IMP

Process View

Mus musculus

17 genes annotated in mouse

cellular response to hypoxia

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cellular response to hypoxia"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cellular response to hypoxia" (in gray)

Name	Description	Probability	Func Analog Organism
Trp53	transformation related protein 53	0.891	Human Zebrafish
Pten	phosphatase and tensin homolog	0.755
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.746
Vegfa	vascular endothelial growth factor A	0.737	Human
Pparg	peroxisome proliferator activated receptor gamma	0.678	Mouse
Mdm2	transformed mouse 3T3 cell double minute 2	0.671	Human
Ptgs2	prostaglandin-endoperoxide synthase 2	0.652	Human
Nos3	nitric oxide synthase 3, endothelial cell	0.615
Gata4	GATA binding protein 4	0.476
Bax	BCL2-associated X protein	0.476	Mouse
Ldb3	LIM domain binding 3	0.353
Lepr	leptin receptor	0.323
Gata6	GATA binding protein 6	0.287	Human
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.241
Thbs1	thrombospondin 1	0.239
Notch2	Notch gene homolog 2 (Drosophila)	0.215	Mouse
Csf1	colony stimulating factor 1 (macrophage)	0.209
Mmp9	matrix metallopeptidase 9	0.205
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.138
Vhl	von Hippel-Lindau tumor suppressor	0.133	Human Fly
Bcl2	B-cell leukemia/lymphoma 2	0.132
Insr	insulin receptor	0.131
Tsc2	tuberous sclerosis 2	0.128	Fly
Pax6	paired box gene 6	0.124
Egln3	EGL nine homolog 3 (C. elegans)	0.109	Fly
Gnrh1	gonadotropin releasing hormone 1	0.105
Otp	orthopedia homolog (Drosophila)	0.099
Cav1	caveolin 1, caveolae protein	0.096
Cd44	CD44 antigen	0.094
Hif1a	hypoxia inducible factor 1, alpha subunit	0.087
Rxra	retinoid X receptor alpha	0.086
Tsc1	tuberous sclerosis 1	0.081	Fly
Egr1	early growth response 1	0.080
Mcl1	myeloid cell leukemia sequence 1	0.078	Mouse
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.078
Junb	Jun-B oncogene	0.072
Egln1	EGL nine homolog 1 (C. elegans)	0.068	Fly
Epas1	endothelial PAS domain protein 1	0.063	Human Mouse Fly
Mdm4	transformed mouse 3T3 cell double minute 4	0.062	Human
Onecut1	one cut domain, family member 1	0.061
Pkd1	polycystic kidney disease 1 homolog	0.055
Dusp1	dual specificity phosphatase 1	0.055
Ahr	aryl-hydrocarbon receptor	0.053
Smad3	MAD homolog 3 (Drosophila)	0.053
Nos2	nitric oxide synthase 2, inducible	0.052
Nos1	nitric oxide synthase 1, neuronal	0.052
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.051
Fgf8	fibroblast growth factor 8	0.050
Rint1	RAD50 interactor 1	0.049
Gdnf	glial cell line derived neurotrophic factor	0.049
Cd36	CD36 antigen	0.049
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.047
Ppp1cc	protein phosphatase 1, catalytic subunit, gamma isoform	0.046
Rb1	retinoblastoma 1	0.045
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.044
Gata1	GATA binding protein 1	0.044
Apc	adenomatosis polyposis coli	0.044
Neurog2	neurogenin 2	0.043	Mouse
Cyr61	cysteine rich protein 61	0.043
ND6	NADH dehydrogenase subunit 6	0.043
Ppargc1a	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	0.042	Rat
Nf2	neurofibromatosis 2	0.042
Neurl1a	neuralized homolog 1A (Drosophila)	0.042
Sim2	single-minded homolog 2 (Drosophila)	0.037	Mouse
Lep	leptin	0.037
Kl	klotho	0.037
Tcfap2a	transcription factor AP-2, alpha	0.037
Neurod1	neurogenic differentiation 1	0.036	Mouse
Hdac1	histone deacetylase 1	0.036
Pnpla2	patatin-like phospholipase domain containing 2	0.036
Tgfb1	transforming growth factor, beta 1	0.035
Dab1	disabled homolog 1 (Drosophila)	0.034
Myod1	myogenic differentiation 1	0.034
Braf	Braf transforming gene	0.034
Fos	FBJ osteosarcoma oncogene	0.033
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.033
Nab2	Ngfi-A binding protein 2	0.031
Il10	interleukin 10	0.031
Bhlhe40	basic helix-loop-helix family, member e40	0.031
Fgf15	fibroblast growth factor 15	0.030
Nr5a2	nuclear receptor subfamily 5, group A, member 2	0.030
Zfp36	zinc finger protein 36	0.029
Elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.029
Ech1	enoyl coenzyme A hydratase 1, peroxisomal	0.029
Egr2	early growth response 2	0.029	Mouse
Stip1	stress-induced phosphoprotein 1	0.028
Lyz2	lysozyme 2	0.027
Ece1	endothelin converting enzyme 1	0.027
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.026
Fzd4	frizzled homolog 4 (Drosophila)	0.026
Foxo1	forkhead box O1	0.025
Foxc2	forkhead box C2	0.025
Ar	androgen receptor	0.025
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.025
Neurod4	neurogenic differentiation 4	0.025	Mouse
Rptor	regulatory associated protein of MTOR, complex 1	0.024
Bmp4	bone morphogenetic protein 4	0.024
Wwtr1	WW domain containing transcription regulator 1	0.023
Ccl2	chemokine (C-C motif) ligand 2	0.023
Prph2	peripherin 2	0.023
Ncoa3	nuclear receptor coactivator 3	0.022
Skil	SKI-like	0.022
Apoe	apolipoprotein E	0.022
Pmaip1	phorbol-12-myristate-13-acetate-induced protein 1	0.022	Human
Agtr1a	angiotensin II receptor, type 1a	0.022
Klf6	Kruppel-like factor 6	0.021
Dll1	delta-like 1 (Drosophila)	0.021
Bbc3	BCL2 binding component 3	0.021
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.021
Irs2	insulin receptor substrate 2	0.021
Fgf23	fibroblast growth factor 23	0.021
Scn9a	sodium channel, voltage-gated, type IX, alpha	0.020
Psen2	presenilin 2	0.020
Nphs2	nephrosis 2 homolog, podocin (human)	0.020
Maff	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)	0.019
Mrpl18	mitochondrial ribosomal protein L18	0.019
Ngfr	nerve growth factor receptor (TNFR superfamily, member 16)	0.019
Edar	ectodysplasin-A receptor	0.019
Hoxa1	homeobox A1	0.019
Plat	plasminogen activator, tissue	0.019
Tlr4	toll-like receptor 4	0.019
Nr4a1	nuclear receptor subfamily 4, group A, member 1	0.019
Egfl7	EGF-like domain 7	0.018
Nf1	neurofibromatosis 1	0.018
Fzr1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.018
Sfrp2	secreted frizzled-related protein 2	0.018
Fgf4	fibroblast growth factor 4	0.018
Arx	aristaless related homeobox	0.017
Ep300	E1A binding protein p300	0.017
Ywhag	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.017
Ebf3	early B-cell factor 3	0.017
Lhx6	LIM homeobox protein 6	0.017
Ppara	peroxisome proliferator activated receptor alpha	0.017	Mouse
Lmx1b	LIM homeobox transcription factor 1 beta	0.016
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.016	Human
Map1lc3b	microtubule-associated protein 1 light chain 3 beta	0.016
Bnip3	BCL2/adenovirus E1B interacting protein 3	0.016	Human
Adrb3	adrenergic receptor, beta 3	0.016
H2afx	H2A histone family, member X	0.016
Prkci	protein kinase C, iota	0.016
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.016
Chrna7	cholinergic receptor, nicotinic, alpha polypeptide 7	0.016
Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	0.015
Kiss1	KiSS-1 metastasis-suppressor	0.015
Hoxc5	homeobox C5	0.015
Ptf1a	pancreas specific transcription factor, 1a	0.015	Mouse
Huwe1	HECT, UBA and WWE domain containing 1	0.015
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.015
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.014
Atxn1	ataxin 1	0.014
Adrb1	adrenergic receptor, beta 1	0.014
Btg2	B-cell translocation gene 2, anti-proliferative	0.014
Clcnka	chloride channel Ka	0.014
Pxn	paxillin	0.014
Cyp24a1	cytochrome P450, family 24, subfamily a, polypeptide 1	0.014
Spp1	secreted phosphoprotein 1	0.014
Foxa2	forkhead box A2	0.014
Serpine1	serine (or cysteine) peptidase inhibitor, clade E, member 1	0.014	Rat
Prkce	protein kinase C, epsilon	0.014
Gja8	gap junction protein, alpha 8	0.014
Tbr1	T-box brain gene 1	0.014
Fgfr1	fibroblast growth factor receptor 1	0.014
Stc2	stanniocalcin 2	0.014
Mybl2	myeloblastosis oncogene-like 2	0.013
Hsd17b10	hydroxysteroid (17-beta) dehydrogenase 10	0.013
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.013
Gypa	glycophorin A	0.013
Spry4	sprouty homolog 4 (Drosophila)	0.013
Fbxw7	F-box and WD-40 domain protein 7	0.013
Barhl1	BarH-like 1 (Drosophila)	0.013
Nfatc2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.013
Canx	calnexin	0.013
Nhlh1	nescient helix loop helix 1	0.013	Mouse
Rbl1	retinoblastoma-like 1 (p107)	0.013
Acvr1	activin A receptor, type 1	0.013
Egfr	epidermal growth factor receptor	0.013
Ctnnb1	catenin (cadherin associated protein), beta 1	0.013
Slc2a1	solute carrier family 2 (facilitated glucose transporter), member 1	0.013
Tert	telomerase reverse transcriptase	0.013
Fam20c	family with sequence similarity 20, member C	0.013
Mecom	MDS1 and EVI1 complex locus	0.013
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.013
Kcnk3	potassium channel, subfamily K, member 3	0.013
Rrm2b	ribonucleotide reductase M2 B (TP53 inducible)	0.013
Bak1	BCL2-antagonist/killer 1	0.013	Mouse
Stat3	signal transducer and activator of transcription 3	0.012
Yap1	yes-associated protein 1	0.012
Mfn2	mitofusin 2	0.012
Pck1	phosphoenolpyruvate carboxykinase 1, cytosolic	0.012
Vav2	vav 2 oncogene	0.012
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.012
Asxl1	additional sex combs like 1 (Drosophila)	0.012
Hipk1	homeodomain interacting protein kinase 1	0.012
Dok1	docking protein 1	0.012
E2f1	E2F transcription factor 1	0.012
Jun	Jun oncogene	0.012
Tcf21	transcription factor 21	0.012
Hspb7	heat shock protein family, member 7 (cardiovascular)	0.012
Crb2	crumbs homolog 2 (Drosophila)	0.012
Tspan12	tetraspanin 12	0.012
Col22a1	collagen, type XXII, alpha 1	0.012
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.012
Atf3	activating transcription factor 3	0.012
Plau	plasminogen activator, urokinase	0.012	Rat
Sec31a	Sec31 homolog A (S. cerevisiae)	0.012
Plin1	perilipin 1	0.011
Cdk5r1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.011
Irx4	Iroquois related homeobox 4 (Drosophila)	0.011
Fosb	FBJ osteosarcoma oncogene B	0.011
Ebf2	early B-cell factor 2	0.011
Neurog3	neurogenin 3	0.011	Mouse
Ccr2	chemokine (C-C motif) receptor 2	0.011
Ywhaz	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.011
Arpc4	actin related protein 2/3 complex, subunit 4	0.011
Gadd45b	growth arrest and DNA-damage-inducible 45 beta	0.011
Mt1	metallothionein 1	0.011
Surf4	surfeit gene 4	0.011
Ptk2	PTK2 protein tyrosine kinase 2	0.011
Snai1	snail homolog 1 (Drosophila)	0.011
Hif3a	hypoxia inducible factor 3, alpha subunit	0.011	Mouse Fly
Zic3	zinc finger protein of the cerebellum 3	0.011
Cd151	CD151 antigen	0.011
Col4a3	collagen, type IV, alpha 3	0.011
Mafk	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)	0.011
Sp3	trans-acting transcription factor 3	0.011
Nkx2-4	NK2 transcription factor related, locus 4 (Drosophila)	0.011
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.011
Vdr	vitamin D receptor	0.010	Mouse
Abcc6	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	0.010
Sox1	SRY-box containing gene 1	0.010
Hnf4a	hepatic nuclear factor 4, alpha	0.010
Rasip1	Ras interacting protein 1	0.010
Ier3	immediate early response 3	0.010
Midn	midnolin	0.010
Map3k6	mitogen-activated protein kinase kinase kinase 6	0.010
Adam17	a disintegrin and metallopeptidase domain 17	0.010
Hes5	hairy and enhancer of split 5 (Drosophila)	0.010
Plxna1	plexin A1	0.010
Mknk2	MAP kinase-interacting serine/threonine kinase 2	0.010
Esrrb	estrogen related receptor, beta	0.010
Ulk1	Unc-51 like kinase 1 (C. elegans)	0.010
Kcnj11	potassium inwardly rectifying channel, subfamily J, member 11	0.010
Bub1b	budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)	0.010
Tob1	transducer of ErbB-2.1	0.010