IMP

Process View

Homo sapiens

15 genes annotated in human

dorsal ventral pattern formation

The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "dorsal ventral pattern formation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "dorsal ventral pattern formation" (in gray)

Name	Description	Probability	Func Analog Organism
SMAD3	SMAD family member 3	0.999	Human
SMAD2	SMAD family member 2	0.997
SMAD1	SMAD family member 1	0.900	Human Zebrafish
BMPR1A	bone morphogenetic protein receptor, type IA	0.694	Human Zebrafish Mouse Fly
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.619
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.441
RBL2	retinoblastoma-like 2 (p130)	0.434
BMP2	bone morphogenetic protein 2	0.368	Zebrafish Fly
PSEN1	presenilin 1	0.367	Mouse Fly
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.342	Human
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.324	Zebrafish
TADA3	transcriptional adaptor 3	0.306
CSNK2A1	casein kinase 2, alpha 1 polypeptide	0.302	Fly
TGFB1	transforming growth factor, beta 1	0.300
FSTL1	follistatin-like 1	0.261	Zebrafish
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.199	Fly
CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	0.195
APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	0.180
FKBP1A	FK506 binding protein 1A, 12kDa	0.155
TGFBR1	transforming growth factor, beta receptor 1	0.151	Human
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.147	Fly
MAFG	v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)	0.143
TWIST1	twist homolog 1 (Drosophila)	0.130
ACVR1	activin A receptor, type I	0.125
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.123	Human
KEAP1	kelch-like ECH-associated protein 1	0.122
NOTCH3	notch 3	0.121	Fly
CHRD	chordin	0.112
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.108
AMMECR1	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1	0.105
APC	adenomatous polyposis coli	0.103	Mouse
HNRNPU	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)	0.102
NOTCH1	notch 1	0.100	Fly
JAG1	jagged 1	0.094	Human Zebrafish
AR	androgen receptor	0.094
C19orf39	chromosome 19 open reading frame 39	0.093
NFKBIB	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	0.092	Fly
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.092
CSNK2B	casein kinase 2, beta polypeptide	0.090
BMP7	bone morphogenetic protein 7	0.089	Zebrafish Fly
SMAD7	SMAD family member 7	0.085	Human
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.080	Zebrafish Mouse
WNT3A	wingless-type MMTV integration site family, member 3A	0.079	Zebrafish Mouse
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.078
HNRNPK	heterogeneous nuclear ribonucleoprotein K	0.074
QKI	quaking homolog, KH domain RNA binding (mouse)	0.074
ERBB2IP	erbb2 interacting protein	0.073
RANBP9	RAN binding protein 9	0.069
DDX3X	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked	0.065
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.062
PAX8	paired box 8	0.061
LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	0.061
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.057
SKIL	SKI-like oncogene	0.056
SMAD4	SMAD family member 4	0.050	Human Fly
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.047
GSK3B	glycogen synthase kinase 3 beta	0.046
FOXA2	forkhead box A2	0.045	Mouse
AKAP11	A kinase (PRKA) anchor protein 11	0.045
EIF4G1	eukaryotic translation initiation factor 4 gamma, 1	0.044
PTCH1	patched 1	0.044
PCBP1	poly(rC) binding protein 1	0.044
PAFAH1B1	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)	0.043	Fly
BMP4	bone morphogenetic protein 4	0.042	Zebrafish Mouse Fly
COL2A1	collagen, type II, alpha 1	0.041
HNRNPA2B1	heterogeneous nuclear ribonucleoprotein A2/B1	0.040
HOXB5	homeobox B5	0.040
IRAK1	interleukin-1 receptor-associated kinase 1	0.040
MAPK8	mitogen-activated protein kinase 8	0.040	Zebrafish Mouse
RBMX	RNA binding motif protein, X-linked	0.040
PML	promyelocytic leukemia	0.039
PKD1	polycystic kidney disease 1 (autosomal dominant)	0.037
NLK	nemo-like kinase	0.037
YBX1	Y box binding protein 1	0.036
HNRNPC	heterogeneous nuclear ribonucleoprotein C (C1/C2)	0.035
NOTCH2	notch 2	0.035	Fly
ZFYVE9	zinc finger, FYVE domain containing 9	0.034
CAV2	caveolin 2	0.034
RAD51	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	0.034	Fly
MYOD1	myogenic differentiation 1	0.032
HOXC8	homeobox C8	0.031
MAPK6	mitogen-activated protein kinase 6	0.031
EIF3A	eukaryotic translation initiation factor 3, subunit A	0.030
NOG	noggin	0.029
AXIN1	axin 1	0.029	Zebrafish Mouse
ATF2	activating transcription factor 2	0.029
LRP6	low density lipoprotein receptor-related protein 6	0.028
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.028
CEBPG	CCAAT/enhancer binding protein (C/EBP), gamma	0.028
HNRNPA0	heterogeneous nuclear ribonucleoprotein A0	0.028
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.028	Fly
CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	0.027	Human
RASA1	RAS p21 protein activator (GTPase activating protein) 1	0.027
FZD7	frizzled homolog 7 (Drosophila)	0.027	Human
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.026
UBR5	ubiquitin protein ligase E3 component n-recognin 5	0.026
EGFR	epidermal growth factor receptor	0.026	Fly
FLNB	filamin B, beta	0.026
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.025
CYFIP2	cytoplasmic FMR1 interacting protein 2	0.024
EIF4G2	eukaryotic translation initiation factor 4 gamma, 2	0.024
DIP2A	DIP2 disco-interacting protein 2 homolog A (Drosophila)	0.024
CDC34	cell division cycle 34 homolog (S. cerevisiae)	0.024
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.024	Mouse
BMP1	bone morphogenetic protein 1	0.024	Zebrafish Fly
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.023	Fly
ENG	endoglin	0.023
FOXP1	forkhead box P1	0.023
PABPC1	poly(A) binding protein, cytoplasmic 1	0.023
BTRC	beta-transducin repeat containing	0.022
TARDBP	TAR DNA binding protein	0.022
FGF2	fibroblast growth factor 2 (basic)	0.022
TP73	tumor protein p73	0.022
FRS2	fibroblast growth factor receptor substrate 2	0.022
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.022
ZMYND11	zinc finger, MYND-type containing 11	0.021
CAPRIN2	caprin family member 2	0.021
TP53BP2	tumor protein p53 binding protein, 2	0.021
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.021
DBP	D site of albumin promoter (albumin D-box) binding protein	0.021
ZIC1	Zic family member 1 (odd-paired homolog, Drosophila)	0.021
XRCC3	X-ray repair complementing defective repair in Chinese hamster cells 3	0.020	Fly
SOX11	SRY (sex determining region Y)-box 11	0.020
RANBP2	RAN binding protein 2	0.020
HDAC2	histone deacetylase 2	0.020
FZD1	frizzled homolog 1 (Drosophila)	0.019	Human
SPG20	spastic paraplegia 20 (Troyer syndrome)	0.019
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.019
WNT5A	wingless-type MMTV integration site family, member 5A	0.018
BBS10	Bardet-Biedl syndrome 10	0.018
GDF5	growth differentiation factor 5	0.018
CXXC5	CXXC finger protein 5	0.018
CIB1	calcium and integrin binding 1 (calmyrin)	0.018
STK36	serine/threonine kinase 36	0.018
SQSTM1	sequestosome 1	0.018
SFRP1	secreted frizzled-related protein 1	0.018
PRMT1	protein arginine methyltransferase 1	0.017
FGFR2	fibroblast growth factor receptor 2	0.017
HNRNPAB	heterogeneous nuclear ribonucleoprotein A/B	0.016	Fly
HNRNPA3	heterogeneous nuclear ribonucleoprotein A3	0.016
USP15	ubiquitin specific peptidase 15	0.016
MANF	mesencephalic astrocyte-derived neurotrophic factor	0.016
TP53	tumor protein p53	0.016
UPF3B	UPF3 regulator of nonsense transcripts homolog B (yeast)	0.016
FOXF2	forkhead box F2	0.016
JUB	jub, ajuba homolog (Xenopus laevis)	0.016
HOXA10	homeobox A10	0.015
TGFB3	transforming growth factor, beta 3	0.015
HNRNPH3	heterogeneous nuclear ribonucleoprotein H3 (2H9)	0.015
CBX4	chromobox homolog 4	0.015
CSNK1E	casein kinase 1, epsilon	0.015
BIK	BCL2-interacting killer (apoptosis-inducing)	0.015
EIF2S2	eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa	0.015
FZD8	frizzled homolog 8 (Drosophila)	0.014	Human Zebrafish
DNAJB2	DnaJ (Hsp40) homolog, subfamily B, member 2	0.014
MAPK9	mitogen-activated protein kinase 9	0.014
DKK1	dickkopf homolog 1 (Xenopus laevis)	0.014
CDX2	caudal type homeobox 2	0.014
NDP	Norrie disease (pseudoglioma)	0.014
PAM	peptidylglycine alpha-amidating monooxygenase	0.014
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.014
C19orf10	chromosome 19 open reading frame 10	0.014
RCN3	reticulocalbin 3, EF-hand calcium binding domain	0.013
LHX5	LIM homeobox 5	0.013
LTBP4	latent transforming growth factor beta binding protein 4	0.013
EYA2	eyes absent homolog 2 (Drosophila)	0.013
SUMO1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)	0.013
HEY1	hairy/enhancer-of-split related with YRPW motif 1	0.013
MBNL1	muscleblind-like (Drosophila)	0.013
GLI2	GLI family zinc finger 2	0.013	Zebrafish Mouse
TFDP2	transcription factor Dp-2 (E2F dimerization partner 2)	0.013	Fly
SGK3	serum/glucocorticoid regulated kinase family, member 3	0.013
HNRPDL	heterogeneous nuclear ribonucleoprotein D-like	0.013	Fly
MAPK14	mitogen-activated protein kinase 14	0.013
PTEN	phosphatase and tensin homolog	0.013
FEV	FEV (ETS oncogene family)	0.013
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.013
ST13	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)	0.013
NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	0.013
AHR	aryl hydrocarbon receptor	0.013
SMAD5	SMAD family member 5	0.013	Human Zebrafish
HOXD9	homeobox D9	0.012
TCF7L1	transcription factor 7-like 1 (T-cell specific, HMG-box)	0.012
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.012
FNDC3B	fibronectin type III domain containing 3B	0.012
TFDP1	transcription factor Dp-1	0.012	Fly
BAX	BCL2-associated X protein	0.012
PKP4	plakophilin 4	0.012
PKD2	polycystic kidney disease 2 (autosomal dominant)	0.012	Zebrafish
PALB2	partner and localizer of BRCA2	0.012
EFNB2	ephrin-B2	0.012
DLX4	distal-less homeobox 4	0.012	Fly
WDR48	WD repeat domain 48	0.012
MSX1	msh homeobox 1	0.011	Fly
WNT11	wingless-type MMTV integration site family, member 11	0.011
HMGA1	high mobility group AT-hook 1	0.011
HOXD13	homeobox D13	0.011
TRAF4	TNF receptor-associated factor 4	0.011
DVL2	dishevelled, dsh homolog 2 (Drosophila)	0.011
EXOC5	exocyst complex component 5	0.011
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.011
SRSF2	serine/arginine-rich splicing factor 2	0.011
FOXB1	forkhead box B1	0.011
PRKAR1A	protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)	0.011
PEX26	peroxisomal biogenesis factor 26	0.011
AQP5	aquaporin 5	0.011
SPAG9	sperm associated antigen 9	0.011
RUNX1	runt-related transcription factor 1	0.010
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.010
ZHX1	zinc fingers and homeoboxes 1	0.010
FOXF1	forkhead box F1	0.010
LGALS8	lectin, galactoside-binding, soluble, 8	0.010
ONECUT1	one cut homeobox 1	0.010
SRI	sorcin	0.010
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.010
MNX1	motor neuron and pancreas homeobox 1	0.010	Mouse