The network for 'positive regulation of bmp signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of bmp signaling pathway

Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity.

Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Fgfr2 fibroblast growth factor receptor 2 1.000
Gli3 GLI-Kruppel family member GLI3 1.000
Ctnnb1 catenin (cadherin associated protein), beta 1 0.999
Otx2 orthodenticle homolog 2 (Drosophila) 0.999
Bmp4 bone morphogenetic protein 4 0.998
Tgfb2 transforming growth factor, beta 2 0.998
Foxc1 forkhead box C1 0.998
Pten phosphatase and tensin homolog 0.997
Sox2 SRY-box containing gene 2 0.996
Eya1 eyes absent 1 homolog (Drosophila) 0.992
Nodal nodal 0.992
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.990
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.989
Foxa2 forkhead box A2 0.989
Fgf8 fibroblast growth factor 8 0.985
Smad4 MAD homolog 4 (Drosophila) 0.984
Pax3 paired box gene 3 0.984
Vegfa vascular endothelial growth factor A 0.984
Pax6 paired box gene 6 0.983
Pax2 paired box gene 2 0.981
Gli2 GLI-Kruppel family member GLI2 0.981
Meox2 mesenchyme homeobox 2 0.975
Hes1 hairy and enhancer of split 1 (Drosophila) 0.974
Nos3 nitric oxide synthase 3, endothelial cell 0.973
Gdnf glial cell line derived neurotrophic factor 0.964
Pitx2 paired-like homeodomain transcription factor 2 0.961
Fgfr1 fibroblast growth factor receptor 1 0.959
Apc adenomatosis polyposis coli 0.958
Wt1 Wilms tumor 1 homolog 0.956
Lmx1b LIM homeobox transcription factor 1 beta 0.956
Fgfr3 fibroblast growth factor receptor 3 0.954
Hand1 heart and neural crest derivatives expressed transcript 1 0.939
Tgfbr2 transforming growth factor, beta receptor II 0.937
Crb2 crumbs homolog 2 (Drosophila) 0.930
Ptch1 patched homolog 1 0.927
En1 engrailed 1 0.920
Nog noggin 0.904
Atoh7 atonal homolog 7 (Drosophila) 0.894
Bcl2 B-cell leukemia/lymphoma 2 0.892
Alx4 aristaless-like homeobox 4 0.886
Gata4 GATA binding protein 4 0.872
Isl1 ISL1 transcription factor, LIM/homeodomain 0.857
Tcfap2a transcription factor AP-2, alpha 0.852
Zic3 zinc finger protein of the cerebellum 3 0.846
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.845
Sox11 SRY-box containing gene 11 0.839
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.835
Kdr kinase insert domain protein receptor 0.830
Smad3 MAD homolog 3 (Drosophila) 0.827
Foxc2 forkhead box C2 0.827
Bmpr1a bone morphogenetic protein receptor, type 1A 0.801
Nkx2-1 NK2 homeobox 1 0.796
Cdh5 cadherin 5 0.784
Bmp7 bone morphogenetic protein 7 0.746
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.738
Rb1 retinoblastoma 1 0.734
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.714
Sox17 SRY-box containing gene 17 0.710
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.688
Hand2 heart and neural crest derivatives expressed transcript 2 0.685
Hoxd13 homeobox D13 0.668
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.664
Foxh1 forkhead box H1 0.660
Notch1 Notch gene homolog 1 (Drosophila) 0.650
Prrx1 paired related homeobox 1 0.648
Gbx2 gastrulation brain homeobox 2 0.647
Notch2 Notch gene homolog 2 (Drosophila) 0.624
Acvr1 activin A receptor, type 1 0.617
Psen1 presenilin 1 0.609
Jag1 jagged 1 0.590
Smad6 MAD homolog 6 (Drosophila) 0.585
Otx1 orthodenticle homolog 1 (Drosophila) 0.584
En2 engrailed 2 0.572
Sox7 SRY-box containing gene 7 0.565
Twist2 twist homolog 2 (Drosophila) 0.552
Pbx1 pre B-cell leukemia transcription factor 1 0.548
