IMP

Process View

Mus musculus

14 genes annotated in mouse

t cell costimulation

The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "t cell costimulation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "t cell costimulation" (in gray)

Name	Description	Probability	Func Analog Organism
Icos	inducible T-cell co-stimulator	0.959	Mouse
Ifng	interferon gamma	0.916
Ccl2	chemokine (C-C motif) ligand 2	0.878
Il4	interleukin 4	0.817
Pdcd1	programmed cell death 1	0.795
Ltb	lymphotoxin B	0.600
Cd7	CD7 antigen	0.560
Lta	lymphotoxin A	0.552	Mouse
Cxcr5	chemokine (C-X-C motif) receptor 5	0.499	Mouse
Cd40	CD40 antigen	0.434
Ccl3	chemokine (C-C motif) ligand 3	0.433	Mouse
Tnfrsf4	tumor necrosis factor receptor superfamily, member 4	0.426
Fasl	Fas ligand (TNF superfamily, member 6)	0.414	Mouse
Klrg1	killer cell lectin-like receptor subfamily G, member 1	0.403
Cd28	CD28 antigen	0.376
Cd6	CD6 antigen	0.357	Mouse
Cxcl13	chemokine (C-X-C motif) ligand 13	0.335
Cd3g	CD3 antigen, gamma polypeptide	0.317	Mouse
Socs1	suppressor of cytokine signaling 1	0.303
Ccr5	chemokine (C-C motif) receptor 5	0.300	Mouse
Tbx21	T-box 21	0.287
Sh2d2a	SH2 domain protein 2A	0.283
Cd3d	CD3 antigen, delta polypeptide	0.269	Mouse
Cxcr3	chemokine (C-X-C motif) receptor 3	0.264	Mouse
Ccr2	chemokine (C-C motif) receptor 2	0.263	Mouse
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.256
Cd4	CD4 antigen	0.230
Il1b	interleukin 1 beta	0.225
Batf	basic leucine zipper transcription factor, ATF-like	0.222
Cd5	CD5 antigen	0.196
Cd8a	CD8 antigen, alpha chain	0.193
Ubd	ubiquitin D	0.191
Ccl7	chemokine (C-C motif) ligand 7	0.185	Mouse
Gzma	granzyme A	0.185
Ctla4	cytotoxic T-lymphocyte-associated protein 4	0.180	Mouse
Gzmb	granzyme B	0.179
Ikzf1	IKAROS family zinc finger 1	0.173
Cd2	CD2 antigen	0.172
Sh2d1a	SH2 domain protein 1A	0.170
Ccl8	chemokine (C-C motif) ligand 8	0.166
Fas	Fas (TNF receptor superfamily member 6)	0.157
Itk	IL2-inducible T-cell kinase	0.152
Folr2	folate receptor 2 (fetal)	0.152
Ctsw	cathepsin W	0.147
Igh	immunoglobulin heavy chain complex	0.142
Klrk1	killer cell lectin-like receptor subfamily K, member 1	0.138
Cd19	CD19 antigen	0.131
Cd96	CD96 antigen	0.122
Ccl4	chemokine (C-C motif) ligand 4	0.119	Mouse
Cd8b1	CD8 antigen, beta chain 1	0.118
Sit1	suppression inducing transmembrane adaptor 1	0.117
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.114
Itgax	integrin alpha X	0.110
Cd3e	CD3 antigen, epsilon polypeptide	0.106
C3ar1	complement component 3a receptor 1	0.100
S100a4	S100 calcium binding protein A4	0.098
Ccr1	chemokine (C-C motif) receptor 1	0.094	Mouse
Pou2af1	POU domain, class 2, associating factor 1	0.093
Gimap7	GTPase, IMAP family member 7	0.091
Cd160	CD160 antigen	0.084
Tnf	tumor necrosis factor	0.084	Mouse
Csf2	colony stimulating factor 2 (granulocyte-macrophage)	0.081
Ccl22	chemokine (C-C motif) ligand 22	0.080
Cxcl10	chemokine (C-X-C motif) ligand 10	0.080
Cd86	CD86 antigen	0.078
Il27ra	interleukin 27 receptor, alpha	0.077
Gzmk	granzyme K	0.075
Ccl9	chemokine (C-C motif) ligand 9	0.074	Mouse
Xcr1	chemokine (C motif) receptor 1	0.074	Mouse
Klrd1	killer cell lectin-like receptor, subfamily D, member 1	0.072
Ccr8	chemokine (C-C motif) receptor 8	0.072	Mouse
Cxcl9	chemokine (C-X-C motif) ligand 9	0.068
Il2rb	interleukin 2 receptor, beta chain	0.066
Nkg7	natural killer cell group 7 sequence	0.063
Gzmc	granzyme C	0.063
Il1rn	interleukin 1 receptor antagonist	0.063
Xcl1	chemokine (C motif) ligand 1	0.061	Mouse
Prdm1	PR domain containing 1, with ZNF domain	0.060
Ccl1	chemokine (C-C motif) ligand 1	0.060	Mouse
Il2ra	interleukin 2 receptor, alpha chain	0.059
Il7	interleukin 7	0.058
Crtam	cytotoxic and regulatory T cell molecule	0.055
Il18rap	interleukin 18 receptor accessory protein	0.055
Ccl12	chemokine (C-C motif) ligand 12	0.053	Mouse
Fcna	ficolin A	0.052
Ccl5	chemokine (C-C motif) ligand 5	0.052	Mouse
Il21r	interleukin 21 receptor	0.052
Zap70	zeta-chain (TCR) associated protein kinase	0.050
Folr4	folate receptor 4 (delta)	0.050
Aire	autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)	0.048
Ikzf3	IKAROS family zinc finger 3	0.046
Ccr7	chemokine (C-C motif) receptor 7	0.045
Cd247	CD247 antigen	0.044
Klrc1	killer cell lectin-like receptor subfamily C, member 1	0.043
Cst7	cystatin F (leukocystatin)	0.042
Irg1	immunoresponsive gene 1	0.040
Slamf8	SLAM family member 8	0.040
Lag3	lymphocyte-activation gene 3	0.039
Klrb1b	killer cell lectin-like receptor subfamily B member 1B	0.039
Tnfsf14	tumor necrosis factor (ligand) superfamily, member 14	0.039
Pdcd1lg2	programmed cell death 1 ligand 2	0.039
Il18r1	interleukin 18 receptor 1	0.037
S100a6	S100 calcium binding protein A6 (calcyclin)	0.036
Cxcl2	chemokine (C-X-C motif) ligand 2	0.035
Tnfsf8	tumor necrosis factor (ligand) superfamily, member 8	0.035
Cma1	chymase 1, mast cell	0.034
Foxp3	forkhead box P3	0.034
Rhoh	ras homolog gene family, member H	0.033
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.032
Prss2	protease, serine, 2	0.032
Anxa2	annexin A2	0.031
Cd27	CD27 antigen	0.031
Tlr2	toll-like receptor 2	0.031
Cd72	CD72 antigen	0.030
Mmp12	matrix metallopeptidase 12	0.029
Ncr1	natural cytotoxicity triggering receptor 1	0.029
Cxcr2	chemokine (C-X-C motif) receptor 2	0.028	Mouse
Mx1	myxovirus (influenza virus) resistance 1	0.028
Mmp3	matrix metallopeptidase 3	0.027
Gimap3	GTPase, IMAP family member 3	0.027
Cxcr6	chemokine (C-X-C motif) receptor 6	0.027	Mouse
Il10	interleukin 10	0.026
Itgal	integrin alpha L	0.026
Il6	interleukin 6	0.026
Gpr132	G protein-coupled receptor 132	0.026
Il1a	interleukin 1 alpha	0.026
Tnfrsf17	tumor necrosis factor receptor superfamily, member 17	0.026
Ly6d	lymphocyte antigen 6 complex, locus D	0.026
Fcer2a	Fc receptor, IgE, low affinity II, alpha polypeptide	0.026
Il12rb2	interleukin 12 receptor, beta 2	0.025
Ccl20	chemokine (C-C motif) ligand 20	0.025
Tg	thyroglobulin	0.025
Tnfrsf13c	tumor necrosis factor receptor superfamily, member 13c	0.024
Aicda	activation-induced cytidine deaminase	0.024
Selp	selectin, platelet	0.024
Cd274	CD274 antigen	0.024	Human
Cd180	CD180 antigen	0.023
Tnfsf11	tumor necrosis factor (ligand) superfamily, member 11	0.023	Mouse
Csf1	colony stimulating factor 1 (macrophage)	0.023
Ch25h	cholesterol 25-hydroxylase	0.023
Btk	Bruton agammaglobulinemia tyrosine kinase	0.022
Itgae	integrin alpha E, epithelial-associated	0.022
Tspo2	translocator protein 2	0.022
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.021
Pla2g2d	phospholipase A2, group IID	0.021
Reg3g	regenerating islet-derived 3 gamma	0.021
Batf2	basic leucine zipper transcription factor, ATF-like 2	0.021
Cd79a	CD79A antigen (immunoglobulin-associated alpha)	0.020
Il12rb1	interleukin 12 receptor, beta 1	0.020
Ccl17	chemokine (C-C motif) ligand 17	0.020	Mouse
Tnfrsf18	tumor necrosis factor receptor superfamily, member 18	0.020
Anxa1	annexin A1	0.019
Sftpd	surfactant associated protein D	0.019
Cd44	CD44 antigen	0.019
Irf4	interferon regulatory factor 4	0.019
Cd80	CD80 antigen	0.019
Endou	endonuclease, polyU-specific	0.019
Pparg	peroxisome proliferator activated receptor gamma	0.018
Mmp9	matrix metallopeptidase 9	0.018
Slamf6	SLAM family member 6	0.018
Blk	B lymphoid kinase	0.018
S100a11	S100 calcium binding protein A11 (calgizzarin)	0.018
Tnfrsf11a	tumor necrosis factor receptor superfamily, member 11a	0.018
S1pr4	sphingosine-1-phosphate receptor 4	0.018
Gbp1	guanylate binding protein 1	0.018
Asprv1	aspartic peptidase, retroviral-like 1	0.017
Serpina3n	serine (or cysteine) peptidase inhibitor, clade A, member 3N	0.017
Cd22	CD22 antigen	0.017
Fcgr1	Fc receptor, IgG, high affinity I	0.017
Tox	thymocyte selection-associated high mobility group box	0.017
Il17a	interleukin 17A	0.017
Lat	linker for activation of T cells	0.016
Ccl11	chemokine (C-C motif) ligand 11	0.016	Mouse
Bdkrb1	bradykinin receptor, beta 1	0.016
Ly9	lymphocyte antigen 9	0.016
Expi	extracellular proteinase inhibitor	0.016
Tnfrsf13b	tumor necrosis factor receptor superfamily, member 13b	0.016
Gfi1	growth factor independent 1	0.015
Cd1d2	CD1d2 antigen	0.015
Saa3	serum amyloid A 3	0.015
Retnla	resistin like alpha	0.014
Mx2	myxovirus (influenza virus) resistance 2	0.014
Rgs1	regulator of G-protein signaling 1	0.014
Art2a-ps	ADP-ribosyltransferase 2a, pseudogene	0.014
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.014
Ccr6	chemokine (C-C motif) receptor 6	0.014	Mouse
Pglyrp2	peptidoglycan recognition protein 2	0.014
Prkcq	protein kinase C, theta	0.014
Slamf7	SLAM family member 7	0.014
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.014
Cd36	CD36 antigen	0.014
AF251705	cDNA sequence AF251705	0.014
LOC100504404	h-2 class II histocompatibility antigen, E-K alpha chain-like	0.013
Nnmt	nicotinamide N-methyltransferase	0.013
Rag2	recombination activating gene 2	0.013
Niacr1	niacin receptor 1	0.013
Il15ra	interleukin 15 receptor, alpha chain	0.013
Clec4d	C-type lectin domain family 4, member d	0.013
Ccr9	chemokine (C-C motif) receptor 9	0.013	Mouse
Krt12	keratin 12	0.013
Ang2	angiogenin, ribonuclease A family, member 2	0.012
Il1rl1	interleukin 1 receptor-like 1	0.012
Sfpi1	SFFV proviral integration 1	0.012
Igk	immunoglobulin kappa chain complex	0.012
Lgals7	lectin, galactose binding, soluble 7	0.012	Mouse
Lep	leptin	0.012
Klra9	killer cell lectin-like receptor subfamily A, member 9	0.012
Nup62-il4i1	Nup62-Il4i1 protein	0.012
Krt27	keratin 27	0.012
AW112010	expressed sequence AW112010	0.012
F2rl2	coagulation factor II (thrombin) receptor-like 2	0.012
Art2b	ADP-ribosyltransferase 2b	0.012
Fcrl1	Fc receptor-like 1	0.012
BC051019	cDNA sequence BC051019	0.012
Gimap4	GTPase, IMAP family member 4	0.012
Slurp1	secreted Ly6/Plaur domain containing 1	0.012
Wnt10a	wingless related MMTV integration site 10a	0.012
Slfn3	schlafen 3	0.011
Dnase1l3	deoxyribonuclease 1-like 3	0.011
Uts2r	urotensin 2 receptor	0.011
Cxcl12	chemokine (C-X-C motif) ligand 12	0.011
Ctsk	cathepsin K	0.011
H2-Eb2	histocompatibility 2, class II antigen E beta2	0.011
Psp	parotid secretory protein	0.011
Plau	plasminogen activator, urokinase	0.011
Cd84	CD84 antigen	0.011
Cstb	cystatin B	0.011
H2-Eb1	histocompatibility 2, class II antigen E beta	0.011
Tlr7	toll-like receptor 7	0.011
Calm4	calmodulin 4	0.011
Cxcl1	chemokine (C-X-C motif) ligand 1	0.011
Clec2i	C-type lectin domain family 2, member i	0.011
Car6	carbonic anhydrase 6	0.011
C3	complement component 3	0.011
Krtap3-1	keratin associated protein 3-1	0.011
Cd209b	CD209b antigen	0.011
Fcrla	Fc receptor-like A	0.011
Ikzf2	IKAROS family zinc finger 2	0.011
Klrb1a	killer cell lectin-like receptor subfamily B member 1A	0.011
Siglec1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.010
Anxa3	annexin A3	0.010
F2rl3	coagulation factor II (thrombin) receptor-like 3	0.010
Hr	hairless	0.010
Sprr3	small proline-rich protein 3	0.010
AI607873	expressed sequence AI607873	0.010
Txk	TXK tyrosine kinase	0.010
Ccrl2	chemokine (C-C motif) receptor-like 2	0.010	Mouse
Reg2	regenerating islet-derived 2	0.010
Slfn2	schlafen 2	0.010
Cx3cr1	chemokine (C-X3-C) receptor 1	0.010	Mouse
Il9r	interleukin 9 receptor	0.010
Gdf3	growth differentiation factor 3	0.010
Ltc4s	leukotriene C4 synthase	0.010
Slamf1	signaling lymphocytic activation molecule family member 1	0.010