IMP

Process View

Mus musculus

19 genes annotated in mouse

Multi-species View

negative regulation of chromatin modification

GO:1903309

Any process that stops, prevents or reduces the frequency, rate or extent of chromatin modification.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in mouse Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of chromatin modification"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of chromatin modification" (in gray)

Name	Description	Probability	Func Analog Organism
Trp53	transformation related protein 53	0.907
Gli2	GLI-Kruppel family member GLI2	0.756
Shh	sonic hedgehog	0.686
Otx2	orthodenticle homolog 2 (Drosophila)	0.678
Dnmt3a	DNA methyltransferase 3A	0.582
Hdac1	histone deacetylase 1	0.522
Pax6	paired box gene 6	0.506
Suz12	suppressor of zeste 12 homolog (Drosophila)	0.475
Jarid2	jumonji, AT rich interactive domain 2	0.470
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.441
Zeb1	zinc finger E-box binding homeobox 1	0.422
Kdm2b	lysine (K)-specific demethylase 2B	0.371
Kdm1a	lysine (K)-specific demethylase 1A	0.304
Msx1	homeobox, msh-like 1	0.290	Mouse
Gata1	GATA binding protein 1	0.266
Hand1	heart and neural crest derivatives expressed transcript 1	0.245	Mouse
Gsc	goosecoid homeobox	0.232
Emx1	empty spiracles homolog 1 (Drosophila)	0.227
Ezh2	enhancer of zeste homolog 2 (Drosophila)	0.191
Igh	immunoglobulin heavy chain complex	0.179
Pax3	paired box gene 3	0.168
Rnf2	ring finger protein 2	0.165
Neurod1	neurogenic differentiation 1	0.159	Mouse
Arid1a	AT rich interactive domain 1A (SWI-like)	0.157
Lef1	lymphoid enhancer binding factor 1	0.157
Foxc2	forkhead box C2	0.151
Prrx1	paired related homeobox 1	0.149
Pou5f1	POU domain, class 5, transcription factor 1	0.135
En1	engrailed 1	0.135
Ikzf1	IKAROS family zinc finger 1	0.130
Pax9	paired box gene 9	0.129	Mouse
Eya1	eyes absent 1 homolog (Drosophila)	0.127
Tal1	T-cell acute lymphocytic leukemia 1	0.124	Mouse
Lhx3	LIM homeobox protein 3	0.122
Dlx5	distal-less homeobox 5	0.119
Msx2	homeobox, msh-like 2	0.114	Mouse
Nhlh1	nescient helix loop helix 1	0.105	Mouse
Tcf3	transcription factor 3	0.103
Atg12	autophagy-related 12 (yeast)	0.103
Dlx2	distal-less homeobox 2	0.102
Gnrh1	gonadotropin releasing hormone 1	0.102
Sox2	SRY-box containing gene 2	0.099
Runx1	runt related transcription factor 1	0.099
Mtf2	metal response element binding transcription factor 2	0.095
Isl1	ISL1 transcription factor, LIM/homeodomain	0.081
Ptf1a	pancreas specific transcription factor, 1a	0.073	Mouse
Cd19	CD19 antigen	0.072
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.071
Slc4a1	solute carrier family 4 (anion exchanger), member 1	0.069
Hmgb1	high mobility group box 1	0.068
Alx3	aristaless-like homeobox 3	0.063
Pdx1	pancreatic and duodenal homeobox 1	0.059
Mecom	MDS1 and EVI1 complex locus	0.058
Pml	promyelocytic leukemia	0.058
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.058
Lhx5	LIM homeobox protein 5	0.057
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.057
Foxp1	forkhead box P1	0.056	Mouse
Rara	retinoic acid receptor, alpha	0.055
Runx1t1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.054
Trim24	tripartite motif-containing 24	0.054
Mdm2	transformed mouse 3T3 cell double minute 2	0.053
Tcfap2a	transcription factor AP-2, alpha	0.050
Ank1	ankyrin 1, erythroid	0.049
Twist2	twist homolog 2 (Drosophila)	0.049	Mouse
Pten	phosphatase and tensin homolog	0.048
Foxn1	forkhead box N1	0.047
Pou4f2	POU domain, class 4, transcription factor 2	0.047
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.047
Hoxd13	homeobox D13	0.046
Fgf8	fibroblast growth factor 8	0.046
Sox11	SRY-box containing gene 11	0.045
Smarca4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.045
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.045
Prrx2	paired related homeobox 2	0.044
Trim28	tripartite motif-containing 28	0.044
Foxp2	forkhead box P2	0.044	Mouse
Hdac2	histone deacetylase 2	0.043
Foxd2	forkhead box D2	0.043
Rbbp4	retinoblastoma binding protein 4	0.042
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.042
Sin3a	transcriptional regulator, SIN3A (yeast)	0.041	Human
Pitx2	paired-like homeodomain transcription factor 2	0.041
Gdf11	growth differentiation factor 11	0.041
Smc3	structural maintenace of chromosomes 3	0.040
Gypa	glycophorin A	0.039
Kiss1	KiSS-1 metastasis-suppressor	0.038
Pum2	pumilio 2 (Drosophila)	0.037
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.037
Abl1	c-abl oncogene 1, non-receptor tyrosine kinase	0.037
Csnk2a1	casein kinase 2, alpha 1 polypeptide	0.035
Onecut1	one cut domain, family member 1	0.034
Neurog3	neurogenin 3	0.034	Mouse
Notch2	Notch gene homolog 2 (Drosophila)	0.034
Zfp362	zinc finger protein 362	0.034
Zfp292	zinc finger protein 292	0.034
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.033
Tbx20	T-box 20	0.033
Trim10	tripartite motif-containing 10	0.033
Chd4	chromodomain helicase DNA binding protein 4	0.033
Hoxa1	homeobox A1	0.032
Rag1	recombination activating gene 1	0.032
Gnai2	guanine nucleotide binding protein (G protein), alpha inhibiting 2	0.032
Gtf2ird1	general transcription factor II I repeat domain-containing 1	0.030
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.030
Smarcc1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.030
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.029
Kdm5b	lysine (K)-specific demethylase 5B	0.029	Mouse
Gfi1b	growth factor independent 1B	0.029
Baz1a	bromodomain adjacent to zinc finger domain 1A	0.028
Mdm4	transformed mouse 3T3 cell double minute 4	0.028
Parp1	poly (ADP-ribose) polymerase family, member 1	0.028
Alx4	aristaless-like homeobox 4	0.028
Bmp7	bone morphogenetic protein 7	0.028
Lhx9	LIM homeobox protein 9	0.027
Nkx2-9	NK2 transcription factor related, locus 9 (Drosophila)	0.026
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.026
Qrich1	glutamine-rich 1	0.026
Nkx2-1	NK2 homeobox 1	0.026
Nfe2	nuclear factor, erythroid derived 2	0.026
Twist1	twist homolog 1 (Drosophila)	0.026
Zic2	zinc finger protein of the cerebellum 2	0.026
Huwe1	HECT, UBA and WWE domain containing 1	0.026
Atoh7	atonal homolog 7 (Drosophila)	0.026	Mouse
Prph2	peripherin 2	0.025
Asxl1	additional sex combs like 1 (Drosophila)	0.025
Efna2	ephrin A2	0.025
Pitx3	paired-like homeodomain transcription factor 3	0.025
Hba-x	hemoglobin X, alpha-like embryonic chain in Hba complex	0.025
Pou4f3	POU domain, class 4, transcription factor 3	0.025
Gli3	GLI-Kruppel family member GLI3	0.025
Runx2	runt related transcription factor 2	0.025
Ezh1	enhancer of zeste homolog 1 (Drosophila)	0.025
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.024
Notch1	Notch gene homolog 1 (Drosophila)	0.024
Mab21l2	mab-21-like 2 (C. elegans)	0.024
Numa1	nuclear mitotic apparatus protein 1	0.024
Brca2	breast cancer 2	0.023
Gpr50	G-protein-coupled receptor 50	0.023
Rag2	recombination activating gene 2	0.023
Gp9	glycoprotein 9 (platelet)	0.023
Cbfa2t3	core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)	0.023
Rhag	Rhesus blood group-associated A glycoprotein	0.022
Prf1	perforin 1 (pore forming protein)	0.022
Dsg4	desmoglein 4	0.022
Neurod4	neurogenic differentiation 4	0.022	Mouse
Sykb	spleen tyrosine kinase	0.022
Hand2	heart and neural crest derivatives expressed transcript 2	0.022	Mouse
Cbx3	chromobox homolog 3 (Drosophila HP1 gamma)	0.022
Hoxa2	homeobox A2	0.021
Foxg1	forkhead box G1	0.021
Mn1	meningioma 1	0.021
Tlx3	T-cell leukemia, homeobox 3	0.021
Hbb-b2	hemoglobin, beta adult minor chain	0.021
Dlx6	distal-less homeobox 6	0.021
Socs1	suppressor of cytokine signaling 1	0.021
Morf4l1	mortality factor 4 like 1	0.021
Hoxb1	homeobox B1	0.021
Yy1	YY1 transcription factor	0.020
Kdm3b	KDM3B lysine (K)-specific demethylase 3B	0.020	Mouse
Pitx1	paired-like homeodomain transcription factor 1	0.020
Atm	ataxia telangiectasia mutated homolog (human)	0.020
Krt14	keratin 14	0.020
Srrm4	serine/arginine repetitive matrix 4	0.020
Dlx1	distal-less homeobox 1	0.020
Hbb-bh1	hemoglobin Z, beta-like embryonic chain	0.020
Foxc1	forkhead box C1	0.020
Evx1	even skipped homeotic gene 1 homolog	0.020
Rhd	Rh blood group, D antigen	0.020
Klf1	Kruppel-like factor 1 (erythroid)	0.020
Ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.020
Sfpi1	SFFV proviral integration 1	0.020	Human
Ermap	erythroblast membrane-associated protein	0.019
Nkx3-2	NK3 homeobox 2	0.019
Cdh23	cadherin 23 (otocadherin)	0.019
ND6	NADH dehydrogenase subunit 6	0.019
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.019
Hoxa11	homeobox A11	0.019
Phox2b	paired-like homeobox 2b	0.019
Ilf3	interleukin enhancer binding factor 3	0.019
Crebbp	CREB binding protein	0.019
Bdnf	brain derived neurotrophic factor	0.019
Trim33	tripartite motif-containing 33	0.019
Arx	aristaless related homeobox	0.018
Hbb-y	hemoglobin Y, beta-like embryonic chain	0.018
Hmx1	H6 homeobox 1	0.018
Hoxc5	homeobox C5	0.018
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.018
Mll1	myeloid/lymphoid or mixed-lineage leukemia 1	0.018
Igl	immunoglobulin lambda chain complex	0.018
Alx1	ALX homeobox 1	0.018
Oc90	otoconin 90	0.018
Polr2a	polymerase (RNA) II (DNA directed) polypeptide A	0.017
Aicda	activation-induced cytidine deaminase	0.017	Mouse
Myf5	myogenic factor 5	0.017
Epor	erythropoietin receptor	0.017
Tmem131	transmembrane protein 131	0.017
Uty	ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome	0.017
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.017
Srrt	serrate RNA effector molecule homolog (Arabidopsis)	0.017
Hoxa10	homeobox A10	0.017
Foxd4	forkhead box D4	0.016
Nat3	N-acetyltransferase 3	0.016
Setx	senataxin	0.016
E2f1	E2F transcription factor 1	0.016
Fgf17	fibroblast growth factor 17	0.016
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.016
Mcl1	myeloid cell leukemia sequence 1	0.016
Ep300	E1A binding protein p300	0.016
Zic1	zinc finger protein of the cerebellum 1	0.016
Gdf3	growth differentiation factor 3	0.016
Rad50	RAD50 homolog (S. cerevisiae)	0.016
Vax1	ventral anterior homeobox containing gene 1	0.015
Alas2	aminolevulinic acid synthase 2, erythroid	0.015
Smo	smoothened homolog (Drosophila)	0.015
Tnnt3	troponin T3, skeletal, fast	0.015
Hes5	hairy and enhancer of split 5 (Drosophila)	0.015
Cbx2	chromobox homolog 2 (Drosophila Pc class)	0.015
Ssrp1	structure specific recognition protein 1	0.014
Rp1	retinitis pigmentosa 1 (human)	0.014
Fgfr1	fibroblast growth factor receptor 1	0.014
Chrnb2	cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)	0.014
Uncx	UNC homeobox	0.014
Cic	capicua homolog (Drosophila)	0.014
Ltf	lactotransferrin	0.014
Hoxd1	homeobox D1	0.014
Tbx15	T-box 15	0.014
Insm1	insulinoma-associated 1	0.014
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.014
Daxx	Fas death domain-associated protein	0.014
Cdx2	caudal type homeobox 2	0.014
Prox1	prospero-related homeobox 1	0.014
Pou2f2	POU domain, class 2, transcription factor 2	0.014
Card11	caspase recruitment domain family, member 11	0.014
Col2a1	collagen, type II, alpha 1	0.013
Matn1	matrilin 1, cartilage matrix protein	0.013
Pou3f2	POU domain, class 3, transcription factor 2	0.013
Fes	feline sarcoma oncogene	0.013
Tab2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	0.013
Trp63	transformation related protein 63	0.013
Elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.013
Hoxa5	homeobox A5	0.013
P2rx1	purinergic receptor P2X, ligand-gated ion channel, 1	0.013
Irf8	interferon regulatory factor 8	0.013
Fbxo38	F-box protein 38	0.013
Plcg2	phospholipase C, gamma 2	0.013
Myog	myogenin	0.013
Csnk2a2	casein kinase 2, alpha prime polypeptide	0.013
Neurog2	neurogenin 2	0.012	Mouse
Crb2	crumbs homolog 2 (Drosophila)	0.012
Fgf15	fibroblast growth factor 15	0.012
Fgf10	fibroblast growth factor 10	0.012
Uba7	ubiquitin-like modifier activating enzyme 7	0.012
Hes1	hairy and enhancer of split 1 (Drosophila)	0.012
Dok1	docking protein 1	0.012
Ebf3	early B-cell factor 3	0.012
Laptm5	lysosomal-associated protein transmembrane 5	0.012
Il9r	interleukin 9 receptor	0.012
Ebf2	early B-cell factor 2	0.012
Epb4.2	erythrocyte protein band 4.2	0.012
Col9a1	collagen, type IX, alpha 1	0.012
Patz1	POZ (BTB) and AT hook containing zinc finger 1	0.012
Etv4	ets variant gene 4 (E1A enhancer binding protein, E1AF)	0.012
Tnks2	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2	0.012
Msh2	mutS homolog 2 (E. coli)	0.012
Hoxd12	homeobox D12	0.012
Tpr	translocated promoter region	0.012
Smc1a	structural maintenance of chromosomes 1A	0.012
Col22a1	collagen, type XXII, alpha 1	0.012
Spna1	spectrin alpha 1	0.012
Gpsm3	G-protein signalling modulator 3 (AGS3-like, C. elegans)	0.012
Tprgl	transformation related protein 63 regulated like	0.012
Cbx1	chromobox homolog 1 (Drosophila HP1 beta)	0.012
Smad4	MAD homolog 4 (Drosophila)	0.012
Neurog1	neurogenin 1	0.012	Mouse
Meox2	mesenchyme homeobox 2	0.012
Rb1	retinoblastoma 1	0.012
Ebf1	early B-cell factor 1	0.011
Brd1	bromodomain containing 1	0.011
Mnx1	motor neuron and pancreas homeobox 1	0.011
Cdca3	cell division cycle associated 3	0.011
Ssbp3	single-stranded DNA binding protein 3	0.011
Dnmt1	DNA methyltransferase (cytosine-5) 1	0.011	Human
Sp6	trans-acting transcription factor 6	0.011
Ywhah	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.011
Fam13b	family with sequence similarity 13, member B	0.011
Vps4a	vacuolar protein sorting 4a (yeast)	0.011
Rcor1	REST corepressor 1	0.011
Mga	MAX gene associated	0.011
Myb	myeloblastosis oncogene	0.011
Mbtd1	mbt domain containing 1	0.011
Bhlha15	basic helix-loop-helix family, member a15	0.011	Mouse
Camp	cathelicidin antimicrobial peptide	0.011
Mis18bp1	MIS18 binding protein 1	0.011
T	brachyury	0.011
Chrng	cholinergic receptor, nicotinic, gamma polypeptide	0.011
Hhex	hematopoietically expressed homeobox	0.011
Tlx2	T-cell leukemia, homeobox 2	0.011
Bhlhe22	basic helix-loop-helix family, member e22	0.011
Gja8	gap junction protein, alpha 8	0.011
Tcfap2c	transcription factor AP-2, gamma	0.011
Srsf4	serine/arginine-rich splicing factor 4	0.011
App	amyloid beta (A4) precursor protein	0.011
Suds3	suppressor of defective silencing 3 homolog (S. cerevisiae)	0.011
Elavl4	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)	0.011
Igf2bp3	insulin-like growth factor 2 mRNA binding protein 3	0.011
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.011
Prph	peripherin	0.011
Hmga2	high mobility group AT-hook 2	0.011
Dcc	deleted in colorectal carcinoma	0.011
Kel	Kell blood group	0.011
Sp1	trans-acting transcription factor 1	0.011
Epha7	Eph receptor A7	0.011
4930404N11Rik	RIKEN cDNA 4930404N11 gene	0.011
Hoxd11	homeobox D11	0.011
Fgf4	fibroblast growth factor 4	0.011
Wnt6	wingless-related MMTV integration site 6	0.011
Tlr9	toll-like receptor 9	0.011
Brd4	bromodomain containing 4	0.011
Shox2	short stature homeobox 2	0.010
Rnf38	ring finger protein 38	0.010
Gip	gastric inhibitory polypeptide	0.010
Baz2a	bromodomain adjacent to zinc finger domain, 2A	0.010
Bap1	Brca1 associated protein 1	0.010
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.010
Lhcgr	luteinizing hormone/choriogonadotropin receptor	0.010
Rho	rhodopsin	0.010
Rint1	RAD50 interactor 1	0.010
N4bp1	NEDD4 binding protein 1	0.010
Tgfb2	transforming growth factor, beta 2	0.010
Clk4	CDC like kinase 4	0.010
Tbx1	T-box 1	0.010
A930001N09Rik	RIKEN cDNA A930001N09 gene	0.010
Irf4	interferon regulatory factor 4	0.010
Gsbs	G substrate	0.010
Atr	ataxia telangiectasia and Rad3 related	0.010
Hemgn	hemogen	0.010