IMP

Process View

Homo sapiens

22 genes annotated in human

regulation of cell killing

Any process that modulates the frequency, rate or extent of cell killing, the process in which a cell brings about the death of another cell, either in the same or a different organism.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of cell killing"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of cell killing" (in gray)

Name	Description	Probability	Func Analog Organism
B2M	beta-2-microglobulin	0.992	Mouse
HLA-B	major histocompatibility complex, class I, B	0.975
HLA-A	major histocompatibility complex, class I, A	0.975
HLA-C	major histocompatibility complex, class I, C	0.975	Human
HLA-G	major histocompatibility complex, class I, G	0.936	Human
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.909
HLA-E	major histocompatibility complex, class I, E	0.870
HLA-F	major histocompatibility complex, class I, F	0.838	Human
KLRD1	killer cell lectin-like receptor subfamily D, member 1	0.789	Human
TAPBP	TAP binding protein (tapasin)	0.784
IL2RB	interleukin 2 receptor, beta	0.739
TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.649	Rat
CCL4	chemokine (C-C motif) ligand 4	0.646	Human
SH2D1A	SH2 domain containing 1A	0.629	Mouse
SLAMF1	signaling lymphocytic activation molecule family member 1	0.621
LILRA6	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6	0.534
CD84	CD84 molecule	0.526
CCR5	chemokine (C-C motif) receptor 5	0.515
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.479
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.435
CCL5	chemokine (C-C motif) ligand 5	0.394	Human
IL8	interleukin 8	0.372
CXCL9	chemokine (C-X-C motif) ligand 9	0.362
IL1B	interleukin 1, beta	0.265
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.240
CCL8	chemokine (C-C motif) ligand 8	0.226	Human
NOSTRIN	nitric oxide synthase trafficker	0.226
CCR1	chemokine (C-C motif) receptor 1	0.179
IL6	interleukin 6 (interferon, beta 2)	0.170
GBA	glucosidase, beta, acid	0.155
MAPK1	mitogen-activated protein kinase 1	0.145
CD2	CD2 molecule	0.143
IFNG	interferon, gamma	0.139
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.122
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.118
CCR7	chemokine (C-C motif) receptor 7	0.110
LILRA1	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	0.107	Human
KLRC3	killer cell lectin-like receptor subfamily C, member 3	0.080	Human
BID	BH3 interacting domain death agonist	0.080
CCL2	chemokine (C-C motif) ligand 2	0.078	Human
CCL20	chemokine (C-C motif) ligand 20	0.077	Human
CCL13	chemokine (C-C motif) ligand 13	0.077	Human
ICAM1	intercellular adhesion molecule 1	0.077
LILRB2	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	0.076	Human
RAB14	RAB14, member RAS oncogene family	0.075
PILRA	paired immunoglobin-like type 2 receptor alpha	0.075
KLRK1	killer cell lectin-like receptor subfamily K, member 1	0.072
ITM2B	integral membrane protein 2B	0.071
CCL7	chemokine (C-C motif) ligand 7	0.070	Human
VAMP4	vesicle-associated membrane protein 4	0.062
DPP4	dipeptidyl-peptidase 4	0.061
CCR2	chemokine (C-C motif) receptor 2	0.061
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.060
SIGLEC7	sialic acid binding Ig-like lectin 7	0.060
CXCL2	chemokine (C-X-C motif) ligand 2	0.059	Mouse
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.059
GZMK	granzyme K (granzyme 3; tryptase II)	0.058
PVRL4	poliovirus receptor-related 4	0.057
CCL22	chemokine (C-C motif) ligand 22	0.054	Human
IL18RAP	interleukin 18 receptor accessory protein	0.053
KLRC2	killer cell lectin-like receptor subfamily C, member 2	0.053	Human
CXCL3	chemokine (C-X-C motif) ligand 3	0.052	Mouse
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.051
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.049	Mouse
PSAP	prosaposin	0.046
CXCR6	chemokine (C-X-C motif) receptor 6	0.045
ABCA1	ATP-binding cassette, sub-family A (ABC1), member 1	0.044
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.042
NKG7	natural killer cell group 7 sequence	0.041
PSMB8	proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)	0.041
TNFRSF12A	tumor necrosis factor receptor superfamily, member 12A	0.038
HK3	hexokinase 3 (white cell)	0.037
PVRL2	poliovirus receptor-related 2 (herpesvirus entry mediator B)	0.037
CD48	CD48 molecule	0.036
LILRB3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.035	Human
INSR	insulin receptor	0.035
TNF	tumor necrosis factor	0.035
CAV1	caveolin 1, caveolae protein, 22kDa	0.034
CCR4	chemokine (C-C motif) receptor 4	0.034
NCSTN	nicastrin	0.033
CD8A	CD8a molecule	0.032
CD163	CD163 molecule	0.031
CLEC10A	C-type lectin domain family 10, member A	0.031
CD3G	CD3g molecule, gamma (CD3-TCR complex)	0.031
GPR171	G protein-coupled receptor 171	0.031
IDE	insulin-degrading enzyme	0.031
ITK	IL2-inducible T-cell kinase	0.031
KLRB1	killer cell lectin-like receptor subfamily B, member 1	0.029	Mouse
XCL2	chemokine (C motif) ligand 2	0.029	Human
GPR65	G protein-coupled receptor 65	0.028
IFI35	interferon-induced protein 35	0.028
CCL11	chemokine (C-C motif) ligand 11	0.027	Human
PVRL1	poliovirus receptor-related 1 (herpesvirus entry mediator C)	0.027	Human
FCN1	ficolin (collagen/fibrinogen domain containing) 1	0.027
SKAP1	src kinase associated phosphoprotein 1	0.027
CXCL5	chemokine (C-X-C motif) ligand 5	0.026	Mouse
CSF2RA	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	0.026
TJP1	tight junction protein 1 (zona occludens 1)	0.025
IL7R	interleukin 7 receptor	0.024	Mouse
NLRP3	NLR family, pyrin domain containing 3	0.024
FASLG	Fas ligand (TNF superfamily, member 6)	0.023
IL10	interleukin 10	0.023
NPC2	Niemann-Pick disease, type C2	0.023
CXCL11	chemokine (C-X-C motif) ligand 11	0.022
IGSF6	immunoglobulin superfamily, member 6	0.022
INHBA	inhibin, beta A	0.021
CXCL10	chemokine (C-X-C motif) ligand 10	0.021
CXCL13	chemokine (C-X-C motif) ligand 13	0.021
DNASE1L3	deoxyribonuclease I-like 3	0.020
KLRF1	killer cell lectin-like receptor subfamily F, member 1	0.020
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.020
ICOS	inducible T-cell co-stimulator	0.020
CD226	CD226 molecule	0.019
CD160	CD160 molecule	0.019
CD22	CD22 molecule	0.019
IL2RG	interleukin 2 receptor, gamma	0.019
FPR3	formyl peptide receptor 3	0.019
XCL1	chemokine (C motif) ligand 1	0.018
SELE	selectin E	0.018
STAT4	signal transducer and activator of transcription 4	0.018
TLR2	toll-like receptor 2	0.018
CD1C	CD1c molecule	0.018
DARC	Duffy blood group, chemokine receptor	0.017
FCAR	Fc fragment of IgA, receptor for	0.017	Human
SH2D2A	SH2 domain containing 2A	0.017
MAP2K4	mitogen-activated protein kinase kinase 4	0.017
CH25H	cholesterol 25-hydroxylase	0.017
ASAH1	N-acylsphingosine amidohydrolase (acid ceramidase) 1	0.017
ZBP1	Z-DNA binding protein 1	0.016
CCL3	chemokine (C-C motif) ligand 3	0.016	Human
PTAFR	platelet-activating factor receptor	0.016
PVRL3	poliovirus receptor-related 3	0.016	Human
KLRC4	killer cell lectin-like receptor subfamily C, member 4	0.016	Human
TPP1	tripeptidyl peptidase I	0.016
SLAMF7	SLAM family member 7	0.016
CCR3	chemokine (C-C motif) receptor 3	0.016
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.016
IL12A	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	0.016
NSF	N-ethylmaleimide-sensitive factor	0.016
GRN	granulin	0.015
CD247	CD247 molecule	0.015
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.015	Human
BCL2L2	BCL2-like 2	0.015
GGA2	golgi-associated, gamma adaptin ear containing, ARF binding protein 2	0.015
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.015
FAS	Fas (TNF receptor superfamily, member 6)	0.015
IL1A	interleukin 1, alpha	0.015
IFITM2	interferon induced transmembrane protein 2 (1-8D)	0.015
CD209	CD209 molecule	0.014	Human
MAPK10	mitogen-activated protein kinase 10	0.014
CTSA	cathepsin A	0.014
IL1R2	interleukin 1 receptor, type II	0.014
TXK	TXK tyrosine kinase	0.014
MYL6	myosin, light chain 6, alkali, smooth muscle and non-muscle	0.014
SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	0.014
KIR3DL2	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2	0.014
CCL19	chemokine (C-C motif) ligand 19	0.013	Human
STAP2	signal transducing adaptor family member 2	0.013
CLEC4D	C-type lectin domain family 4, member D	0.013	Human
CCL17	chemokine (C-C motif) ligand 17	0.013	Human
CMKLR1	chemokine-like receptor 1	0.013
KLRC1	killer cell lectin-like receptor subfamily C, member 1	0.013	Human
CLEC4E	C-type lectin domain family 4, member E	0.013	Human
KIR3DL1	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1	0.013
PRKCQ	protein kinase C, theta	0.013
HFE	hemochromatosis	0.012	Human
LGALS2	lectin, galactoside-binding, soluble, 2	0.012
SIRPB1	signal-regulatory protein beta 1	0.012
EMR3	egf-like module containing, mucin-like, hormone receptor-like 3	0.012
ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	0.012
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.012
IRF2	interferon regulatory factor 2	0.012
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.012
IL7	interleukin 7	0.012
AOAH	acyloxyacyl hydrolase (neutrophil)	0.012
LEPROT	leptin receptor overlapping transcript	0.012
LILRA3	leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3	0.012	Human
BTN3A2	butyrophilin, subfamily 3, member A2	0.012
IFNGR1	interferon gamma receptor 1	0.012
IRF4	interferon regulatory factor 4	0.011
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.011
GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	0.011
CD96	CD96 molecule	0.011
CD86	CD86 molecule	0.011
CLEC5A	C-type lectin domain family 5, member A	0.011
TREM1	triggering receptor expressed on myeloid cells 1	0.011
SNX3	sorting nexin 3	0.011
CCL23	chemokine (C-C motif) ligand 23	0.011	Human
GZMA	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)	0.011
GZMH	granzyme H (cathepsin G-like 2, protein h-CCPX)	0.011
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.011
OS9	osteosarcoma amplified 9, endoplasmic reticulum lectin	0.010
IL12RB1	interleukin 12 receptor, beta 1	0.010
OSTM1	osteopetrosis associated transmembrane protein 1	0.010
LAMP3	lysosomal-associated membrane protein 3	0.010
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.010
VCAM1	vascular cell adhesion molecule 1	0.010
KLRG1	killer cell lectin-like receptor subfamily G, member 1	0.010	Human
CD72	CD72 molecule	0.010
C3AR1	complement component 3a receptor 1	0.010
AGAP2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	0.010
FTL	ferritin, light polypeptide	0.010