 0.018
YPR157W hypothetical protein 0.018
CTK3 Ctk3p 0.018
RPI1 Rpi1p 0.017
YOL036W hypothetical protein 0.017
STE13 Ste13p 0.017
TOK1 Tok1p 0.017
RIB2 Rib2p 0.017
KRE6 Kre6p 0.017
RMA1 Rma1p 0.017
PHM8 Phm8p 0.016
SWI1 Swi1p 0.016
RDS2 Rds2p 0.016
NTO1 Nto1p 0.016
YNL234W hypothetical protein 0.016
ACA1 Aca1p 0.016
RIM101 Rim101p 0.015
UBP9 Ubp9p 0.015
CUE4 Cue4p 0.015
GAT1 Gat1p 0.015
UFD2 Ufd2p 0.015
TIP1 Tip1p 0.015
STP4 Stp4p 0.015
MON2 Mon2p 0.015
GAT2 Gat2p 0.015