Gata6 GATA binding protein 6 0.538
Runx2 runt related transcription factor 2 0.529
Eng endoglin 0.511
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.509
She src homology 2 domain-containing transforming protein E 0.509
Ret ret proto-oncogene 0.497
Msx1 homeobox, msh-like 1 0.495
Emx1 empty spiracles homolog 1 (Drosophila) 0.482
Acvrl1 activin A receptor, type II-like 1 0.482
Gas1 growth arrest specific 1 0.480
Egfr epidermal growth factor receptor 0.479
Fgf10 fibroblast growth factor 10 0.477
Smo smoothened homolog (Drosophila) 0.476
Fgf15 fibroblast growth factor 15 0.470
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.468
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.466
Lhx1 LIM homeobox protein 1 0.462
Lmx1a LIM homeobox transcription factor 1 alpha 0.447
Ebf3 early B-cell factor 3 0.446
Ptprb protein tyrosine phosphatase, receptor type, B 0.443
Pou5f1 POU domain, class 5, transcription factor 1 0.436
Ednrb endothelin receptor type B 0.407
Pou4f2 POU domain, class 4, transcription factor 2 0.397
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
ten-1 Protein TEN-1 0.082
egl-18 Protein EGL-18 0.059
daf-4 Protein DAF-4 0.055
daf-14 Protein DAF-14 0.050
lag-2 Protein LAG-2 0.045
sel-8 Protein SEL-8 0.039
lmn-1 Protein LMN-1 0.035
pha-4 Protein PHA-4 0.034
let-60 Protein LET-60 0.033
elt-6 Protein ELT-6 0.033
daf-1 Protein DAF-1 0.028
crm-1 Protein CRM-1 0.027
aars-2 Protein AARS-2 0.027
lrp-2 Protein LRP-2 0.025
T21B6.3 Protein T21B6.3 0.024
atgp-1 Protein ATGP-1 0.023
clr-1 Protein CLR-1 0.023
cam-1 Protein CAM-1 0.023
nhr-67 Protein NHR-67 0.022
C35C5.6 Protein C35C5.6 0.020
egl-15 Protein EGL-15 0.020
sma-6 Protein SMA-6 0.019
pqn-71 Protein PQN-71 0.019
F07A11.2 Protein F07A11.2 0.018
dhhc-2 Protein DHHC-2 0.018
CELE_Y57G11C.22 Protein Y57G11C.22 0.018
cnd-1 Protein CND-1 0.018
daf-11 Protein DAF-11 0.018
skn-1 Protein SKN-1 0.017
edc-3 Protein EDC-3 0.017
hlh-30 Protein HLH-30 0.015
sma-3 Protein SMA-3 0.015
wdr-5.3 Protein WDR-5.3 0.015
inx-3 Protein INX-3 0.015
ulp-2 Protein ULP-2 0.015
CELE_F25E5.1 Protein F25E5.1 0.015
CELE_R09F10.3 Protein R09F10.3 0.015
sulp-2 Protein SULP-2 0.015
del-5 Protein DEL-5 0.014
C44C1.1 Protein C44C1.1 0.014
atg-16.1 Protein ATG-16.1 0.014
lin-36 Protein LIN-36 0.014
CELE_T04A8.7 Protein T04A8.7 0.014
scrm-1 Protein SCRM-1 0.014
vab-1 Protein VAB-1 0.013
twk-25 Protein TWK-25 0.013
bar-1 Protein BAR-1 0.013
pvf-1 Protein PVF-1 0.013
egl-46 Protein EGL-46 0.013
gei-8 Protein GEI-8 0.013
dis-3 Protein DIS-3 0.013
nhr-14 Protein NHR-14 0.012
H10E21.1 Protein H10E21.1 0.012
trim-9 Protein TRIM-9 0.011
flt-1 Protein FLT-1 0.011
scd-1 Protein SCD-1 0.011
lin-12 Protein LIN-12 0.011
ced-5 Protein CED-5 0.011
rsd-3 Protein RSD-3 0.011
pop-1 Protein POP-1 0.011
nhr-71 Protein NHR-71 0.011
unc-43 Protein UNC-43 0.011
ceh-13 Protein CEH-13 0.011
npr-1 Protein NPR-1 0.011
mth-2 Protein MTH-2 0.011
daf-7 Protein DAF-7 0.010
pac-1 Protein PAC-1 0.010
perm-1 Protein PERM-1 0.010
CELE_C27D8.3 Protein C27D8.3 0.010
unc-73 Protein UNC-73 0.010
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
vent ventral expressed homeobox 0.257
bmp2b bone morphogenetic protein 2b 0.214
jag1b jagged 1b 0.133
dlc deltaC 0.103
slc6a6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 0.075
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.069
lhx2b LIM homeobox 2b 0.062
ihha Indian hedgehog homolog a 0.058
sesn1 sestrin 1 0.048
satb2 SATB homeobox 2 0.047
bmp4 bone morphogenetic protein 4 0.044
gro1 groucho 1 0.044
dusp6 dual specificity phosphatase 6 0.042
evx1 even-skipped homeobox 1 0.039
mmp2 matrix metalloproteinase 2 0.038
gdf6b growth differentiation factor 6b 0.038
rxrbb retinoid x receptor, beta b 0.037
nkd1 naked cuticle homolog 1 (Drosophila) 0.033
unc5b unc-5 homolog B (C. elegans) 0.032
wnt8a wingless-type MMTV integration site family, member 8a 0.032
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.032
fgfr1b fibroblast growth factor receptor 1b 0.031
vsx2 visual system homeobox 2 0.029
notch2 notch homolog 2 0.028
dlb deltaB 0.027
acvr2a activin receptor IIa 0.026
edn1 endothelin 1 0.025
tbx18 T-box 18 0.024
tjp1 tight junction protein 1 (zona occludens 1) 0.023
si:ch73-60e21.1 si:ch73-60e21.1 0.023
ctsl1b cathepsin L, 1 b 0.023
bmpr2a bone morphogenetic protein receptor, type II a (serine/threonine kinase) 0.023
chd chordin 0.022
prdm5 PR domain containing 5 0.021
nipblb novel protein similar to vertebrate Nipped-B homolog and nipped-b homolog b (Drosophila) 0.021
ccm2 cerebral cavernous malformation 2 0.021
fgfr4 fibroblast growth factor receptor 4 0.021
nort notch-regulated transcript 0.020
barx2 BarH-like homeobox 2 0.019
dlx2a distal-less homeobox gene 2a 0.019
dlx5a distal-less homeobox gene 5a 0.019
crabp2b cellular retinoic acid binding protein 2, b 0.019
dcc deleted in colorectal carcinoma 0.019
ahr2 aryl hydrocarbon receptor 2 0.018
tbx2a T-box gene 2a 0.018
fibin fin bud initiation factor 0.018
rxrga retinoid x receptor, gamma a 0.017
fzd7a frizzled homolog 7a 0.017
akap12b A kinase (PRKA) anchor protein (gravin) 12b 0.017
ephb4b eph receptor B4b 0.017
sulf1 sulfatase 1 0.017
dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.017
mcoln1 mucolipin 1 0.016
fkbp5 FK506 binding protein 5 0.016
fgf16 fibroblast growth factor 16 0.015
mchr1b melanin-concentrating hormone receptor 1b 0.015
cpla2 cytosolic phospholipase a2 0.015
prdm1a PR domain containing 1a, with ZNF domain 0.015
cdon cell adhesion molecule-related/down-regulated by oncogenes 0.014
LOC100000687 signal peptide, CUB and EGF-like domain-containing protein 3-like 0.014
iqgap1 IQ motif containing GTPase activating protein 1 0.014
nkx2.5 NK2 transcription factor related 5 0.014
phf21a PHD finger protein 21A 0.013
atoh7 atonal homolog 7 0.013
nr6a1a nuclear receptor subfamily 6, group A, member 1a 0.013
hoxd13a homeo box D13a 0.013
glcea glucuronyl C5-epimerase a 0.013
fzd5 frizzled homolog 5 0.013
chsy1 chondroitin sulfate synthase 1 0.013
klf2a Kruppel-like factor 2a 0.013
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.012
hoxa11a homeo box A11a 0.012
lhx1b LIM homeobox 1b 0.012
cpa1 carboxypeptidase A1 (pancreatic) 0.012
her6 hairy-related 6 0.012
cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit 0.012
mga MAX gene associated 0.012
six1b sine oculis homeobox homolog 1b 0.012
igf1rb insulin-like growth factor 1b receptor 0.012
gli2a GLI-Kruppel family member GLI2a 0.011
dact2 dapper homolog 2, antagonist of beta-catenin (xenopus) 0.011
hapln3 hyaluronan and proteoglycan link protein 3 0.011
hoxa13b homeo box A13b 0.011
tgfb2 transforming growth factor, beta 2 0.011
lef1 lymphocyte enhancer binding factor 1 0.011
chpf chondroitin polymerizing factor 0.011
enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.011
edar ectodysplasin A receptor 0.011
slc30a7 solute carrier family 30 (zinc transporter), member 7 0.011
ptenb phosphatase and tensin homolog B (mutated in multiple advanced cancers 1) 0.011
wu:fj39b01 wu:fj39b01 0.011
gbx2 gastrulation brain homeo box 2 0.011
im:7165141 im:7165141 0.010
slc4a2a solute carrier family 4, anion exchanger, member 2a 0.010
gna12 guanine nucleotide binding protein (G protein) alpha 12 0.010
ctgf connective tissue growth factor 0.010
mtnr1ba melatonin receptor type 1B a 0.010
tbx16 T-box gene 16 0.010
wu:fk76c08 wu:fk76c08 0.010
wu:fc18d04 wu:fc18d04 0.010
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
E(spl) Enhancer of split 0.995
HLHm7 E(spl) region transcript m7 0.990
HLHmdelta E(spl) region transcript mdelta 0.981
HLHmbeta E(spl) region transcript mbeta 0.976
HLHmgamma E(spl) region transcript mgamma 0.959
HLHm5 E(spl) region transcript m5 0.928
tkv thickveins 0.913
Mad Mothers against dpp 0.894
Dad Daughters against dpp 0.888
malpha E(spl) region transcript malpha 0.835
gbb glass bottom boat 0.811
HLHm3 E(spl) region transcript m3 0.484
ci cubitus interruptus 0.436
m4 E(spl) region transcript m4 0.411
m2 E(spl) region transcript m2 0.405
Tl Toll 0.366
ac achaete 0.249
hh hedgehog 0.218
wg wingless 0.206
Tom Twin of m4 0.166
Smox Smad on X 0.145
gro groucho 0.143
Su(H) Suppressor of Hairless 0.136
Med Medea 0.130
sc scute 0.129
shn schnurri 0.109
en engrailed 0.088
emc extra macrochaetae 0.082
dally division abnormally delayed 0.068
da daughterless 0.057
neur neuralized 0.052
Egfr Epidermal growth factor receptor 0.049
tok tolkin 0.048
Sema-1a CG18405 gene product from transcript CG18405-RD 0.047
BobA Brother of Bearded A 0.047
dpp decapentaplegic 0.044
mys myospheroid 0.042
beta-Spec beta Spectrin 0.038
sd scalloped 0.037
sog short gastrulation 0.037
Sulf1 Sulfated 0.035
brat brain tumor 0.035
Snoo Sno oncogene 0.033
kn knot 0.028
dock dreadlocks 0.025
ase asense 0.024
kuz kuzbanian 0.023
l(2)gl lethal (2) giant larvae 0.023
sax saxophone 0.023
insc inscuteable 0.023
kek5 kekkon5 0.023
daw dawdle 0.022
wit wishful thinking 0.021
nmo nemo 0.019
inv invected 0.019
dm diminutive 0.018
run runt 0.018
noc no ocelli 0.017
zpg zero population growth 0.017
lbk lambik 0.016
sna snail 0.015
bib big brain 0.015
NetB Netrin-B 0.015
Ubqn Ubiquilin 0.015
Notum CG13076 gene product from transcript CG13076-RB 0.015
tll tailless 0.015
CG12424 CG12424 gene product from transcript CG12424-RC 0.015
tap target of Poxn 0.014
nub nubbin 0.013
slp1 sloppy paired 1 0.013
salm spalt major 0.013
argos CG4531 gene product from transcript CG4531-RA 0.013
zen zerknullt 0.013
sll slalom 0.013
myoglianin CG1838 gene product from transcript CG1838-RD 0.013
CG3194 CG3194 gene product from transcript CG3194-RB 0.013
eff effete 0.012
Sara Smad anchor for receptor activation 0.012
tld tolloid 0.012
CG32372 CG32372 gene product from transcript CG32372-RA 0.012
ham hamlet 0.012
babo baboon 0.012
Taf1 TBP-associated factor 1 0.011
hth homothorax 0.011
CG31352 CG31352 gene product from transcript CG31352-RA 0.011
gt giant 0.011
H Hairless 0.011
Myo31DF Myosin 31DF 0.011
LamC Lamin C 0.010
slmb supernumerary limbs 0.010
ptc patched 0.010
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
SMAD3 SMAD family member 3 1.000
SMAD2 SMAD family member 2 1.000
SMAD7 SMAD family member 7 0.999
SMAD1 SMAD family member 1 0.998
TGFB1 transforming growth factor, beta 1 0.997
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.996
NOTCH1 notch 1 0.966
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.966
FN1 fibronectin 1 0.947
JAG1 jagged 1 0.896
SMAD4 SMAD family member 4 0.855
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.826
SMAD5 SMAD family member 5 0.778
VEGFA vascular endothelial growth factor A 0.569
NRP1 neuropilin 1 0.564
FKBP1A FK506 binding protein 1A, 12kDa 0.514
CTGF connective tissue growth factor 0.488
BMP2 bone morphogenetic protein 2 0.403
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.329
SKIL SKI-like oncogene 0.325
CDH5 cadherin 5, type 2 (vascular endothelium) 0.269
FBLN1 fibulin 1 0.253
ZFYVE9 zinc finger, FYVE domain containing 9 0.251
CYR61 cysteine-rich, angiogenic inducer, 61 0.209
TGFBR1 transforming growth factor, beta receptor 1 0.203
CXXC5 CXXC finger protein 5 0.168
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.143
NOTCH3 notch 3 0.135
SKI v-ski sarcoma viral oncogene homolog (avian) 0.132
SMAD6 SMAD family member 6 0.129
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.110
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.098
GDF5 growth differentiation factor 5 0.093
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.089
SPG20 spastic paraplegia 20 (Troyer syndrome) 0.067
MAML1 mastermind-like 1 (Drosophila) 0.062
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 0.051
BMPR1A bone morphogenetic protein receptor, type IA 0.051
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.044
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.043
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.039
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.034
ATXN1L ataxin 1-like 0.033
PARVA parvin, alpha 0.032
PRKG1 protein kinase, cGMP-dependent, type I 0.030
PXN paxillin 0.030
DLL1 delta-like 1 (Drosophila) 0.029
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.029
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like 0.028
AR androgen receptor 0.028
AMOTL2 angiomotin like 2 0.027
NOTCH2NL notch 2 N-terminal like 0.026
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.023
TBX5 T-box 5 0.023
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 0.023
HEY1 hairy/enhancer-of-split related with YRPW motif 1 0.023
MSX2 msh homeobox 2 0.022
FHL2 four and a half LIM domains 2 0.022
ZEB2 zinc finger E-box binding homeobox 2 0.022
PARVB parvin, beta 0.021
FSTL1 follistatin-like 1 0.021
NOTCH2 notch 2 0.021
MSX1 msh homeobox 1 0.021
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.019
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.019
FBXL15 F-box and leucine-rich repeat protein 15 0.017
BMP4 bone morphogenetic protein 4 0.017
SOX7 SRY (sex determining region Y)-box 7 0.017
SNIP1 Smad nuclear interacting protein 1 0.016
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.015
ENG endoglin 0.015
DDR2 discoidin domain receptor tyrosine kinase 2 0.015
EPAS1 endothelial PAS domain protein 1 0.014
SCARB2 scavenger receptor class B, member 2 0.013
SPEN spen homolog, transcriptional regulator (Drosophila) 0.013
AXIN1 axin 1 0.013
PAM peptidylglycine alpha-amidating monooxygenase 0.013
RXRA retinoid X receptor, alpha 0.012
EBF1 early B-cell factor 1 0.012
PDGFC platelet derived growth factor C 0.012
RNF11 ring finger protein 11 0.012
MED25 mediator complex subunit 25 0.012
TRAF4 TNF receptor-associated factor 4 0.011
DSE dermatan sulfate epimerase 0.011
ZNF331 zinc finger protein 331 0.011
BCL2 B-cell CLL/lymphoma 2 0.011
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism