IMP

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Homo sapiens

22 genes annotated in human

interleukin 1 beta production

The appearance of interleukin-1 beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "interleukin 1 beta production"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "interleukin 1 beta production" (in gray)

Name	Description	Probability	Func Analog Organism
NLRC4	NLR family, CARD domain containing 4	0.991
PYCARD	PYD and CARD domain containing	0.858
HP	haptoglobin	0.728
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.703
RIPK2	receptor-interacting serine-threonine kinase 2	0.700
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.610	Mouse Rat
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.524
SNTB2	syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)	0.469
CCL4	chemokine (C-C motif) ligand 4	0.421
SMAD2	SMAD family member 2	0.329
APOC1	apolipoprotein C-I	0.302
ELANE	elastase, neutrophil expressed	0.270	Human
NKG7	natural killer cell group 7 sequence	0.247
HSPB8	heat shock 22kDa protein 8	0.222
PRF1	perforin 1 (pore forming protein)	0.214
GNLY	granulysin	0.181
FZD1	frizzled homolog 1 (Drosophila)	0.169
MPO	myeloperoxidase	0.151
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.149	Human
CCR7	chemokine (C-C motif) receptor 7	0.139	Mouse
APOC3	apolipoprotein C-III	0.138
A2M	alpha-2-macroglobulin	0.130
IL1R1	interleukin 1 receptor, type I	0.124
CTSG	cathepsin G	0.121	Human
IDE	insulin-degrading enzyme	0.109
SOCS3	suppressor of cytokine signaling 3	0.096
ARRB1	arrestin, beta 1	0.089
IL7R	interleukin 7 receptor	0.085
GPR171	G protein-coupled receptor 171	0.083
CST7	cystatin F (leukocystatin)	0.080
ALB	albumin	0.077
IFNGR1	interferon gamma receptor 1	0.077
IL1RN	interleukin 1 receptor antagonist	0.073
IL2RB	interleukin 2 receptor, beta	0.072
CD3D	CD3d molecule, delta (CD3-TCR complex)	0.072
PYDC2	pyrin domain containing 2	0.068
GPR65	G protein-coupled receptor 65	0.065
LCAT	lecithin-cholesterol acyltransferase	0.065
CXCL9	chemokine (C-X-C motif) ligand 9	0.062
SQSTM1	sequestosome 1	0.061
AZU1	azurocidin 1	0.054
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.054
IL18RAP	interleukin 18 receptor accessory protein	0.054
EGR2	early growth response 2	0.050
CD8A	CD8a molecule	0.046
GBP1	guanylate binding protein 1, interferon-inducible	0.045
SOCS1	suppressor of cytokine signaling 1	0.045
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.044
CFL1	cofilin 1 (non-muscle)	0.044
SRGN	serglycin	0.044
CLEC4G	C-type lectin domain family 4, member G	0.042
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.042
CCL19	chemokine (C-C motif) ligand 19	0.042	Mouse
PRTN3	proteinase 3	0.041	Human
ITK	IL2-inducible T-cell kinase	0.038
BAG3	BCL2-associated athanogene 3	0.038
RNASE3	ribonuclease, RNase A family, 3	0.038
KLRB1	killer cell lectin-like receptor subfamily B, member 1	0.037
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.036
ATM	ataxia telangiectasia mutated	0.035
BTN3A1	butyrophilin, subfamily 3, member A1	0.035
IRF8	interferon regulatory factor 8	0.035
SP100	SP100 nuclear antigen	0.034
TARP	TCR gamma alternate reading frame protein	0.034
CARD16	caspase recruitment domain family, member 16	0.033
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.033
STAT4	signal transducer and activator of transcription 4	0.033
MS4A1	membrane-spanning 4-domains, subfamily A, member 1	0.032
KLRD1	killer cell lectin-like receptor subfamily D, member 1	0.031
POLR2L	polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa	0.030
ARHGAP25	Rho GTPase activating protein 25	0.029
CCL20	chemokine (C-C motif) ligand 20	0.029
TRIM38	tripartite motif containing 38	0.028
BCL2A1	BCL2-related protein A1	0.028
APOA2	apolipoprotein A-II	0.027
JAK3	Janus kinase 3	0.027
IFNG	interferon, gamma	0.027
IL18	interleukin 18 (interferon-gamma-inducing factor)	0.027
CD3G	CD3g molecule, gamma (CD3-TCR complex)	0.026
CD48	CD48 molecule	0.026
GSK3B	glycogen synthase kinase 3 beta	0.026
