The network for 'creatine metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

creatine metabolic process

The chemical reactions and pathways involving creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle.

Mus musculus
Name Description Probability Func Analog Organism
Stat5b signal transducer and activator of transcription 5B 0.999
Stat5a signal transducer and activator of transcription 5A 0.999
Lepr leptin receptor 0.992
Esr1 estrogen receptor 1 (alpha) 0.990
Stat3 signal transducer and activator of transcription 3 0.974
Ar androgen receptor 0.924
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.849
Irf9 interferon regulatory factor 9 0.822
Ghr growth hormone receptor 0.512
Cav1 caveolin 1, caveolae protein 0.510
Kit kit oncogene 0.376
Foxp3 forkhead box P3 0.325
Pparg peroxisome proliferator activated receptor gamma 0.222
Il6st interleukin 6 signal transducer 0.177
Lep leptin 0.170
Il1r1 interleukin 1 receptor, type I 0.142
Stat6 signal transducer and activator of transcription 6 0.134
Kiss1 KiSS-1 metastasis-suppressor 0.127
Nckap1l NCK associated protein 1 like 0.123
Ahr aryl-hydrocarbon receptor 0.112
Stat1 signal transducer and activator of transcription 1 0.111
Stat2 signal transducer and activator of transcription 2 0.109
Trim21 tripartite motif-containing 21 0.099
Trp53 transformation related protein 53 0.099
Irgm1 immunity-related GTPase family M member 1 0.093
Ncoa3 nuclear receptor coactivator 3 0.084
Myd88 myeloid differentiation primary response gene 88 0.082
Tgfb1 transforming growth factor, beta 1 0.066
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.061
Igf1 insulin-like growth factor 1 0.061
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.059
Fas Fas (TNF receptor superfamily member 6) 0.051
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.047
Smad3 MAD homolog 3 (Drosophila) 0.046
Il10 interleukin 10 0.036
Irs2 insulin receptor substrate 2 0.035
Bglap bone gamma carboxyglutamate protein 0.035
Ifnar2 interferon (alpha and beta) receptor 2 0.034
Irgm2 immunity-related GTPase family M member 2 0.034
Tapbp TAP binding protein 0.033
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.032
Il4ra interleukin 4 receptor, alpha 0.031
Tlr4 toll-like receptor 4 0.031
Lgals9 lectin, galactose binding, soluble 9 0.028
Csf1 colony stimulating factor 1 (macrophage) 0.028
Lyz2 lysozyme 2 0.027
Clock circadian locomotor output cycles kaput 0.025
Prlr prolactin receptor 0.024
Wwox WW domain-containing oxidoreductase 0.024
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.024
Nfil3 nuclear factor, interleukin 3, regulated 0.023
H2-D1 histocompatibility 2, D region locus 1 0.023
Lhcgr luteinizing hormone/choriogonadotropin receptor 0.023
Adar adenosine deaminase, RNA-specific 0.022
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.021
Parp14 poly (ADP-ribose) polymerase family, member 14 0.021
Pten phosphatase and tensin homolog 0.020
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.020
Gnrh1 gonadotropin releasing hormone 1 0.020
Pnpla2 patatin-like phospholipase domain containing 2 0.020
Thra thyroid hormone receptor alpha 0.019
Nos3 nitric oxide synthase 3, endothelial cell 0.019
Col1a1 collagen, type I, alpha 1 0.019
Jak2 Janus kinase 2 0.017
Parp9 poly (ADP-ribose) polymerase family, member 9 0.017
Spna1 spectrin alpha 1 0.016
Igtp interferon gamma induced GTPase 0.016
Ldlr low density lipoprotein receptor 0.016
Lgals3bp lectin, galactoside-binding, soluble, 3 binding protein 0.014
Uba7 ubiquitin-like modifier activating enzyme 7 0.014
Arid1b AT rich interactive domain 1B (SWI-like) 0.013
Ifi35 interferon-induced protein 35 0.013
Parp10 poly (ADP-ribose) polymerase family, member 10 0.013
Irs1 insulin receptor substrate 1 0.013
Npc1 Niemann Pick type C1 0.012
H2-K1 histocompatibility 2, K1, K region 0.012
Lgals8 lectin, galactose binding, soluble 8 0.011
Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 0.011
Usp18 ubiquitin specific peptidase 18 0.011
Gnai2 guanine nucleotide binding protein (G protein), alpha inhibiting 2 0.010
Nr1h3 nuclear receptor subfamily 1, group H, member 3 0.010
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.528
LAT linker for activation of T cells 0.319
INSR insulin receptor 0.243
PTPRB protein tyrosine phosphatase, receptor type, B 0.030
JAK2 Janus kinase 2 0.021
PTPN3 protein tyrosine phosphatase, non-receptor type 3 0.018
STAT5A signal transducer and activator of transcription 5A 0.015
PTPN2 protein tyrosine phosphatase, non-receptor type 2 0.012
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.010
BCAR1 breast cancer anti-estrogen resistance 1 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism