IMP

Process View

Homo sapiens

23 genes annotated in human

nephron epithelium development

GO:0072009

The process whose specific outcome is the progression of the nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The nephron epithelium is a tissue that covers the surface of a nephron.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "nephron epithelium development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "nephron epithelium development" (in gray)

Name	Description	Probability	Func Analog Organism
NOTCH1	notch 1	0.999	Mouse
FGFR2	fibroblast growth factor receptor 2	0.999
JAG1	jagged 1	0.984	Mouse
SMAD3	SMAD family member 3	0.930
VEGFA	vascular endothelial growth factor A	0.928	Mouse
NOTCH3	notch 3	0.923
FGF1	fibroblast growth factor 1 (acidic)	0.908
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.889
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.809
CUL3	cullin 3	0.769
NRP1	neuropilin 1	0.662
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.614
KLHL3	kelch-like 3 (Drosophila)	0.576
EGR3	early growth response 3	0.576	Human
ADRB1	adrenergic, beta-1-, receptor	0.553
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.547
FGFR1	fibroblast growth factor receptor 1	0.435
MEIS1	Meis homeobox 1	0.429
WNK4	WNK lysine deficient protein kinase 4	0.399
MEIS2	Meis homeobox 2	0.384
ADAM17	ADAM metallopeptidase domain 17	0.372
TSC22D4	TSC22 domain family, member 4	0.365
PKD2	polycystic kidney disease 2 (autosomal dominant)	0.325
FGF10	fibroblast growth factor 10	0.290	Human
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.283
COL2A1	collagen, type II, alpha 1	0.256
NKX2-1	NK2 homeobox 1	0.241
DPYSL4	dihydropyrimidinase-like 4	0.236
FGF8	fibroblast growth factor 8 (androgen-induced)	0.220
SOX2	SRY (sex determining region Y)-box 2	0.211
KLHL12	kelch-like 12 (Drosophila)	0.208	Human
FGF18	fibroblast growth factor 18	0.202
FSTL1	follistatin-like 1	0.199
MDFI	MyoD family inhibitor	0.198
LAPTM5	lysosomal protein transmembrane 5	0.196
TCF4	transcription factor 4	0.188
DAPK1	death-associated protein kinase 1	0.184
PKD1	polycystic kidney disease 1 (autosomal dominant)	0.180
NOTCH2	notch 2	0.173	Mouse
HOXA10	homeobox A10	0.164
HOXB5	homeobox B5	0.162
CDC25B	cell division cycle 25 homolog B (S. pombe)	0.159
MEOX1	mesenchyme homeobox 1	0.146
CCNE1	cyclin E1	0.144
TIMP3	TIMP metallopeptidase inhibitor 3	0.135
MSN	moesin	0.130
KLHL2	kelch-like 2, Mayven (Drosophila)	0.116	Human
SKIL	SKI-like oncogene	0.113
ENG	endoglin	0.110
BMP7	bone morphogenetic protein 7	0.106
FGF4	fibroblast growth factor 4	0.105	Human
MAML1	mastermind-like 1 (Drosophila)	0.099
MAGED2	melanoma antigen family D, 2	0.098
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.091
GLIS2	GLIS family zinc finger 2	0.089
PAX8	paired box 8	0.087
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.085
JAG2	jagged 2	0.080
EGR2	early growth response 2	0.073	Human
PJA1	praja ring finger 1	0.071
BMP2	bone morphogenetic protein 2	0.070	Human Mouse
DLL1	delta-like 1 (Drosophila)	0.070	Mouse
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.069
PARVA	parvin, alpha	0.069
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.068	Zebrafish
BMP4	bone morphogenetic protein 4	0.068
NGFR	nerve growth factor receptor	0.064
HDAC4	histone deacetylase 4	0.063
SH3GL3	SH3-domain GRB2-like 3	0.060
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.060
PRMT6	protein arginine methyltransferase 6	0.059
BCAM	basal cell adhesion molecule (Lutheran blood group)	0.056
HMGA1	high mobility group AT-hook 1	0.055
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.052
HDAC9	histone deacetylase 9	0.046
TRPV5	transient receptor potential cation channel, subfamily V, member 5	0.044
PDGFA	platelet-derived growth factor alpha polypeptide	0.044
TGFB3	transforming growth factor, beta 3	0.044
THBS1	thrombospondin 1	0.044
EGR1	early growth response 1	0.043	Human
ZNF512B	zinc finger protein 512B	0.042
TGFB2	transforming growth factor, beta 2	0.041
SOX1	SRY (sex determining region Y)-box 1	0.041
PAX2	paired box 2	0.041
DSCAML1	Down syndrome cell adhesion molecule like 1	0.041
SFRP1	secreted frizzled-related protein 1	0.040
INHBB	inhibin, beta B	0.039
WNT1	wingless-type MMTV integration site family, member 1	0.038	Human Mouse Fly
PDX1	pancreatic and duodenal homeobox 1	0.037
SOX9	SRY (sex determining region Y)-box 9	0.036	Mouse
COL6A1	collagen, type VI, alpha 1	0.035
HMGA2	high mobility group AT-hook 2	0.034
FGF3	fibroblast growth factor 3	0.033	Human
IRX4	iroquois homeobox 4	0.033
CLDN4	claudin 4	0.032
FOSB	FBJ murine osteosarcoma viral oncogene homolog B	0.032
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.031
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.031
OXSR1	oxidative-stress responsive 1	0.030
ATXN1L	ataxin 1-like	0.030
AQP5	aquaporin 5	0.029
HNF1B	HNF1 homeobox B	0.029
COL7A1	collagen, type VII, alpha 1	0.029
TAOK1	TAO kinase 1	0.029
SMAD9	SMAD family member 9	0.028
FGFR3	fibroblast growth factor receptor 3	0.028
NFIB	nuclear factor I/B	0.028
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.028	Mouse
PCBD2	pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2	0.028
CACNA1G	calcium channel, voltage-dependent, T type, alpha 1G subunit	0.027
LBX1	ladybird homeobox 1	0.027
HNF1A	HNF1 homeobox A	0.027	Human
TGFBR1	transforming growth factor, beta receptor 1	0.027
HOXD13	homeobox D13	0.027
FOXC1	forkhead box C1	0.026
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.026
RAX	retina and anterior neural fold homeobox	0.025
SIM2	single-minded homolog 2 (Drosophila)	0.024
PAX3	paired box 3	0.023
SNAI1	snail homolog 1 (Drosophila)	0.023
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.023
PDGFC	platelet derived growth factor C	0.023
TP73	tumor protein p73	0.023
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.023
PAX7	paired box 7	0.023
EYA2	eyes absent homolog 2 (Drosophila)	0.022
SPTBN1	spectrin, beta, non-erythrocytic 1	0.022
IGFBP5	insulin-like growth factor binding protein 5	0.022
FOXD3	forkhead box D3	0.022
CCDC48	coiled-coil domain containing 48	0.022
NFE2L2	nuclear factor (erythroid-derived 2)-like 2	0.022
IER2	immediate early response 2	0.022
NCOR2	nuclear receptor corepressor 2	0.021
CXXC5	CXXC finger protein 5	0.021
XIAP	X-linked inhibitor of apoptosis	0.021
FOXA2	forkhead box A2	0.021
CASK	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	0.021
EP300	E1A binding protein p300	0.021
SOX11	SRY (sex determining region Y)-box 11	0.021
RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	0.021
HOXB9	homeobox B9	0.021
IHH	Indian hedgehog	0.020
PHLDA1	pleckstrin homology-like domain, family A, member 1	0.020
MED28	mediator complex subunit 28	0.020
NAB2	NGFI-A binding protein 2 (EGR1 binding protein 2)	0.020
CALCA	calcitonin-related polypeptide alpha	0.020
STK36	serine/threonine kinase 36	0.019
AMOTL1	angiomotin like 1	0.019
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.019
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.019
WNT3	wingless-type MMTV integration site family, member 3	0.019	Human
VSX1	visual system homeobox 1	0.019
NEUROG2	neurogenin 2	0.018
PTPN14	protein tyrosine phosphatase, non-receptor type 14	0.018
HES2	hairy and enhancer of split 2 (Drosophila)	0.018
FGF7	fibroblast growth factor 7	0.018	Human
EPAS1	endothelial PAS domain protein 1	0.018
FBXW7	F-box and WD repeat domain containing 7	0.018
DUSP6	dual specificity phosphatase 6	0.018
NOVA2	neuro-oncological ventral antigen 2	0.018
PROX1	prospero homeobox 1	0.018
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.018
MNX1	motor neuron and pancreas homeobox 1	0.018
GDNF	glial cell derived neurotrophic factor	0.018
IQGAP1	IQ motif containing GTPase activating protein 1	0.018
NPAS1	neuronal PAS domain protein 1	0.018
BMPR1A	bone morphogenetic protein receptor, type IA	0.017
LNX1	ligand of numb-protein X 1	0.017
WIF1	WNT inhibitory factor 1	0.017
TEAD4	TEA domain family member 4	0.017
CDC25A	cell division cycle 25 homolog A (S. pombe)	0.017
BCL2L1	BCL2-like 1	0.017
HBEGF	heparin-binding EGF-like growth factor	0.016
ID4	inhibitor of DNA binding 4, dominant negative helix-loop-helix protein	0.016
DPPA4	developmental pluripotency associated 4	0.016
WNT10A	wingless-type MMTV integration site family, member 10A	0.016	Human
MYCN	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.016
TCF7L1	transcription factor 7-like 1 (T-cell specific, HMG-box)	0.016
TLX1	T-cell leukemia homeobox 1	0.016
PTH2	parathyroid hormone 2	0.016
TCF21	transcription factor 21	0.015	Mouse
HS3ST6	heparan sulfate (glucosamine) 3-O-sulfotransferase 6	0.015
TINAGL1	tubulointerstitial nephritis antigen-like 1	0.015
OVOL1	ovo-like 1(Drosophila)	0.015
SDC2	syndecan 2	0.015
NOG	noggin	0.015	Mouse
EFNA2	ephrin-A2	0.015
FOXN4	forkhead box N4	0.015
FOXF1	forkhead box F1	0.015
NFE2L1	nuclear factor (erythroid-derived 2)-like 1	0.015
LMO4	LIM domain only 4	0.015
RSPO2	R-spondin 2 homolog (Xenopus laevis)	0.015
NOTCH2NL	notch 2 N-terminal like	0.015
SPEN	spen homolog, transcriptional regulator (Drosophila)	0.015
SMAD2	SMAD family member 2	0.015
FOXL1	forkhead box L1	0.015
CDX2	caudal type homeobox 2	0.015
HNF4A	hepatocyte nuclear factor 4, alpha	0.015
HOXD10	homeobox D10	0.015
TBCD	tubulin folding cofactor D	0.015
OTX2	orthodenticle homeobox 2	0.015
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.014
WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	0.014
DGCR14	DiGeorge syndrome critical region gene 14	0.014
HIVEP1	human immunodeficiency virus type I enhancer binding protein 1	0.014
MYOD1	myogenic differentiation 1	0.014
RBPMS	RNA binding protein with multiple splicing	0.014
PYY	peptide YY	0.014
SIX2	SIX homeobox 2	0.014	Mouse
FRS2	fibroblast growth factor receptor substrate 2	0.014
LIMS1	LIM and senescent cell antigen-like domains 1	0.014
ENTPD2	ectonucleoside triphosphate diphosphohydrolase 2	0.014
EYA1	eyes absent homolog 1 (Drosophila)	0.014
WNK1	WNK lysine deficient protein kinase 1	0.014	Human
SLC30A2	solute carrier family 30 (zinc transporter), member 2	0.013
CLDN1	claudin 1	0.013
TAL1	T-cell acute lymphocytic leukemia 1	0.013
PAPPA	pregnancy-associated plasma protein A, pappalysin 1	0.013
POU2F1	POU class 2 homeobox 1	0.013
CD93	CD93 molecule	0.013
PRKCQ	protein kinase C, theta	0.013
HMX1	H6 family homeobox 1	0.013
ANGPT1	angiopoietin 1	0.013
ZNF331	zinc finger protein 331	0.013
SMAD7	SMAD family member 7	0.013
CSF2	colony stimulating factor 2 (granulocyte-macrophage)	0.012
GAS1	growth arrest-specific 1	0.012
WNT3A	wingless-type MMTV integration site family, member 3A	0.012
NPHP1	nephronophthisis 1 (juvenile)	0.012
FGFR4	fibroblast growth factor receptor 4	0.012
BBS1	Bardet-Biedl syndrome 1	0.012
IRX5	iroquois homeobox 5	0.012
LRDD	leucine-rich repeats and death domain containing	0.012
COL4A5	collagen, type IV, alpha 5	0.012
EPHA8	EPH receptor A8	0.012
SLC6A2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	0.012
BARHL1	BarH-like homeobox 1	0.012
DNAJC1	DnaJ (Hsp40) homolog, subfamily C, member 1	0.012
NBPF10	neuroblastoma breakpoint family, member 10	0.012
WNT9B	wingless-type MMTV integration site family, member 9B	0.012	Human
GHSR	growth hormone secretagogue receptor	0.012
SLC7A11	solute carrier family 7, (cationic amino acid transporter, y+ system) member 11	0.011
FZD7	frizzled homolog 7 (Drosophila)	0.011
TFAP2C	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	0.011
FOXF2	forkhead box F2	0.011
SIX3	SIX homeobox 3	0.011
TBX2	T-box 2	0.011
LHX9	LIM homeobox 9	0.011
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.011
CLDN7	claudin 7	0.011
ACP5	acid phosphatase 5, tartrate resistant	0.011
NKX6-1	NK6 homeobox 1	0.011
ECEL1	endothelin converting enzyme-like 1	0.011
RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	0.011
NPHS2	nephrosis 2, idiopathic, steroid-resistant (podocin)	0.011
NOTCH4	notch 4	0.011
FGF5	fibroblast growth factor 5	0.011	Human
CDH16	cadherin 16, KSP-cadherin	0.011
HMX3	H6 family homeobox 3	0.011
SHH	sonic hedgehog	0.011
CD248	CD248 molecule, endosialin	0.011
WNK2	WNK lysine deficient protein kinase 2	0.011	Human
ESPN	espin	0.011
TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)	0.011
TP53BP2	tumor protein p53 binding protein, 2	0.011
LAMC3	laminin, gamma 3	0.011
EVX1	even-skipped homeobox 1	0.011
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.011
SEMA3F	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	0.011
STC1	stanniocalcin 1	0.011
CDH3	cadherin 3, type 1, P-cadherin (placental)	0.011
HOXD1	homeobox D1	0.010
FGF19	fibroblast growth factor 19	0.010
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.010
WT1	Wilms tumor 1	0.010
NKPD1	NTPase, KAP family P-loop domain containing 1	0.010
HOXD11	homeobox D11	0.010	Mouse
EZR	ezrin	0.010
ARID1B	AT rich interactive domain 1B (SWI1-like)	0.010
AMBRA1	autophagy/beclin-1 regulator 1	0.010
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.010
MAFG	v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)	0.010
CAMSAP1	calmodulin regulated spectrin-associated protein 1	0.010
ZNF746	zinc finger protein 746	0.010
SOAT1	sterol O-acyltransferase 1	0.010
DLL4	delta-like 4 (Drosophila)	0.010
TEK	TEK tyrosine kinase, endothelial	0.010
OTP	orthopedia homeobox	0.010