IMP

Process View

Mus musculus

10 genes annotated in mouse

cytoplasmic pattern recognition receptor signaling pathway

Any series of molecular signals generated as a consequence of a cytoplasmic pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cytoplasmic pattern recognition receptor signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cytoplasmic pattern recognition receptor signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	1.000
Myd88	myeloid differentiation primary response gene 88	1.000
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	1.000
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	1.000
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	1.000
Tnf	tumor necrosis factor	0.995
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.991
Lyz2	lysozyme 2	0.989
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.988
Cd44	CD44 antigen	0.978
Ddx60	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	0.969
Tlr4	toll-like receptor 4	0.936
Casp1	caspase 1	0.891
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.880	Human
Traf6	TNF receptor-associated factor 6	0.876
Stat3	signal transducer and activator of transcription 3	0.813
Pycard	PYD and CARD domain containing	0.755
Ccl2	chemokine (C-C motif) ligand 2	0.746
Tnip1	TNFAIP3 interacting protein 1	0.702
Ticam1	toll-like receptor adaptor molecule 1	0.683
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.605	Mouse
Igh	immunoglobulin heavy chain complex	0.593
Unc93b1	unc-93 homolog B1 (C. elegans)	0.591
Il1r1	interleukin 1 receptor, type I	0.507
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.493
Nfkbiz	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.471
Birc3	baculoviral IAP repeat-containing 3	0.435
Traf2	TNF receptor-associated factor 2	0.428
Tgfb1	transforming growth factor, beta 1	0.343
Tlr2	toll-like receptor 2	0.334	Mouse
Sykb	spleen tyrosine kinase	0.328
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.296
Icam1	intercellular adhesion molecule 1	0.290
Cd40	CD40 antigen	0.267
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.242
Il10	interleukin 10	0.226
Dhx58	DEXH (Asp-Glu-X-His) box polypeptide 58	0.212
Ikbkg	inhibitor of kappaB kinase gamma	0.197
Pik3ap1	phosphoinositide-3-kinase adaptor protein 1	0.185
Il1b	interleukin 1 beta	0.162
Sfpi1	SFFV proviral integration 1	0.152
Irak1	interleukin-1 receptor-associated kinase 1	0.150
Aim2	absent in melanoma 2	0.147
Ccr2	chemokine (C-C motif) receptor 2	0.141
Nfkbie	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.141	Mouse
Irak4	interleukin-1 receptor-associated kinase 4	0.140
Irf1	interferon regulatory factor 1	0.119
Traf3	TNF receptor-associated factor 3	0.118
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.117
Nlrp3	NLR family, pyrin domain containing 3	0.109	Mouse
Cd14	CD14 antigen	0.106
Mavs	mitochondrial antiviral signaling protein	0.101
Fas	Fas (TNF receptor superfamily member 6)	0.094
Mrpl3	mitochondrial ribosomal protein L3	0.091
Trim25	tripartite motif-containing 25	0.076
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.070
Gbp5	guanylate binding protein 5	0.064
Stx11	syntaxin 11	0.061
Epsti1	epithelial stromal interaction 1 (breast)	0.061
Bcl3	B-cell leukemia/lymphoma 3	0.061	Mouse
BC006779	cDNA sequence BC006779	0.061
Mvp	major vault protein	0.052
Bcl6	B-cell leukemia/lymphoma 6	0.051
Dtx3l	deltex 3-like (Drosophila)	0.049
Tor3a	torsin family 3, member A	0.044
Ooep	oocyte expressed protein homolog (dog)	0.044
Ifit1	interferon-induced protein with tetratricopeptide repeats 1	0.041
Ms4a4c	membrane-spanning 4-domains, subfamily A, member 4C	0.041
Cxcl10	chemokine (C-X-C motif) ligand 10	0.039
Atr	ataxia telangiectasia and Rad3 related	0.039
Rel	reticuloendotheliosis oncogene	0.039
Parp14	poly (ADP-ribose) polymerase family, member 14	0.039
Socs3	suppressor of cytokine signaling 3	0.038
Cyld	cylindromatosis (turban tumor syndrome)	0.038
2010106G01Rik	RIKEN cDNA 2010106G01 gene	0.038
Trim21	tripartite motif-containing 21	0.037
Ccr1	chemokine (C-C motif) receptor 1	0.034
Ikbke	inhibitor of kappaB kinase epsilon	0.030
Il17ra	interleukin 17 receptor A	0.030
Mlkl	mixed lineage kinase domain-like	0.028
Ltbr	lymphotoxin B receptor	0.028
Prkcd	protein kinase C, delta	0.026
Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.026
Foxp3	forkhead box P3	0.026
Ddx58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	0.025	Human Mouse
Smad4	MAD homolog 4 (Drosophila)	0.023
Rnf135	ring finger protein 135	0.023
Irak3	interleukin-1 receptor-associated kinase 3	0.022
Mefv	Mediterranean fever	0.022
Tnks2	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2	0.021
Il4ra	interleukin 4 receptor, alpha	0.021
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.021
Cd33	CD33 antigen	0.020
Prdm1	PR domain containing 1, with ZNF domain	0.020
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.019
Irgm1	immunity-related GTPase family M member 1	0.019
Pyhin1	pyrin and HIN domain family, member 1	0.019
Tmem173	transmembrane protein 173	0.018
Drosha	drosha, ribonuclease type III	0.018
Lair1	leukocyte-associated Ig-like receptor 1	0.018
Slfn1	schlafen 1	0.018
Zc3h12a	zinc finger CCCH type containing 12A	0.017
Spp1	secreted phosphoprotein 1	0.017
Samd9l	sterile alpha motif domain containing 9-like	0.017
D14Ertd668e	DNA segment, Chr 14, ERATO Doi 668, expressed	0.016
Mx2	myxovirus (influenza virus) resistance 2	0.016
Vdr	vitamin D receptor	0.016
Naip2	NLR family, apoptosis inhibitory protein 2	0.016
Nfe2l2	nuclear factor, erythroid derived 2, like 2	0.015
Pim1	proviral integration site 1	0.015
Mmp9	matrix metallopeptidase 9	0.015
Csf1	colony stimulating factor 1 (macrophage)	0.015
Oasl1	2'-5' oligoadenylate synthetase-like 1	0.015
Atad3a	ATPase family, AAA domain containing 3A	0.015
Ccl3	chemokine (C-C motif) ligand 3	0.014
Runx1	runt related transcription factor 1	0.014
Ubc	ubiquitin C	0.014
Il22	interleukin 22	0.014
Siglece	sialic acid binding Ig-like lectin E	0.014
Hif1a	hypoxia inducible factor 1, alpha subunit	0.014
Eif2ak2	eukaryotic translation initiation factor 2-alpha kinase 2	0.014
Fcgr4	Fc receptor, IgG, low affinity IV	0.014
Naip6	NLR family, apoptosis inhibitory protein 6	0.014
Ly96	lymphocyte antigen 96	0.013
Zbp1	Z-DNA binding protein 1	0.013
Mcl1	myeloid cell leukemia sequence 1	0.013
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.013
Samhd1	SAM domain and HD domain, 1	0.013
Pou2af1	POU domain, class 2, associating factor 1	0.013
Irf7	interferon regulatory factor 7	0.012
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.012
Tnfaip2	tumor necrosis factor, alpha-induced protein 2	0.012
Cd19	CD19 antigen	0.012
Klra2	killer cell lectin-like receptor, subfamily A, member 2	0.012
Lepr	leptin receptor	0.012
Il6	interleukin 6	0.012
Herc6	hect domain and RLD 6	0.012
Stat1	signal transducer and activator of transcription 1	0.011
Tlr5	toll-like receptor 5	0.011	Mouse
Trim30a	tripartite motif-containing 30A	0.011
Safb	scaffold attachment factor B	0.011
Trim30d	tripartite motif-containing 30D	0.011
Fadd	Fas (TNFRSF6)-associated via death domain	0.011
Adam17	a disintegrin and metallopeptidase domain 17	0.010
2010003K11Rik	RIKEN cDNA 2010003K11 gene	0.010
Tlr3	toll-like receptor 3	0.010
Stat6	signal transducer and activator of transcription 6	0.010