IMP

Process View

Homo sapiens

26 genes annotated in human

interleukin 1 production

The appearance of interleukin-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "interleukin 1 production"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "interleukin 1 production" (in gray)

Name	Description	Probability	Func Analog Organism
S100A6	S100 calcium binding protein A6	0.995	Human
PYCARD	PYD and CARD domain containing	0.987
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.978	Mouse Rat
NLRC4	NLR family, CARD domain containing 4	0.852
HDAC2	histone deacetylase 2	0.819
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.740
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.644
RIPK2	receptor-interacting serine-threonine kinase 2	0.496
S100A16	S100 calcium binding protein A16	0.408
HP	haptoglobin	0.399
IL1R1	interleukin 1 receptor, type I	0.393
S100A4	S100 calcium binding protein A4	0.371	Human
PLP2	proteolipid protein 2 (colonic epithelium-enriched)	0.282
SNTB2	syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)	0.262
TICAM2	toll-like receptor adaptor molecule 2	0.236
SRGN	serglycin	0.232
APOC1	apolipoprotein C-I	0.226
LY96	lymphocyte antigen 96	0.196
FKBP4	FK506 binding protein 4, 59kDa	0.189
ALB	albumin	0.160
TMSB10	thymosin beta 10	0.156
AXL	AXL receptor tyrosine kinase	0.152
CAPG	capping protein (actin filament), gelsolin-like	0.139
S100B	S100 calcium binding protein B	0.137
GNLY	granulysin	0.131
PRF1	perforin 1 (pore forming protein)	0.129
CCL4	chemokine (C-C motif) ligand 4	0.126
PYDC2	pyrin domain containing 2	0.104
AREG	amphiregulin	0.101
S100A10	S100 calcium binding protein A10	0.099	Human
SOCS1	suppressor of cytokine signaling 1	0.090
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.086
IL1RAP	interleukin 1 receptor accessory protein	0.081
A2M	alpha-2-macroglobulin	0.080
EMP3	epithelial membrane protein 3	0.079
LGALS1	lectin, galactoside-binding, soluble, 1	0.079
LMNA	lamin A/C	0.078
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.075
IL8	interleukin 8	0.067
S100A11	S100 calcium binding protein A11	0.064	Human
LGALS3	lectin, galactoside-binding, soluble, 3	0.061
IRAK2	interleukin-1 receptor-associated kinase 2	0.058
IL7R	interleukin 7 receptor	0.058
S100A2	S100 calcium binding protein A2	0.057	Human
APOC3	apolipoprotein C-III	0.055
IDE	insulin-degrading enzyme	0.054
IL1B	interleukin 1, beta	0.054	Mouse
FZD1	frizzled homolog 1 (Drosophila)	0.052
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.048
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.046
SP1	Sp1 transcription factor	0.044
SOCS3	suppressor of cytokine signaling 3	0.044
EGR2	early growth response 2	0.043
FHL2	four and a half LIM domains 2	0.042
LCAT	lecithin-cholesterol acyltransferase	0.041
TIMP1	TIMP metallopeptidase inhibitor 1	0.041
TLR2	toll-like receptor 2	0.040
BCL2A1	BCL2-related protein A1	0.039
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.039
ITK	IL2-inducible T-cell kinase	0.039
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.039
TRIM22	tripartite motif containing 22	0.038
NKG7	natural killer cell group 7 sequence	0.038
MPO	myeloperoxidase	0.037
ATP2B2	ATPase, Ca++ transporting, plasma membrane 2	0.037
S100A1	S100 calcium binding protein A1	0.037
GPR171	G protein-coupled receptor 171	0.036
CARD16	caspase recruitment domain family, member 16	0.036
RRAS	related RAS viral (r-ras) oncogene homolog	0.035
APOA1	apolipoprotein A-I	0.035
TSPO	translocator protein (18kDa)	0.035
IFNGR1	interferon gamma receptor 1	0.035
MEFV	Mediterranean fever	0.034
CFLAR	CASP8 and FADD-like apoptosis regulator	0.034
IL1RN	interleukin 1 receptor antagonist	0.033
SAMD9	sterile alpha motif domain containing 9	0.033
CSTB	cystatin B (stefin B)	0.033
APOA2	apolipoprotein A-II	0.032
CLEC2B	C-type lectin domain family 2, member B	0.032
TPSB2	tryptase beta 2 (gene/pseudogene)	0.032
GZMK	granzyme K (granzyme 3; tryptase II)	0.031	Human
C1QA	complement component 1, q subcomponent, A chain	0.031
ARRB1	arrestin, beta 1	0.031
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.031
AZU1	azurocidin 1	0.030
IGF1R	insulin-like growth factor 1 receptor	0.030
ATM	ataxia telangiectasia mutated	0.030
TRAF3IP3	TRAF3 interacting protein 3	0.030
CD3D	CD3d molecule, delta (CD3-TCR complex)	0.030
ELANE	elastase, neutrophil expressed	0.029	Human
LY9	lymphocyte antigen 9	0.029
HSPB8	heat shock 22kDa protein 8	0.029
CXCL9	chemokine (C-X-C motif) ligand 9	0.027
FAS	Fas (TNF receptor superfamily, member 6)	0.026
BAG3	BCL2-associated athanogene 3	0.026
CCR7	chemokine (C-C motif) receptor 7	0.025	Mouse
SMAD2	SMAD family member 2	0.025
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.025	Human
APOC2	apolipoprotein C-II	0.025
AIM2	absent in melanoma 2	0.025
GORAB	golgin, RAB6-interacting	0.025
PLAUR	plasminogen activator, urokinase receptor	0.024
CLEC4G	C-type lectin domain family 4, member G	0.024
TNIP1	TNFAIP3 interacting protein 1	0.024
FGA	fibrinogen alpha chain	0.024
CXCL2	chemokine (C-X-C motif) ligand 2	0.023
MVP	major vault protein	0.023
CXCR6	chemokine (C-X-C motif) receptor 6	0.023
TNF	tumor necrosis factor	0.023
BAX	BCL2-associated X protein	0.022
CXCL3	chemokine (C-X-C motif) ligand 3	0.022
TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	0.022
IL18	interleukin 18 (interferon-gamma-inducing factor)	0.021
DNTT	deoxynucleotidyltransferase, terminal	0.021
CCL19	chemokine (C-C motif) ligand 19	0.021	Mouse
CD8A	CD8a molecule	0.021
PML	promyelocytic leukemia	0.021
SH3BGRL3	SH3 domain binding glutamic acid-rich protein like 3	0.020
IFNG	interferon, gamma	0.020
KLRD1	killer cell lectin-like receptor subfamily D, member 1	0.020
GPR65	G protein-coupled receptor 65	0.020
IGSF6	immunoglobulin superfamily, member 6	0.020
C2orf18	chromosome 2 open reading frame 18	0.020
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.019
PRTN3	proteinase 3	0.019	Human
IL2RB	interleukin 2 receptor, beta	0.019
CASP4	caspase 4, apoptosis-related cysteine peptidase	0.019	Mouse
SFN	stratifin	0.019
CRIP1	cysteine-rich protein 1 (intestinal)	0.019
IL1A	interleukin 1, alpha	0.019
IL18RAP	interleukin 18 receptor accessory protein	0.019
CTSG	cathepsin G	0.018	Human
ANXA2	annexin A2	0.018
KYNU	kynureninase	0.018
ARHGAP25	Rho GTPase activating protein 25	0.018
SESN2	sestrin 2	0.018
ITGB7	integrin, beta 7	0.018
LTF	lactotransferrin	0.018
KLRK1	killer cell lectin-like receptor subfamily K, member 1	0.018
CARD6	caspase recruitment domain family, member 6	0.018
IL10RB	interleukin 10 receptor, beta	0.018
SLAMF7	SLAM family member 7	0.017
PLAU	plasminogen activator, urokinase	0.017
MS4A1	membrane-spanning 4-domains, subfamily A, member 1	0.017
GZMH	granzyme H (cathepsin G-like 2, protein h-CCPX)	0.017	Human
CTSW	cathepsin W	0.017
STAT4	signal transducer and activator of transcription 4	0.017
CSTA	cystatin A (stefin A)	0.017
IL21R	interleukin 21 receptor	0.016
STX12	syntaxin 12	0.016
DAXX	death-domain associated protein	0.016
ANXA1	annexin A1	0.016
TICAM1	toll-like receptor adaptor molecule 1	0.016
TLR1	toll-like receptor 1	0.016
CD3G	CD3g molecule, gamma (CD3-TCR complex)	0.016
GBP5	guanylate binding protein 5	0.016
CCL5	chemokine (C-C motif) ligand 5	0.016
TFEC	transcription factor EC	0.016
GZMA	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)	0.015	Human
SERPINB1	serpin peptidase inhibitor, clade B (ovalbumin), member 1	0.015
LRP6	low density lipoprotein receptor-related protein 6	0.015
ICOS	inducible T-cell co-stimulator	0.015
HIPK2	homeodomain interacting protein kinase 2	0.015
CST7	cystatin F (leukocystatin)	0.015
GNL3L	guanine nucleotide binding protein-like 3 (nucleolar)-like	0.015
SH2B1	SH2B adaptor protein 1	0.015
SLAMF1	signaling lymphocytic activation molecule family member 1	0.015
TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	0.015
NLRP3	NLR family, pyrin domain containing 3	0.015
PTPRE	protein tyrosine phosphatase, receptor type, E	0.015
NMI	N-myc (and STAT) interactor	0.015
PVRIG	poliovirus receptor related immunoglobulin domain containing	0.015
JAK3	Janus kinase 3	0.014
RNASE3	ribonuclease, RNase A family, 3	0.014
NR0B2	nuclear receptor subfamily 0, group B, member 2	0.014
HDC	histidine decarboxylase	0.014
RNF31	ring finger protein 31	0.014
HSF1	heat shock transcription factor 1	0.014
KLRB1	killer cell lectin-like receptor subfamily B, member 1	0.014
PLTP	phospholipid transfer protein	0.014
APOE	apolipoprotein E	0.014	Human
CCL20	chemokine (C-C motif) ligand 20	0.014	Rat
CPA3	carboxypeptidase A3 (mast cell)	0.014
GMFG	glia maturation factor, gamma	0.014
CMA1	chymase 1, mast cell	0.014
ICAM1	intercellular adhesion molecule 1	0.013
GZMM	granzyme M (lymphocyte met-ase 1)	0.013
PEA15	phosphoprotein enriched in astrocytes 15	0.013
CSNK1D	casein kinase 1, delta	0.013
TAX1BP3	Tax1 (human T-cell leukemia virus type I) binding protein 3	0.013
BIRC3	baculoviral IAP repeat containing 3	0.013
NCF2	neutrophil cytosolic factor 2	0.013
ELF4	E74-like factor 4 (ets domain transcription factor)	0.013
HCP5	HLA complex P5	0.013
SERPINB9	serpin peptidase inhibitor, clade B (ovalbumin), member 9	0.013
TNFRSF10C	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain	0.013
HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	0.013
ADAMDEC1	ADAM-like, decysin 1	0.012
PRG2	proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)	0.012
CCL22	chemokine (C-C motif) ligand 22	0.012
RB1	retinoblastoma 1	0.012
UTF1	undifferentiated embryonic cell transcription factor 1	0.012
RNASE4	ribonuclease, RNase A family, 4	0.012
MAGEB18	melanoma antigen family B, 18	0.012
IRF8	interferon regulatory factor 8	0.012
CD7	CD7 molecule	0.012
TREM1	triggering receptor expressed on myeloid cells 1	0.012
SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.012
TRAT1	T cell receptor associated transmembrane adaptor 1	0.012
NPC2	Niemann-Pick disease, type C2	0.012
CD96	CD96 molecule	0.012
BIN2	bridging integrator 2	0.012
TNFSF13B	tumor necrosis factor (ligand) superfamily, member 13b	0.012
S100A13	S100 calcium binding protein A13	0.011
ZC3H12A	zinc finger CCCH-type containing 12A	0.011
IL18R1	interleukin 18 receptor 1	0.011
CXCL13	chemokine (C-X-C motif) ligand 13	0.011
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.011
MYD88	myeloid differentiation primary response gene (88)	0.011
GNA15	guanine nucleotide binding protein (G protein), alpha 15 (Gq class)	0.011
CCL8	chemokine (C-C motif) ligand 8	0.011
NCKAP1L	NCK-associated protein 1-like	0.011
LTC4S	leukotriene C4 synthase	0.011
RASGRP1	RAS guanyl releasing protein 1 (calcium and DAG-regulated)	0.011
MYST1	MYST histone acetyltransferase 1	0.011
TXNDC2	thioredoxin domain containing 2 (spermatozoa)	0.011
EBI3	Epstein-Barr virus induced 3	0.011
CXCR3	chemokine (C-X-C motif) receptor 3	0.011
IL6	interleukin 6 (interferon, beta 2)	0.011
IL12RB2	interleukin 12 receptor, beta 2	0.011
OPTN	optineurin	0.011
TSPAN4	tetraspanin 4	0.011
SLAMF8	SLAM family member 8	0.011
PTPN5	protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)	0.011
USP42	ubiquitin specific peptidase 42	0.011
TNFRSF12A	tumor necrosis factor receptor superfamily, member 12A	0.011
TKT	transketolase	0.011
LILRB5	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	0.010
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.010
YY1	YY1 transcription factor	0.010
RUNX3	runt-related transcription factor 3	0.010
IGJ	immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides	0.010
CHST11	carbohydrate (chondroitin 4) sulfotransferase 11	0.010
AHNAK	AHNAK nucleoprotein	0.010
BTN3A2	butyrophilin, subfamily 3, member A2	0.010
EMP1	epithelial membrane protein 1	0.010
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.010
CCL1	chemokine (C-C motif) ligand 1	0.010
CD84	CD84 molecule	0.010
SLFN12	schlafen family member 12	0.010
DEFA4	defensin, alpha 4, corticostatin	0.010
CCR4	chemokine (C-C motif) receptor 4	0.010
BTN3A1	butyrophilin, subfamily 3, member A1	0.010