KLRK1	killer cell lectin-like receptor subfamily K, member 1	0.025
C2orf18	chromosome 2 open reading frame 18	0.025
CTSW	cathepsin W	0.025
CPA3	carboxypeptidase A3 (mast cell)	0.024
HDC	histidine decarboxylase	0.024
TRIM22	tripartite motif containing 22	0.024
IGSF6	immunoglobulin superfamily, member 6	0.023
IGJ	immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides	0.023
TNFRSF10C	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain	0.023
PGLYRP1	peptidoglycan recognition protein 1	0.023
TNIP2	TNFAIP3 interacting protein 2	0.023
LTF	lactotransferrin	0.022
CLEC2B	C-type lectin domain family 2, member B	0.022
EMR1	egf-like module containing, mucin-like, hormone receptor-like 1	0.022
TRAF3IP3	TRAF3 interacting protein 3	0.022
SF3B4	splicing factor 3b, subunit 4, 49kDa	0.022
PVRIG	poliovirus receptor related immunoglobulin domain containing	0.022
C1QA	complement component 1, q subcomponent, A chain	0.022
GPR18	G protein-coupled receptor 18	0.022	Human
RPL11	ribosomal protein L11	0.021
RAB5C	RAB5C, member RAS oncogene family	0.021
STX12	syntaxin 12	0.021
APOC2	apolipoprotein C-II	0.021
NMI	N-myc (and STAT) interactor	0.021
ZC3H12A	zinc finger CCCH-type containing 12A	0.021
CMA1	chymase 1, mast cell	0.020
BAX	BCL2-associated X protein	0.020
CAPG	capping protein (actin filament), gelsolin-like	0.020
CARD6	caspase recruitment domain family, member 6	0.020
LRP6	low density lipoprotein receptor-related protein 6	0.020
CYTIP	cytohesin 1 interacting protein	0.020
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.019
CAMP	cathelicidin antimicrobial peptide	0.019
CCR2	chemokine (C-C motif) receptor 2	0.019
HCP5	HLA complex P5	0.019
ICAM1	intercellular adhesion molecule 1	0.019
IL10RA	interleukin 10 receptor, alpha	0.019
ITGB7	integrin, beta 7	0.019
IRF4	interferon regulatory factor 4	0.019
P2RY10	purinergic receptor P2Y, G-protein coupled, 10	0.018
TNF	tumor necrosis factor	0.018
NLRP1	NLR family, pyrin domain containing 1	0.018
IL1B	interleukin 1, beta	0.018	Mouse
FGA	fibrinogen alpha chain	0.018
IL21R	interleukin 21 receptor	0.018
TRAT1	T cell receptor associated transmembrane adaptor 1	0.018
PRG2	proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)	0.018
AIM2	absent in melanoma 2	0.017
TTR	transthyretin	0.017
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.017
DEFA4	defensin, alpha 4, corticostatin	0.017
LY9	lymphocyte antigen 9	0.017
CCL5	chemokine (C-C motif) ligand 5	0.017
INADL	InaD-like (Drosophila)	0.017
CAV1	caveolin 1, caveolae protein, 22kDa	0.017
CSTA	cystatin A (stefin A)	0.017
HLA-DRB4	major histocompatibility complex, class II, DR beta 4	0.017
IL10	interleukin 10	0.017
SLAMF7	SLAM family member 7	0.017
APOA1	apolipoprotein A-I	0.016
MS4A3	membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)	0.016
CCL8	chemokine (C-C motif) ligand 8	0.016
BPI	bactericidal/permeability-increasing protein	0.016
NLRP3	NLR family, pyrin domain containing 3	0.016
LTC4S	leukotriene C4 synthase	0.016
AOAH	acyloxyacyl hydrolase (neutrophil)	0.016
IL18R1	interleukin 18 receptor 1	0.016
SOD2	superoxide dismutase 2, mitochondrial	0.016
FCN1	ficolin (collagen/fibrinogen domain containing) 1	0.015
FHL2	four and a half LIM domains 2	0.015
TP53BP1	tumor protein p53 binding protein 1	0.015
TXNDC2	thioredoxin domain containing 2 (spermatozoa)	0.015
C1QC	complement component 1, q subcomponent, C chain	0.015
TNFRSF17	tumor necrosis factor receptor superfamily, member 17	0.015
DNTT	deoxynucleotidyltransferase, terminal	0.015
SELL	selectin L	0.015
CCL21	chemokine (C-C motif) ligand 21	0.015
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.015	Mouse
ANG	angiogenin, ribonuclease, RNase A family, 5	0.015
TAGAP	T-cell activation RhoGTPase activating protein	0.015
BIN2	bridging integrator 2	0.014
KYNU	kynureninase	0.014
RETN	resistin	0.014
RASGRP1	RAS guanyl releasing protein 1 (calcium and DAG-regulated)	0.014
IL1A	interleukin 1, alpha	0.014
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.014
IL6	interleukin 6 (interferon, beta 2)	0.014
MAPK14	mitogen-activated protein kinase 14	0.014
BTN3A2	butyrophilin, subfamily 3, member A2	0.014
ABCA1	ATP-binding cassette, sub-family A (ABC1), member 1	0.014
KLRF1	killer cell lectin-like receptor subfamily F, member 1	0.014
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.014
CCL22	chemokine (C-C motif) ligand 22	0.014
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.014
NCF2	neutrophil cytosolic factor 2	0.013
FCAR	Fc fragment of IgA, receptor for	0.013
TXNDC3	thioredoxin domain containing 3 (spermatozoa)	0.013
TLR2	toll-like receptor 2	0.013
RNF31	ring finger protein 31	0.013
EVI2A	ecotropic viral integration site 2A	0.013
CSF2RA	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	0.013
FAIM3	Fas apoptotic inhibitory molecule 3	0.013
RNASEL	ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)	0.013
GBP5	guanylate binding protein 5	0.013
PLTP	phospholipid transfer protein	0.013
LY96	lymphocyte antigen 96	0.013
SLAMF1	signaling lymphocytic activation molecule family member 1	0.013
AR	androgen receptor	0.013
KLRG1	killer cell lectin-like receptor subfamily G, member 1	0.013
LILRB5	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	0.013
CD38	CD38 molecule	0.012
CD2	CD2 molecule	0.012
MYST1	MYST histone acetyltransferase 1	0.012
OPTN	optineurin	0.012
CXCL2	chemokine (C-X-C motif) ligand 2	0.012
SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.012
CSF3R	colony stimulating factor 3 receptor (granulocyte)	0.012
GPR183	G protein-coupled receptor 183	0.012
SLAMF8	SLAM family member 8	0.012
STAT5A	signal transducer and activator of transcription 5A	0.012
CLEC10A	C-type lectin domain family 10, member A	0.012
ITGAM	integrin, alpha M (complement component 3 receptor 3 subunit)	0.012
POU2F1	POU class 2 homeobox 1	0.012
CXCL3	chemokine (C-X-C motif) ligand 3	0.012
IL8	interleukin 8	0.012
CASP5	caspase 5, apoptosis-related cysteine peptidase	0.012
IL2RA	interleukin 2 receptor, alpha	0.012
UTS2R	urotensin 2 receptor	0.012
CD160	CD160 molecule	0.012
AQP9	aquaporin 9	0.012
C1QB	complement component 1, q subcomponent, B chain	0.012
CXCL13	chemokine (C-X-C motif) ligand 13	0.012
CD83	CD83 molecule	0.012
STX11	syntaxin 11	0.011
IGL@	immunoglobulin lambda locus	0.011
IL12RB2	interleukin 12 receptor, beta 2	0.011
HBD	hemoglobin, delta	0.011
ICOS	inducible T-cell co-stimulator	0.011
GIMAP4	GTPase, IMAP family member 4	0.011
PRAM1	PML-RARA regulated adaptor molecule 1	0.011
CXCR3	chemokine (C-X-C motif) receptor 3	0.011
MS4A2	membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)	0.011
NFE2	nuclear factor (erythroid-derived 2), 45kDa	0.011
DEDD	death effector domain containing	0.011
PTGIR	prostaglandin I2 (prostacyclin) receptor (IP)	0.011
MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	0.011
MEFV	Mediterranean fever	0.011
CCL13	chemokine (C-C motif) ligand 13	0.011
FLT3	fms-related tyrosine kinase 3	0.011
S100A12	S100 calcium binding protein A12	0.011
CEBPA	CCAAT/enhancer binding protein (C/EBP), alpha	0.011
TLR1	toll-like receptor 1	0.011
IL2RG	interleukin 2 receptor, gamma	0.011
CD69	CD69 molecule	0.010
CD96	CD96 molecule	0.010
CLC	Charcot-Leyden crystal protein	0.010
HBB	hemoglobin, beta	0.010
DPYD	dihydropyrimidine dehydrogenase	0.010
HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	0.010
MTHFD1L	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like	0.010
TKT	transketolase	0.010
SP1	Sp1 transcription factor	0.010
GPR84	G protein-coupled receptor 84	0.010
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.010
SERPINB9	serpin peptidase inhibitor, clade B (ovalbumin), member 9	0.010
KRT1	keratin 1	0.010
SH2B1	SH2B adaptor protein 1	0.010
IL16	interleukin 16 (lymphocyte chemoattractant factor)	0.010
EFTUD2	elongation factor Tu GTP binding domain containing 2	0.010
GZMA	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)	0.010	Human
SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	0.010
HPR	haptoglobin-related protein	0.010