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Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of systemic arterial blood pressure"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of systemic arterial blood pressure" (in gray)

Name	Description	Probability	Func Analog Organism
Ren1	renin 1 structural	0.997
Nos3	nitric oxide synthase 3, endothelial cell	0.995
Lepr	leptin receptor	0.953
Adrb1	adrenergic receptor, beta 1	0.863
Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.813
Bdkrb2	bradykinin receptor, beta 2	0.765	Mouse
Pnpla2	patatin-like phospholipase domain containing 2	0.749
Ar	androgen receptor	0.732
Bbs2	Bardet-Biedl syndrome 2 (human)	0.702
Kl	klotho	0.664
Rac1	RAS-related C3 botulinum substrate 1	0.647
Pparg	peroxisome proliferator activated receptor gamma	0.617
Agtr1a	angiotensin II receptor, type 1a	0.528	Mouse
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.509
Crhr1	corticotropin releasing hormone receptor 1	0.486
Ptgs2	prostaglandin-endoperoxide synthase 2	0.438
Wt1	Wilms tumor 1 homolog	0.352
Cav1	caveolin 1, caveolae protein	0.346
Sstr4	somatostatin receptor 4	0.343
Col4a3	collagen, type IV, alpha 3	0.339
Cckbr	cholecystokinin B receptor	0.314
Adrb2	adrenergic receptor, beta 2	0.305
Grid1	glutamate receptor, ionotropic, delta 1	0.301
Agt	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	0.227
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.225
Cyld	cylindromatosis (turban tumor syndrome)	0.208
Stat3	signal transducer and activator of transcription 3	0.202
Drd2	dopamine receptor D2	0.197
Alx3	aristaless-like homeobox 3	0.191
Ghr	growth hormone receptor	0.186
Slc12a1	solute carrier family 12, member 1	0.183
Ldlr	low density lipoprotein receptor	0.173
Chrm1	cholinergic receptor, muscarinic 1, CNS	0.167
Nos1	nitric oxide synthase 1, neuronal	0.166
Tgfbr2	transforming growth factor, beta receptor II	0.165
Ddah1	dimethylarginine dimethylaminohydrolase 1	0.162
Lhx6	LIM homeobox protein 6	0.153
Smad6	MAD homolog 6 (Drosophila)	0.145
Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	0.137
Agtr2	angiotensin II receptor, type 2	0.128
Sstr3	somatostatin receptor 3	0.126
Pgr	progesterone receptor	0.121
Agtrap	angiotensin II, type I receptor-associated protein	0.117
Sstr1	somatostatin receptor 1	0.116
Htr1d	5-hydroxytryptamine (serotonin) receptor 1D	0.114	Mouse
Lep	leptin	0.113
Efemp2	epidermal growth factor-containing fibulin-like extracellular matrix protein 2	0.112
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.106
Adrb3	adrenergic receptor, beta 3	0.106
Smad7	MAD homolog 7 (Drosophila)	0.104
Mas1	MAS1 oncogene	0.098
Aqp2	aquaporin 2	0.093
Tmem64	transmembrane protein 64	0.093
Kcnk3	potassium channel, subfamily K, member 3	0.084
Ppargc1a	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	0.084
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.081
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.080
Fbn1	fibrillin 1	0.079
Bbs1	Bardet-Biedl syndrome 1 (human)	0.078
Tgfbr3	transforming growth factor, beta receptor III	0.078
Tgfbr1	transforming growth factor, beta receptor I	0.077
Npy2r	neuropeptide Y receptor Y2	0.076
Calca	calcitonin/calcitonin-related polypeptide, alpha	0.076
Grm2	glutamate receptor, metabotropic 2	0.073
Dvl1	dishevelled, dsh homolog 1 (Drosophila)	0.073
Hrh1	histamine receptor H1	0.071
Nos2	nitric oxide synthase 2, inducible	0.070
Btn1a1	butyrophilin, subfamily 1, member A1	0.067
Clock	circadian locomotor output cycles kaput	0.066
Ret	ret proto-oncogene	0.065
Vegfa	vascular endothelial growth factor A	0.064
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.064
Tgfb1	transforming growth factor, beta 1	0.064
Otog	otogelin	0.063
Wnt7a	wingless-related MMTV integration site 7A	0.062
Chia	chitinase, acidic	0.055
Gabrg3	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 3	0.053
Fgf4	fibroblast growth factor 4	0.052
Hcrt	hypocretin	0.051
Shc3	src homology 2 domain-containing transforming protein C3	0.051
Oprd1	opioid receptor, delta 1	0.050
Glra1	glycine receptor, alpha 1 subunit	0.050
Npy1r	neuropeptide Y receptor Y1	0.049
ND6	NADH dehydrogenase subunit 6	0.049
Syt6	synaptotagmin VI	0.047
Apoe	apolipoprotein E	0.045
Adora2a	adenosine A2a receptor	0.044
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.042
Foxd2	forkhead box D2	0.041
Pcdh12	protocadherin 12	0.040
Ikzf4	IKAROS family zinc finger 4	0.040
Esr1	estrogen receptor 1 (alpha)	0.040
Arap3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	0.039
Bhlhe40	basic helix-loop-helix family, member e40	0.039
Tacr1	tachykinin receptor 1	0.038
Kcnj6	potassium inwardly-rectifying channel, subfamily J, member 6	0.038
Npy5r	neuropeptide Y receptor Y5	0.038
Kcnj11	potassium inwardly rectifying channel, subfamily J, member 11	0.037
She	src homology 2 domain-containing transforming protein E	0.037
Adra2c	adrenergic receptor, alpha 2c	0.037	Mouse
Pdgfb	platelet derived growth factor, B polypeptide	0.036
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.036
Fabp4	fatty acid binding protein 4, adipocyte	0.035
Atp2b2	ATPase, Ca++ transporting, plasma membrane 2	0.035
Rbpjl	recombination signal binding protein for immunoglobulin kappa J region-like	0.035
Tead4	TEA domain family member 4	0.034
Gpr26	G protein-coupled receptor 26	0.033
Odz1	odd Oz/ten-m homolog 1 (Drosophila)	0.033
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.032
Tnfrsf11a	tumor necrosis factor receptor superfamily, member 11a	0.032
Kcna2	potassium voltage-gated channel, shaker-related subfamily, member 2	0.032
Acr	acrosin prepropeptide	0.031
Htr1a	5-hydroxytryptamine (serotonin) receptor 1A	0.031	Mouse
Krt86	keratin 86	0.030
Kcnk4	potassium channel, subfamily K, member 4	0.030
Pax2	paired box gene 2	0.030
Esr2	estrogen receptor 2 (beta)	0.029
Arnt	aryl hydrocarbon receptor nuclear translocator	0.028
Kcnh1	potassium voltage-gated channel, subfamily H (eag-related), member 1	0.028
Ctsk	cathepsin K	0.028
Htr7	5-hydroxytryptamine (serotonin) receptor 7	0.028	Mouse
Galnt6	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6	0.028
Bcan	brevican	0.027
Bglap	bone gamma carboxyglutamate protein	0.027
Hpcal4	hippocalcin-like 4	0.027
Gpr27	G protein-coupled receptor 27	0.027
Mal	myelin and lymphocyte protein, T-cell differentiation protein	0.026
Insr	insulin receptor	0.026
Mog	myelin oligodendrocyte glycoprotein	0.026
Has1	hyaluronan synthase1	0.025
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.025
Grb10	growth factor receptor bound protein 10	0.025
Prkg1	protein kinase, cGMP-dependent, type I	0.025
Prdx6	peroxiredoxin 6	0.025
Spry4	sprouty homolog 4 (Drosophila)	0.024
Olfr1509	olfactory receptor 1509	0.024
Vcl	vinculin	0.024
P2rx7	purinergic receptor P2X, ligand-gated ion channel, 7	0.024
Ctsl	cathepsin L	0.024
Csmd1	CUB and Sushi multiple domains 1	0.024
Galr2	galanin receptor 2	0.023
Edn3	endothelin 3	0.023
Nfatc2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.023
U46068	cDNA sequence U46068	0.023
Cyp19a1	cytochrome P450, family 19, subfamily a, polypeptide 1	0.022
Sftpa1	surfactant associated protein A1	0.022
Nr3c2	nuclear receptor subfamily 3, group C, member 2	0.022
B3gat1	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	0.022
Dmkn	dermokine	0.022
Gria1	glutamate receptor, ionotropic, AMPA1 (alpha 1)	0.022
Panx2	pannexin 2	0.021
Fndc7	fibronectin type III domain containing 7	0.021
Irs1	insulin receptor substrate 1	0.021
Itga1	integrin alpha 1	0.021
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.021
Tnfrsf8	tumor necrosis factor receptor superfamily, member 8	0.021
Colq	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	0.020
Ednrb	endothelin receptor type B	0.020
Pgd	phosphogluconate dehydrogenase	0.020
Cx3cr1	chemokine (C-X3-C) receptor 1	0.020
Ncoa3	nuclear receptor coactivator 3	0.020
Gng4	guanine nucleotide binding protein (G protein), gamma 4	0.020
Trh	thyrotropin releasing hormone	0.020
Ptafr	platelet-activating factor receptor	0.020
Kcnab3	potassium voltage-gated channel, shaker-related subfamily, beta member 3	0.020
Pten	phosphatase and tensin homolog	0.020
Col4a4	collagen, type IV, alpha 4	0.020
Maf	avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog	0.020
Cd1d2	CD1d2 antigen	0.019
Il12b	interleukin 12b	0.019
Slc16a8	solute carrier family 16 (monocarboxylic acid transporters), member 8	0.019
Tm4sf1	transmembrane 4 superfamily member 1	0.019
Kcnv1	potassium channel, subfamily V, member 1	0.019
Cnr1	cannabinoid receptor 1 (brain)	0.019
3110047P20Rik	RIKEN cDNA 3110047P20 gene	0.018
Lag3	lymphocyte-activation gene 3	0.018
Nppc	natriuretic peptide type C	0.018
Cacna1e	calcium channel, voltage-dependent, R type, alpha 1E subunit	0.018
Kcnk6	potassium inwardly-rectifying channel, subfamily K, member 6	0.018
Shisa9	shisa homolog 9 (Xenopus laevis)	0.018
Fshr	follicle stimulating hormone receptor	0.018
H2-M9	histocompatibility 2, M region locus 9	0.018
Slc32a1	solute carrier family 32 (GABA vesicular transporter), member 1	0.018
Pcmtd1	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1	0.018
Mc5r	melanocortin 5 receptor	0.018
Sebox	SEBOX homeobox	0.018
Tff2	trefoil factor 2 (spasmolytic protein 1)	0.018
Trp53bp1	transformation related protein 53 binding protein 1	0.017
Opn1sw	opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)	0.017
Drd4	dopamine receptor D4	0.017
Kiss1	KiSS-1 metastasis-suppressor	0.017
Fmo3	flavin containing monooxygenase 3	0.017
Ids	iduronate 2-sulfatase	0.017
Pspn	persephin	0.017
Prm3	protamine 3	0.017
Gjd2	gap junction protein, delta 2	0.017
Matn1	matrilin 1, cartilage matrix protein	0.017
Csf2	colony stimulating factor 2 (granulocyte-macrophage)	0.017
Foxb2	forkhead box B2	0.017
F2rl2	coagulation factor II (thrombin) receptor-like 2	0.017
Ucp3	uncoupling protein 3 (mitochondrial, proton carrier)	0.017
Bmp8b	bone morphogenetic protein 8b	0.017
Kcns2	K+ voltage-gated channel, subfamily S, 2	0.016
Ralbp1	ralA binding protein 1	0.016
Nxph2	neurexophilin 2	0.016
Kcne2	potassium voltage-gated channel, Isk-related subfamily, gene 2	0.016
Cacng5	calcium channel, voltage-dependent, gamma subunit 5	0.016
Epas1	endothelial PAS domain protein 1	0.016
Tnfsf11	tumor necrosis factor (ligand) superfamily, member 11	0.016
Dusp1	dual specificity phosphatase 1	0.016
Gsx1	GS homeobox 1	0.016
Atp11c	ATPase, class VI, type 11C	0.016
Chrng	cholinergic receptor, nicotinic, gamma polypeptide	0.016
Uts2r	urotensin 2 receptor	0.016
Pax4	paired box gene 4	0.016
Klk4	kallikrein related-peptidase 4 (prostase, enamel matrix, prostate)	0.016
Cntn4	contactin 4	0.016
Adipoq	adiponectin, C1Q and collagen domain containing	0.016
Krtap5-4	keratin associated protein 5-4	0.016
Egr2	early growth response 2	0.015
Bglap-rs1	bone gamma-carboxyglutamate protein, related sequence 1	0.015
3110079O15Rik	RIKEN cDNA 3110079O15 gene	0.015
Slc12a5	solute carrier family 12, member 5	0.015
Rgs6	regulator of G-protein signaling 6	0.015
Kcna4	potassium voltage-gated channel, shaker-related subfamily, member 4	0.015
Hr	hairless	0.015
Abhd5	abhydrolase domain containing 5	0.015
Cfd	complement factor D (adipsin)	0.015
Ern2	endoplasmic reticulum (ER) to nucleus signalling 2	0.015
Fzd4	frizzled homolog 4 (Drosophila)	0.015
Pramel6	preferentially expressed antigen in melanoma like 6	0.014
Egr4	early growth response 4	0.014
Epha6	Eph receptor A6	0.014
Cyp4a14	cytochrome P450, family 4, subfamily a, polypeptide 14	0.014
Fzr1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.014
Nppb	natriuretic peptide type B	0.014
Clcnka	chloride channel Ka	0.014
Col25a1	collagen, type XXV, alpha 1	0.014
Hs3st2	heparan sulfate (glucosamine) 3-O-sulfotransferase 2	0.014
Olfr90	olfactory receptor 90	0.014
Fosb	FBJ osteosarcoma oncogene B	0.014
Hrk	harakiri, BCL2 interacting protein (contains only BH3 domain)	0.014
Cyp4a10	cytochrome P450, family 4, subfamily a, polypeptide 10	0.014
Socs5	suppressor of cytokine signaling 5	0.014
Mkks	McKusick-Kaufman syndrome protein	0.014
Skil	SKI-like	0.014
Vdr	vitamin D receptor	0.013
Bdkrb1	bradykinin receptor, beta 1	0.013	Mouse
Hpca	hippocalcin	0.013
Lmx1b	LIM homeobox transcription factor 1 beta	0.013
Mobp	myelin-associated oligodendrocytic basic protein	0.013
Syn2	synapsin II	0.013
Htr5a	5-hydroxytryptamine (serotonin) receptor 5A	0.013	Mouse
Mpp5	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)	0.013
Kcnj3	potassium inwardly-rectifying channel, subfamily J, member 3	0.013
Tbc1d4	TBC1 domain family, member 4	0.013
Dvl2	dishevelled 2, dsh homolog (Drosophila)	0.013
Dhh	desert hedgehog	0.013
Apln	apelin	0.013
Scrg1	scrapie responsive gene 1	0.013
Htr1f	5-hydroxytryptamine (serotonin) receptor 1F	0.013	Mouse
Amh	anti-Mullerian hormone	0.013
Acvrl1	activin A receptor, type II-like 1	0.013
Kcnj9	potassium inwardly-rectifying channel, subfamily J, member 9	0.013
Hbegf	heparin-binding EGF-like growth factor	0.013
Cer1	cerberus 1 homolog (Xenopus laevis)	0.013
5430421N21Rik	RIKEN cDNA 5430421N21 gene	0.013
Axin1	axin 1	0.013
Cyp7a1	cytochrome P450, family 7, subfamily a, polypeptide 1	0.013
Nxph1	neurexophilin 1	0.013
Htr4	5 hydroxytryptamine (serotonin) receptor 4	0.012	Mouse
Chrna7	cholinergic receptor, nicotinic, alpha polypeptide 7	0.012
Pdpk1	3-phosphoinositide dependent protein kinase 1	0.012
Ptgs1	prostaglandin-endoperoxide synthase 1	0.012
Gab2	growth factor receptor bound protein 2-associated protein 2	0.012
Fos	FBJ osteosarcoma oncogene	0.012
Sprr2e	small proline-rich protein 2E	0.012
Fgf2	fibroblast growth factor 2	0.012
Rasal1	RAS protein activator like 1 (GAP1 like)	0.012
Ccl22	chemokine (C-C motif) ligand 22	0.012
Rasgrp1	RAS guanyl releasing protein 1	0.012
Ltc4s	leukotriene C4 synthase	0.012
Ppp1r1b	protein phosphatase 1, regulatory (inhibitor) subunit 1B	0.012
Gabrd	gamma-aminobutyric acid (GABA) A receptor, subunit delta	0.012
Krt36	keratin 36	0.012
Vip	vasoactive intestinal polypeptide	0.012
Prkaca	protein kinase, cAMP dependent, catalytic, alpha	0.011
Traf6	TNF receptor-associated factor 6	0.011
Mc3r	melanocortin 3 receptor	0.011
Egr1	early growth response 1	0.011
Gpr3	G-protein coupled receptor 3	0.011
Epha8	Eph receptor A8	0.011
Sema6d	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	0.011
Gzmk	granzyme K	0.011
Adora2b	adenosine A2b receptor	0.011
Zfr2	zinc finger RNA binding protein 2	0.011
Flt1	FMS-like tyrosine kinase 1	0.011
Rora	RAR-related orphan receptor alpha	0.011
Htr2c	5-hydroxytryptamine (serotonin) receptor 2C	0.011	Mouse
Prox1	prospero-related homeobox 1	0.011
Pmepa1	prostate transmembrane protein, androgen induced 1	0.011
Chrna6	cholinergic receptor, nicotinic, alpha polypeptide 6	0.011
Cyp27b1	cytochrome P450, family 27, subfamily b, polypeptide 1	0.011
Atp4a	ATPase, H+/K+ exchanging, gastric, alpha polypeptide	0.011
Tac2	tachykinin 2	0.011
Ttc7	tetratricopeptide repeat domain 7	0.011
Kcnd3	potassium voltage-gated channel, Shal-related family, member 3	0.011
Tcf7l2	transcription factor 7-like 2, T-cell specific, HMG-box	0.011
Gfra2	glial cell line derived neurotrophic factor family receptor alpha 2	0.011
Cacng2	calcium channel, voltage-dependent, gamma subunit 2	0.010
Gpr12	G-protein coupled receptor 12	0.010
Psg17	pregnancy specific glycoprotein 17	0.010
Atp7a	ATPase, Cu++ transporting, alpha polypeptide	0.010
Nptx2	neuronal pentraxin 2	0.010
Grm1	glutamate receptor, metabotropic 1	0.010
Rnf11	ring finger protein 11	0.010
Stat5b	signal transducer and activator of transcription 5B	0.010
Pcnxl2	pecanex-like 2 (Drosophila)	0.010
Ptprn2	protein tyrosine phosphatase, receptor type, N polypeptide 2	0.010
Wnt7b	wingless-related MMTV integration site 7B	0.010
Cckar	cholecystokinin A receptor	0.010
Ngb	neuroglobin	0.010
Ccr1l1	chemokine (C-C motif) receptor 1-like 1	0.010
Cpd	carboxypeptidase D	0.010
Mlph	melanophilin	0.010
Robo2	roundabout homolog 2 (Drosophila)	0.010
Gja5	gap junction protein, alpha 5	0.010
Lhb	luteinizing hormone beta	0.010
Sftpc	surfactant associated protein C	0.010