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Homo sapiens

4 genes annotated in human

mast cell activation involved in immune response

The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response.

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Gene Predictions

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Name	Description	Probability	Func Analog Organism
SYK	spleen tyrosine kinase	0.999	Mouse Rat
LCK	lymphocyte-specific protein tyrosine kinase	0.999
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.980
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.943
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.900
BLNK	B-cell linker	0.770
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.717
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.666
VEGFA	vascular endothelial growth factor A	0.655
UBASH3B	ubiquitin associated and SH3 domain containing B	0.638
EGFR	epidermal growth factor receptor	0.629
GAB1	GRB2-associated binding protein 1	0.578
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.548	Human
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.529	Mouse
IL4R	interleukin 4 receptor	0.458	Mouse
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.415
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.404
FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	0.396
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.352
SOS1	son of sevenless homolog 1 (Drosophila)	0.351
LAT	linker for activation of T cells	0.348
NRP1	neuropilin 1	0.312
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.306	Human
VAV1	vav 1 guanine nucleotide exchange factor	0.242
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.222
CRH	corticotropin releasing hormone	0.202
TFF1	trefoil factor 1	0.190
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.189	Human
GRB2	growth factor receptor-bound protein 2	0.182
FCER1G	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	0.180	Mouse
BTK	Bruton agammaglobulinemia tyrosine kinase	0.171	Rat
PLCG1	phospholipase C, gamma 1	0.151
SLA	Src-like-adaptor	0.144
IL2RG	interleukin 2 receptor, gamma	0.140
SPRR2A	small proline-rich protein 2A	0.135
IL4	interleukin 4	0.130	Mouse
PGF	placental growth factor	0.124
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.104
HCK	hemopoietic cell kinase	0.103
PDGFA	platelet-derived growth factor alpha polypeptide	0.103
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.097
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.096
PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	0.090
FYB	FYN binding protein	0.090
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.088	Human
ZNF746	zinc finger protein 746	0.086
AXL	AXL receptor tyrosine kinase	0.081
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.078
BAI1	brain-specific angiogenesis inhibitor 1	0.076
SH3KBP1	SH3-domain kinase binding protein 1	0.065
CARD11	caspase recruitment domain family, member 11	0.062
IBTK	inhibitor of Bruton agammaglobulinemia tyrosine kinase	0.055
FASLG	Fas ligand (TNF superfamily, member 6)	0.053
PDGFC	platelet derived growth factor C	0.050
ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	0.047
CSF3R	colony stimulating factor 3 receptor (granulocyte)	0.047
C1orf93	chromosome 1 open reading frame 93	0.045
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.043
HCLS1	hematopoietic cell-specific Lyn substrate 1	0.042
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.038
KITLG	KIT ligand	0.036
FGFR1	fibroblast growth factor receptor 1	0.036
SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.035
PRKCQ	protein kinase C, theta	0.030
HK3	hexokinase 3 (white cell)	0.030
CD33	CD33 molecule	0.029
SOS2	son of sevenless homolog 2 (Drosophila)	0.028
LDLR	low density lipoprotein receptor	0.027
FYN	FYN oncogene related to SRC, FGR, YES	0.027
CDH5	cadherin 5, type 2 (vascular endothelium)	0.027
PTPRB	protein tyrosine phosphatase, receptor type, B	0.027
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.027
GAS7	growth arrest-specific 7	0.026
TYROBP	TYRO protein tyrosine kinase binding protein	0.026
EPHA8	EPH receptor A8	0.026
JAK2	Janus kinase 2	0.024
FCGR3B	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	0.024
APOBR	apolipoprotein B receptor	0.023
MAP4K1	mitogen-activated protein kinase kinase kinase kinase 1	0.023
DOK3	docking protein 3	0.022
WIPF1	WAS/WASL interacting protein family, member 1	0.021
ARID3A	AT rich interactive domain 3A (BRIGHT-like)	0.021
CD37	CD37 molecule	0.021
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.021
PTEN	phosphatase and tensin homolog	0.020
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.020
ARAP1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	0.020
SPI1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.019
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.019
SH2B2	SH2B adaptor protein 2	0.019
GHR	growth hormone receptor	0.019
PRKCB	protein kinase C, beta	0.019
MAPK8	mitogen-activated protein kinase 8	0.019
SBF1	SET binding factor 1	0.019
GIT1	G protein-coupled receptor kinase interacting ArfGAP 1	0.018
SASH3	SAM and SH3 domain containing 3	0.018
FLT4	fms-related tyrosine kinase 4	0.017	Human
LRRC25	leucine rich repeat containing 25	0.017
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.017
PTAFR	platelet-activating factor receptor	0.017
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.017
AIF1	allograft inflammatory factor 1	0.017
FOXF2	forkhead box F2	0.017
CSF2RA	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	0.017
FNBP1	formin binding protein 1	0.017
CAV1	caveolin 1, caveolae protein, 22kDa	0.017
SH3BP5	SH3-domain binding protein 5 (BTK-associated)	0.016
HDC	histidine decarboxylase	0.016
FCGR2B	Fc fragment of IgG, low affinity IIb, receptor (CD32)	0.016
NSF	N-ethylmaleimide-sensitive factor	0.016
PIK3AP1	phosphoinositide-3-kinase adaptor protein 1	0.016
SIGLEC9	sialic acid binding Ig-like lectin 9	0.016
CMIP	c-Maf-inducing protein	0.016
RET	ret proto-oncogene	0.016
CD300LF	CD300 molecule-like family member f	0.016	Human
ABI3	ABI family, member 3	0.016
STK4	serine/threonine kinase 4	0.016
GPSM3	G-protein signaling modulator 3	0.016
SIRPB1	signal-regulatory protein beta 1	0.016
PARK2	parkinson protein 2, E3 ubiquitin protein ligase (parkin)	0.016
PIK3CB	phosphoinositide-3-kinase, catalytic, beta polypeptide	0.015
CTSG	cathepsin G	0.015
HPGDS	hematopoietic prostaglandin D synthase	0.015
DPEP2	dipeptidase 2	0.015
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.015
PIM1	pim-1 oncogene	0.015
MAP2	microtubule-associated protein 2	0.015
CEACAM4	carcinoembryonic antigen-related cell adhesion molecule 4	0.015
MYO1F	myosin IF	0.015
EMR1	egf-like module containing, mucin-like, hormone receptor-like 1	0.015
CD300A	CD300a molecule	0.014
PILRA	paired immunoglobin-like type 2 receptor alpha	0.014
AQP9	aquaporin 9	0.014
AKAP2	A kinase (PRKA) anchor protein 2	0.014
CPA3	carboxypeptidase A3 (mast cell)	0.014
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.014
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.014
GRB7	growth factor receptor-bound protein 7	0.014
KRT8	keratin 8	0.014
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.014
MPEG1	macrophage expressed 1	0.014
SPRY4	sprouty homolog 4 (Drosophila)	0.014
NCK2	NCK adaptor protein 2	0.014
ITGAM	integrin, alpha M (complement component 3 receptor 3 subunit)	0.014
CR1	complement component (3b/4b) receptor 1 (Knops blood group)	0.014
PACSIN2	protein kinase C and casein kinase substrate in neurons 2	0.013
TBXAS1	thromboxane A synthase 1 (platelet)	0.013
C5AR1	complement component 5a receptor 1	0.013
LILRB3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.013
ALOX5	arachidonate 5-lipoxygenase	0.013
PIK3R5	phosphoinositide-3-kinase, regulatory subunit 5	0.013
CD300C	CD300c molecule	0.013	Human
TAB1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.013
CD163	CD163 molecule	0.013
ZC3HC1	zinc finger, C3HC-type containing 1	0.013
TREM2	triggering receptor expressed on myeloid cells 2	0.013
CD68	CD68 molecule	0.013
TMF1	TATA element modulatory factor 1	0.012
TNFAIP8L2	tumor necrosis factor, alpha-induced protein 8-like 2	0.012
DUSP23	dual specificity phosphatase 23	0.012
NFAM1	NFAT activating protein with ITAM motif 1	0.012
ALOX5AP	arachidonate 5-lipoxygenase-activating protein	0.012
ROBO4	roundabout homolog 4, magic roundabout (Drosophila)	0.012
CD93	CD93 molecule	0.012
FAM82A2	family with sequence similarity 82, member A2	0.012
NCF4	neutrophil cytosolic factor 4, 40kDa	0.012
MAPK3	mitogen-activated protein kinase 3	0.012
HSH2D	hematopoietic SH2 domain containing	0.012
SRGAP2	SLIT-ROBO Rho GTPase activating protein 2	0.012
REPS2	RALBP1 associated Eps domain containing 2	0.012
IL17RA	interleukin 17 receptor A	0.012
KIAA0930	KIAA0930	0.012
LY6G6F	lymphocyte antigen 6 complex, locus G6F	0.011
LRMP	lymphoid-restricted membrane protein	0.011
PARVG	parvin, gamma	0.011
SIGLEC7	sialic acid binding Ig-like lectin 7	0.011
RHOU	ras homolog gene family, member U	0.011
FCN1	ficolin (collagen/fibrinogen domain containing) 1	0.011
CD2	CD2 molecule	0.011
LST1	leukocyte specific transcript 1	0.011
HSPG2	heparan sulfate proteoglycan 2	0.011
PLEKHO2	pleckstrin homology domain containing, family O member 2	0.011
LRRC33	leucine rich repeat containing 33	0.011
IRF5	interferon regulatory factor 5	0.011
EPOR	erythropoietin receptor	0.011
LILRA2	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2	0.011
HOXB7	homeobox B7	0.011
SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	0.011
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.011
RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6	0.011
CD2AP	CD2-associated protein	0.010
CD101	CD101 molecule	0.010
CD300LB	CD300 molecule-like family member b	0.010	Human
STAB1	stabilin 1	0.010
CLEC4A	C-type lectin domain family 4, member A	0.010
EMR2	egf-like module containing, mucin-like, hormone receptor-like 2	0.010
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.010
PROM1	prominin 1	0.010
MPRIP	myosin phosphatase Rho interacting protein	0.010
OSCAR	osteoclast associated, immunoglobulin-like receptor	0.010
PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.010
TSC2	tuberous sclerosis 2	0.010
SPRY2	sprouty homolog 2 (Drosophila)	0.010
GPR18	G protein-coupled receptor 18	0.010
IL13	interleukin 13	0.010
SIGLEC5	sialic acid binding Ig-like lectin 5	0.010
TCAP	titin-cap (telethonin)	0.010
DENND1C	DENN/MADD domain containing 1C	0.010
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.010
ADAP2	ArfGAP with dual PH domains 2	0.010