The network for 'glycosaminoglycan metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

glycosaminoglycan metabolic process

The chemical reactions and pathways involving glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars. Formerly known as mucopolysaccharides, they include hyaluronic acid and chondroitin, which provide lubrication in joints and form part of the matrix of cartilage. The three-dimensional structure of these molecules enables them to trap water, which forms a gel and gives glycosaminoglycans their elastic properties.

Mus musculus
Name Description Probability Func Analog Organism
Tgfb2 transforming growth factor, beta 2 0.886
Bgn biglycan 0.723
Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 0.690
Gli3 GLI-Kruppel family member GLI3 0.639
Eya1 eyes absent 1 homolog (Drosophila) 0.630
Hexa hexosaminidase A 0.396
Lum lumican 0.365
Foxc1 forkhead box C1 0.360
Egfr epidermal growth factor receptor 0.308
Hexb hexosaminidase B 0.300
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.287
Fmod fibromodulin 0.273
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.217
H2-Aa histocompatibility 2, class II antigen A, alpha 0.195
Pthlh parathyroid hormone-like peptide 0.185
Dcn decorin 0.162
Meox2 mesenchyme homeobox 2 0.138
Nos3 nitric oxide synthase 3, endothelial cell 0.102
Vdr vitamin D receptor 0.095
Lyz2 lysozyme 2 0.092
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.087
Rxra retinoid X receptor alpha 0.085
Myd88 myeloid differentiation primary response gene 88 0.083
Lmx1b LIM homeobox transcription factor 1 beta 0.082
Lepr leptin receptor 0.079
Nkx2-1 NK2 homeobox 1 0.078
Islr immunoglobulin superfamily containing leucine-rich repeat 0.077
H2-Ab1 histocompatibility 2, class II antigen A, beta 1 0.074
Tgfa transforming growth factor alpha 0.070
Adam17 a disintegrin and metallopeptidase domain 17 0.069
Grn granulin 0.067
Amhr2 anti-Mullerian hormone type 2 receptor 0.065
Otx2 orthodenticle homolog 2 (Drosophila) 0.065
Pitx2 paired-like homeodomain transcription factor 2 0.064
Nog noggin 0.063
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.061
Pax8 paired box gene 8 0.057
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.057
Foxh1 forkhead box H1 0.056
Bmp4 bone morphogenetic protein 4 0.055
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.054
Foxf2 forkhead box F2 0.052
Cel carboxyl ester lipase 0.052
Csf1 colony stimulating factor 1 (macrophage) 0.050
Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 0.049
Gbx2 gastrulation brain homeobox 2 0.049
Pten phosphatase and tensin homolog 0.048
Postn periostin, osteoblast specific factor 0.048
1700080E11Rik RIKEN cDNA 1700080E11 gene 0.047
Col1a2 collagen, type I, alpha 2 0.047
Ghr growth hormone receptor 0.046
Ctrb1 chymotrypsinogen B1 0.046
Serping1 serine (or cysteine) peptidase inhibitor, clade G, member 1 0.043
Grb10 growth factor receptor bound protein 10 0.043
Ogn osteoglycin 0.042
Tgfbr2 transforming growth factor, beta receptor II 0.042
Timp2 tissue inhibitor of metalloproteinase 2 0.042
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.041
Igf1r insulin-like growth factor I receptor 0.041
H2-DMa histocompatibility 2, class II, locus DMa 0.039
Lrp1 low density lipoprotein receptor-related protein 1 0.039
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.038
Adra2a adrenergic receptor, alpha 2a 0.038
Ins1 insulin I 0.038
Ptf1a pancreas specific transcription factor, 1a 0.037
Otx1 orthodenticle homolog 1 (Drosophila) 0.037
Agap3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 0.036
Socs1 suppressor of cytokine signaling 1 0.035
Aebp1 AE binding protein 1 0.034
Adam19 a disintegrin and metallopeptidase domain 19 (meltrin beta) 0.033
Apoe apolipoprotein E 0.033
Galnt2 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 0.033
Col8a2 collagen, type VIII, alpha 2 0.033
Mmp9 matrix metallopeptidase 9 0.032
Dpt dermatopontin 0.031
Lamp2 lysosomal-associated membrane protein 2 0.031
Colec12 collectin sub-family member 12 0.030
Impdh1 inosine 5'-phosphate dehydrogenase 1 0.030
Fgfrl1 fibroblast growth factor receptor-like 1 0.030
Reg3b regenerating islet-derived 3 beta 0.029
Abi3bp ABI gene family, member 3 (NESH) binding protein 0.029
Cdkn1c cyclin-dependent kinase inhibitor 1C (P57) 0.029
Flt4 FMS-like tyrosine kinase 4 0.028
Treml1 triggering receptor expressed on myeloid cells-like 1 0.028
Jag1 jagged 1 0.028
Cacna1f calcium channel, voltage-dependent, alpha 1F subunit 0.028
Notch2 Notch gene homolog 2 (Drosophila) 0.027
Ins2 insulin II 0.027
Slc8a2 solute carrier family 8 (sodium/calcium exchanger), member 2 0.027
Pax6 paired box gene 6 0.027
Npc1 Niemann Pick type C1 0.027
H2-Eb1 histocompatibility 2, class II antigen E beta 0.026
Pax2 paired box gene 2 0.026
Fgf8 fibroblast growth factor 8 0.026
Itm2c integral membrane protein 2C 0.026
Fgfr3 fibroblast growth factor receptor 3 0.026
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.026
Lamp1 lysosomal-associated membrane protein 1 0.025
Pkd1 polycystic kidney disease 1 homolog 0.025
Arap3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 0.025
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
sqv-8 Protein SQV-8 0.432
imp-3 Protein IMP-3 0.094
sqv-1 Protein SQV-1 0.089
F25H2.7 Protein F25H2.7 0.054
CELE_C34D4.4 Protein C34D4.4 0.047
grld-1 Protein GRLD-1 0.047
F59A3.4 Protein F59A3.4 0.046
nhr-20 Protein NHR-20 0.025
sqv-2 Protein SQV-2 0.024
pal-1 Protein PAL-1 0.022
tac-1 Protein TAC-1 0.021
C18A3.2 Protein C18A3.2 0.020
csnk-1 Protein CSNK-1 0.020
ZK652.6 Protein ZK652.6 0.019
cup-5 Protein CUP-5 0.018
F29G9.2 Protein F29G9.2 0.017
F25H2.6 Protein F25H2.6 0.016
rab-5 Protein RAB-5 0.015
unc-69 Protein UNC-69 0.015
rpn-1 Protein RPN-1 0.014
F37D6.2 Protein F37D6.2 0.014
CELE_Y52B11A.2 Protein Y52B11A.2 0.014
sec-10 Protein SEC-10 0.013
vps-54 Protein VPS-54 0.012
K02A6.2 Protein K02A6.2 0.012
rap-1 Protein RAP-1 0.010
tat-1 Protein TAT-1 0.010
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Danio rerio
Name Description Probability Func Analog Organism
sec24d SEC24 family, member D (S. cerevisiae) 0.955
zgc:158603 zgc:158603 0.724
uxs1 UDP-glucuronic acid decarboxylase 1 0.522
plcb3 phospholipase C, beta 3 (phosphatidylinositol-specific) 0.356
sulf1 sulfatase 1 0.356
slc35b2 solute carrier family 35, member B2 0.239
cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 0.174
gle1 GLE1 RNA export mediator homolog (yeast) 0.146
ext2 exostoses (multiple) 2 0.121
extl3 exostoses (multiple)-like 3 0.092
xylt1 xylosyltransferase 1 0.092
lmo4a LIM domain only 4a 0.075
col11a1a collagen, type XI, alpha 1a 0.073
LOC100000687 signal peptide, CUB and EGF-like domain-containing protein 3-like 0.068
cfl2l cofilin 2, like 0.067
ptpra protein tyrosine phosphatase, receptor type, A 0.066
sulf2l sulfatase 2, like 0.063
ecrg4a esophageal cancer related gene 4a 0.062
dlx5a distal-less homeobox gene 5a 0.055
igfbp3 insulin-like growth factor binding protein 3 0.050
matn4 matrilin 4 0.048
fam20b family with sequence similarity 20, member B (H. sapiens) 0.045
esrra estrogen-related receptor alpha 0.042
sufu suppressor of fused homolog (Drosophila) 0.042
col10a1 collagen, type X, alpha 1 0.034
rpz rapunzel 0.033
hspg2 heparan sulfate proteoglycan 2 0.031
kdr kinase insert domain receptor (a type III receptor tyrosine kinase) 0.031
prdm5 PR domain containing 5 0.029
sept6 septin 6 0.028
lhx2b LIM homeobox 2b 0.028
lox lysyl oxidase 0.025
wnt9a wingless-type MMTV integration site family, member 9A 0.024
wif1 wnt inhibitory factor 1 0.023
col12a1 collagen, type XII, alpha 1 0.023
col5a2l collagen, type V, alpha 2-like 0.022
ptprja protein tyrosine phosphatase, receptor type, J a 0.021
glcea glucuronyl C5-epimerase a 0.019
grifin galectin related inter-fiber protein 0.019
lass2 LAG1 homolog, ceramide synthase 2 (S. cerevisiae) 0.018
col1a1a collagen, type I, alpha 1a 0.018
zgc:111821 zgc:111821 0.018
sec13 SEC13 homolog (S. cerevisiae) 0.018
sb:cb1035 sb:cb1035 0.018
zgc:113210 zgc:113210 0.017
acana aggrecan a 0.017
ptprjb protein tyrosine phosphatase, receptor type, J b 0.016
msxd muscle segment homeobox D 0.016
sox9a SRY-box containing gene 9a 0.016
ugdh UDP-glucose dehydrogenase 0.016
disp1 dispatched homolog 1 (Drosophila) 0.015
col2a1a collagen type II, alpha-1a 0.014
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.013
zgc:171495 zgc:171495 0.013
ptn pleiotrophin 0.013
zgc:153063 zgc:153063 0.013
phf21a PHD finger protein 21A 0.013
actn1 actinin, alpha 1 0.013
wnt9b wingless-type MMTV integration site family, member 9B 0.013
fn1 fibronectin 1 0.013
cap1 Cap1 CAP, adenylate cyclase-associated protein 1 0.013
thbs1 thrombospondin 1 0.012
wu:fj39b01 wu:fj39b01 0.012
ldlrap1a low density lipoprotein receptor adaptor protein 1a 0.012
LOC556849 ectonucleoside triphosphate diphosphohydrolase 5-like 0.012
stab1l stabilin 1-like 0.012
olig4 oligodendrocyte transcription factor 4 0.012
spon2a spondin 2a, extracellular matrix protein 0.012
arl4ca ADP-ribosylation factor-like 4Ca 0.012
pid1 phosphotyrosine interaction domain containing 1 0.012
bmp16 bone morphogenetic protein 16 0.012
ptprk protein tyrosine phosphatase, receptor type, K 0.012
zp3 zona pellucida glycoprotein 3 0.012
ecm2 extracellular matrix protein 2, female organ and adipocyte specific 0.012
nkd1 naked cuticle homolog 1 (Drosophila) 0.011
pcsk5b proprotein convertase subtilisin/kexin type 5b 0.011
sparc secreted acidic cysteine rich glycoprotein 0.011
sox11b SRY-box containing gene 11b 0.011
pmp22a peripheral myelin protein 22a 0.011
st3gal2l ST3 beta-galactoside alpha-2,3-sialyltransferase 2, like 0.011
pold1 polymerase (DNA directed), delta 1, catalytic subunit 0.011
prdm16 PR domain containing 16 0.011
scxa scleraxis homolog A (mouse) 0.011
ihha Indian hedgehog homolog a 0.011
si:dkey-12o15.1 si:dkey-12o15.1 0.011
hs6st2 heparan sulfate 6-O-sulfotransferase 2 0.010
rab7 RAB7, member RAS oncogene family 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
ttv tout-velu 0.902
Ext2 CG8433 gene product from transcript CG8433-RA 0.730
PGRP-SA Peptidoglycan recognition protein SA 0.650
SPE Spatzle-Processing Enzyme 0.618
AttA Attacin-A 0.586
PGRP-SD CG7496 gene product from transcript CG7496-RA 0.425
por porcupine 0.424
Rel Relish 0.349
disp dispatched 0.340
AttC Attacin-C 0.267
GNBP3 Gram-negative bacteria binding protein 3 0.264
sfl sulfateless 0.258
grass Gram-positive Specific Serine protease 0.232
modSP modular serine protease 0.220
botv brother of tout-velu 0.110
GNBP1 Gram-negative bacteria binding protein 1 0.087
PGRP-SC1b CG8577 gene product from transcript CG8577-RA 0.081
IM1 Immune induced molecule 1 0.076
jing CG9397 gene product from transcript CG9397-RI 0.072
Gsc Goosecoid 0.057
Sp7 Serine protease 7 0.055
PGRP-SC1a CG14746 gene product from transcript CG14746-RA 0.051
CG42863 CG42863 gene product from transcript CG42863-RB 0.049
pirk poor Imd response upon knock-in 0.045
arr arrow 0.036
PGRP-LB Peptidoglycan recognition protein LB 0.034
CG9184 CG9184 gene product from transcript CG9184-RB 0.033
Bre1 CG10542 gene product from transcript CG10542-RA 0.032
Hs6st Heparan sulfate 6-O-sulfotransferase 0.031
Pvr PDGF- and VEGF-receptor related 0.027
rasp CG11495 gene product from transcript CG11495-RA 0.026
nct nicastrin 0.025
Duox Dual oxidase 0.024
eater CG6124 gene product from transcript CG6124-RB 0.022
CG15917 CG15917 gene product from transcript CG15917-RA 0.022
Spn1 Serine protease inhibitor 1 0.021
Spn27A Serpin 27A 0.021
fon fondue 0.018
imd immune deficiency 0.017
Krn Keren 0.017
Drs Drosomycin 0.016
CG5390 CG5390 gene product from transcript CG5390-RA 0.016
Irc Immune-regulated catalase 0.015
upd2 unpaired 2 0.015
Cat Catalase 0.015
psh persephone 0.014
EloA Elongin A 0.014
Reg-5 Rhythmically expressed gene 5 0.013
PGRP-LF Peptidoglycan recognition protein LF 0.013
CG5880 CG5880 gene product from transcript CG5880-RA 0.013
heix heixuedian 0.013
bbg big bang 0.013
cbs centrosomin's beautiful sister 0.013
CG18594 CG18594 gene product from transcript CG18594-RA 0.012
Gadd45 CG11086 gene product from transcript CG11086-RA 0.011
Dredd Death related ced-3/Nedd2-like protein 0.011
CG3505 CG3505 gene product from transcript CG3505-RA 0.011
CG9870 CG9870 gene product from transcript CG9870-RA 0.010
TepIII Thiolester containing protein III 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.923
FGFR2 fibroblast growth factor receptor 2 0.777
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.761
TEK TEK tyrosine kinase, endothelial 0.634
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.579
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.575
IL1R1 interleukin 1 receptor, type I 0.542
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.479
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.396
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.365
BCL3 B-cell CLL/lymphoma 3 0.263
HIP1 huntingtin interacting protein 1 0.223
FGF1 fibroblast growth factor 1 (acidic) 0.215
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.179
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.162
NUMB numb homolog (Drosophila) 0.127
FGA fibrinogen alpha chain 0.123
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.106
NRP1 neuropilin 1 0.095
PLAUR plasminogen activator, urokinase receptor 0.085
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 0.081
ENG endoglin 0.073
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.066
THBS1 thrombospondin 1 0.065
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.061
COL6A1 collagen, type VI, alpha 1 0.061
FGF10 fibroblast growth factor 10 0.054
MET met proto-oncogene (hepatocyte growth factor receptor) 0.047
MSN moesin 0.044
APP amyloid beta (A4) precursor protein 0.043
IL8 interleukin 8 0.040
TOM1L1 target of myb1 (chicken)-like 1 0.039
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.039
FGF7 fibroblast growth factor 7 0.038
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.036
FGFR1 fibroblast growth factor receptor 1 0.036
EGFR epidermal growth factor receptor 0.034
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.033
CAV1 caveolin 1, caveolae protein, 22kDa 0.031
PTPRJ protein tyrosine phosphatase, receptor type, J 0.030
COL6A2 collagen, type VI, alpha 2 0.027
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.026
HSPG2 heparan sulfate proteoglycan 2 0.026
DKK1 dickkopf homolog 1 (Xenopus laevis) 0.026
TGFBR1 transforming growth factor, beta receptor 1 0.025
FGF2 fibroblast growth factor 2 (basic) 0.022
DCN decorin 0.022
COL2A1 collagen, type II, alpha 1 0.022
INHBA inhibin, beta A 0.022
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.022
OCRL oculocerebrorenal syndrome of Lowe 0.021
STC1 stanniocalcin 1 0.021
TGFB1 transforming growth factor, beta 1 0.021
COL4A2 collagen, type IV, alpha 2 0.021
ELN elastin 0.020
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) 0.020
DDR2 discoidin domain receptor tyrosine kinase 2 0.019
PLCG1 phospholipase C, gamma 1 0.019
FNDC3B fibronectin type III domain containing 3B 0.019
PLAU plasminogen activator, urokinase 0.019
IGFBP5 insulin-like growth factor binding protein 5 0.019
FSTL1 follistatin-like 1 0.019
CNTF ciliary neurotrophic factor 0.019
COL5A1 collagen, type V, alpha 1 0.018
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.018
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.018
CAPRIN2 caprin family member 2 0.018
FRS2 fibroblast growth factor receptor substrate 2 0.018
BMP1 bone morphogenetic protein 1 0.017
TGFB3 transforming growth factor, beta 3 0.017
ACSL4 acyl-CoA synthetase long-chain family member 4 0.017
ICAM1 intercellular adhesion molecule 1 0.017
MRC2 mannose receptor, C type 2 0.017
MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) 0.017
FBN1 fibrillin 1 0.016
MBL2 mannose-binding lectin (protein C) 2, soluble 0.016
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.016
TGFB2 transforming growth factor, beta 2 0.016
B3GAT3 beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I) 0.016
COL4A1 collagen, type IV, alpha 1 0.016
IL1R2 interleukin 1 receptor, type II 0.015
ZNF431 zinc finger protein 431 0.015
MAN1B1 mannosidase, alpha, class 1B, member 1 0.015
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.015
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.015
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.015
VEGFC vascular endothelial growth factor C 0.014
VEGFA vascular endothelial growth factor A 0.014
PCOLCE procollagen C-endopeptidase enhancer 0.014
LAMA2 laminin, alpha 2 0.014
CHPF chondroitin polymerizing factor 0.014
TIMP3 TIMP metallopeptidase inhibitor 3 0.013
DOCK7 dedicator of cytokinesis 7 0.013
DPT dermatopontin 0.013
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma 0.013
BMP2 bone morphogenetic protein 2 0.013
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 0.013
CTSB cathepsin B 0.013
CD81 CD81 molecule 0.013
CSPG4 chondroitin sulfate proteoglycan 4 0.013
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism