The network for 'leukocyte activation involved in immune response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

leukocyte activation involved in immune response

A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.

Homo sapiens
Name Description Probability Func Analog Organism
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.996
FHL2 four and a half LIM domains 2 0.973
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.782
SYK spleen tyrosine kinase 0.753
IL4R interleukin 4 receptor 0.616
CCR5 chemokine (C-C motif) receptor 5 0.506
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.494
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.440
CXCL2 chemokine (C-X-C motif) ligand 2 0.436
TGIF1 TGFB-induced factor homeobox 1 0.385
CCL4 chemokine (C-C motif) ligand 4 0.379
ENG endoglin 0.361
PTPRC protein tyrosine phosphatase, receptor type, C 0.355
SNAP23 synaptosomal-associated protein, 23kDa 0.350
BLNK B-cell linker 0.289
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 0.287
SOCS3 suppressor of cytokine signaling 3 0.282
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.265
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.263
APLF aprataxin and PNKP like factor 0.252
IL2RG interleukin 2 receptor, gamma 0.237
CD80 CD80 molecule 0.234
CCR1 chemokine (C-C motif) receptor 1 0.232
ICAM1 intercellular adhesion molecule 1 0.228
CXCL9 chemokine (C-X-C motif) ligand 9 0.226
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.223
BIRC3 baculoviral IAP repeat containing 3 0.217
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.209
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.197
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.192
CCL2 chemokine (C-C motif) ligand 2 0.185
HK3 hexokinase 3 (white cell) 0.182
CD33 CD33 molecule 0.172
LIN9 lin-9 homolog (C. elegans) 0.168
CCR7 chemokine (C-C motif) receptor 7 0.167
CD63 CD63 molecule 0.167
BRCA1 breast cancer 1, early onset 0.162
CCR2 chemokine (C-C motif) receptor 2 0.155
TICAM2 toll-like receptor adaptor molecule 2 0.144
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.144
MDC1 mediator of DNA-damage checkpoint 1 0.134
RAD50 RAD50 homolog (S. cerevisiae) 0.126
PECAM1 platelet/endothelial cell adhesion molecule 0.120
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.117
PSEN2 presenilin 2 (Alzheimer disease 4) 0.116
CCL22 chemokine (C-C motif) ligand 22 0.114
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.110
FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.110
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.110
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.106
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.104
NLRP3 NLR family, pyrin domain containing 3 0.103
NLRC4 NLR family, CARD domain containing 4 0.100
IL7R interleukin 7 receptor 0.099
CD84 CD84 molecule 0.098
CLEC10A C-type lectin domain family 10, member A 0.098
SIGLEC7 sialic acid binding Ig-like lectin 7 0.093
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.091
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.090
ESR1 estrogen receptor 1 0.085
RBBP8 retinoblastoma binding protein 8 0.085
MLH1 mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) 0.084
RXRA retinoid X receptor, alpha 0.080
GBA glucosidase, beta, acid 0.077
MSH2 mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) 0.077
VCAM1 vascular cell adhesion molecule 1 0.074
PPL periplakin 0.073
TFF1 trefoil factor 1 0.073
CD2 CD2 molecule 0.072
TLR2 toll-like receptor 2 0.071
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.071
EMR1 egf-like module containing, mucin-like, hormone receptor-like 1 0.070
IL23A interleukin 23, alpha subunit p19 0.068
ZNF830 zinc finger protein 830 0.068
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.067
TP53BP1 tumor protein p53 binding protein 1 0.066
HCK hemopoietic cell kinase 0.066
LAT linker for activation of T cells 0.066
IRF4 interferon regulatory factor 4 0.065
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.064
IL1B interleukin 1, beta 0.064
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.063
CDH5 cadherin 5, type 2 (vascular endothelium) 0.063
PILRA paired immunoglobin-like type 2 receptor alpha 0.063
IL8 interleukin 8 0.063
MSH6 mutS homolog 6 (E. coli) 0.062
SLAMF1 signaling lymphocytic activation molecule family member 1 0.062
SPI1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.061
CYBB cytochrome b-245, beta polypeptide 0.061
HLA-DMA major histocompatibility complex, class II, DM alpha 0.061
CD48 CD48 molecule 0.060
CD86 CD86 molecule 0.060
AR androgen receptor 0.060
MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) 0.059
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 0.058
IL2RB interleukin 2 receptor, beta 0.057
CCL5 chemokine (C-C motif) ligand 5 0.056
CAV1 caveolin 1, caveolae protein, 22kDa 0.055
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.054
NCOR2 nuclear receptor corepressor 2 0.054
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Tnf tumor necrosis factor 0.999
Ccr2 chemokine (C-C motif) receptor 2 0.998
Cd40 CD40 antigen 0.997
Fyn Fyn proto-oncogene 0.986
Il2rg interleukin 2 receptor, gamma chain 0.983
Lyz2 lysozyme 2 0.982
Inpp5d inositol polyphosphate-5-phosphatase D 0.976
Lepr leptin receptor 0.971
Ptprc protein tyrosine phosphatase, receptor type, C 0.962
Ptk2 PTK2 protein tyrosine kinase 2 0.954
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.950
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.950
Il10 interleukin 10 0.950
Ikzf1 IKAROS family zinc finger 1 0.940
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.930
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.924
Il10ra interleukin 10 receptor, alpha 0.920
Fasl Fas ligand (TNF superfamily, member 6) 0.907
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.904
Tlr4 toll-like receptor 4 0.900
Il4 interleukin 4 0.897
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.895
Runx1 runt related transcription factor 1 0.881
Ccr1 chemokine (C-C motif) receptor 1 0.871
Stat6 signal transducer and activator of transcription 6 0.871
Pyhin1 pyrin and HIN domain family, member 1 0.869
Il1b interleukin 1 beta 0.861
Siglec1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.850
Il18rap interleukin 18 receptor accessory protein 0.847
Prf1 perforin 1 (pore forming protein) 0.839
Il2 interleukin 2 0.839
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.836
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.821
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.812
Casp1 caspase 1 0.811
Prdm1 PR domain containing 1, with ZNF domain 0.807
Irf5 interferon regulatory factor 5 0.804
Socs1 suppressor of cytokine signaling 1 0.789
Stat5b signal transducer and activator of transcription 5B 0.777
Hck hemopoietic cell kinase 0.773
Ccl4 chemokine (C-C motif) ligand 4 0.770
Bcl6 B-cell leukemia/lymphoma 6 0.769
Slamf1 signaling lymphocytic activation molecule family member 1 0.769
Fgf10 fibroblast growth factor 10 0.763
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.761
Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) 0.756
Cd28 CD28 antigen 0.745
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.739
Ccl2 chemokine (C-C motif) ligand 2 0.729
Itgal integrin alpha L 0.728
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.721
Fas Fas (TNF receptor superfamily member 6) 0.721
Ltb lymphotoxin B 0.711
Batf basic leucine zipper transcription factor, ATF-like 0.700
Sfpi1 SFFV proviral integration 1 0.700
Il2rb interleukin 2 receptor, beta chain 0.697
Pten phosphatase and tensin homolog 0.696
Ncr1 natural cytotoxicity triggering receptor 1 0.695
Ccr5 chemokine (C-C motif) receptor 5 0.689
Cd7 CD7 antigen 0.677
Il4ra interleukin 4 receptor, alpha 0.674
Nlrp3 NLR family, pyrin domain containing 3 0.668
AF251705 cDNA sequence AF251705 0.666
Atm ataxia telangiectasia mutated homolog (human) 0.661
Jak2 Janus kinase 2 0.661
Cd14 CD14 antigen 0.658
Ifng interferon gamma 0.657
Ccr7 chemokine (C-C motif) receptor 7 0.657
Clec4d C-type lectin domain family 4, member d 0.655
Csf3r colony stimulating factor 3 receptor (granulocyte) 0.648
Lilrb3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 0.646
Trp53 transformation related protein 53 0.643
Selp selectin, platelet 0.639
Bmp5 bone morphogenetic protein 5 0.638
Pitx1 paired-like homeodomain transcription factor 1 0.633
Ctsw cathepsin W 0.629
Ldb3 LIM domain binding 3 0.627
Cxcr5 chemokine (C-X-C motif) receptor 5 0.623
Ccr6 chemokine (C-C motif) receptor 6 0.622
P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 0.615
Il18r1 interleukin 18 receptor 1 0.608
Tlr2 toll-like receptor 2 0.607
Lcp2 lymphocyte cytosolic protein 2 0.605
Cd86 CD86 antigen 0.603
Fcer2a Fc receptor, IgE, low affinity II, alpha polypeptide 0.602
Cxcr4 chemokine (C-X-C motif) receptor 4 0.599
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.593
Pdcd1 programmed cell death 1 0.593
Zeb1 zinc finger E-box binding homeobox 1 0.592
Nos2 nitric oxide synthase 2, inducible 0.592
Itk IL2-inducible T-cell kinase 0.584
Cd247 CD247 antigen 0.583
Gzmk granzyme K 0.576
Cish cytokine inducible SH2-containing protein 0.572
Gpr132 G protein-coupled receptor 132 0.567
Cd160 CD160 antigen 0.565
B2m beta-2 microglobulin 0.564
Msr1 macrophage scavenger receptor 1 0.562
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.560
Tbx3 T-box 3 0.557
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Hck hemopoietic cell kinase 0.626
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.589
Ptprc protein tyrosine phosphatase, receptor type, C 0.547
Ptafr platelet-activating factor receptor 0.340
Il2rb interleukin 2 receptor, beta 0.335
Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.324
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.262
Cd4 Cd4 molecule 0.258
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.237
Cybb cytochrome b-245, beta polypeptide 0.237
Cd247 Cd247 molecule 0.216
Ms4a11 membrane-spanning 4-domains, subfamily A, member 11 0.210
Vav1 vav 1 guanine nucleotide exchange factor 0.191
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.169
Calm1 calmodulin 1 0.146
Ctse cathepsin E 0.140
Mmp12 matrix metallopeptidase 12 0.139
Il1b interleukin 1 beta 0.122
Il2rg interleukin 2 receptor, gamma 0.114
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.107
Slc25a5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.102
Cd38 CD38 molecule 0.097
Tgfbr3 transforming growth factor, beta receptor III 0.094
Ppp2ca protein phosphatase 2, catalytic subunit, alpha isoform 0.089
Morf4l2 mortality factor 4 like 2 0.085
Clec4a3 C-type lectin domain family 4, member a3 0.082
Pgam1 phosphoglycerate mutase 1 (brain) 0.079
RGD1304644 similar to RIKEN cDNA 2310046K01 0.078
Inpp5d inositol polyphosphate-5-phosphatase D 0.076
Atp6ap1 ATPase, H+ transporting, lysosomal accessory protein 1 0.076
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.075
Casp1 caspase 1 0.074
Mef2d myocyte enhancer factor 2D 0.073
Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.071
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.069
Neurl3 neuralized homolog 3 (Drosophila) 0.068
Igsf6 immunoglobulin superfamily, member 6 0.067
Pde3a phosphodiesterase 3A, cGMP inhibited 0.067
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.066
Ptger2 prostaglandin E receptor 2 (subtype EP2) 0.062
Tgfbr2 transforming growth factor, beta receptor II 0.061
Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.061
Cd53 Cd53 molecule 0.060
Ccr5 chemokine (C-C motif) receptor 5 0.060
Tbxas1 thromboxane A synthase 1, platelet 0.059
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.059
Pik3cd phosphoinositide-3-kinase, catalytic, delta polypeptide 0.058
Sirpa signal-regulatory protein alpha 0.058
Acap1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 0.057
Atp1b1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.056
C5ar1 complement component 5a receptor 1 0.055
Tnfrsf14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.054
Icam1 intercellular adhesion molecule 1 0.053
Il9r interleukin 9 receptor 0.052
Lta lymphotoxin alpha (TNF superfamily, member 1) 0.051
Wdr1 WD repeat domain 1 0.048
Padi3 peptidyl arginine deiminase, type III 0.047
Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 0.047
Ciita class II, major histocompatibility complex, transactivator 0.047
Tlr4 toll-like receptor 4 0.047
Actr3 ARP3 actin-related protein 3 homolog (yeast) 0.047
Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.045
Cd8b CD8b molecule 0.044
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.044
Cd3g CD3 molecule, gamma 0.043
Klhl6 kelch-like 6 (Drosophila) 0.043
Ptpn1 protein tyrosine phosphatase, non-receptor type 1 0.043
Olr1496 olfactory receptor 1496 0.039
Gzmk granzyme K 0.039
Cxcr3 chemokine (C-X-C motif) receptor 3 0.038
Psd4 pleckstrin and Sec7 domain containing 4 0.038
Prlhr prolactin releasing hormone receptor 0.037
Cd68 Cd68 molecule 0.037
Ripk3 receptor-interacting serine-threonine kinase 3 0.037
Hpgds hematopoietic prostaglandin D synthase 0.035
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.034
Srxn1 sulfiredoxin 1 homolog (S. cerevisiae) 0.034
Slc15a3 solute carrier family 15, member 3 0.034
Ccl3 chemokine (C-C motif) ligand 3 0.033
Hspa8 heat shock protein 8 0.033
Olr1469 olfactory receptor Olr1469 0.033
Folr2 folate receptor 2 (fetal) 0.033
Batf3 basic leucine zipper transcription factor, ATF-like 3 0.032
Csf1 colony stimulating factor 1 (macrophage) 0.032
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.032
Cpa3 carboxypeptidase A3, mast cell 0.031
Hdac7 histone deacetylase 7 0.031
Atp6v1a ATPase, H+ transporting, lysosomal V1 subunit A 0.031
Ugt2b7 UDP glucuronosyltransferase 2 family, polypeptide B7 0.031
Nrarp Notch-regulated ankyrin repeat protein 0.031
Arl11 ADP-ribosylation factor-like 11 0.031
Ncan neurocan 0.030
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.030
Sell selectin L 0.029
Cx3cr1 chemokine (C-X3-C motif) receptor 1 0.029
Icos inducible T-cell co-stimulator 0.029
Laptm5 lysosomal protein transmembrane 5 0.029
Stat3 signal transducer and activator of transcription 3 0.028
Cd86 CD86 molecule 0.028
Tlr7 toll-like receptor 7 0.027
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism