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Homo sapiens

22 genes annotated in human

myotube differentiation

The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "myotube differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "myotube differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
EGFR	epidermal growth factor receptor	0.994
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.992
GRB2	growth factor receptor-bound protein 2	0.983
HDAC4	histone deacetylase 4	0.755
IQGAP1	IQ motif containing GTPase activating protein 1	0.608
CEACAM6	carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)	0.604	Human
NOTCH1	notch 1	0.551
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.550
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.386
JAG1	jagged 1	0.362
CEACAM1	carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)	0.334	Human
AR	androgen receptor	0.301
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.297
CAV1	caveolin 1, caveolae protein, 22kDa	0.294
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.242
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.240
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.221
PSG9	pregnancy specific beta-1-glycoprotein 9	0.210	Human
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.197
NCK1	NCK adaptor protein 1	0.192	Fly
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.184
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.157
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.157	Zebrafish
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.149
NCOR2	nuclear receptor corepressor 2	0.149
TTN	titin	0.146
ATXN1	ataxin 1	0.140
DOCK1	dedicator of cytokinesis 1	0.130	Fly
ESR1	estrogen receptor 1	0.117
TBX5	T-box 5	0.117	Human
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.117
MEF2C	myocyte enhancer factor 2C	0.117
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.116	Zebrafish
SRF	serum response factor (c-fos serum response element-binding transcription factor)	0.108
KAT2B	K(lysine) acetyltransferase 2B	0.092
CREBBP	CREB binding protein	0.090
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.086
PTK2	PTK2 protein tyrosine kinase 2	0.085
FSTL1	follistatin-like 1	0.074
BMPR1A	bone morphogenetic protein receptor, type IA	0.074
IGF2R	insulin-like growth factor 2 receptor	0.073
ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	0.064
CEACAM5	carcinoembryonic antigen-related cell adhesion molecule 5	0.064
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.063
MYH7B	myosin, heavy chain 7B, cardiac muscle, beta	0.060
ACTR2	ARP2 actin-related protein 2 homolog (yeast)	0.059
ITSN1	intersectin 1 (SH3 domain protein)	0.059
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.058
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.057	Mouse
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.056
GGA2	golgi-associated, gamma adaptin ear containing, ARF binding protein 2	0.055
NCOR1	nuclear receptor corepressor 1	0.053
PTRF	polymerase I and transcript release factor	0.053
IRS1	insulin receptor substrate 1	0.049
ALDOA	aldolase A, fructose-bisphosphate	0.047
LDHA	lactate dehydrogenase A	0.046
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.042
SH3BP2	SH3-domain binding protein 2	0.040
LAT	linker for activation of T cells	0.039
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.037
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.037
RABEP1	rabaptin, RAB GTPase binding effector protein 1	0.037
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.036
PSG6	pregnancy specific beta-1-glycoprotein 6	0.036	Human
ARPC5	actin related protein 2/3 complex, subunit 5, 16kDa	0.036
TRIM63	tripartite motif containing 63	0.036
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.035	Fly
WIPF1	WAS/WASL interacting protein family, member 1	0.035
LTA	lymphotoxin alpha (TNF superfamily, member 1)	0.035
PRKD2	protein kinase D2	0.034
JUN	jun proto-oncogene	0.034
FLNA	filamin A, alpha	0.034
MYL9	myosin, light chain 9, regulatory	0.034
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.034
RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	0.033	Fly
BCL6	B-cell CLL/lymphoma 6	0.033
PSG4	pregnancy specific beta-1-glycoprotein 4	0.033
IGF1R	insulin-like growth factor 1 receptor	0.033	Fly
IGF2	insulin-like growth factor 2 (somatomedin A)	0.032	Human
ARPC2	actin related protein 2/3 complex, subunit 2, 34kDa	0.032
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.032
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.032
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.032
ATF3	activating transcription factor 3	0.031
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.031
UTRN	utrophin	0.031
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.031
RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	0.030
VAV1	vav 1 guanine nucleotide exchange factor	0.030	Fly
DTNA	dystrobrevin, alpha	0.030
SMAD3	SMAD family member 3	0.029
GAB1	GRB2-associated binding protein 1	0.029
SYNRG	synergin, gamma	0.029
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.028
SMAD1	SMAD family member 1	0.028
TESK1	testis-specific kinase 1	0.028
FYN	FYN oncogene related to SRC, FGR, YES	0.027
ELMO1	engulfment and cell motility 1	0.027	Fly
FBLN1	fibulin 1	0.027
JUND	jun D proto-oncogene	0.026
LIMS1	LIM and senescent cell antigen-like domains 1	0.026
IL2RG	interleukin 2 receptor, gamma	0.026
CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	0.025
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.025
UBASH3B	ubiquitin associated and SH3 domain containing B	0.025
PSG5	pregnancy specific beta-1-glycoprotein 5	0.024	Human
FN1	fibronectin 1	0.024
CEBPG	CCAAT/enhancer binding protein (C/EBP), gamma	0.024
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.024
COASY	CoA synthase	0.024
CNOT8	CCR4-NOT transcription complex, subunit 8	0.024
PSG1	pregnancy specific beta-1-glycoprotein 1	0.023
EPAS1	endothelial PAS domain protein 1	0.023
CSRP3	cysteine and glycine-rich protein 3 (cardiac LIM protein)	0.023
EP300	E1A binding protein p300	0.023
ABI1	abl-interactor 1	0.023
GAPDH	glyceraldehyde-3-phosphate dehydrogenase	0.023	Fly
PGK1	phosphoglycerate kinase 1	0.023
MTMR12	myotubularin related protein 12	0.022
IGFBP5	insulin-like growth factor binding protein 5	0.022	Human
ITGB1BP3	integrin beta 1 binding protein 3	0.022
PGAM1	phosphoglycerate mutase 1 (brain)	0.021
IGFBP4	insulin-like growth factor binding protein 4	0.021	Human
RANBP9	RAN binding protein 9	0.020
FHL2	four and a half LIM domains 2	0.020
FOXO3	forkhead box O3	0.020	Fly
GPI	glucose-6-phosphate isomerase	0.019
NCOA6	nuclear receptor coactivator 6	0.019
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.019
PTPRC	protein tyrosine phosphatase, receptor type, C	0.018
SIRT1	sirtuin 1	0.018
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.018
BCL2L1	BCL2-like 1	0.018
GGA1	golgi-associated, gamma adaptin ear containing, ARF binding protein 1	0.018
PTCH1	patched 1	0.018
NLRC4	NLR family, CARD domain containing 4	0.018
HCK	hemopoietic cell kinase	0.017
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.017
DLL1	delta-like 1 (Drosophila)	0.017
CAST	calpastatin	0.017
SYK	spleen tyrosine kinase	0.017
SOS1	son of sevenless homolog 1 (Drosophila)	0.017
SMAD4	SMAD family member 4	0.017
PAX8	paired box 8	0.017
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.017
PNRC1	proline-rich nuclear receptor coactivator 1	0.017
HDAC9	histone deacetylase 9	0.016	Human Mouse
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.016
DMD	dystrophin	0.016	Mouse
PLCG1	phospholipase C, gamma 1	0.016
CEACAM7	carcinoembryonic antigen-related cell adhesion molecule 7	0.016	Human
PSG3	pregnancy specific beta-1-glycoprotein 3	0.016
MAPK8	mitogen-activated protein kinase 8	0.016
NOTCH3	notch 3	0.016	Human
ARPC3	actin related protein 2/3 complex, subunit 3, 21kDa	0.015
ARPC1B	actin related protein 2/3 complex, subunit 1B, 41kDa	0.015
VCL	vinculin	0.015
GRB10	growth factor receptor-bound protein 10	0.015
VAV2	vav 2 guanine nucleotide exchange factor	0.015	Fly
GATA4	GATA binding protein 4	0.015
SH3RF1	SH3 domain containing ring finger 1	0.014
GAB2	GRB2-associated binding protein 2	0.014
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.014
INO80B	INO80 complex subunit B	0.014
ACTB	actin, beta	0.014
ZYX	zyxin	0.014
PTPN12	protein tyrosine phosphatase, non-receptor type 12	0.013
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.013
H3F3C	H3 histone, family 3C	0.013
MDFI	MyoD family inhibitor	0.013
PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.013
RARA	retinoic acid receptor, alpha	0.013
NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	0.013
NCOA2	nuclear receptor coactivator 2	0.013
HDAC5	histone deacetylase 5	0.013
FOXP3	forkhead box P3	0.013
DPP4	dipeptidyl-peptidase 4	0.013
TMOD3	tropomodulin 3 (ubiquitous)	0.013
MYOZ1	myozenin 1	0.012
GNAI3	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	0.012
EMP3	epithelial membrane protein 3	0.012
DTNB	dystrobrevin, beta	0.012
WDR1	WD repeat domain 1	0.012
PPARA	peroxisome proliferator-activated receptor alpha	0.012
TCF4	transcription factor 4	0.012
SORL1	sortilin-related receptor, L(DLR class) A repeats containing	0.012	Human
DDR1	discoidin domain receptor tyrosine kinase 1	0.012
CXCL11	chemokine (C-X-C motif) ligand 11	0.012
MYOD1	myogenic differentiation 1	0.012
ZHX1	zinc fingers and homeoboxes 1	0.012
PARVA	parvin, alpha	0.012
AXL	AXL receptor tyrosine kinase	0.011
EXOC5	exocyst complex component 5	0.011
TNKS2	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2	0.011
TF	transferrin	0.011
CSK	c-src tyrosine kinase	0.011
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.011
RHOU	ras homolog gene family, member U	0.011
PDLIM7	PDZ and LIM domain 7 (enigma)	0.011
HCLS1	hematopoietic cell-specific Lyn substrate 1	0.011
USP14	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)	0.011
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.011
HSPB2	heat shock 27kDa protein 2	0.011
DBP	D site of albumin promoter (albumin D-box) binding protein	0.011
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.011
CEACAM8	carcinoembryonic antigen-related cell adhesion molecule 8	0.011	Human
S100A6	S100 calcium binding protein A6	0.011
STK10	serine/threonine kinase 10	0.010
RBPMS	RNA binding protein with multiple splicing	0.010
BTF3	basic transcription factor 3	0.010
MEF2A	myocyte enhancer factor 2A	0.010	Human Fly
RUNX1	runt-related transcription factor 1	0.010
MKL1	megakaryoblastic leukemia (translocation) 1	0.010
RICTOR	RPTOR independent companion of MTOR, complex 2	0.010
SORT1	sortilin 1	0.010
OSTF1	osteoclast stimulating factor 1	0.010