IMP

Process View

Mus musculus

23 genes annotated in mouse

middle ear morphogenesis

The process in which the anatomical structures of the middle ear are generated and organized. The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window).

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "middle ear morphogenesis"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "middle ear morphogenesis" (in gray)

Name	Description	Probability	Func Analog Organism
Shh	sonic hedgehog	0.999
Msx1	homeobox, msh-like 1	0.997
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.996
Eya1	eyes absent 1 homolog (Drosophila)	0.990
Pitx2	paired-like homeodomain transcription factor 2	0.987
Hoxa1	homeobox A1	0.977	Mouse
Prrx1	paired related homeobox 1	0.970
Tbx3	T-box 3	0.967	Mouse
Pitx1	paired-like homeodomain transcription factor 1	0.957
Sox9	SRY-box containing gene 9	0.940
Tbx1	T-box 1	0.930
Foxc1	forkhead box C1	0.930
Gli3	GLI-Kruppel family member GLI3	0.927
Hand2	heart and neural crest derivatives expressed transcript 2	0.925
Hand1	heart and neural crest derivatives expressed transcript 1	0.922
Hoxd3	homeobox D3	0.920
Fgfr2	fibroblast growth factor receptor 2	0.919	Mouse
Foxc2	forkhead box C2	0.900
Hoxa2	homeobox A2	0.892
Fgf10	fibroblast growth factor 10	0.864
Dlx5	distal-less homeobox 5	0.861
Foxg1	forkhead box G1	0.855
Ednra	endothelin receptor type A	0.825
Sox2	SRY-box containing gene 2	0.822
Pax3	paired box gene 3	0.806
Vangl2	vang-like 2 (van gogh, Drosophila)	0.785
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.776	Mouse
Pax9	paired box gene 9	0.774
Pax2	paired box gene 2	0.768
Isl1	ISL1 transcription factor, LIM/homeodomain	0.737
Otx2	orthodenticle homolog 2 (Drosophila)	0.721
Hoxa3	homeobox A3	0.721
Tcfap2a	transcription factor AP-2, alpha	0.715
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.689	Mouse
Fgf8	fibroblast growth factor 8	0.617
Gsc	goosecoid homeobox	0.608
Gli2	GLI-Kruppel family member GLI2	0.607
Hoxa5	homeobox A5	0.582
Pbx1	pre B-cell leukemia transcription factor 1	0.562
Fgfr1	fibroblast growth factor receptor 1	0.559
Gbx2	gastrulation brain homeobox 2	0.551
Dlx2	distal-less homeobox 2	0.550
Bmp4	bone morphogenetic protein 4	0.546
Chrd	chordin	0.541
Zeb1	zinc finger E-box binding homeobox 1	0.507
Fgfr3	fibroblast growth factor receptor 3	0.500	Mouse
Tlx3	T-cell leukemia, homeobox 3	0.491
Msx2	homeobox, msh-like 2	0.476	Mouse
Nkx3-2	NK3 homeobox 2	0.445
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.445
Tcf21	transcription factor 21	0.317
Meox2	mesenchyme homeobox 2	0.312
Hoxb3	homeobox B3	0.303
Twist2	twist homolog 2 (Drosophila)	0.295
Ntf3	neurotrophin 3	0.290
Chd7	chromodomain helicase DNA binding protein 7	0.285
Hoxa13	homeobox A13	0.283
Runx2	runt related transcription factor 2	0.276
Bmp7	bone morphogenetic protein 7	0.271
Sox11	SRY-box containing gene 11	0.267
Hoxb5	homeobox B5	0.249
Sall4	sal-like 4 (Drosophila)	0.249
Hoxb4	homeobox B4	0.245
Prrx2	paired related homeobox 2	0.234
Smo	smoothened homolog (Drosophila)	0.229
Lef1	lymphoid enhancer binding factor 1	0.225
Jag1	jagged 1	0.223
Lrp6	low density lipoprotein receptor-related protein 6	0.217
Pdx1	pancreatic and duodenal homeobox 1	0.216
Bdnf	brain derived neurotrophic factor	0.208
Pou3f4	POU domain, class 3, transcription factor 4	0.192
Hoxb1	homeobox B1	0.183	Mouse
Rarb	retinoic acid receptor, beta	0.171
Hoxd13	homeobox D13	0.168
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.168
Hoxa10	homeobox A10	0.165
Hoxd11	homeobox D11	0.162
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.155	Mouse
Alx4	aristaless-like homeobox 4	0.148
Uncx	UNC homeobox	0.139
Dlx1	distal-less homeobox 1	0.137
Nkx6-1	NK6 homeobox 1	0.133
Emx2	empty spiracles homolog 2 (Drosophila)	0.132
Hes1	hairy and enhancer of split 1 (Drosophila)	0.129
Efna4	ephrin A4	0.126
Wt1	Wilms tumor 1 homolog	0.118
Rarg	retinoic acid receptor, gamma	0.115
Ret	ret proto-oncogene	0.113
Hmx2	H6 homeobox 2	0.110
Pax6	paired box gene 6	0.107
Gata3	GATA binding protein 3	0.106
Dlx6	distal-less homeobox 6	0.105
Smad6	MAD homolog 6 (Drosophila)	0.105
Pou4f3	POU domain, class 4, transcription factor 3	0.101
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.097
Hoxc5	homeobox C5	0.082
Barx1	BarH-like homeobox 1	0.082
Lmx1a	LIM homeobox transcription factor 1 alpha	0.082
Sharpin	SHANK-associated RH domain interacting protein	0.080
Pax7	paired box gene 7	0.078
Pthlh	parathyroid hormone-like peptide	0.077
Hoxb6	homeobox B6	0.076
Wnt6	wingless-related MMTV integration site 6	0.074
Hoxa11	homeobox A11	0.071
Trp63	transformation related protein 63	0.071
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.070
Rara	retinoic acid receptor, alpha	0.070
Evx2	even skipped homeotic gene 2 homolog	0.067
Aldh1a3	aldehyde dehydrogenase family 1, subfamily A3	0.067
Max	Max protein	0.067
Lhx9	LIM homeobox protein 9	0.066
Notch1	Notch gene homolog 1 (Drosophila)	0.065
Tgfb2	transforming growth factor, beta 2	0.064
Cyp26a1	cytochrome P450, family 26, subfamily a, polypeptide 1	0.064
Twist1	twist homolog 1 (Drosophila)	0.064
Lhx5	LIM homeobox protein 5	0.063
Ighmbp2	immunoglobulin mu binding protein 2	0.062
Tbx15	T-box 15	0.062	Mouse
Insm1	insulinoma-associated 1	0.060
Alx1	ALX homeobox 1	0.059
Dll1	delta-like 1 (Drosophila)	0.059
Fgf3	fibroblast growth factor 3	0.058
Hmx3	H6 homeobox 3	0.057
Hoxc6	homeobox C6	0.057
Capn6	calpain 6	0.056
Shox2	short stature homeobox 2	0.053
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.052
Foxd3	forkhead box D3	0.052
Hoxa4	homeobox A4	0.052
Bmp5	bone morphogenetic protein 5	0.051
Pax8	paired box gene 8	0.051
Hes5	hairy and enhancer of split 5 (Drosophila)	0.051
Foxa2	forkhead box A2	0.050
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.050
Hoxa9	homeobox A9	0.050
Gfra1	glial cell line derived neurotrophic factor family receptor alpha 1	0.049
T	brachyury	0.048	Mouse
Nodal	nodal	0.048
Hmx1	H6 homeobox 1	0.048
Ptk7	PTK7 protein tyrosine kinase 7	0.046
Nkx2-6	NK2 transcription factor related, locus 6 (Drosophila)	0.046	Mouse
Zfp503	zinc finger protein 503	0.045
Nr2f1	nuclear receptor subfamily 2, group F, member 1	0.045
Hoxd4	homeobox D4	0.045
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.044
Fgf18	fibroblast growth factor 18	0.044
Wnt5a	wingless-related MMTV integration site 5A	0.044
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.043
Tlx2	T-cell leukemia, homeobox 2	0.043
Dll4	delta-like 4 (Drosophila)	0.042
Tbx2	T-box 2	0.042	Mouse
Ebf3	early B-cell factor 3	0.042
Tbx5	T-box 5	0.042	Mouse
Hoxd1	homeobox D1	0.041	Mouse
Hoxb9	homeobox B9	0.040
Foxb1	forkhead box B1	0.039
Boc	biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein	0.039
Nog	noggin	0.039	Human
Scn5a	sodium channel, voltage-gated, type V, alpha	0.038
Foxh1	forkhead box H1	0.038
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.038
Hoxc4	homeobox C4	0.037
Gata6	GATA binding protein 6	0.037
Hoxa7	homeobox A7	0.036
Neurog1	neurogenin 1	0.036
Rybp	RING1 and YY1 binding protein	0.036
Rnf2	ring finger protein 2	0.036
Pou5f1	POU domain, class 5, transcription factor 1	0.035
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.035
Hoxd9	homeobox D9	0.035
Efnb2	ephrin B2	0.034
Gata4	GATA binding protein 4	0.034
Mesp1	mesoderm posterior 1	0.034
Nhlh1	nescient helix loop helix 1	0.034
Hoxb2	homeobox B2	0.033	Mouse
Sall3	sal-like 3 (Drosophila)	0.033
Wnt3a	wingless-related MMTV integration site 3A	0.033
Rpl35	ribosomal protein L35	0.032
Hcn4	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	0.032
Cxadr	coxsackie virus and adenovirus receptor	0.032
Tcf15	transcription factor 15	0.032
Tshz1	teashirt zinc finger family member 1	0.032
Ptch1	patched homolog 1	0.032
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.032
Fzd8	frizzled homolog 8 (Drosophila)	0.032
Hesx1	homeobox gene expressed in ES cells	0.031
Dlk1	delta-like 1 homolog (Drosophila)	0.031
Foxd2	forkhead box D2	0.030
Figla	folliculogenesis specific basic helix-loop-helix	0.030
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.030
Zic2	zinc finger protein of the cerebellum 2	0.030
Col13a1	collagen, type XIII, alpha 1	0.030
Gas1	growth arrest specific 1	0.030
Mnx1	motor neuron and pancreas homeobox 1	0.029
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.029
Gli1	GLI-Kruppel family member GLI1	0.029
Gata5	GATA binding protein 5	0.029
Pou3f3	POU domain, class 3, transcription factor 3	0.028
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.027	Mouse
Vax1	ventral anterior homeobox containing gene 1	0.027
Gja5	gap junction protein, alpha 5	0.027
Evx1	even skipped homeotic gene 1 homolog	0.027
Tbx4	T-box 4	0.026	Mouse
Prdm6	PR domain containing 6	0.026
Npr3	natriuretic peptide receptor 3	0.026
Magel2	melanoma antigen, family L, 2	0.026
Fbn2	fibrillin 2	0.026
Egr2	early growth response 2	0.026
Efna2	ephrin A2	0.025
Nf1	neurofibromatosis 1	0.025
Gpc3	glypican 3	0.025
Myog	myogenin	0.025
Foxf1a	forkhead box F1a	0.025
Sall1	sal-like 1 (Drosophila)	0.025
Tcof1	Treacher Collins Franceschetti syndrome 1, homolog	0.025
Hba-x	hemoglobin X, alpha-like embryonic chain in Hba complex	0.025
Dach1	dachshund 1 (Drosophila)	0.024
Gdnf	glial cell line derived neurotrophic factor	0.024
Rrh	retinal pigment epithelium derived rhodopsin homolog	0.024
Msx3	homeobox, msh-like 3	0.023	Mouse
Mn1	meningioma 1	0.023
Cnga3	cyclic nucleotide gated channel alpha 3	0.023
Alx3	aristaless-like homeobox 3	0.023
Zic3	zinc finger protein of the cerebellum 3	0.022
Ptf1a	pancreas specific transcription factor, 1a	0.022
Irx5	Iroquois related homeobox 5 (Drosophila)	0.022
Hoxd10	homeobox D10	0.022
Sim2	single-minded homolog 2 (Drosophila)	0.022
Nrg1	neuregulin 1	0.022
Egfr	epidermal growth factor receptor	0.022
Pou4f2	POU domain, class 4, transcription factor 2	0.022
Omp	olfactory marker protein	0.022
Lhx3	LIM homeobox protein 3	0.021
Bmp2	bone morphogenetic protein 2	0.021
Ngfr	nerve growth factor receptor (TNFR superfamily, member 16)	0.021
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.021	Mouse
Zfp771	zinc finger protein 771	0.021
Isl2	insulin related protein 2 (islet 2)	0.021
Hoxc8	homeobox C8	0.021
Bnc1	basonuclin 1	0.021
Pitx3	paired-like homeodomain transcription factor 3	0.020
Foxe1	forkhead box E1	0.020
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.020
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.020
Dmrt3	doublesex and mab-3 related transcription factor 3	0.020
Il4	interleukin 4	0.020
Otp	orthopedia homolog (Drosophila)	0.020
Kcnk3	potassium channel, subfamily K, member 3	0.020
Pax1	paired box gene 1	0.020
Fev	FEV (ETS oncogene family)	0.020
Emx1	empty spiracles homolog 1 (Drosophila)	0.019
Six5	sine oculis-related homeobox 5 homolog (Drosophila)	0.019	Mouse
Gsx2	GS homeobox 2	0.019
Igf2bp1	insulin-like growth factor 2 mRNA binding protein 1	0.019
Fgfrl1	fibroblast growth factor receptor-like 1	0.019
Osr1	odd-skipped related 1 (Drosophila)	0.019
Kcnj15	potassium inwardly-rectifying channel, subfamily J, member 15	0.019
Dbx1	developing brain homeobox 1	0.019
Foxp2	forkhead box P2	0.019
Lrp4	low density lipoprotein receptor-related protein 4	0.018
Foxa1	forkhead box A1	0.018
Col2a1	collagen, type II, alpha 1	0.018
Prph	peripherin	0.018
Mks1	Meckel syndrome, type 1	0.018
Rsph6a	radial spoke head 6 homolog A (Chlamydomonas)	0.018
Ctf1	cardiotrophin 1	0.018
Nfatc4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	0.018
Tcfcp2l1	transcription factor CP2-like 1	0.018
Lbx2	ladybird homeobox homolog 2 (Drosophila)	0.018
Cbx2	chromobox homolog 2 (Drosophila Pc class)	0.018
Zfhx4	zinc finger homeodomain 4	0.018
Nr2f2	nuclear receptor subfamily 2, group F, member 2	0.018
Sox1	SRY-box containing gene 1	0.017
Sox13	SRY-box containing gene 13	0.017
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.017
Hoxd12	homeobox D12	0.017
Matn3	matrilin 3	0.017
Nanog	Nanog homeobox	0.017
Ryr1	ryanodine receptor 1, skeletal muscle	0.017
Runx3	runt related transcription factor 3	0.017
Noto	notochord homolog (Xenopus laevis)	0.017
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.017
Hoxc9	homeobox C9	0.016
Etv2	ets variant gene 2	0.016
Fbln1	fibulin 1	0.016
Apcdd1	adenomatosis polyposis coli down-regulated 1	0.016
Hoxb8	homeobox B8	0.016
BC057022	cDNA sequence BC057022	0.016
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.016
Nkx2-1	NK2 homeobox 1	0.016	Mouse
Otx1	orthodenticle homolog 1 (Drosophila)	0.016
Efs	embryonal Fyn-associated substrate	0.016
Hoxd8	homeobox D8	0.016
Zic1	zinc finger protein of the cerebellum 1	0.015
Htt	huntingtin	0.015
Eda	ectodysplasin-A	0.015
Socs1	suppressor of cytokine signaling 1	0.015
Atoh1	atonal homolog 1 (Drosophila)	0.015
Slc34a2	solute carrier family 34 (sodium phosphate), member 2	0.015
Sp6	trans-acting transcription factor 6	0.015
Prx	periaxin	0.015
Padi1	peptidyl arginine deiminase, type I	0.015
Dkk2	dickkopf homolog 2 (Xenopus laevis)	0.014
Padi3	peptidyl arginine deiminase, type III	0.014
Rag2	recombination activating gene 2	0.014
Krt14	keratin 14	0.014
Psen1	presenilin 1	0.014
Tcfap2c	transcription factor AP-2, gamma	0.014
Gja3	gap junction protein, alpha 3	0.014
En1	engrailed 1	0.014
Mecom	MDS1 and EVI1 complex locus	0.014
Rhcg	Rhesus blood group-associated C glycoprotein	0.014
Grem1	gremlin 1	0.014
Ntf5	neurotrophin 5	0.014
Slc2a4	solute carrier family 2 (facilitated glucose transporter), member 4	0.014
Cdx2	caudal type homeobox 2	0.013
Cgnl1	cingulin-like 1	0.013
Lhx4	LIM homeobox protein 4	0.013
Rhbdl3	rhomboid, veinlet-like 3 (Drosophila)	0.013
Maf	avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog	0.013
Fgf16	fibroblast growth factor 16	0.013
Gpr182	G protein-coupled receptor 182	0.013
Lfng	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	0.013
Pkdcc	protein kinase domain containing, cytoplasmic	0.013
Hs3st3b1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1	0.013
Bmf	BCL2 modifying factor	0.013
Lhx1	LIM homeobox protein 1	0.013
Sox3	SRY-box containing gene 3	0.013
Nkx3-1	NK-3 transcription factor, locus 1 (Drosophila)	0.013
Fgf15	fibroblast growth factor 15	0.013
Hsd11b2	hydroxysteroid 11-beta dehydrogenase 2	0.013
Barx2	BarH-like homeobox 2	0.013
S1pr4	sphingosine-1-phosphate receptor 4	0.013
Ifng	interferon gamma	0.013
Wnt11	wingless-related MMTV integration site 11	0.013
Sp8	trans-acting transcription factor 8	0.013
Ntn3	netrin 3	0.013
Tead2	TEA domain family member 2	0.013
Rgnef	Rho-guanine nucleotide exchange factor	0.013
Pcdh12	protocadherin 12	0.013
Tgif1	TGFB-induced factor homeobox 1	0.013
Cdh23	cadherin 23 (otocadherin)	0.013
Srms	src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites	0.012
Fzd10	frizzled homolog 10 (Drosophila)	0.012
Cyp51	cytochrome P450, family 51	0.012
Mesp2	mesoderm posterior 2	0.012
Chrng	cholinergic receptor, nicotinic, gamma polypeptide	0.012
Sox21	SRY-box containing gene 21	0.012
Foxd1	forkhead box D1	0.012
Nfia	nuclear factor I/A	0.012
Zic4	zinc finger protein of the cerebellum 4	0.012
Lag3	lymphocyte-activation gene 3	0.012
Emid2	EMI domain containing 2	0.012
Atoh7	atonal homolog 7 (Drosophila)	0.012
P2ry4	pyrimidinergic receptor P2Y, G-protein coupled, 4	0.012
Ager	advanced glycosylation end product-specific receptor	0.012
Meis2	Meis homeobox 2	0.012
Tlx1	T-cell leukemia, homeobox 1	0.012
Hmga2	high mobility group AT-hook 2	0.012
Myl7	myosin, light polypeptide 7, regulatory	0.012
Foxa3	forkhead box A3	0.012
Rfx2	regulatory factor X, 2 (influences HLA class II expression)	0.012
Insm2	insulinoma-associated 2	0.011
Hapln3	hyaluronan and proteoglycan link protein 3	0.011
Efnb1	ephrin B1	0.011
Ctnnb1	catenin (cadherin associated protein), beta 1	0.011
Esr2	estrogen receptor 2 (beta)	0.011
Spry2	sprouty homolog 2 (Drosophila)	0.011
Bscl2	Bernardinelli-Seip congenital lipodystrophy 2 homolog (human)	0.011
Vsx1	visual system homeobox 1 homolog (zebrafish)	0.011
Zadh2	zinc binding alcohol dehydrogenase, domain containing 2	0.011
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.011
Ror1	receptor tyrosine kinase-like orphan receptor 1	0.011
Gal	galanin	0.011
Papln	papilin, proteoglycan-like sulfated glycoprotein	0.011
Grb10	growth factor receptor bound protein 10	0.011
Fzd2	frizzled homolog 2 (Drosophila)	0.011
Hnf1b	HNF1 homeobox B	0.011
Rprm	reprimo, TP53 dependent G2 arrest mediator candidate	0.011
Irx6	Iroquois related homeobox 6 (Drosophila)	0.011
Avp	arginine vasopressin	0.011
Zbtb7c	zinc finger and BTB domain containing 7C	0.011
Tead3	TEA domain family member 3	0.011
Col22a1	collagen, type XXII, alpha 1	0.011
Plac1	placental specific protein 1	0.011
Phlda2	pleckstrin homology-like domain, family A, member 2	0.011
Hes7	hairy and enhancer of split 7 (Drosophila)	0.011
Sp7	Sp7 transcription factor 7	0.010
Myt1	myelin transcription factor 1	0.010
Htr1f	5-hydroxytryptamine (serotonin) receptor 1F	0.010
Igfbpl1	insulin-like growth factor binding protein-like 1	0.010
4930527J03Rik	RIKEN cDNA 4930527J03 gene	0.010
Irs4	insulin receptor substrate 4	0.010
Cfc1	cripto, FRL-1, cryptic family 1	0.010
Olig3	oligodendrocyte transcription factor 3	0.010
Fgf17	fibroblast growth factor 17	0.010
Gdf3	growth differentiation factor 3	0.010
Rdh10	retinol dehydrogenase 10 (all-trans)	0.010
Rps15	ribosomal protein S15	0.010