The network for 'odontogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

odontogenesis

The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food.

Mus musculus
Name Description Probability Func Analog Organism
Fgfr2 fibroblast growth factor receptor 2 1.000
Shh sonic hedgehog 1.000
Tbx3 T-box 3 0.999
Bmp4 bone morphogenetic protein 4 0.999
Pax2 paired box gene 2 0.999
Msx1 homeobox, msh-like 1 0.998
Bmp7 bone morphogenetic protein 7 0.998
Ctnnb1 catenin (cadherin associated protein), beta 1 0.997
Fgfr1 fibroblast growth factor receptor 1 0.995
Gli2 GLI-Kruppel family member GLI2 0.992
Csf1 colony stimulating factor 1 (macrophage) 0.990
Bcl2 B-cell leukemia/lymphoma 2 0.983
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.975
Prrx1 paired related homeobox 1 0.974
Pthlh parathyroid hormone-like peptide 0.971
Col1a1 collagen, type I, alpha 1 0.968
Tbx1 T-box 1 0.967
Fgf8 fibroblast growth factor 8 0.965
Pax3 paired box gene 3 0.962
Gli3 GLI-Kruppel family member GLI3 0.962
Hoxa13 homeobox A13 0.961
Wt1 Wilms tumor 1 homolog 0.957
Hoxd13 homeobox D13 0.957
Otx2 orthodenticle homolog 2 (Drosophila) 0.948
Wnt3a wingless-related MMTV integration site 3A 0.947
Msx2 homeobox, msh-like 2 0.943
Dlx5 distal-less homeobox 5 0.941
Ret ret proto-oncogene 0.931
Hoxa1 homeobox A1 0.919
Hand1 heart and neural crest derivatives expressed transcript 1 0.918
Pax9 paired box gene 9 0.917
Lef1 lymphoid enhancer binding factor 1 0.911
Vegfa vascular endothelial growth factor A 0.910
Foxc1 forkhead box C1 0.908
Pax8 paired box gene 8 0.904
Hoxd11 homeobox D11 0.899
Rarg retinoic acid receptor, gamma 0.898
Pax6 paired box gene 6 0.896
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.893
Gsc goosecoid homeobox 0.888
Trp63 transformation related protein 63 0.883
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.876
Lhx1 LIM homeobox protein 1 0.874
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.870
Foxc2 forkhead box C2 0.869
Gdnf glial cell line derived neurotrophic factor 0.864
Zic3 zinc finger protein of the cerebellum 3 0.857
Prrx2 paired related homeobox 2 0.842
Notch2 Notch gene homolog 2 (Drosophila) 0.838
Apc adenomatosis polyposis coli 0.832
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.821
Hand2 heart and neural crest derivatives expressed transcript 2 0.811
Tcf21 transcription factor 21 0.811
Pten phosphatase and tensin homolog 0.804
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.801
Eya1 eyes absent 1 homolog (Drosophila) 0.794
Runx2 runt related transcription factor 2 0.793
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.783
Bglap bone gamma carboxyglutamate protein 0.782
Nodal nodal 0.768
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.764
Hoxa11 homeobox A11 0.757
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.754
Gbx2 gastrulation brain homeobox 2 0.748
Smo smoothened homolog (Drosophila) 0.748
Alx4 aristaless-like homeobox 4 0.742
Amhr2 anti-Mullerian hormone type 2 receptor 0.742
Smad6 MAD homolog 6 (Drosophila) 0.736
Lama5 laminin, alpha 5 0.728
Ar androgen receptor 0.727
Chrd chordin 0.724
Kiss1 KiSS-1 metastasis-suppressor 0.703
Dlx2 distal-less homeobox 2 0.691
Inhba inhibin beta-A 0.688
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.685
Hoxa2 homeobox A2 0.684
Nog noggin 0.679
Fgfr3 fibroblast growth factor receptor 3 0.676
Emx2 empty spiracles homolog 2 (Drosophila) 0.674
Ikzf1 IKAROS family zinc finger 1 0.659
Ptf1a pancreas specific transcription factor, 1a 0.657
Klk1b11 kallikrein 1-related peptidase b11 0.655
Sox9 SRY-box containing gene 9 0.647
Tcfap2a transcription factor AP-2, alpha 0.639
Sox2 SRY-box containing gene 2 0.635
Smad4 MAD homolog 4 (Drosophila) 0.631
En1 engrailed 1 0.631
Zeb1 zinc finger E-box binding homeobox 1 0.623
Itga3 integrin alpha 3 0.618
T brachyury 0.618
Lep leptin 0.579
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.577
Rara retinoic acid receptor, alpha 0.571
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.561
Pou3f4 POU domain, class 3, transcription factor 4 0.555
Pbx1 pre B-cell leukemia transcription factor 1 0.555
Lrp6 low density lipoprotein receptor-related protein 6 0.552
Sp6 trans-acting transcription factor 6 0.550
Eng endoglin 0.542
Gas1 growth arrest specific 1 0.540
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
sox9a SRY-box containing gene 9a 0.923
shha sonic hedgehog a 0.879
tbx1 T-box 1 0.724
bmp2b bone morphogenetic protein 2b 0.697
boc brother of CDO 0.623
fgf8a fibroblast growth factor 8 a 0.501
chd chordin 0.405
fgf3 fibroblast growth factor 3 0.366
ptch2 patched 2 0.311
col1a2 collagen, type I, alpha 2 0.303
prkci protein kinase C, iota 0.283
fgf4 fibroblast growth factor 4 0.189
smad5 MAD homolog 5 (Drosophila) 0.180
disp1 dispatched homolog 1 (Drosophila) 0.176
pbx4 pre-B-cell leukemia transcription factor 4 0.173
gpr126 G protein-coupled receptor 126 0.169
emx3 empty spiracles homeobox 3 0.167
mib mind bomb 0.165
dlx2a distal-less homeobox gene 2a 0.162
dlx6a distal-less homeobox gene 6a 0.151
ptch1 patched 1 0.150
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.149
gdf6a growth differentiation factor 6a 0.143
dlx4a distal-less homeobox gene 4a 0.138
prdm1a PR domain containing 1a, with ZNF domain 0.114
etv5b ets variant 5b 0.107
foxi1 forkhead box I1 0.104
lhx2b LIM homeobox 2b 0.104
acvr1l activin A receptor, type I like 0.097
dlx5a distal-less homeobox gene 5a 0.087
fgfrl1b fibroblast growth factor receptor-like 1b 0.086
fgfrl1a fibroblast growth factor receptor-like 1a 0.084
jag1b jagged 1b 0.081
pax9 paired box gene 9 0.080
eya1 eyes absent homolog 1 0.075
dlx4b distal-less homeobox gene 4b 0.071
wnt5b wingless-type MMTV integration site family, member 5b 0.068
spns2 spinster homolog 2 (Drosophila) 0.067
pdgfaa platelet-derived growth factor alpha a 0.064
cdh1 cadherin 1, epithelial 0.063
arhgef7b Rho guanine nucleotide exchange factor (GEF) 7b 0.062
bmpr2b bone morphogenetic protein receptor, type II b (serine/threonine kinase) 0.061
pax2a paired box gene 2a 0.061
nkx2.3 NK2 transcription factor related 3 0.061
plcg1 phospholipase C, gamma 1 0.058
epb41l5 erythrocyte membrane protein band 4.1 like 5 0.053
ccm2 cerebral cavernous malformation 2 0.052
fras1 Fraser syndrome 1 0.050
sox10 SRY-box containing gene 10 0.048
bmp4 bone morphogenetic protein 4 0.048
twist3 twist3 0.047
sema3aa semaphorin 3aa 0.047
nkx3.2 NK3 homeobox 2 0.045
apc adenomatosis polyposis coli 0.044
acvr2a activin receptor IIa 0.044
bmp1a bone morphogenetic protein 1a 0.042
pard6gb par-6 partitioning defective 6 homolog gamma B (C. elegans) 0.041
nadl1.1 neural adhesion molecule L1.1 0.038
ndr2 nodal-related 2 0.038
lamb1a laminin, beta 1a 0.037
cdh23 cadherin-like 23 0.034
prdm5 PR domain containing 5 0.034
smo smoothened homolog (Drosophila) 0.033
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.033
extl3 exostoses (multiple)-like 3 0.031
lpl lipoprotein lipase 0.030
edn1 endothelin 1 0.029
slit2 slit (Drosophila) homolog 2 0.028
bmpr2a bone morphogenetic protein receptor, type II a (serine/threonine kinase) 0.028
dzip1 DAZ interacting protein 1 0.028
dlx2b distal-less homeobox gene 2b 0.027
slc12a2 solute carrier family 12 (potassium/chloride transporters), member 2 0.027
axin1 axin 1 0.027
postn periostin, osteoblast specific factor 0.027
hand2 heart and neural crest derivatives expressed transcript 2 0.027
fgfr1a fibroblast growth factor receptor 1a 0.025
synj1 synaptojanin 1 0.025
jag2 jagged 2 0.025
fgfr3 fibroblast growth factor receptor 3 0.024
plcb3 phospholipase C, beta 3 (phosphatidylinositol-specific) 0.024
si:dkeyp-50f5.1 si:dkeyp-50f5.1 0.024
acvr2b activin receptor IIb 0.022
bmp2a bone morphogenetic protein 2a 0.021
cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) 0.021
dkk1b dickkopf 1b 0.020
msxd muscle segment homeobox D 0.020
dspa desmoplakin a 0.020
igfbp3 insulin-like growth factor binding protein 3 0.020
ctsl1b cathepsin L, 1 b 0.020
foxg1a forkhead box G1a 0.019
hoxa13b homeo box A13b 0.019
slit3 slit (Drosophila) homolog 3 0.019
fn1 fibronectin 1 0.018
mab21l2 mab-21-like 2 0.018
cxcr4a chemokine (C-X-C motif) receptor 4a 0.018
fabp2 fatty acid binding protein 2, intestinal 0.017
runx2a runt-related transcription factor 2a 0.017
robo3 roundabout homolog 3 0.016
pea3 ETS-domain transcription factor pea3 0.016
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.015
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.000
FHL2 four and a half LIM domains 2 0.997
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.975
AR androgen receptor 0.889
COL1A1 collagen, type I, alpha 1 0.859
ENG endoglin 0.820
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.734
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.715
FN1 fibronectin 1 0.713
PXN paxillin 0.700
COL3A1 collagen, type III, alpha 1 0.699
DDR2 discoidin domain receptor tyrosine kinase 2 0.690
FSTL1 follistatin-like 1 0.660
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.603
PDIA3 protein disulfide isomerase family A, member 3 0.602
LAMB1 laminin, beta 1 0.588
COL1A2 collagen, type I, alpha 2 0.562
FLNA filamin A, alpha 0.549
COL7A1 collagen, type VII, alpha 1 0.523
BMPR1A bone morphogenetic protein receptor, type IA 0.487
ITGB4 integrin, beta 4 0.480
BMP2 bone morphogenetic protein 2 0.476
PVRL4 poliovirus receptor-related 4 0.474
MMS22L MMS22-like, DNA repair protein 0.422
PSEN1 presenilin 1 0.373
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.313
KLK10 kallikrein-related peptidase 10 0.302
MSX1 msh homeobox 1 0.270
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.265
TRIM29 tripartite motif containing 29 0.234
FGF1 fibroblast growth factor 1 (acidic) 0.211
SCHIP1 schwannomin interacting protein 1 0.207
KRT5 keratin 5 0.193
HIC1 hypermethylated in cancer 1 0.183
COL5A2 collagen, type V, alpha 2 0.178
MDFI MyoD family inhibitor 0.168
SETD8 SET domain containing (lysine methyltransferase) 8 0.159
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.150
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 0.140
BMP4 bone morphogenetic protein 4 0.137
COL2A1 collagen, type II, alpha 1 0.129
CREBBP CREB binding protein 0.126
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.122
TGFB3 transforming growth factor, beta 3 0.120
KLK7 kallikrein-related peptidase 7 0.116
NOTCH3 notch 3 0.116
CTGF connective tissue growth factor 0.113
GLIS2 GLIS family zinc finger 2 0.112
RBPMS RNA binding protein with multiple splicing 0.109
WNT11 wingless-type MMTV integration site family, member 11 0.108
MSX2 msh homeobox 2 0.107
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.105
FOXF2 forkhead box F2 0.104
TLN1 talin 1 0.104
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.103
LOX lysyl oxidase 0.102
COL6A1 collagen, type VI, alpha 1 0.101
EDAR ectodysplasin A receptor 0.101
APC adenomatous polyposis coli 0.100
PCGF1 polycomb group ring finger 1 0.098
MYO10 myosin X 0.098
FGF10 fibroblast growth factor 10 0.093
HDAC1 histone deacetylase 1 0.089
FGF18 fibroblast growth factor 18 0.088
MXRA5 matrix-remodelling associated 5 0.078
EPHB3 EPH receptor B3 0.077
BCAM basal cell adhesion molecule (Lutheran blood group) 0.075
FBLN1 fibulin 1 0.074
SNTG2 syntrophin, gamma 2 0.073
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.072
BGN biglycan 0.072
CDSN corneodesmosin 0.070
EIF2C2 eukaryotic translation initiation factor 2C, 2 0.069
GFI1B growth factor independent 1B transcription repressor 0.069
TCF4 transcription factor 4 0.069
GJB3 gap junction protein, beta 3, 31kDa 0.069
KLK5 kallikrein-related peptidase 5 0.068
BAK1 BCL2-antagonist/killer 1 0.068
RNF144B ring finger protein 144B 0.068
VCL vinculin 0.067
MMP11 matrix metallopeptidase 11 (stromelysin 3) 0.066
WNT1 wingless-type MMTV integration site family, member 1 0.065
BAX BCL2-associated X protein 0.064
GSK3B glycogen synthase kinase 3 beta 0.064
POU5F1 POU class 5 homeobox 1 0.064
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.063
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.062
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.061
FZD10 frizzled homolog 10 (Drosophila) 0.060
NCOR2 nuclear receptor corepressor 2 0.059
FGF8 fibroblast growth factor 8 (androgen-induced) 0.059
NOG noggin 0.057
IGFBP5 insulin-like growth factor binding protein 5 0.057
ADAM12 ADAM metallopeptidase domain 12 0.056
NGF nerve growth factor (beta polypeptide) 0.055
JAG1 jagged 1 0.055
TP53 tumor protein p53 0.055
COL17A1 collagen, type XVII, alpha 1 0.054
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.053
DKK1 dickkopf homolog 1 (Xenopus laevis) 0.053
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Rattus norvegicus
Name Description Probability Func Analog Organism
Col3a1 collagen, type III, alpha 1 0.930
Col1a1 collagen, type I, alpha 1 0.881
Col1a2 collagen, type I, alpha 2 0.690
Lum lumican 0.554
Postn periostin, osteoblast specific factor 0.390
Fn1 fibronectin 1 0.360
Col5a2 collagen, type V, alpha 2 0.356
Lox lysyl oxidase 0.205
Aspn asporin 0.119
Col5a1 collagen, type V, alpha 1 0.117
Dcn decorin 0.113
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.110
Ogn osteoglycin 0.097
Fbn1 fibrillin 1 0.093
Vcan versican 0.084
Mpz myelin protein zero 0.076
Aebp1 AE binding protein 1 0.064
Fgfr2 fibroblast growth factor receptor 2 0.063
Dnase1 deoxyribonuclease I 0.059
Sparc secreted protein, acidic, cysteine-rich (osteonectin) 0.058
Sema3a sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.055
Bcl2 B-cell CLL/lymphoma 2 0.048
Mmp2 matrix metallopeptidase 2 0.047
Il3 interleukin 3 0.044
Gja5 gap junction protein, alpha 5 0.044
Klk1l kallikrein 1-like peptidase 0.043
Loxl1 lysyl oxidase-like 1 0.042
Col4a5 collagen, type IV, alpha 5 0.042
Ccdc80 coiled-coil domain containing 80 0.042
Col12a1 collagen, type XII, alpha 1 0.042
Vim vimentin 0.041
Vdr vitamin D (1,25- dihydroxyvitamin D3) receptor 0.041
Plcb2 phospholipase C, beta 2 0.040
Ppy pancreatic polypeptide 0.040
Mip major intrinsic protein of lens fiber 0.040
Pgc progastricsin (pepsinogen C) 0.039
Pnliprp2 pancreatic lipase-related protein 2 0.039
Col14a1 collagen, type XIV, alpha 1 0.039
Kcns1 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1 0.038
Ddr1 discoidin domain receptor tyrosine kinase 1 0.038
Boc biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein 0.038
Nmbr neuromedin B receptor 0.038
Gja1 gap junction protein, alpha 1 0.038
Lect1 leukocyte cell derived chemotaxin 1 0.038
Unc5b unc-5 homolog B (C. elegans) 0.037
Mfap4 microfibrillar-associated protein 4 0.037
Cercam cerebral endothelial cell adhesion molecule 0.037
Colec12 collectin sub-family member 12 0.037
Id1 inhibitor of DNA binding 1 0.036
Col8a1 collagen, type VIII, alpha 1 0.036
Capn6 calpain 6 0.035
RGD1565927 similar to 4631422O05Rik protein 0.035
Col6a2 collagen, type VI, alpha 2 0.034
Adrb1 adrenergic, beta-1-, receptor 0.034
Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 0.034
Ctsk cathepsin K 0.034
Bmp6 bone morphogenetic protein 6 0.033
Plxdc2 plexin domain containing 2 0.033
Gria2 glutamate receptor, ionotropic, AMPA 2 0.033
Igfbp7 insulin-like growth factor binding protein 7 0.033
Fat2 FAT tumor suppressor homolog 2 (Drosophila) 0.032
Bgn biglycan 0.031
Col11a1 collagen, type XI, alpha 1 0.031
Amelx amelogenin X chromosome 0.030
Tnc tenascin C 0.030
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.029
Agtr2 angiotensin II receptor, type 2 0.029
Olr1641 olfactory receptor 1641 0.028
Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 0.027
Omd osteomodulin 0.027
Sdcbp syndecan binding protein 0.027
Slit3 slit homolog 3 (Drosophila) 0.027
Ndfip1 Nedd4 family interacting protein 1 0.027
Pspn persephin 0.027
Scnn1b sodium channel, nonvoltage-gated 1, beta 0.026
Ng23 Ng23 protein 0.026
Eln elastin 0.025
Alpl alkaline phosphatase, liver/bone/kidney 0.025
Lamc1 laminin, gamma 1 0.025
Lrp1 low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) 0.025
Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 0.025
Nkd1 naked cuticle homolog 1 (Drosophila) 0.025
C1r complement component 1, r subcomponent 0.024
Grk1 G protein-coupled receptor kinase 1 0.024
Rhoj ras homolog gene family, member J 0.024
Chrna2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 0.024
Ctnnd2 catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein) 0.024
Crhr2 corticotropin releasing hormone receptor 2 0.024
Slc6a2 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 0.024
Aqp4 aquaporin 4 0.023
Nptxr neuronal pentraxin receptor 0.023
Dab2 disabled homolog 2 (Drosophila) 0.023
Tead1 TEA domain family member 1 0.023
Hist1h1a histone cluster 1, H1a 0.023
Ptafr platelet-activating factor receptor 0.023
Chrna7 cholinergic receptor, nicotinic, alpha 7 0.023
Padi3 peptidyl arginine deiminase, type III 0.023
Muc1 mucin 1, cell surface associated 0.023
Pla2g5 phospholipase A2, group V 0.023
Atp2b3 ATPase, Ca++ transporting, plasma membrane 3 0.023
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism