IMP

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Homo sapiens

14 genes annotated in human

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smoothened signaling pathway

GO:0007224

A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "smoothened signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "smoothened signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.971
SUFU	suppressor of fused homolog (Drosophila)	0.809	Mouse
BTRC	beta-transducin repeat containing	0.764	Fly
BBS10	Bardet-Biedl syndrome 10	0.699
DCAF7	DDB1 and CUL4 associated factor 7	0.695
TP53	tumor protein p53	0.503
GLI1	GLI family zinc finger 1	0.502
CUL1	cullin 1	0.485
FGF1	fibroblast growth factor 1 (acidic)	0.446
APC	adenomatous polyposis coli	0.393
FSTL1	follistatin-like 1	0.390
FBXW11	F-box and WD repeat domain containing 11	0.377	Fly
BMPR1A	bone morphogenetic protein receptor, type IA	0.372
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.310	Fly
GLI3	GLI family zinc finger 3	0.289	Human Mouse Fly
NR0B1	nuclear receptor subfamily 0, group B, member 1	0.285
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.270
SKP1	S-phase kinase-associated protein 1	0.264
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.262	Human
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.258
TGFB1	transforming growth factor, beta 1	0.256
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.255
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	0.220
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.218
ZAP70	zeta-chain (TCR) associated protein kinase 70kDa	0.209
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.188
NFYA	nuclear transcription factor Y, alpha	0.172
AR	androgen receptor	0.161
PDE6D	phosphodiesterase 6D, cGMP-specific, rod, delta	0.149
PTCH1	patched 1	0.139
SASS6	spindle assembly 6 homolog (C. elegans)	0.133
CREBBP	CREB binding protein	0.122
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.114	Mouse Fly
SMO	smoothened homolog (Drosophila)	0.106
RCN3	reticulocalbin 3, EF-hand calcium binding domain	0.104
CD247	CD247 molecule	0.102
CDC34	cell division cycle 34 homolog (S. cerevisiae)	0.098
CENPJ	centromere protein J	0.096
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.095
BBS4	Bardet-Biedl syndrome 4	0.089
STK36	serine/threonine kinase 36	0.088	Mouse
CSNK1E	casein kinase 1, epsilon	0.085
BMP1	bone morphogenetic protein 1	0.080
LCK	lymphocyte-specific protein tyrosine kinase	0.080
YAP1	Yes-associated protein 1	0.078
ERBB2IP	erbb2 interacting protein	0.077
CSNK2A1	casein kinase 2, alpha 1 polypeptide	0.075	Fly
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.070
TGFB3	transforming growth factor, beta 3	0.070
AKAP11	A kinase (PRKA) anchor protein 11	0.069
CSNK2B	casein kinase 2, beta polypeptide	0.065
GSK3B	glycogen synthase kinase 3 beta	0.065	Fly
BBS2	Bardet-Biedl syndrome 2	0.062
DYRK1B	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B	0.059	Human
RUNX1	runt-related transcription factor 1	0.049
BECN1	beclin 1, autophagy related	0.046
FGFR1	fibroblast growth factor receptor 1	0.042
AXIN1	axin 1	0.042
DYRK4	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4	0.040	Human
LZTS2	leucine zipper, putative tumor suppressor 2	0.039
STRN3	striatin, calmodulin binding protein 3	0.039
FGF10	fibroblast growth factor 10	0.039
ARL6	ADP-ribosylation factor-like 6	0.039	Mouse
UBR1	ubiquitin protein ligase E3 component n-recognin 1	0.037
MAP4K1	mitogen-activated protein kinase kinase kinase kinase 1	0.037
BBS9	Bardet-Biedl syndrome 9	0.032
FGFR2	fibroblast growth factor receptor 2	0.032	Mouse
UBE2M	ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)	0.032	Fly
SIRT1	sirtuin 1	0.032
DYRK2	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2	0.031
BCL2L1	BCL2-like 1	0.029
FBXO33	F-box protein 33	0.029
MAPK14	mitogen-activated protein kinase 14	0.028
FBXW2	F-box and WD repeat domain containing 2	0.028
ARF6	ADP-ribosylation factor 6	0.027
SMAD3	SMAD family member 3	0.027
ARL4D	ADP-ribosylation factor-like 4D	0.026
CEBPE	CCAAT/enhancer binding protein (C/EBP), epsilon	0.026
UNC119	unc-119 homolog (C. elegans)	0.024
NEK1	NIMA (never in mitosis gene a)-related kinase 1	0.024
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.024
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.024
FERMT2	fermitin family member 2	0.024
RTF1	Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.023
CSNK1G3	casein kinase 1, gamma 3	0.023
RAD54B	RAD54 homolog B (S. cerevisiae)	0.023
RBL1	retinoblastoma-like 1 (p107)	0.023
GLI2	GLI family zinc finger 2	0.022
WEE1	WEE1 homolog (S. pombe)	0.022
ATF2	activating transcription factor 2	0.022
AKIP1	A kinase (PRKA) interacting protein 1	0.022
PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.021
LAT	linker for activation of T cells	0.021
TP53BP2	tumor protein p53 binding protein, 2	0.021
TCF4	transcription factor 4	0.021
AXIN2	axin 2	0.021
CDH2	cadherin 2, type 1, N-cadherin (neuronal)	0.020
FOXF2	forkhead box F2	0.020
KIF5B	kinesin family member 5B	0.019
PEX26	peroxisomal biogenesis factor 26	0.019
GNB2	guanine nucleotide binding protein (G protein), beta polypeptide 2	0.019
CEP135	centrosomal protein 135kDa	0.019
CUX1	cut-like homeobox 1	0.019
ID4	inhibitor of DNA binding 4, dominant negative helix-loop-helix protein	0.019
ANKRD13C	ankyrin repeat domain 13C	0.018
BBS1	Bardet-Biedl syndrome 1	0.018
TTC8	tetratricopeptide repeat domain 8	0.017
RB1	retinoblastoma 1	0.017	Mouse
ZIC1	Zic family member 1 (odd-paired homolog, Drosophila)	0.017	Mouse
FHL1	four and a half LIM domains 1	0.017
LEF1	lymphoid enhancer-binding factor 1	0.017
SFRP1	secreted frizzled-related protein 1	0.016
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.016
FGF7	fibroblast growth factor 7	0.016
SOX2	SRY (sex determining region Y)-box 2	0.015
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.015
MID1IP1	MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))	0.014
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.014
NRP1	neuropilin 1	0.014
FBXW7	F-box and WD repeat domain containing 7	0.014
CDK6	cyclin-dependent kinase 6	0.014
DYNC2H1	dynein, cytoplasmic 2, heavy chain 1	0.014
RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	0.014
SYK	spleen tyrosine kinase	0.014
BSG	basigin (Ok blood group)	0.014
SETD7	SET domain containing (lysine methyltransferase) 7	0.013
PRKAR2B	protein kinase, cAMP-dependent, regulatory, type II, beta	0.013
AES	amino-terminal enhancer of split	0.013
PML	promyelocytic leukemia	0.013
NEUROD1	neurogenic differentiation 1	0.013
RYR2	ryanodine receptor 2 (cardiac)	0.013
KRT18	keratin 18	0.013
PPP1R14A	protein phosphatase 1, regulatory (inhibitor) subunit 14A	0.013
SPECC1L	sperm antigen with calponin homology and coiled-coil domains 1-like	0.012
FZD7	frizzled homolog 7 (Drosophila)	0.012
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.012
AMBRA1	autophagy/beclin-1 regulator 1	0.012
CNTF	ciliary neurotrophic factor	0.012
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.012
BMP4	bone morphogenetic protein 4	0.011
NUB1	negative regulator of ubiquitin-like proteins 1	0.011
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.011
ALDOB	aldolase B, fructose-bisphosphate	0.011
MTHFD1L	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like	0.011
PCBP2	poly(rC) binding protein 2	0.011
CHEK1	CHK1 checkpoint homolog (S. pombe)	0.011
BBS7	Bardet-Biedl syndrome 7	0.011	Mouse
LHX2	LIM homeobox 2	0.011
CDX2	caudal type homeobox 2	0.011
TMTC3	transmembrane and tetratricopeptide repeat containing 3	0.011
SNIP1	Smad nuclear interacting protein 1	0.011
GLIS2	GLIS family zinc finger 2	0.011	Human Mouse
TGFB2	transforming growth factor, beta 2	0.011
BAD	BCL2-associated agonist of cell death	0.011
LAMA4	laminin, alpha 4	0.011
RBBP8	retinoblastoma binding protein 8	0.011
NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	0.010
QPRT	quinolinate phosphoribosyltransferase	0.010
ATF6	activating transcription factor 6	0.010
NR0B2	nuclear receptor subfamily 0, group B, member 2	0.010
TCF7L1	transcription factor 7-like 1 (T-cell specific, HMG-box)	0.010
SIRT6	sirtuin 6	0.010
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.010
MPRIP	myosin phosphatase Rho interacting protein	0.010
CDC73	cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.010	Fly
SOX11	SRY (sex determining region Y)-box 11	0.010