IMP

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Mus musculus

3 genes annotated in mouse

ascending aorta morphogenesis

The process in which the anatomical structures of the ascending aorta are generated and organized. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "ascending aorta morphogenesis"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "ascending aorta morphogenesis" (in gray)

Name	Description	Probability	Func Analog Organism
Gli3	GLI-Kruppel family member GLI3	1.000
Shh	sonic hedgehog	1.000
Emx1	empty spiracles homolog 1 (Drosophila)	1.000
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.999
Fgfr2	fibroblast growth factor receptor 2	0.999
Eya1	eyes absent 1 homolog (Drosophila)	0.998
Foxc1	forkhead box C1	0.997
Pax3	paired box gene 3	0.997
Efnb2	ephrin B2	0.996
Otx2	orthodenticle homolog 2 (Drosophila)	0.995
Fgf8	fibroblast growth factor 8	0.993
Tcfap2a	transcription factor AP-2, alpha	0.985
Hand1	heart and neural crest derivatives expressed transcript 1	0.978
Foxc2	forkhead box C2	0.975
Hand2	heart and neural crest derivatives expressed transcript 2	0.973
Jag1	jagged 1	0.972
Prrx1	paired related homeobox 1	0.972
Tgfb2	transforming growth factor, beta 2	0.963
Fgfr1	fibroblast growth factor receptor 1	0.961
Chd7	chromodomain helicase DNA binding protein 7	0.957
Bmp4	bone morphogenetic protein 4	0.952
Nog	noggin	0.951
Smo	smoothened homolog (Drosophila)	0.949
Fgfr3	fibroblast growth factor receptor 3	0.934
Msx1	homeobox, msh-like 1	0.933
Foxg1	forkhead box G1	0.911
Isl1	ISL1 transcription factor, LIM/homeodomain	0.906
Pax6	paired box gene 6	0.821
Otx1	orthodenticle homolog 1 (Drosophila)	0.807
Pax2	paired box gene 2	0.804
Zeb1	zinc finger E-box binding homeobox 1	0.796
Sox17	SRY-box containing gene 17	0.796	Mouse
Meox2	mesenchyme homeobox 2	0.788
Vangl2	vang-like 2 (van gogh, Drosophila)	0.767
Gbx2	gastrulation brain homeobox 2	0.741
Gli2	GLI-Kruppel family member GLI2	0.737
Hes1	hairy and enhancer of split 1 (Drosophila)	0.730
Emx2	empty spiracles homolog 2 (Drosophila)	0.723
Alx4	aristaless-like homeobox 4	0.720
Cldn5	claudin 5	0.712
Pitx2	paired-like homeodomain transcription factor 2	0.690
Bmp7	bone morphogenetic protein 7	0.677
Fgf10	fibroblast growth factor 10	0.671
Ednra	endothelin receptor type A	0.655
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.646
Rb1	retinoblastoma 1	0.645
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.621
Gata4	GATA binding protein 4	0.615
Hey1	hairy/enhancer-of-split related with YRPW motif 1	0.612	Mouse
Sox11	SRY-box containing gene 11	0.607	Mouse
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.602
Rarb	retinoic acid receptor, beta	0.552
Sox9	SRY-box containing gene 9	0.506	Mouse
Hes5	hairy and enhancer of split 5 (Drosophila)	0.495	Mouse
She	src homology 2 domain-containing transforming protein E	0.462
Sox2	SRY-box containing gene 2	0.453	Mouse
Hesx1	homeobox gene expressed in ES cells	0.404
Rara	retinoic acid receptor, alpha	0.396
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.391
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.361
Rarg	retinoic acid receptor, gamma	0.353
Nf1	neurofibromatosis 1	0.331
Tbx2	T-box 2	0.330
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.311
Ctnnb1	catenin (cadherin associated protein), beta 1	0.306
Alx3	aristaless-like homeobox 3	0.295
Smad6	MAD homolog 6 (Drosophila)	0.294
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.294
Dlx5	distal-less homeobox 5	0.281
Ptch1	patched homolog 1	0.276
Prrx2	paired related homeobox 2	0.254
Alx1	ALX homeobox 1	0.209
Notch3	Notch gene homolog 3 (Drosophila)	0.199
Aplnr	apelin receptor	0.197
Pbx1	pre B-cell leukemia transcription factor 1	0.192
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.192
Tbx1	T-box 1	0.189
Insm1	insulinoma-associated 1	0.186
Sall3	sal-like 3 (Drosophila)	0.185
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.183
Tie1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.176
Sox4	SRY-box containing gene 4	0.172
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.172
Hes3	hairy and enhancer of split 3 (Drosophila)	0.168	Mouse
Gsc	goosecoid homeobox	0.163
Pitx1	paired-like homeodomain transcription factor 1	0.162
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.156
Foxi3	forkhead box I3	0.155
Kdr	kinase insert domain protein receptor	0.152
Lmx1b	LIM homeobox transcription factor 1 beta	0.143
Tcf15	transcription factor 15	0.140
Tbx3	T-box 3	0.129
Cdh5	cadherin 5	0.126
Col2a1	collagen, type II, alpha 1	0.121
Ptprb	protein tyrosine phosphatase, receptor type, B	0.121
Meox1	mesenchyme homeobox 1	0.113
Nos3	nitric oxide synthase 3, endothelial cell	0.108
Lef1	lymphoid enhancer binding factor 1	0.108
Lhx3	LIM homeobox protein 3	0.108
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.106
Bcl6b	B-cell CLL/lymphoma 6, member B	0.105
Notch1	Notch gene homolog 1 (Drosophila)	0.101
Tcfap2c	transcription factor AP-2, gamma	0.100
Fgf3	fibroblast growth factor 3	0.092
Jag2	jagged 2	0.090
Efs	embryonal Fyn-associated substrate	0.087
Bmp2	bone morphogenetic protein 2	0.086
Efna1	ephrin A1	0.084
Tbx10	T-box 10	0.083
Pkd1	polycystic kidney disease 1 homolog	0.082
Dll1	delta-like 1 (Drosophila)	0.081
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.081
Tbx15	T-box 15	0.080
Sox18	SRY-box containing gene 18	0.079	Mouse
Hoxa2	homeobox A2	0.078
Gja4	gap junction protein, alpha 4	0.078
Hoxa1	homeobox A1	0.076
Dlx1	distal-less homeobox 1	0.072
Ntf3	neurotrophin 3	0.071
Adcy4	adenylate cyclase 4	0.070
Hoxa3	homeobox A3	0.066
Slc9a3r2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.066
Flt1	FMS-like tyrosine kinase 1	0.066
Rasip1	Ras interacting protein 1	0.064
Pou3f3	POU domain, class 3, transcription factor 3	0.061
Pou5f1	POU domain, class 5, transcription factor 1	0.060
Eng	endoglin	0.060
Runx2	runt related transcription factor 2	0.060
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.059
Flt4	FMS-like tyrosine kinase 4	0.057
Dll4	delta-like 4 (Drosophila)	0.056
Hic1	hypermethylated in cancer 1	0.053
Kcnk2	potassium channel, subfamily K, member 2	0.053
Efna2	ephrin A2	0.053
En1	engrailed 1	0.052
Ebf3	early B-cell factor 3	0.052
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.051
Ednrb	endothelin receptor type B	0.051
Gata3	GATA binding protein 3	0.051
Efnb1	ephrin B1	0.051
Fzd2	frizzled homolog 2 (Drosophila)	0.051
Ldb2	LIM domain binding 2	0.050
Wnt5a	wingless-related MMTV integration site 5A	0.048
Hoxa5	homeobox A5	0.048
Msx2	homeobox, msh-like 2	0.046
Bmper	BMP-binding endothelial regulator	0.046
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.046
Bmp5	bone morphogenetic protein 5	0.045
En2	engrailed 2	0.045
Sall4	sal-like 4 (Drosophila)	0.045
Hoxd13	homeobox D13	0.043
Hhex	hematopoietically expressed homeobox	0.042
Sox3	SRY-box containing gene 3	0.042	Mouse
Id1	inhibitor of DNA binding 1	0.041
Btbd17	BTB (POZ) domain containing 17	0.039
Gas1	growth arrest specific 1	0.039
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.039
Sox7	SRY-box containing gene 7	0.038	Mouse
Dmrt1	doublesex and mab-3 related transcription factor 1	0.038
Ret	ret proto-oncogene	0.038
Epha4	Eph receptor A4	0.038
Lbx1	ladybird homeobox homolog 1 (Drosophila)	0.038
Vegfa	vascular endothelial growth factor A	0.037
Twist2	twist homolog 2 (Drosophila)	0.037
Lrp6	low density lipoprotein receptor-related protein 6	0.036
Ephb2	Eph receptor B2	0.036
Ushbp1	Usher syndrome 1C binding protein 1	0.036
Atoh7	atonal homolog 7 (Drosophila)	0.036
Robo4	roundabout homolog 4 (Drosophila)	0.036
Pcdh12	protocadherin 12	0.035
Wnt3a	wingless-related MMTV integration site 3A	0.035
Cd248	CD248 antigen, endosialin	0.035
Hoxb6	homeobox B6	0.035
Lhx5	LIM homeobox protein 5	0.035
Id3	inhibitor of DNA binding 3	0.034
Tek	endothelial-specific receptor tyrosine kinase	0.034
Pou3f1	POU domain, class 3, transcription factor 1	0.034
Gata2	GATA binding protein 2	0.034
Tgfb1i1	transforming growth factor beta 1 induced transcript 1	0.033
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.033
Pthlh	parathyroid hormone-like peptide	0.033
Nkx6-1	NK6 homeobox 1	0.033
Col13a1	collagen, type XIII, alpha 1	0.032
Arap3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	0.032
Bmp6	bone morphogenetic protein 6	0.032
Gast	gastrin	0.031
Esam	endothelial cell-specific adhesion molecule	0.031
Col1a1	collagen, type I, alpha 1	0.031
Gli1	GLI-Kruppel family member GLI1	0.031
Kcnq1	potassium voltage-gated channel, subfamily Q, member 1	0.029
Acvrl1	activin A receptor, type II-like 1	0.029
Acvr1	activin A receptor, type 1	0.029
Sox13	SRY-box containing gene 13	0.029
Tead4	TEA domain family member 4	0.028
Nkd1	naked cuticle 1 homolog (Drosophila)	0.028
Zfp503	zinc finger protein 503	0.028
Trp63	transformation related protein 63	0.028
Acan	aggrecan	0.028
Kitl	kit ligand	0.027
Mmrn2	multimerin 2	0.027
Wnt4	wingless-related MMTV integration site 4	0.027
Cabp7	calcium binding protein 7	0.027
Pofut1	protein O-fucosyltransferase 1	0.027
Foxf1a	forkhead box F1a	0.026
Msx3	homeobox, msh-like 3	0.026
Zfp703	zinc finger protein 703	0.026
Crhr2	corticotropin releasing hormone receptor 2	0.026
Neurog2	neurogenin 2	0.025
Rprm	reprimo, TP53 dependent G2 arrest mediator candidate	0.025
Kit	kit oncogene	0.025
Lmx1a	LIM homeobox transcription factor 1 alpha	0.025
Xpo4	exportin 4	0.025
Bdnf	brain derived neurotrophic factor	0.024
Id4	inhibitor of DNA binding 4	0.024
Shank3	SH3/ankyrin domain gene 3	0.024
Npr2	natriuretic peptide receptor 2	0.023
Fzd8	frizzled homolog 8 (Drosophila)	0.023
Arx	aristaless related homeobox	0.023
Ramp2	receptor (calcitonin) activity modifying protein 2	0.023
Dlx2	distal-less homeobox 2	0.023
Mcam	melanoma cell adhesion molecule	0.023
BC020535	cDNA sequence BC020535	0.023
Edar	ectodysplasin-A receptor	0.023
Hoxb13	homeobox B13	0.022
Arvcf	armadillo repeat gene deleted in velo-cardio-facial syndrome	0.021
Krt17	keratin 17	0.021
Fgf4	fibroblast growth factor 4	0.021
Pou3f4	POU domain, class 3, transcription factor 4	0.020
Gsbs	G substrate	0.020
Nynrin	NYN domain and retroviral integrase containing	0.020
Pdgfb	platelet derived growth factor, B polypeptide	0.020
Nes	nestin	0.020
Adam19	a disintegrin and metallopeptidase domain 19 (meltrin beta)	0.020
Zic2	zinc finger protein of the cerebellum 2	0.020
Hspa12b	heat shock protein 12B	0.020
Gja1	gap junction protein, alpha 1	0.020
Fgf18	fibroblast growth factor 18	0.020
Dock1	dedicator of cytokinesis 1	0.020
Foxf2	forkhead box F2	0.020
Col22a1	collagen, type XXII, alpha 1	0.019
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.019
Pax1	paired box gene 1	0.019
Apln	apelin	0.019
Emid1	EMI domain containing 1	0.019
Phlda2	pleckstrin homology-like domain, family A, member 2	0.018
Irs1	insulin receptor substrate 1	0.018
Srrm4	serine/arginine repetitive matrix 4	0.018
Myl3	myosin, light polypeptide 3	0.018
Tril	TLR4 interactor with leucine-rich repeats	0.018
Wnt1	wingless-related MMTV integration site 1	0.018
A530016L24Rik	RIKEN cDNA A530016L24 gene	0.018
Mn1	meningioma 1	0.018
Hrh2	histamine receptor H2	0.018
Egfl7	EGF-like domain 7	0.018
Notch4	Notch gene homolog 4 (Drosophila)	0.018
Matn4	matrilin 4	0.017
Tmeff2	transmembrane protein with EGF-like and two follistatin-like domains 2	0.017
Colq	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	0.017
Barhl2	BarH-like 2 (Drosophila)	0.017
Mapk12	mitogen-activated protein kinase 12	0.017
Foxd2	forkhead box D2	0.017
Wnt6	wingless-related MMTV integration site 6	0.017
Podxl	podocalyxin-like	0.017
Mmp15	matrix metallopeptidase 15	0.017
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.017
Edn3	endothelin 3	0.017
Irx3	Iroquois related homeobox 3 (Drosophila)	0.017
Krt16	keratin 16	0.016
Crabp2	cellular retinoic acid binding protein II	0.016
Tal1	T-cell acute lymphocytic leukemia 1	0.016
Sfn	stratifin	0.016
Ddah2	dimethylarginine dimethylaminohydrolase 2	0.016
Rpl38	ribosomal protein L38	0.016
Nkx2-1	NK2 homeobox 1	0.016
Icam2	intercellular adhesion molecule 2	0.016
Tshz3	teashirt zinc finger family member 3	0.016
Twist1	twist homolog 1 (Drosophila)	0.016
Npr3	natriuretic peptide receptor 3	0.016
Hs6st3	heparan sulfate 6-O-sulfotransferase 3	0.016
Foxd1	forkhead box D1	0.016
Tbx6	T-box 6	0.016
Vax1	ventral anterior homeobox containing gene 1	0.016
Acvr2b	activin receptor IIB	0.016
Tcf21	transcription factor 21	0.015
Ptk7	PTK7 protein tyrosine kinase 7	0.015
Nr2f1	nuclear receptor subfamily 2, group F, member 1	0.015
Krt72-ps	keratin 72, pseudogene	0.015
Ptprm	protein tyrosine phosphatase, receptor type, M	0.015
Klk8	kallikrein related-peptidase 8	0.015
Fam173a	family with sequence similarity 173, member A	0.015
Olig2	oligodendrocyte transcription factor 2	0.015
Slc12a2	solute carrier family 12, member 2	0.015
Fgf15	fibroblast growth factor 15	0.015
Gpr152	G protein-coupled receptor 152	0.015
Ikbkap	inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein	0.015
Dpysl4	dihydropyrimidinase-like 4	0.015
Gm13290	predicted gene 13290	0.015
Myct1	myc target 1	0.015
Nanog	Nanog homeobox	0.014
Rspo1	R-spondin homolog (Xenopus laevis)	0.014
Apcdd1	adenomatosis polyposis coli down-regulated 1	0.014
Kif26a	kinesin family member 26A	0.014
Snai1	snail homolog 1 (Drosophila)	0.014
Nobox	NOBOX oogenesis homeobox	0.014
Ephb3	Eph receptor B3	0.014
Hoxa13	homeobox A13	0.014
Nkx2-2	NK2 transcription factor related, locus 2 (Drosophila)	0.014
Ankrd2	ankyrin repeat domain 2 (stretch responsive muscle)	0.014
Nrarp	Notch-regulated ankyrin repeat protein	0.014
Dmrtb1	DMRT-like family B with proline-rich C-terminal, 1	0.014
Apaf1	apoptotic peptidase activating factor 1	0.014
Tox3	TOX high mobility group box family member 3	0.014
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.014
Fign	fidgetin	0.014
Adrb1	adrenergic receptor, beta 1	0.014
Mest	mesoderm specific transcript	0.013
Cxcl12	chemokine (C-X-C motif) ligand 12	0.013
T	brachyury	0.013
Hoxa4	homeobox A4	0.013
Irx5	Iroquois related homeobox 5 (Drosophila)	0.013
Arhgef15	Rho guanine nucleotide exchange factor (GEF) 15	0.013
Sncg	synuclein, gamma	0.013
Gh	growth hormone	0.013
Fhl3	four and a half LIM domains 3	0.013
Rdh10	retinol dehydrogenase 10 (all-trans)	0.013
Tgif2	TGFB-induced factor homeobox 2	0.013
Mitf	microphthalmia-associated transcription factor	0.013
Hoxc4	homeobox C4	0.013
Ptrf	polymerase I and transcript release factor	0.013
Hhip	Hedgehog-interacting protein	0.013
Etv4	ets variant gene 4 (E1A enhancer binding protein, E1AF)	0.013
Gcom1	GRINL1A complex locus	0.013
Cdc42ep1	CDC42 effector protein (Rho GTPase binding) 1	0.012
Krtap3-3	keratin associated protein 3-3	0.012
Msi1	Musashi homolog 1(Drosophila)	0.012
Fbn2	fibrillin 2	0.012
Hoxb2	homeobox B2	0.012
Ltbp4	latent transforming growth factor beta binding protein 4	0.012
Hdac7	histone deacetylase 7	0.012
Zic1	zinc finger protein of the cerebellum 1	0.012
Clec14a	C-type lectin domain family 14, member a	0.012
Kcnj8	potassium inwardly-rectifying channel, subfamily J, member 8	0.012
Myl7	myosin, light polypeptide 7, regulatory	0.012
Helt	Hey-like transcription factor (zebrafish)	0.012	Mouse
Fam171a1	family with sequence similarity 171, member A1	0.012
Tead2	TEA domain family member 2	0.012
Shank1	SH3/ankyrin domain gene 1	0.012
Fgf17	fibroblast growth factor 17	0.012
Tnni1	troponin I, skeletal, slow 1	0.012
Nudt14	nudix (nucleoside diphosphate linked moiety X)-type motif 14	0.012
Ier5l	immediate early response 5-like	0.012
Axin2	axin2	0.012
Eda	ectodysplasin-A	0.012
Hoxb5	homeobox B5	0.012
Emcn	endomucin	0.012
Rhox6	reproductive homeobox 6	0.012
Wnt7a	wingless-related MMTV integration site 7A	0.011
Nkd2	naked cuticle 2 homolog (Drosophila)	0.011
Pax5	paired box gene 5	0.011
Gdnf	glial cell line derived neurotrophic factor	0.011
Fuz	fuzzy homolog (Drosophila)	0.011
Ssbp3	single-stranded DNA binding protein 3	0.011
Trp53	transformation related protein 53	0.011
Gpc3	glypican 3	0.011
Fabp9	fatty acid binding protein 9, testis	0.011
Scube1	signal peptide, CUB domain, EGF-like 1	0.011
Nr2f6	nuclear receptor subfamily 2, group F, member 6	0.011
Hoxb4	homeobox B4	0.011
Phex	phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)	0.011
Hba-x	hemoglobin X, alpha-like embryonic chain in Hba complex	0.011
Accn4	amiloride-sensitive cation channel 4, pituitary	0.011
Col15a1	collagen, type XV, alpha 1	0.011
Pcyt2	phosphate cytidylyltransferase 2, ethanolamine	0.011
Sema3f	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	0.011
Smad7	MAD homolog 7 (Drosophila)	0.011
Crlf1	cytokine receptor-like factor 1	0.011
Sema6c	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C	0.011
Col11a1	collagen, type XI, alpha 1	0.011
Epha3	Eph receptor A3	0.011
Dach1	dachshund 1 (Drosophila)	0.011
Zbtb46	zinc finger and BTB domain containing 46	0.011
Chst2	carbohydrate sulfotransferase 2	0.011
Crabp1	cellular retinoic acid binding protein I	0.010
Mtss1l	metastasis suppressor 1-like	0.010
Foxb2	forkhead box B2	0.010
Wnt11	wingless-related MMTV integration site 11	0.010
Epas1	endothelial PAS domain protein 1	0.010
Neurod1	neurogenic differentiation 1	0.010
1700018A14Rik	RIKEN cDNA 1700018A14 gene	0.010
Hcrt	hypocretin	0.010
Lrp4	low density lipoprotein receptor-related protein 4	0.010
Tnp1	transition protein 1	0.010
2810449G22Rik	RIKEN cDNA 2810449G22 gene	0.010
Ephb4	Eph receptor B4	0.010
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.010
Barx2	BarH-like homeobox 2	0.010
Rcor2	REST corepressor 2	0.010
Bnc1	basonuclin 1	0.010
Rgnef	Rho-guanine nucleotide exchange factor	0.010
Sema3g	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G	0.010
Higd1b	HIG1 domain family, member 1B	0.010
Ptprg	protein tyrosine phosphatase, receptor type, G	0.010