The network for 'erythrocyte differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

erythrocyte differentiation

The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.

Mus musculus
Name Description Probability Func Analog Organism
Spna1 spectrin alpha 1 1.000
Epor erythropoietin receptor 1.000
Slc4a1 solute carrier family 4 (anion exchanger), member 1 1.000
Hbb-b1 hemoglobin, beta adult major chain 1.000
Ank1 ankyrin 1, erythroid 1.000
Pten phosphatase and tensin homolog 1.000
Gata4 GATA binding protein 4 0.999
Shh sonic hedgehog 0.999
Gata1 GATA binding protein 1 0.998
Ikzf1 IKAROS family zinc finger 1 0.996
Spnb1 spectrin beta 1 0.996
Klf1 Kruppel-like factor 1 (erythroid) 0.995
Nos3 nitric oxide synthase 3, endothelial cell 0.993
Smad4 MAD homolog 4 (Drosophila) 0.991
Hbb-b2 hemoglobin, beta adult minor chain 0.990
Tal1 T-cell acute lymphocytic leukemia 1 0.989
Kit kit oncogene 0.987
Pbx1 pre B-cell leukemia transcription factor 1 0.981
Nodal nodal 0.976
Trp53 transformation related protein 53 0.976
Slc40a1 solute carrier family 40 (iron-regulated transporter), member 1 0.973
Neurod1 neurogenic differentiation 1 0.968
Apc adenomatosis polyposis coli 0.968
Add2 adducin 2 (beta) 0.968
Ctnnb1 catenin (cadherin associated protein), beta 1 0.967
Tgfbr2 transforming growth factor, beta receptor II 0.966
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.965
Fgfr1 fibroblast growth factor receptor 1 0.965
Hand2 heart and neural crest derivatives expressed transcript 2 0.963
Exoc6 exocyst complex component 6 0.961
Bmp4 bone morphogenetic protein 4 0.958
Isl1 ISL1 transcription factor, LIM/homeodomain 0.957
Smad1 MAD homolog 1 (Drosophila) 0.956
Jak2 Janus kinase 2 0.954
Gypa glycophorin A 0.944
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.944
Stat5b signal transducer and activator of transcription 5B 0.937
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.933
Gfi1b growth factor independent 1B 0.931
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.925
Gata6 GATA binding protein 6 0.924
Gli3 GLI-Kruppel family member GLI3 0.921
Kdr kinase insert domain protein receptor 0.917
Vegfa vascular endothelial growth factor A 0.911
Kiss1 KiSS-1 metastasis-suppressor 0.908
Stat3 signal transducer and activator of transcription 3 0.905
Zic3 zinc finger protein of the cerebellum 3 0.900
Pax6 paired box gene 6 0.889
Otx2 orthodenticle homolog 2 (Drosophila) 0.882
Slc11a2 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 0.879
Hes1 hairy and enhancer of split 1 (Drosophila) 0.874
Tgfb1 transforming growth factor, beta 1 0.868
Ptf1a pancreas specific transcription factor, 1a 0.867
Vhl von Hippel-Lindau tumor suppressor 0.866
Meox2 mesenchyme homeobox 2 0.854
Sox4 SRY-box containing gene 4 0.847
Irf9 interferon regulatory factor 9 0.840
Pitx2 paired-like homeodomain transcription factor 2 0.839
Lhx3 LIM homeobox protein 3 0.837
Fgfr2 fibroblast growth factor receptor 2 0.832
Hif1a hypoxia inducible factor 1, alpha subunit 0.832
Rarg retinoic acid receptor, gamma 0.827
Jag1 jagged 1 0.809
Smad3 MAD homolog 3 (Drosophila) 0.801
Tcfap2a transcription factor AP-2, alpha 0.796
Smad2 MAD homolog 2 (Drosophila) 0.786
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.781
Id1 inhibitor of DNA binding 1 0.779
Notch2 Notch gene homolog 2 (Drosophila) 0.776
Acvr1 activin A receptor, type 1 0.776
Stat1 signal transducer and activator of transcription 1 0.775
Sox2 SRY-box containing gene 2 0.767
Hoxa13 homeobox A13 0.760
Neurog2 neurogenin 2 0.759
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.756
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.755
Pax8 paired box gene 8 0.748
Arid4a AT rich interactive domain 4A (RBP1-like) 0.739
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.738
Foxp3 forkhead box P3 0.737
Runx1t1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.734
Notch1 Notch gene homolog 1 (Drosophila) 0.734
Csf1 colony stimulating factor 1 (macrophage) 0.733
Trim10 tripartite motif-containing 10 0.729
Stat5a signal transducer and activator of transcription 5A 0.725
Ar androgen receptor 0.721
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.720
Fgf8 fibroblast growth factor 8 0.720
Rara retinoic acid receptor, alpha 0.718
Thra thyroid hormone receptor alpha 0.713
Id3 inhibitor of DNA binding 3 0.711
Esr1 estrogen receptor 1 (alpha) 0.711
Smad6 MAD homolog 6 (Drosophila) 0.695
Hba-a2 hemoglobin alpha, adult chain 2 0.691
Mapk8 mitogen-activated protein kinase 8 0.683
Hba-x hemoglobin X, alpha-like embryonic chain in Hba complex 0.673
Tgfb2 transforming growth factor, beta 2 0.672
Epas1 endothelial PAS domain protein 1 0.666
Tcf21 transcription factor 21 0.662
Rxra retinoid X receptor alpha 0.662
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
alas2 aminolevulinate, delta-, synthetase 2 0.997
gata1a GATA binding protein 1a 0.993
tfr1a transferrin receptor 1a 0.992
epb41 erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) 0.986
pitx2 paired-like homeodomain transcription factor 2 0.984
slc4a1a solute carrier family 4, anion exchanger, member 1a 0.984
hbbe1.1 hemoglobin beta embryonic-1.1 0.983
LOC566708 FL cytokine receptor-like 0.976
pax2a paired box gene 2a 0.948
klf4 Kruppel-like factor 4 0.937
hbae3 hemoglobin alpha embryonic-3 0.880
gata6 GATA-binding protein 6 0.877
isl1 islet1 0.869
cmyb transcription factor cmyb 0.850
hbae1 hemoglobin alpha embryonic-1 0.781
hbbe3 hemoglobin beta embryonic-3 0.761
tbx5a T-box 5a 0.743
trim33 tripartite motif-containing 33 0.737
plcg1 phospholipase C, gamma 1 0.727
bmp2b bone morphogenetic protein 2b 0.713
znfl2a zinc finger-like gene 2a 0.711
cahz carbonic anhydrase 0.644
rpl11 ribosomal protein L11 0.634
gfi1.1 growth factor independent 1.1 0.621
hand2 heart and neural crest derivatives expressed transcript 2 0.608
ikzf1 IKAROS family zinc finger 1 (Ikaros) 0.600
lmo2 LIM domain only 2 (rhombotin-like 1) 0.596
LOC100151531 zinc finger protein Gfi-1b-like 0.553
epor erythropoietin receptor 0.553
hoxd4a homeo box D4a 0.551
pdcd2 programmed cell death 2 0.545
fgf24 fibroblast growth factor 24 0.532
hbbe2 hemoglobin beta embryonic-2 0.497
hnf1ba HNF1 homeobox Ba 0.496
hhex hematopoietically expressed homeobox 0.494
hdr hematopoietic death receptor 0.478
fech ferrochelatase 0.460
drl draculin 0.460
myca myelocytomatosis oncogene a 0.447
rhag Rhesus blood group-associated glycoprotein 0.442
slc25a37 solute carrier family 25, member 37 0.438
tbx1 T-box 1 0.426
myl7 myosin, light polypeptide 7, regulatory 0.419
ppox protoporphyrinogen oxidase 0.418
tbx16 T-box gene 16 0.394
sox7 SRY-box containing gene 7 0.389
trpv6 transient receptor potential cation channel, subfamily V, member 6 0.376
rpl23a ribosomal protein L23a 0.366
tbx6 T-box gene 6 0.366
tal1 T-cell acute lymphocytic leukemia 1 0.365
runx1 runt-related transcription factor 1 0.356
isl2a islet2a 0.354
uros uroporphyrinogen III synthase 0.350
cfl2l cofilin 2, like 0.345
rpl36a ribosomal protein L36A 0.338
lft2 lefty2 0.338
si:dkeyp-66d7.2 si:dkeyp-66d7.2 0.328
smchd1 structural maintenance of chromosomes flexible hinge domain containing 1 0.311
spns2 spinster homolog 2 (Drosophila) 0.305
mpx myeloid-specific peroxidase 0.302
hmbsb hydroxymethylbilane synthase, b 0.292
sptb spectrin, beta, erythrocytic 0.285
atoh1a atonal homolog 1a 0.281
aplnrb apelin receptor b 0.274
cx30.3 connexin 30.3 0.265
cpox coproporphyrinogen oxidase 0.260
f2r coagulation factor II (thrombin) receptor 0.257
mll myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.254
rpl14 ribosomal protein L14 0.251
atoh1b atonal homolog 1b 0.238
fgf10a fibroblast growth factor 10a 0.237
nkx2.5 NK2 transcription factor related 5 0.232
hoxc6a homeo box C6a 0.217
eomesa eomesodermin homolog a 0.210
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.208
glcci1 glucocorticoid induced transcript 1 0.202
olig4 oligodendrocyte transcription factor 4 0.195
vegfc vascular endothelial growth factor c 0.189
kita kit receptor a 0.185
lcp1 lymphocyte cytosolic plastin 1 0.184
msxc muscle segment homeobox C 0.181
gon4l gon-4-like (C.elegans) 0.173
cdx4 caudal type homeo box transcription factor 4 0.163
rpl12 ribosomal protein L12 0.159
mll4b myeloid/lymphoid or mixed-lineage leukemia 4b 0.158
nphs1l nephrosis 1, congenital, Finnish type (nephrin)-like 0.154
dlc deltaC 0.153
eef1b2 eukaryotic translation elongation factor 1 beta 2 0.148
vldlr very low density lipoprotein receptor 0.146
acvr2b activin receptor IIb 0.145
urod uroporphyrinogen decarboxylase 0.143
hoxb4a homeo box B4a 0.139
rpl9 ribosomal protein L9 0.139
ass1 argininosuccinate synthetase 1 0.138
tbx2b T-box 2b 0.134
tbx24 T-box 24 0.131
slc17a7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 0.129
rxrba retinoid x receptor, beta a 0.129
nfe2 nuclear factor, erythroid-derived 2 0.129
adora2aa adenosine A2a receptor a 0.125
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
JUN jun proto-oncogene 1.000
SP1 Sp1 transcription factor 0.973
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.970
EP300 E1A binding protein p300 0.970
SMAD2 SMAD family member 2 0.954
TAL1 T-cell acute lymphocytic leukemia 1 0.947
CREBBP CREB binding protein 0.899
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.896
TP53 tumor protein p53 0.890
ATF3 activating transcription factor 3 0.876
DDIT3 DNA-damage-inducible transcript 3 0.871
HSPA1B heat shock 70kDa protein 1B 0.839
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.746
RUNX1 runt-related transcription factor 1 0.732
FOS FBJ murine osteosarcoma viral oncogene homolog 0.724
XIAP X-linked inhibitor of apoptosis 0.723
DUSP1 dual specificity phosphatase 1 0.617
INSR insulin receptor 0.603
TCF12 transcription factor 12 0.601
GATA1 GATA binding protein 1 (globin transcription factor 1) 0.517
SMAD3 SMAD family member 3 0.505
CDK2 cyclin-dependent kinase 2 0.480
NCOR2 nuclear receptor corepressor 2 0.402
ATF4 activating transcription factor 4 (tax-responsive enhancer element B67) 0.393
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.385
KLF4 Kruppel-like factor 4 (gut) 0.378
GATA2 GATA binding protein 2 0.368
KLF6 Kruppel-like factor 6 0.331
HBB hemoglobin, beta 0.330
SMAD1 SMAD family member 1 0.326
HSPA1A heat shock 70kDa protein 1A 0.322
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.321
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.319
HBG2 hemoglobin, gamma G 0.317
RPS11 ribosomal protein S11 0.312
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 0.311
HOXA5 homeobox A5 0.310
NFE2L2 nuclear factor (erythroid-derived 2)-like 2 0.309
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.304
AR androgen receptor 0.302
RPS15 ribosomal protein S15 0.301
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.295
RPS10 ribosomal protein S10 0.295
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.290
NCOA6 nuclear receptor coactivator 6 0.286
STAT1 signal transducer and activator of transcription 1, 91kDa 0.281
DAXX death-domain associated protein 0.271
APAF1 apoptotic peptidase activating factor 1 0.268
CCND1 cyclin D1 0.262
HOXB5 homeobox B5 0.260
HOXA10 homeobox A10 0.259
RPS5 ribosomal protein S5 0.234
KAT2B K(lysine) acetyltransferase 2B 0.228
SLC4A1 solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) 0.227
NRP1 neuropilin 1 0.223
GABPA GA binding protein transcription factor, alpha subunit 60kDa 0.218
NCOA1 nuclear receptor coactivator 1 0.214
PPP1R15A protein phosphatase 1, regulatory (inhibitor) subunit 15A 0.194
JUNB jun B proto-oncogene 0.191
FOXO1 forkhead box O1 0.177
BMP2 bone morphogenetic protein 2 0.175
LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.171
CFLAR CASP8 and FADD-like apoptosis regulator 0.166
SPTB spectrin, beta, erythrocytic 0.162
RHAG Rh-associated glycoprotein 0.160
PBX1 pre-B-cell leukemia homeobox 1 0.156
RPS27 ribosomal protein S27 0.154
GHR growth hormone receptor 0.154
FAS Fas (TNF receptor superfamily, member 6) 0.142
RBBP4 retinoblastoma binding protein 4 0.139
HIPK2 homeodomain interacting protein kinase 2 0.134
ANK1 ankyrin 1, erythrocytic 0.134
BAG3 BCL2-associated athanogene 3 0.132
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.132
SKI v-ski sarcoma viral oncogene homolog (avian) 0.129
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.129
PARK2 parkinson protein 2, E3 ubiquitin protein ligase (parkin) 0.126
RPS16 ribosomal protein S16 0.123
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 0.118
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.109
NCOA2 nuclear receptor coactivator 2 0.107
SQSTM1 sequestosome 1 0.106
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.104
BMPR1A bone morphogenetic protein receptor, type IA 0.102
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.099
RPS19 ribosomal protein S19 0.098
HOXB6 homeobox B6 0.092
RPS4X ribosomal protein S4, X-linked 0.091
RPS3A ribosomal protein S3A 0.089
SMAD4 SMAD family member 4 0.087
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B 0.087
ETS1 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) 0.084
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.083
MYOD1 myogenic differentiation 1 0.080
GAS7 growth arrest-specific 7 0.078
HOXA7 homeobox A7 0.077
E2F1 E2F transcription factor 1 0.072
RPS2 ribosomal protein S2 0.072
KITLG KIT ligand 0.071
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.071
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Rattus norvegicus
Name Description Probability Func Analog Organism
Hbb-b1 hemoglobin, beta adult major chain 0.568
Alas2 aminolevulinate, delta-, synthase 2 0.481
Jak1 Janus kinase 1 0.214
LOC100364212 heterogeneous nuclear ribonucleoprotein K-like 0.153
LOC100134871 beta globin minor gene 0.123
Casp3 caspase 3 0.076
Cfp complement factor properdin 0.073
Gja5 gap junction protein, alpha 5 0.065
Ckm creatine kinase, muscle 0.061
Sp1 Sp1 transcription factor 0.060
Jak2 Janus kinase 2 0.056
Slco2b1 solute carrier organic anion transporter family, member 2b1 0.051
Smad1 SMAD family member 1 0.051
Rpl34 ribosomal protein L34 0.050
Ptprc protein tyrosine phosphatase, receptor type, C 0.048
N4bp2l2 NEDD4 binding protein 2-like 2 0.048
Hif1a hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.046
Sirpa signal-regulatory protein alpha 0.046
Actc1 actin, alpha, cardiac muscle 1 0.045
Dag1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.044
Dok1 docking protein 1 0.044
Marcks myristoylated alanine rich protein kinase C substrate 0.043
LOC689064 beta-globin 0.043
H3f3b H3 histone, family 3B 0.043
Baz1a bromodomain adjacent to zinc finger domain, 1A 0.041
Smc4 structural maintenance of chromosomes 4 0.040
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.040
Prdm2 PR domain containing 2, with ZNF domain 0.037
Pecam1 platelet/endothelial cell adhesion molecule 1 0.036
Pcdhga11 protocadherin gamma subfamily A, 11 0.036
Stk3 serine/threonine kinase 3 (STE20 homolog, yeast) 0.036
Vegfa vascular endothelial growth factor A 0.036
Rpl36a ribosomal protein L36a 0.036
Hpcal1 hippocalcin-like 1 0.035
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.035
Serpina1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.034
Adam17 ADAM metallopeptidase domain 17 0.034
LOC499782 similar to 60S ribosomal protein L12 0.034
Sox17 SRY (sex determining region Y)-box 17 0.033
Nrd1 nardilysin 1 0.033
Gpr116 G protein-coupled receptor 116 0.033
Myo1b myosin Ib 0.032
Il1r1 interleukin 1 receptor, type I 0.031
Hnrpm heterogeneous nuclear ribonucleoprotein M 0.031
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.031
Trim28 tripartite motif-containing 28 0.031
Mcm6 minichromosome maintenance complex component 6 0.030
Hbb hemoglobin, beta 0.030
Ptpn12 protein tyrosine phosphatase, non-receptor type 12 0.030
Map3k1 mitogen activated protein kinase kinase kinase 1 0.030
Slc9a3r2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 0.030
Bcl2 B-cell CLL/lymphoma 2 0.030
Pls3 plastin 3 (T-isoform) 0.030
Ampd1 adenosine monophosphate deaminase 1 (isoform M) 0.029
Asip agouti signaling protein 0.029
Cox8b cytochrome c oxidase, subunit VIIIb 0.028
Ugdh UDP-glucose dehydrogenase 0.028
Usf2 upstream transcription factor 2, c-fos interacting 0.028
Rpl3l ribosomal protein L3-like 0.027
Synpo synaptopodin 0.027
Rara retinoic acid receptor, alpha 0.027
Flt1 FMS-related tyrosine kinase 1 0.027
Esam endothelial cell adhesion molecule 0.027
Mmp3 matrix metallopeptidase 3 0.027
Map3k7ip1 mitogen-activated protein kinase kinase kinase 7 interacting protein 1 0.027
Chd4 chromodomain helicase DNA binding protein 4 0.027
Casp2 caspase 2 0.027
Hras Harvey rat sarcoma virus oncogene 0.026
Cish cytokine inducible SH2-containing protein 0.026
Cpd carboxypeptidase D 0.026
Tgfbr2 transforming growth factor, beta receptor II 0.026
Laptm5 lysosomal protein transmembrane 5 0.026
Acvr1 activin A receptor, type I 0.026
Bmp7 bone morphogenetic protein 7 0.026
Elk4 ELK4, ETS-domain protein (SRF accessory protein 1) 0.025
Bmp6 bone morphogenetic protein 6 0.025
Csk c-src tyrosine kinase 0.025
Tnni2 troponin I type 2 (skeletal, fast) 0.025
Rap1b RAP1B, member of RAS oncogene family 0.025
Iqgap1 IQ motif containing GTPase activating protein 1 0.025
Acsl5 acyl-CoA synthetase long-chain family member 5 0.025
Ckmt2 creatine kinase, mitochondrial 2, sarcomeric 0.024
Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase 0.024
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.024
Gja3 gap junction protein, alpha 3 0.024
Myoz2 myozenin 2 0.024
Foxc2 forkhead box C2 0.024
Camkk2 calcium/calmodulin-dependent protein kinase kinase 2, beta 0.024
Myom1 myomesin 1 0.023
Cacng1 calcium channel, voltage-dependent, gamma subunit 1 0.023
LOC287167 globin, alpha 0.023
Ptges prostaglandin E synthase 0.023
Pde4b phosphodiesterase 4B, cAMP specific 0.023
Birc2 baculoviral IAP repeat-containing 2 0.023
Bat3 HLA-B-associated transcript 3 0.023
Gdf10 growth differentiation factor 10 0.023
Arnt aryl hydrocarbon receptor nuclear translocator 0.023
Lepr leptin receptor 0.023
Zfp36 zinc finger protein 36 0.023
Rab3il1 RAB3A interacting protein (rabin3)-like 1 0.022
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism