IMP
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mitotic g1 dna damage checkpoint
A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G1/S transition of the cell cycle in response to DNA damage.
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Click on a gene's description to view its network relationships with genes known to be involved in "mitotic g1 dna damage checkpoint"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Trp53 | transformation related protein 53 | 1.000 | ||
| Rb1 | retinoblastoma 1 | 0.996 | ||
| Cdkn1b | cyclin-dependent kinase inhibitor 1B | 0.986 | ||
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.936 | ||
| Trp63 | transformation related protein 63 | 0.888 | Mouse | |
| Mdm2 | transformed mouse 3T3 cell double minute 2 | 0.874 | Human | |
| Pten | phosphatase and tensin homolog | 0.867 | ||
| Apc | adenomatosis polyposis coli | 0.853 | ||
| Mdm4 | transformed mouse 3T3 cell double minute 4 | 0.846 | ||
| Kras | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 0.790 | ||
| Cdkn1a | cyclin-dependent kinase inhibitor 1A (P21) | 0.716 | Human | |
| Cdk4 | cyclin-dependent kinase 4 | 0.656 | ||
| Msh2 | mutS homolog 2 (E. coli) | 0.600 | ||
| Daxx | Fas death domain-associated protein | 0.516 | ||
| Col1a1 | collagen, type I, alpha 1 | 0.505 | ||
| Kit | kit oncogene | 0.468 | ||
| Sox9 | SRY-box containing gene 9 | 0.447 | ||
| Cdkn2a | cyclin-dependent kinase inhibitor 2A | 0.424 | ||
| Braf | Braf transforming gene | 0.424 | ||
| Itgb1 | integrin beta 1 (fibronectin receptor beta) | 0.403 | ||
| Meox2 | mesenchyme homeobox 2 | 0.357 | ||
| Rara | retinoic acid receptor, alpha | 0.301 | ||
| Nf1 | neurofibromatosis 1 | 0.260 | ||
| Nbn | nibrin | 0.229 | ||
| Brca1 | breast cancer 1 | 0.227 | ||
| Thbs1 | thrombospondin 1 | 0.174 | ||
| Notch1 | Notch gene homolog 1 (Drosophila) | 0.158 | ||
| Cdkn2c | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | 0.154 | ||
| Shh | sonic hedgehog | 0.151 | ||
| Runx1 | runt related transcription factor 1 | 0.141 | ||
| Fgfr2 | fibroblast growth factor receptor 2 | 0.141 | ||
| Ptch1 | patched homolog 1 | 0.138 | ||
| E2f1 | E2F transcription factor 1 | 0.137 | ||
| Rxra | retinoid X receptor alpha | 0.128 | ||
| Sfn | stratifin | 0.127 | ||
| Ppp1cc | protein phosphatase 1, catalytic subunit, gamma isoform | 0.126 | ||
| Stk11 | serine/threonine kinase 11 | 0.121 | ||
| Trp73 | transformation related protein 73 | 0.104 | Mouse | |
| Nf2 | neurofibromatosis 2 | 0.102 | ||
| Hdac1 | histone deacetylase 1 | 0.101 | ||
| Cdk6 | cyclin-dependent kinase 6 | 0.094 | ||
| Atm | ataxia telangiectasia mutated homolog (human) | 0.088 | ||
| Hprt | hypoxanthine guanine phosphoribosyl transferase | 0.082 | ||
| Ccnd3 | cyclin D3 | 0.082 | ||
| Prkdc | protein kinase, DNA activated, catalytic polypeptide | 0.081 | ||
| Ptpn11 | protein tyrosine phosphatase, non-receptor type 11 | 0.074 | ||
| Foxo3 | forkhead box O3 | 0.074 | ||
| Dnajc9 | DnaJ (Hsp40) homolog, subfamily C, member 9 | 0.065 | ||
| Pcna | proliferating cell nuclear antigen | 0.064 | ||
| Rfc3 | replication factor C (activator 1) 3 | 0.064 | ||
| Vhl | von Hippel-Lindau tumor suppressor | 0.062 | ||
| Cdk2 | cyclin-dependent kinase 2 | 0.062 | ||
| Efnb2 | ephrin B2 | 0.060 | ||
| Hhat | hedgehog acyltransferase | 0.054 | ||
| Serinc1 | serine incorporator 1 | 0.050 | ||
| Hif1a | hypoxia inducible factor 1, alpha subunit | 0.048 | ||
| Brca2 | breast cancer 2 | 0.047 | ||
| Abl1 | c-abl oncogene 1, non-receptor tyrosine kinase | 0.042 | ||
| Xpa | xeroderma pigmentosum, complementation group A | 0.042 | ||
| Emx2 | empty spiracles homolog 2 (Drosophila) | 0.041 | ||
| Tcf3 | transcription factor 3 | 0.039 | ||
| Rbl1 | retinoblastoma-like 1 (p107) | 0.038 | ||
| Mmp14 | matrix metallopeptidase 14 (membrane-inserted) | 0.037 | ||
| Rpa1 | replication protein A1 | 0.037 | ||
| Tgfb2 | transforming growth factor, beta 2 | 0.037 | ||
| Psen1 | presenilin 1 | 0.037 | ||
| Hipk1 | homeodomain interacting protein kinase 1 | 0.036 | ||
| Ahr | aryl-hydrocarbon receptor | 0.036 | ||
| Srsf9 | serine/arginine-rich splicing factor 9 | 0.036 | ||
| Gadd45a | growth arrest and DNA-damage-inducible 45 alpha | 0.036 | ||
| Rbl2 | retinoblastoma-like 2 | 0.035 | ||
| Yap1 | yes-associated protein 1 | 0.034 | ||
| Elavl1 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) | 0.033 | ||
| Zbtb45 | zinc finger and BTB domain containing 45 | 0.033 | ||
| Tsc1 | tuberous sclerosis 1 | 0.032 | ||
| Bmp4 | bone morphogenetic protein 4 | 0.031 | ||
| Rarb | retinoic acid receptor, beta | 0.029 | ||
| Irf6 | interferon regulatory factor 6 | 0.029 | ||
| Pdgfra | platelet derived growth factor receptor, alpha polypeptide | 0.029 | ||
| Trpc2 | transient receptor potential cation channel, subfamily C, member 2 | 0.028 | ||
| Nfe2l2 | nuclear factor, erythroid derived 2, like 2 | 0.028 | ||
| Nde1 | nuclear distribution gene E homolog 1 (A nidulans) | 0.028 | ||
| Ret | ret proto-oncogene | 0.027 | ||
| Ccnd2 | cyclin D2 | 0.026 | ||
| Pax3 | paired box gene 3 | 0.026 | ||
| Cul9 | cullin 9 | 0.026 | ||
| Numa1 | nuclear mitotic apparatus protein 1 | 0.025 | ||
| Sox11 | SRY-box containing gene 11 | 0.024 | ||
| Fbn1 | fibrillin 1 | 0.024 | ||
| Sin3a | transcriptional regulator, SIN3A (yeast) | 0.023 | ||
| Eif4a2 | eukaryotic translation initiation factor 4A2 | 0.023 | ||
| Krt14 | keratin 14 | 0.023 | ||
| Skil | SKI-like | 0.022 | ||
| Cdx2 | caudal type homeobox 2 | 0.022 | ||
| Kitl | kit ligand | 0.021 | ||
| Smo | smoothened homolog (Drosophila) | 0.021 | ||
| Ikbkap | inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein | 0.021 | ||
| Bcl2 | B-cell leukemia/lymphoma 2 | 0.021 | ||
| Parp1 | poly (ADP-ribose) polymerase family, member 1 | 0.020 | ||
| Huwe1 | HECT, UBA and WWE domain containing 1 | 0.020 | ||
| Zfand6 | zinc finger, AN1-type domain 6 | 0.020 | ||
| Mt2 | metallothionein 2 | 0.019 | ||
| Chtf8 | CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) | 0.019 | ||
| Lef1 | lymphoid enhancer binding factor 1 | 0.019 | ||
| Cad | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase | 0.019 | ||
| Mum1 | melanoma associated antigen (mutated) 1 | 0.018 | ||
| Ccnd1 | cyclin D1 | 0.018 | Human | |
| Thap11 | THAP domain containing 11 | 0.018 | ||
| Klf5 | Kruppel-like factor 5 | 0.017 | ||
| Vill | villin-like | 0.017 | ||
| Cxcr4 | chemokine (C-X-C motif) receptor 4 | 0.016 | ||
| Nfya | nuclear transcription factor-Y alpha | 0.016 | ||
| Yipf4 | Yip1 domain family, member 4 | 0.016 | ||
| Sipa1 | signal-induced proliferation associated gene 1 | 0.016 | ||
| Raf1 | v-raf-leukemia viral oncogene 1 | 0.016 | ||
| Cdkn2d | cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) | 0.016 | ||
| Atl2 | atlastin GTPase 2 | 0.016 | ||
| Lpcat1 | lysophosphatidylcholine acyltransferase 1 | 0.016 | ||
| Bcl2l11 | BCL2-like 11 (apoptosis facilitator) | 0.016 | ||
| Ifng | interferon gamma | 0.015 | ||
| Rfwd2 | ring finger and WD repeat domain 2 | 0.015 | ||
| Rfc1 | replication factor C (activator 1) 1 | 0.015 | ||
| Bcl2l1 | BCL2-like 1 | 0.015 | ||
| Mycn | v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) | 0.015 | ||
| Atg12 | autophagy-related 12 (yeast) | 0.015 | ||
| Fadd | Fas (TNFRSF6)-associated via death domain | 0.015 | ||
| Rprd1b | regulation of nuclear pre-mRNA domain containing 1B | 0.015 | ||
| Hmgb3 | high mobility group box 3 | 0.015 | ||
| Papss1 | 3'-phosphoadenosine 5'-phosphosulfate synthase 1 | 0.015 | ||
| Asxl1 | additional sex combs like 1 (Drosophila) | 0.015 | ||
| Apex2 | apurinic/apyrimidinic endonuclease 2 | 0.014 | ||
| Rrm1 | ribonucleotide reductase M1 | 0.014 | ||
| Gga2 | golgi associated, gamma adaptin ear containing, ARF binding protein 2 | 0.014 | ||
| Ralb | v-ral simian leukemia viral oncogene homolog B (ras related) | 0.014 | ||
| Fcho1 | FCH domain only 1 | 0.014 | ||
| Fbxl3 | F-box and leucine-rich repeat protein 3 | 0.014 | ||
| Ttf1 | transcription termination factor, RNA polymerase I | 0.014 | ||
| Pms2 | postmeiotic segregation increased 2 (S. cerevisiae) | 0.014 | ||
| Fam103a1 | family with sequence similarity 103, member A1 | 0.014 | ||
| Pkp3 | plakophilin 3 | 0.014 | ||
| Epb4.1 | erythrocyte protein band 4.1 | 0.014 | ||
| Cdrt4 | CMT1A duplicated region transcript 4 | 0.014 | ||
| Pigr | polymeric immunoglobulin receptor | 0.014 | ||
| 2900092E17Rik | RIKEN cDNA 2900092E17 gene | 0.014 | ||
| Gja1 | gap junction protein, alpha 1 | 0.014 | ||
| Ifrd2 | interferon-related developmental regulator 2 | 0.014 | ||
| Gata3 | GATA binding protein 3 | 0.014 | ||
| Nbeal2 | neurobeachin-like 2 | 0.013 | ||
| Tnfrsf18 | tumor necrosis factor receptor superfamily, member 18 | 0.013 | ||
| Cables1 | CDK5 and Abl enzyme substrate 1 | 0.013 | ||
| Ccng1 | cyclin G1 | 0.013 | ||
| Ets1 | E26 avian leukemia oncogene 1, 5' domain | 0.013 | ||
| Isl1 | ISL1 transcription factor, LIM/homeodomain | 0.013 | ||
| Unc119b | unc-119 homolog B (C. elegans) | 0.013 | ||
| Myh3 | myosin, heavy polypeptide 3, skeletal muscle, embryonic | 0.013 | ||
| Exosc7 | exosome component 7 | 0.013 | ||
| March6 | membrane-associated ring finger (C3HC4) 6 | 0.013 | ||
| Llgl1 | lethal giant larvae homolog 1 (Drosophila) | 0.013 | ||
| Cldn7 | claudin 7 | 0.013 | ||
| Prss8 | protease, serine, 8 (prostasin) | 0.012 | ||
| Nhej1 | nonhomologous end-joining factor 1 | 0.012 | ||
| Zbtb32 | zinc finger and BTB domain containing 32 | 0.012 | ||
| Sox4 | SRY-box containing gene 4 | 0.012 | Human | |
| Hes1 | hairy and enhancer of split 1 (Drosophila) | 0.012 | ||
| Mmp11 | matrix metallopeptidase 11 | 0.012 | ||
| Slc39a4 | solute carrier family 39 (zinc transporter), member 4 | 0.012 | ||
| Unk | unkempt homolog (Drosophila) | 0.012 | ||
| Fgfr1 | fibroblast growth factor receptor 1 | 0.012 | ||
| Rpia | ribose 5-phosphate isomerase A | 0.012 | ||
| Rnf8 | ring finger protein 8 | 0.012 | ||
| Mfng | MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 0.012 | ||
| Lrp6 | low density lipoprotein receptor-related protein 6 | 0.012 | ||
| Mapk14 | mitogen-activated protein kinase 14 | 0.012 | ||
| Haus4 | HAUS augmin-like complex, subunit 4 | 0.012 | ||
| E2f4 | E2F transcription factor 4 | 0.012 | ||
| Gins4 | GINS complex subunit 4 (Sld5 homolog) | 0.012 | ||
| Wdr90 | WD repeat domain 90 | 0.012 | ||
| Cnih | cornichon homolog (Drosophila) | 0.012 | ||
| Krt7 | keratin 7 | 0.012 | ||
| Fuz | fuzzy homolog (Drosophila) | 0.012 | ||
| Wwox | WW domain-containing oxidoreductase | 0.012 | ||
| Tacstd2 | tumor-associated calcium signal transducer 2 | 0.012 | ||
| Suv420h2 | suppressor of variegation 4-20 homolog 2 (Drosophila) | 0.012 | ||
| Gmnn | geminin | 0.012 | ||
| Hoxa5 | homeobox A5 | 0.011 | ||
| Htt | huntingtin | 0.011 | ||
| Parp2 | poly (ADP-ribose) polymerase family, member 2 | 0.011 | ||
| Vangl2 | vang-like 2 (van gogh, Drosophila) | 0.011 | ||
| Fgfr3 | fibroblast growth factor receptor 3 | 0.011 | ||
| Krt8 | keratin 8 | 0.011 | ||
| Fancc | Fanconi anemia, complementation group C | 0.011 | ||
| Atp6v1d | ATPase, H+ transporting, lysosomal V1 subunit D | 0.011 | ||
| 4833439L19Rik | RIKEN cDNA 4833439L19 gene | 0.011 | ||
| Fam60a | family with sequence similarity 60, member A | 0.011 | ||
| Ap1m2 | adaptor protein complex AP-1, mu 2 subunit | 0.011 | ||
| Cyb5r4 | cytochrome b5 reductase 4 | 0.011 | ||
| Gins3 | GINS complex subunit 3 (Psf3 homolog) | 0.011 | ||
| Usp21 | ubiquitin specific peptidase 21 | 0.011 | ||
| Camta2 | calmodulin binding transcription activator 2 | 0.011 | ||
| Spice1 | spindle and centriole associated protein 1 | 0.011 | ||
| Foxp1 | forkhead box P1 | 0.011 | ||
| Fbl | fibrillarin | 0.011 | ||
| Gle1 | GLE1 RNA export mediator (yeast) | 0.011 | ||
| Mitf | microphthalmia-associated transcription factor | 0.011 | ||
| Adar | adenosine deaminase, RNA-specific | 0.011 | ||
| Rnf34 | ring finger protein 34 | 0.011 | ||
| Ift88 | intraflagellar transport 88 homolog (Chlamydomonas) | 0.011 | ||
| Gli2 | GLI-Kruppel family member GLI2 | 0.011 | ||
| Id1 | inhibitor of DNA binding 1 | 0.011 | ||
| Med4 | mediator of RNA polymerase II transcription, subunit 4 homolog (yeast) | 0.011 | ||
| Dicer1 | Dicer1, Dcr-1 homolog (Drosophila) | 0.011 | ||
| Jmjd5 | jumonji domain containing 5 | 0.011 | ||
| Pold1 | polymerase (DNA directed), delta 1, catalytic subunit | 0.010 | ||
| Lmna | lamin A | 0.010 | ||
| Tspan14 | tetraspanin 14 | 0.010 | ||
| Mlh1 | mutL homolog 1 (E. coli) | 0.010 | ||
| Prps2 | phosphoribosyl pyrophosphate synthetase 2 | 0.010 | ||
| Lamc2 | laminin, gamma 2 | 0.010 | ||
| AF366264 | cDNA sequence AF366264 | 0.010 | ||
| Helb | helicase (DNA) B | 0.010 | ||
| Rccd1 | RCC1 domain containing 1 | 0.010 | ||
| Tprgl | transformation related protein 63 regulated like | 0.010 | ||
| Gli3 | GLI-Kruppel family member GLI3 | 0.010 | ||
| Aicda | activation-induced cytidine deaminase | 0.010 | ||
| Htatip2 | HIV-1 tat interactive protein 2, homolog (human) | 0.010 | ||
| Hes6 | hairy and enhancer of split 6 (Drosophila) | 0.010 | ||
| Rint1 | RAD50 interactor 1 | 0.010 | ||
| Smarcd1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 | 0.010 | ||
| Ildr1 | immunoglobulin-like domain containing receptor 1 | 0.010 | ||
| Robo1 | roundabout homolog 1 (Drosophila) | 0.010 | ||
| Rfc4 | replication factor C (activator 1) 4 | 0.010 | ||
| Usf1 | upstream transcription factor 1 | 0.010 |