The network for 'membrane protein proteolysis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

membrane protein proteolysis

The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains.

Mus musculus
Name Description Probability Func Analog Organism
Psen1 presenilin 1 0.987
Notch2 Notch gene homolog 2 (Drosophila) 0.715
App amyloid beta (A4) precursor protein 0.570
Lamp2 lysosomal-associated membrane protein 2 0.490
Ctsb cathepsin B 0.428
Klf3 Kruppel-like factor 3 (basic) 0.401
Aph1a anterior pharynx defective 1a homolog (C. elegans) 0.361
Adam15 a disintegrin and metallopeptidase domain 15 (metargidin) 0.223
Adam19 a disintegrin and metallopeptidase domain 19 (meltrin beta) 0.182
Prnp prion protein 0.170
Adam12 a disintegrin and metallopeptidase domain 12 (meltrin alpha) 0.157
Ncstn nicastrin 0.152
Ctnnb1 catenin (cadherin associated protein), beta 1 0.121
Il1r1 interleukin 1 receptor, type I 0.112
Agtr1a angiotensin II receptor, type 1a 0.093
Psap prosaposin 0.091
Fbn1 fibrillin 1 0.080
Apoe apolipoprotein E 0.080
Psen2 presenilin 2 0.073
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.072
Ldlr low density lipoprotein receptor 0.071
Fgr Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog 0.064
Il6 interleukin 6 0.053
Asah1 N-acylsphingosine amidohydrolase 1 0.052
Hif1a hypoxia inducible factor 1, alpha subunit 0.050
Ngp neutrophilic granule protein 0.048
Vav2 vav 2 oncogene 0.047
Dmd dystrophin, muscular dystrophy 0.047
Erlin2 ER lipid raft associated 2 0.045
Syvn1 synovial apoptosis inhibitor 1, synoviolin 0.042
Mmp2 matrix metallopeptidase 2 0.041
Abca1 ATP-binding cassette, sub-family A (ABC1), member 1 0.040
Aplp2 amyloid beta (A4) precursor-like protein 2 0.039
Thbs1 thrombospondin 1 0.039
Lgmn legumain 0.037
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.036
Adam17 a disintegrin and metallopeptidase domain 17 0.034
Efemp2 epidermal growth factor-containing fibulin-like extracellular matrix protein 2 0.034
Notch1 Notch gene homolog 1 (Drosophila) 0.033
Adam9 a disintegrin and metallopeptidase domain 9 (meltrin gamma) 0.033
Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.032
P2rx3 purinergic receptor P2X, ligand-gated ion channel, 3 0.032
Il1rn interleukin 1 receptor antagonist 0.031
Snap23 synaptosomal-associated protein 23 0.031
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.031
Efnb2 ephrin B2 0.028
Sirpa signal-regulatory protein alpha 0.027
Mobkl1b MOB1, Mps One Binder kinase activator-like 1B (yeast) 0.026
Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 0.025
Mertk c-mer proto-oncogene tyrosine kinase 0.025
Atp11c ATPase, class VI, type 11C 0.025
Gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 0.025
Cx3cr1 chemokine (C-X3-C) receptor 1 0.025
Tnf tumor necrosis factor 0.023
C3 complement component 3 0.023
Ltf lactotransferrin 0.023
Pard3 par-3 (partitioning defective 3) homolog (C. elegans) 0.023
Axl AXL receptor tyrosine kinase 0.022
Lox lysyl oxidase 0.022
Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 0.022
Idua iduronidase, alpha-L- 0.021
Vhl von Hippel-Lindau tumor suppressor 0.021
Dlg1 discs, large homolog 1 (Drosophila) 0.020
Eln elastin 0.020
Npc2 Niemann Pick type C2 0.020
L1cam L1 cell adhesion molecule 0.020
Ctsz cathepsin Z 0.020
Plbd2 phospholipase B domain containing 2 0.019
Myo7a myosin VIIA 0.019
Ctsl cathepsin L 0.019
Klf15 Kruppel-like factor 15 0.019
Tgfbr1 transforming growth factor, beta receptor I 0.019
Stam2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 0.018
Cd14 CD14 antigen 0.018
Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.018
Tgfb1 transforming growth factor, beta 1 0.018
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.017
Adam23 a disintegrin and metallopeptidase domain 23 0.017
Ctsa cathepsin A 0.016
Jup junction plakoglobin 0.016
Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 0.016
Il6st interleukin 6 signal transducer 0.016
Pax1 paired box gene 1 0.016
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.016
Pold4 polymerase (DNA-directed), delta 4 0.015
Wt1 Wilms tumor 1 homolog 0.015
D19Wsu162e DNA segment, Chr 19, Wayne State University 162, expressed 0.015
Camp cathelicidin antimicrobial peptide 0.015
Lta lymphotoxin A 0.015
Spp1 secreted phosphoprotein 1 0.014
Cd44 CD44 antigen 0.014
Hif3a hypoxia inducible factor 3, alpha subunit 0.014
Bcl3 B-cell leukemia/lymphoma 3 0.014
Ptgs2 prostaglandin-endoperoxide synthase 2 0.014
Sema6d sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 0.014
Epb4.1l2 erythrocyte protein band 4.1-like 2 0.014
Glis2 GLIS family zinc finger 2 0.013
Ggta1 glycoprotein galactosyltransferase alpha 1, 3 0.013
Lamp1 lysosomal-associated membrane protein 1 0.013
B3gnt1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 0.013
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
sqh spaghetti squash 0.179
Rho1 CG8416 gene product from transcript CG8416-RB 0.090
Ice CG7788 gene product from transcript CG7788-RA 0.086
crb crumbs 0.041
Cul-3 Cullin-3 0.030
lqf liquid facets 0.027
mop myopic 0.020
Sulf1 Sulfated 0.017
Mmp1 Matrix metalloproteinase 1 0.017
Pak3 CG14895 gene product from transcript CG14895-RA 0.016
CG10992 CG10992 gene product from transcript CG10992-RA 0.014
capt capulet 0.014
bib big brain 0.014
CG6359 CG6359 gene product from transcript CG6359-RA 0.013
Atg1 Autophagy-specific gene 1 0.013
Sop2 Suppressor of profilin 2 0.013
aop anterior open 0.012
Vps25 Vacuolar protein sorting 25 0.012
rho-4 rhomboid-4 0.011
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Homo sapiens
Name Description Probability Func Analog Organism
ADAM15 ADAM metallopeptidase domain 15 1.000
SNX9 sorting nexin 9 0.988
FASLG Fas ligand (TNF superfamily, member 6) 0.987
PSEN1 presenilin 1 0.939
APP amyloid beta (A4) precursor protein 0.929
NCSTN nicastrin 0.898
DNM1 dynamin 1 0.880
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.838
SNX33 sorting nexin 33 0.838
APH1A anterior pharynx defective 1 homolog A (C. elegans) 0.834
DNM2 dynamin 2 0.814
IL1R1 interleukin 1 receptor, type I 0.769
NCF1 neutrophil cytosolic factor 1 0.760
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.640
TRAF5 TNF receptor-associated factor 5 0.618
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.593
TRAF1 TNF receptor-associated factor 1 0.578
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.536
PACSIN1 protein kinase C and casein kinase substrate in neurons 1 0.470
ABI2 abl-interactor 2 0.448
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.446
TRADD TNFRSF1A-associated via death domain 0.435
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.387
NCF2 neutrophil cytosolic factor 2 0.327
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 0.249
GHR growth hormone receptor 0.219
PSEN2 presenilin 2 (Alzheimer disease 4) 0.216
DLG1 discs, large homolog 1 (Drosophila) 0.214
FLNB filamin B, beta 0.213
IL22RA2 interleukin 22 receptor, alpha 2 0.211
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.204
UTRN utrophin 0.191
A2M alpha-2-macroglobulin 0.190
TRAF2 TNF receptor-associated factor 2 0.187
HP haptoglobin 0.180
CD63 CD63 molecule 0.170
IL10RA interleukin 10 receptor, alpha 0.158
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.150
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) 0.150
PSENEN presenilin enhancer 2 homolog (C. elegans) 0.117
ADAM12 ADAM metallopeptidase domain 12 0.115
CYBA cytochrome b-245, alpha polypeptide 0.114
IL1RN interleukin 1 receptor antagonist 0.111
BIRC3 baculoviral IAP repeat containing 3 0.108
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.108
FNBP1 formin binding protein 1 0.102
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.100
SH3D19 SH3 domain containing 19 0.096
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived) 0.093
BCAR1 breast cancer anti-estrogen resistance 1 0.093
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.091
SNAP23 synaptosomal-associated protein, 23kDa 0.085
APOC1 apolipoprotein C-I 0.083
IL1B interleukin 1, beta 0.081
FYN FYN oncogene related to SRC, FGR, YES 0.080
TRAF3 TNF receptor-associated factor 3 0.080
ITK IL2-inducible T-cell kinase 0.079
CTSA cathepsin A 0.077
YAP1 Yes-associated protein 1 0.077
IL22RA1 interleukin 22 receptor, alpha 1 0.075
AGTR2 angiotensin II receptor, type 2 0.075
PSAP prosaposin 0.072
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.072
CD14 CD14 molecule 0.070
IL1R2 interleukin 1 receptor, type II 0.067
HCK hemopoietic cell kinase 0.066
ANKRD28 ankyrin repeat domain 28 0.065
PTPN23 protein tyrosine phosphatase, non-receptor type 23 0.064
SH3PXD2A SH3 and PX domains 2A 0.064
LAMP1 lysosomal-associated membrane protein 1 0.060
IL1RAP interleukin 1 receptor accessory protein 0.059
TNF tumor necrosis factor 0.054
MYL9 myosin, light chain 9, regulatory 0.053
P4HB prolyl 4-hydroxylase, beta polypeptide 0.048
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.046
RIPK2 receptor-interacting serine-threonine kinase 2 0.046
WASL Wiskott-Aldrich syndrome-like 0.045
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.045
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 0.044
PTPRA protein tyrosine phosphatase, receptor type, A 0.043
TGFBI transforming growth factor, beta-induced, 68kDa 0.043
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.042
LCAT lecithin-cholesterol acyltransferase 0.042
CBLC Cas-Br-M (murine) ecotropic retroviral transforming sequence c 0.041
PLAUR plasminogen activator, urokinase receptor 0.038
MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) 0.038
CD44 CD44 molecule (Indian blood group) 0.037
TRPM6 transient receptor potential cation channel, subfamily M, member 6 0.037
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.037
TP73 tumor protein p73 0.036
ADAM9 ADAM metallopeptidase domain 9 0.034
APOC3 apolipoprotein C-III 0.033
MED28 mediator complex subunit 28 0.032
CCL20 chemokine (C-C motif) ligand 20 0.031
IGFBP3 insulin-like growth factor binding protein 3 0.031
IFI30 interferon, gamma-inducible protein 30 0.030
ACTA2 actin, alpha 2, smooth muscle, aorta 0.030
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.029
PKP4 plakophilin 4 0.029
FGA fibrinogen alpha chain 0.028
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism