IMP

Process View

Mus musculus

2 genes annotated in mouse

Multi-species View

positive regulation of interleukin 18 production

GO:0032741

Any process that activates or increases the frequency, rate, or extent of interleukin-18 production.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of interleukin 18 production"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of interleukin 18 production" (in gray)

Name	Description	Probability	Func Analog Organism
Tlr4	toll-like receptor 4	0.997	Mouse
Myd88	myeloid differentiation primary response gene 88	0.980
Tlr2	toll-like receptor 2	0.966
Il10	interleukin 10	0.885
Ticam1	toll-like receptor adaptor molecule 1	0.860
Cd44	CD44 antigen	0.811
Ccr2	chemokine (C-C motif) receptor 2	0.810
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.724
Ccl2	chemokine (C-C motif) ligand 2	0.697
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.425
Casp1	caspase 1	0.370
Fas	Fas (TNF receptor superfamily member 6)	0.351
Cd14	CD14 antigen	0.330
Spp1	secreted phosphoprotein 1	0.289
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.236
Lepr	leptin receptor	0.217
Lyz2	lysozyme 2	0.211
Ccl4	chemokine (C-C motif) ligand 4	0.196
Ifng	interferon gamma	0.193
Cd33	CD33 antigen	0.182
Lair1	leukocyte-associated Ig-like receptor 1	0.178
Irak4	interleukin-1 receptor-associated kinase 4	0.174
Il1r1	interleukin 1 receptor, type I	0.159
Btk	Bruton agammaglobulinemia tyrosine kinase	0.156
Nos2	nitric oxide synthase 2, inducible	0.155
Cd300ld	CD300 molecule-like family member d	0.154
Vdr	vitamin D receptor	0.119
Cd180	CD180 antigen	0.119	Mouse
Pparg	peroxisome proliferator activated receptor gamma	0.118
Siglece	sialic acid binding Ig-like lectin E	0.117
Il6	interleukin 6	0.116
Nlrp3	NLR family, pyrin domain containing 3	0.097
Ly96	lymphocyte antigen 96	0.091
Aim2	absent in melanoma 2	0.085
Pilra	paired immunoglobin-like type 2 receptor alpha	0.079
Fcgr4	Fc receptor, IgG, low affinity IV	0.075
Ncoa3	nuclear receptor coactivator 3	0.075
Klra2	killer cell lectin-like receptor, subfamily A, member 2	0.070
Il1b	interleukin 1 beta	0.067
Clec5a	C-type lectin domain family 5, member a	0.057
Tnf	tumor necrosis factor	0.056	Rat
Csf3r	colony stimulating factor 3 receptor (granulocyte)	0.054
Gm12185	predicted gene 12185	0.050
Pik3cg	phosphoinositide-3-kinase, catalytic, gamma polypeptide	0.048
Ddx60	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	0.046
Nfam1	Nfat activating molecule with ITAM motif 1	0.045
Hpgds	hematopoietic prostaglandin D synthase	0.044
Ly9	lymphocyte antigen 9	0.044
Pyhin1	pyrin and HIN domain family, member 1	0.040
Ccr6	chemokine (C-C motif) receptor 6	0.039
2610015P09Rik	RIKEN cDNA 2610015P09 gene	0.039
Cysltr1	cysteinyl leukotriene receptor 1	0.039
Pik3ap1	phosphoinositide-3-kinase adaptor protein 1	0.036
Sykb	spleen tyrosine kinase	0.036
Naip2	NLR family, apoptosis inhibitory protein 2	0.036
Cav1	caveolin 1, caveolae protein	0.036
Ldlr	low density lipoprotein receptor	0.035
Mefv	Mediterranean fever	0.035
Ikbkg	inhibitor of kappaB kinase gamma	0.034
Mmp9	matrix metallopeptidase 9	0.031
Slamf6	SLAM family member 6	0.031
Cd84	CD84 antigen	0.030
Csprs	component of Sp100-rs	0.030
Tlr8	toll-like receptor 8	0.029	Mouse
D14Ertd668e	DNA segment, Chr 14, ERATO Doi 668, expressed	0.029
Clec4b1	C-type lectin domain family 4, member b1	0.029
Slamf8	SLAM family member 8	0.029
Tnfrsf14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.028
Gm885	predicted gene 885	0.028
P2ry13	purinergic receptor P2Y, G-protein coupled 13	0.027
Ccl3	chemokine (C-C motif) ligand 3	0.027
Ms4a4c	membrane-spanning 4-domains, subfamily A, member 4C	0.026
BC013712	cDNA sequence BC013712	0.026
Emr4	EGF-like module containing, mucin-like, hormone receptor-like sequence 4	0.026
Gpr84	G protein-coupled receptor 84	0.026
Rgs18	regulator of G-protein signaling 18	0.025
Tlr9	toll-like receptor 9	0.025
Havcr2	hepatitis A virus cellular receptor 2	0.025
5430427O19Rik	RIKEN cDNA 5430427O19 gene	0.025
Ms4a6d	membrane-spanning 4-domains, subfamily A, member 6D	0.025
Naip6	NLR family, apoptosis inhibitory protein 6	0.023
C3	complement component 3	0.023
Trim30d	tripartite motif-containing 30D	0.023
Cybb	cytochrome b-245, beta polypeptide	0.023
Tlr5	toll-like receptor 5	0.023	Mouse
Slamf7	SLAM family member 7	0.022
Cblb	Casitas B-lineage lymphoma b	0.021
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.021
Trem3	triggering receptor expressed on myeloid cells 3	0.021
Casp12	caspase 12	0.021
Arhgap25	Rho GTPase activating protein 25	0.021
Ms4a7	membrane-spanning 4-domains, subfamily A, member 7	0.020
Stat3	signal transducer and activator of transcription 3	0.020
Pilrb1	paired immunoglobin-like type 2 receptor beta 1	0.020
Cd86	CD86 antigen	0.020
Ifitm6	interferon induced transmembrane protein 6	0.020
Tgfb1	transforming growth factor, beta 1	0.020
Tbxas1	thromboxane A synthase 1, platelet	0.019
Npy1r	neuropeptide Y receptor Y1	0.019
Tifab	TRAF-interacting protein with forkhead-associated domain, family member B	0.019
Clec7a	C-type lectin domain family 7, member a	0.019
Rgs1	regulator of G-protein signaling 1	0.019
Cd300lf	CD300 antigen like family member F	0.019
Ptgs2	prostaglandin-endoperoxide synthase 2	0.019
Klra17	killer cell lectin-like receptor, subfamily A, member 17	0.019
Clec4a2	C-type lectin domain family 4, member a2	0.019
C3ar1	complement component 3a receptor 1	0.019
Pdcd1lg2	programmed cell death 1 ligand 2	0.019
Ccr5	chemokine (C-C motif) receptor 5	0.019
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.018
Slfn4	schlafen 4	0.018
Abcg3	ATP-binding cassette, sub-family G (WHITE), member 3	0.018
Stap1	signal transducing adaptor family member 1	0.018
Rel	reticuloendotheliosis oncogene	0.018
Fam111a	family with sequence similarity 111, member A	0.018
Fcgr1	Fc receptor, IgG, high affinity I	0.018
Klra9	killer cell lectin-like receptor subfamily A, member 9	0.018
Cysltr2	cysteinyl leukotriene receptor 2	0.017
Samhd1	SAM domain and HD domain, 1	0.017
Siglec1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.017
Ms4a8a	membrane-spanning 4-domains, subfamily A, member 8A	0.017
Fyb	FYN binding protein	0.017
Cd22	CD22 antigen	0.017
Kynu	kynureninase (L-kynurenine hydrolase)	0.017
Igsf6	immunoglobulin superfamily, member 6	0.017
Unc93b1	unc-93 homolog B1 (C. elegans)	0.017
Gm6377	predicted gene 6377	0.017
Il10ra	interleukin 10 receptor, alpha	0.017
Lat2	linker for activation of T cells family, member 2	0.017
AB124611	cDNA sequence AB124611	0.016
Gbgt1	globoside alpha-1,3-N-acetylgalactosaminyltransferase 1	0.016
Ccr1	chemokine (C-C motif) receptor 1	0.016
Tnfrsf13b	tumor necrosis factor receptor superfamily, member 13b	0.016
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.016
Clec4d	C-type lectin domain family 4, member d	0.016
Klrk1	killer cell lectin-like receptor subfamily K, member 1	0.016
Niacr1	niacin receptor 1	0.016
Tirap	toll-interleukin 1 receptor (TIR) domain-containing adaptor protein	0.016
Apobr	apolipoprotein B receptor	0.015
Kmo	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)	0.015
Epsti1	epithelial stromal interaction 1 (breast)	0.015
Birc3	baculoviral IAP repeat-containing 3	0.015
Lep	leptin	0.015
Clec4n	C-type lectin domain family 4, member n	0.015
Pycard	PYD and CARD domain containing	0.014
Pkhd1l1	polycystic kidney and hepatic disease 1-like 1	0.014
Irg1	immunoresponsive gene 1	0.014
G6pd2	glucose-6-phosphate dehydrogenase 2	0.014
Cd36	CD36 antigen	0.014
Slc37a2	solute carrier family 37 (glycerol-3-phosphate transporter), member 2	0.014
Cdca3	cell division cycle associated 3	0.013
Naip1	NLR family, apoptosis inhibitory protein 1	0.013
Ly6i	lymphocyte antigen 6 complex, locus I	0.013
Samd9l	sterile alpha motif domain containing 9-like	0.013
5430435G22Rik	RIKEN cDNA 5430435G22 gene	0.013
Slamf1	signaling lymphocytic activation molecule family member 1	0.013
Ms4a6c	membrane-spanning 4-domains, subfamily A, member 6C	0.013
Slfn8	schlafen 8	0.013
Slamf9	SLAM family member 9	0.013
Clec4a3	C-type lectin domain family 4, member a3	0.013
Il18	interleukin 18	0.013
Cd209a	CD209a antigen	0.012
Pou2af1	POU domain, class 2, associating factor 1	0.012
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.012
Tnfsf14	tumor necrosis factor (ligand) superfamily, member 14	0.012
Cxcl13	chemokine (C-X-C motif) ligand 13	0.012
Gpr35	G protein-coupled receptor 35	0.012
A630033H20Rik	RIKEN cDNA A630033H20 gene	0.012
Gm7609	predicted pseudogene 7609	0.012
Gpr65	G-protein coupled receptor 65	0.012
Msr1	macrophage scavenger receptor 1	0.012
Apbb1ip	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein	0.012
Ikzf1	IKAROS family zinc finger 1	0.012
Mmp8	matrix metallopeptidase 8	0.012
Ccl24	chemokine (C-C motif) ligand 24	0.012
Cd300lb	CD300 antigen like family member B	0.012
Tnfrsf23	tumor necrosis factor receptor superfamily, member 23	0.011
Zfp455	zinc finger protein 455	0.011
Gpr34	G protein-coupled receptor 34	0.011
Rab32	RAB32, member RAS oncogene family	0.011
Cd209f	CD209f antigen	0.011
Sh2d1b2	SH2 domain protein 1B2	0.011
Irak3	interleukin-1 receptor-associated kinase 3	0.011
Oasl1	2'-5' oligoadenylate synthetase-like 1	0.011
Ikzf3	IKAROS family zinc finger 3	0.011
Fcgr3	Fc receptor, IgG, low affinity III	0.011
Clec2i	C-type lectin domain family 2, member i	0.011
Il1rn	interleukin 1 receptor antagonist	0.011
Btla	B and T lymphocyte associated	0.011
Hk3	hexokinase 3	0.011
Adam21	a disintegrin and metallopeptidase domain 21	0.011
Aoah	acyloxyacyl hydrolase	0.011
Gm5045	predicted gene 5045	0.011
Reg3d	regenerating islet-derived 3 delta	0.011
Tcfec	transcription factor EC	0.011
Oas1b	2'-5' oligoadenylate synthetase 1B	0.011
Klrb1f	killer cell lectin-like receptor subfamily B member 1F	0.010
Mnda	myeloid cell nuclear differentiation antigen	0.010
Lpxn	leupaxin	0.010
Ikbkb	inhibitor of kappaB kinase beta	0.010
Aqp12	aquaporin 12	0.010
Gp2	glycoprotein 2 (zymogen granule membrane)	0.010
Adap2	ArfGAP with dual PH domains 2	0.010
Vsig4	V-set and immunoglobulin domain containing 4	0.010
P2ry12	purinergic receptor P2Y, G-protein coupled 12	0.010