The network for 'fibroblast growth factor receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

fibroblast growth factor receptor signaling pathway

The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.

Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Grb2 growth factor receptor bound protein 2 1.000
Fgf8 fibroblast growth factor 8 0.998
Gata4 GATA binding protein 4 0.997
Fgfr3 fibroblast growth factor receptor 3 0.993
Gli3 GLI-Kruppel family member GLI3 0.988
Lef1 lymphoid enhancer binding factor 1 0.987
Pax3 paired box gene 3 0.986
Dok1 docking protein 1 0.980
Cbl Casitas B-lineage lymphoma 0.978
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.976
Gli2 GLI-Kruppel family member GLI2 0.975
Egfr epidermal growth factor receptor 0.974
Kl klotho 0.969
Pax2 paired box gene 2 0.961
Inpp5d inositol polyphosphate-5-phosphatase D 0.961
Shc1 src homology 2 domain-containing transforming protein C1 0.951
Fgfr2 fibroblast growth factor receptor 2 0.947
Fgf18 fibroblast growth factor 18 0.942
Ntf3 neurotrophin 3 0.935
Pitx2 paired-like homeodomain transcription factor 2 0.933
Twist2 twist homolog 2 (Drosophila) 0.931
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.907
Gab2 growth factor receptor bound protein 2-associated protein 2 0.899
Ret ret proto-oncogene 0.866
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.856
Tgfb2 transforming growth factor, beta 2 0.834
Msx2 homeobox, msh-like 2 0.832
Lhx1 LIM homeobox protein 1 0.810
Meox2 mesenchyme homeobox 2 0.804
Gata6 GATA binding protein 6 0.799
Foxc1 forkhead box C1 0.792
Tbx3 T-box 3 0.774
Hoxd11 homeobox D11 0.717
Col1a1 collagen, type I, alpha 1 0.713
Sox9 SRY-box containing gene 9 0.698
Wnt3a wingless-related MMTV integration site 3A 0.696
Bmp4 bone morphogenetic protein 4 0.692
Nog noggin 0.646
Dok2 docking protein 2 0.644
Usp8 ubiquitin specific peptidase 8 0.644
En1 engrailed 1 0.640
Csf1 colony stimulating factor 1 (macrophage) 0.636
Smpd3 sphingomyelin phosphodiesterase 3, neutral 0.630
Pthlh parathyroid hormone-like peptide 0.621
Wnt10b wingless related MMTV integration site 10b 0.617
Map4k1 mitogen-activated protein kinase kinase kinase kinase 1 0.612
Nos3 nitric oxide synthase 3, endothelial cell 0.608
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.607
Rarb retinoic acid receptor, beta 0.592
Spry4 sprouty homolog 4 (Drosophila) 0.588
Cd22 CD22 antigen 0.576
Fgf10 fibroblast growth factor 10 0.564
Zfpm2 zinc finger protein, multitype 2 0.552
Nodal nodal 0.535
Fzd8 frizzled homolog 8 (Drosophila) 0.520
Wnt5a wingless-related MMTV integration site 5A 0.508
Lrp2 low density lipoprotein receptor-related protein 2 0.463
Phex phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets) 0.463
Lmx1a LIM homeobox transcription factor 1 alpha 0.452
Spry2 sprouty homolog 2 (Drosophila) 0.439
Hoxa11 homeobox A11 0.415
Gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 0.414
Rxra retinoid X receptor alpha 0.409
Wnt4 wingless-related MMTV integration site 4 0.402
Thbs2 thrombospondin 2 0.384
Jag1 jagged 1 0.383
Flt4 FMS-like tyrosine kinase 4 0.375
Bmpr1a bone morphogenetic protein receptor, type 1A 0.371
Acvr1 activin A receptor, type 1 0.371
Crk v-crk sarcoma virus CT10 oncogene homolog (avian) 0.361
Fbn1 fibrillin 1 0.357
Tnc tenascin C 0.348
Fli1 Friend leukemia integration 1 0.343
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.340
Sulf2 sulfatase 2 0.336
Prrx1 paired related homeobox 1 0.328
Klf3 Kruppel-like factor 3 (basic) 0.327
Zap70 zeta-chain (TCR) associated protein kinase 0.326
Axin2 axin2 0.316
Pkdcc protein kinase domain containing, cytoplasmic 0.308
Gata5 GATA binding protein 5 0.305
Tbx15 T-box 15 0.301
Otx1 orthodenticle homolog 1 (Drosophila) 0.298
Ctnnb1 catenin (cadherin associated protein), beta 1 0.292
Trp53 transformation related protein 53 0.291
Alx4 aristaless-like homeobox 4 0.288
Acan aggrecan 0.285
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.279
Gas1 growth arrest specific 1 0.276
Ptk2 PTK2 protein tyrosine kinase 2 0.268
Src Rous sarcoma oncogene 0.267
Foxf1a forkhead box F1a 0.267
Snai1 snail homolog 1 (Drosophila) 0.261
Fgfrl1 fibroblast growth factor receptor-like 1 0.260
Vav1 vav 1 oncogene 0.258
Gli1 GLI-Kruppel family member GLI1 0.256
Pou3f3 POU domain, class 3, transcription factor 3 0.256
Gab1 growth factor receptor bound protein 2-associated protein 1 0.253
Fgf2 fibroblast growth factor 2 0.252
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
let-60 Protein LET-60 0.749
pry-1 Protein PRY-1 0.461
bar-1 Protein BAR-1 0.168
egl-15 Protein EGL-15 0.158
sos-1 Protein SOS-1 0.050
mep-1 Protein MEP-1 0.050
mef-2 Protein MEF-2 0.046
gck-2 Protein GCK-2 0.046
pxf-1 Protein PXF-1 0.038
unc-40 Protein UNC-40 0.031
sel-8 Protein SEL-8 0.031
pop-1 Protein POP-1 0.016
col-111 Protein COL-111 0.015
grd-2 Protein GRD-2 0.015
hmg-1.2 Protein HMG-1.2 0.014
dcap-2 Protein DCAP-2 0.014
sma-6 Protein SMA-6 0.014
T28B11.1 Protein T28B11.1 0.014
F13B6.1 Protein F13B6.1 0.013
C45G9.6 Protein C45G9.6 0.012
let-756 Protein LET-756 0.012
nhr-67 Protein NHR-67 0.012
F46G10.2 Protein F46G10.2 0.011
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Danio rerio
Name Description Probability Func Analog Organism
fgf3 fibroblast growth factor 3 0.879
twist3 twist3 0.424
wnt8b wingless-type MMTV integration site family, member 8b 0.422
dlx5a distal-less homeobox gene 5a 0.416
chd chordin 0.411
tbx1 T-box 1 0.402
wnt4a wingless-type MMTV integration site family, member 4a 0.297
fgf17 fibroblast growth factor 17 0.291
ippk inositol 1,3,4,5,6-pentakisphosphate 2-kinase 0.279
ptch2 patched 2 0.278
robo3 roundabout homolog 3 0.261
cdx1b caudal type homeobox 1 b 0.202
dharma dharma 0.199
bmp4 bone morphogenetic protein 4 0.179
spry4 sprouty (Drosophila) homolog 4 0.176
dusp6 dual specificity phosphatase 6 0.173
wnt1 wingless-type MMTV integration site family, member 1 0.159
wnt10a wingless-type MMTV integration site family, member 10a 0.139
sulf1 sulfatase 1 0.126
wnt5b wingless-type MMTV integration site family, member 5b 0.115
bmp2a bone morphogenetic protein 2a 0.102
mll myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.099
fzd7a frizzled homolog 7a 0.099
bmp2b bone morphogenetic protein 2b 0.097
ndr1 nodal-related 1 0.095
foxa2 forkhead box A2 0.093
flh floating head 0.091
spns2 spinster homolog 2 (Drosophila) 0.089
etv5a ets variant 5a 0.088
dkk1b dickkopf 1b 0.086
zic3 zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila) 0.086
lratb lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b) 0.083
wnt9a wingless-type MMTV integration site family, member 9A 0.078
lft1 lefty1 0.077
smad9 MAD homolog 9 (Drosophila) 0.075
wnt3a wingless-type MMTV integration site family, member 3A 0.075
wif1 wnt inhibitory factor 1 0.071
bmp1a bone morphogenetic protein 1a 0.066
fos v-fos FBJ murine osteosarcoma viral oncogene homolog 0.065
pea3 ETS-domain transcription factor pea3 0.061
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.059
fgf4 fibroblast growth factor 4 0.059
zbtb4 zinc finger and BTB domain containing 4 0.057
bon bonnie and clyde 0.055
wnt10b wingless-type MMTV integration site family, member 10b 0.053
ephb4b eph receptor B4b 0.052
nipblb novel protein similar to vertebrate Nipped-B homolog and nipped-b homolog b (Drosophila) 0.051
tbx2b T-box 2b 0.051
brd4 bromodomain containing 4 0.049
shha sonic hedgehog a 0.049
twist1b twist1b 0.048
gata2a GATA-binding protein 2a 0.047
slc30a7 solute carrier family 30 (zinc transporter), member 7 0.044
lft2 lefty2 0.044
smox spermine oxidase 0.044
sec24d SEC24 family, member D (S. cerevisiae) 0.044
bmpr1aa bone morphogenetic protein receptor, type 1aa 0.044
fgf8a fibroblast growth factor 8 a 0.044
wnt2 wingless-type MMTV integration site family member 2 0.043
foxd3 forkhead box D3 0.043
emx3 empty spiracles homeobox 3 0.042
fn1 fibronectin 1 0.041
foxa1 forkhead box A1 0.041
ihha Indian hedgehog homolog a 0.040
aplnrb apelin receptor b 0.040
wnt3 wingless-type MMTV integration site family, member 3 0.040
wnt7aa wingless-type MMTV integration site family, member 7Aa 0.039
nr2f1a nuclear receptor subfamily 2, group F, member 1a 0.039
lef1 lymphocyte enhancer binding factor 1 0.038
sfrp1a secreted frizzled-related protein 1a 0.038
runx2b runt-related transcription factor 2b 0.037
mmp15b matrix metallopeptidase 15b 0.037
og9x OG9 homeobox gene 0.037
boc brother of CDO 0.037
ptenb phosphatase and tensin homolog B (mutated in multiple advanced cancers 1) 0.037
si:dkey-273o13.1 si:dkey-273o13.1 0.036
runx3 runt-related transcription factor 3 0.036
wnt9b wingless-type MMTV integration site family, member 9B 0.035
grhl2b grainyhead-like 2b (Drosophila) 0.035
frzb frizzled-related protein 0.035
pcdh8 protocadherin 8 0.034
gli2a GLI-Kruppel family member GLI2a 0.034
gpc4 glypican 4 0.033
spon2a spondin 2a, extracellular matrix protein 0.033
wnt5a wingless-type MMTV integration site family, member 5a 0.033
col5a1 procollagen, type V, alpha 1 0.033
vax1 ventral anterior homeobox 1 0.033
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.032
meis2.2 myeloid ecotropic viral integration site 2.2 0.032
ntla no tail a 0.031
hmx4 H6 family homeobox 4 0.031
smad7 MAD, mothers against decapentaplegic homolog 7 (Drosophila) 0.031
sulf2l sulfatase 2, like 0.031
notum3 notum 3 0.030
klf4 Kruppel-like factor 4 0.030
sfrp5 secreted frizzled-related protein 5 0.030
col11a2 collagen type XI alpha-2 0.030
hoxd4a homeo box D4a 0.029
vent ventral expressed homeobox 0.029
wls wntless homolog (Drosophila) 0.029
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Drosophila melanogaster
Name Description Probability Func Analog Organism
stumps CG31317 gene product from transcript CG31317-RC 0.745
sfl sulfateless 0.360
sr stripe 0.217
Shc SHC-adaptor protein 0.200
Ext2 CG8433 gene product from transcript CG8433-RA 0.198
btl breathless 0.140
hipk homeodomain interacting protein kinase 0.134
Hs6st Heparan sulfate 6-O-sulfotransferase 0.127
CG12004 CG12004 gene product from transcript CG12004-RC 0.092
Rab2 Rab-protein 2 0.090
lgs legless 0.075
Hrs Hepatocyte growth factor regulated tyrosine kinase substrate 0.050
botv brother of tout-velu 0.049
dgo diego 0.046
hbs hibris 0.046
pnt pointed 0.044
mbc myoblast city 0.043
bnl branchless 0.037
ttv tout-velu 0.036
dock dreadlocks 0.035
otk off-track 0.033
plexB plexin B 0.032
kni knirps 0.031
dos daughter of sevenless 0.030
in inturned 0.028
frc fringe connection 0.027
sog short gastrulation 0.024
htl heartless 0.021
kirre kin of irre 0.021
wg wingless 0.021
PTP-ER Protein tyrosine phosphatase-ERK/Enhancer of Ras1 0.020
Stam Signal transducing adaptor molecule 0.020
inv invected 0.019
sll slalom 0.019
por porcupine 0.018
lab labial 0.017
stwl stonewall 0.017
Apc APC-like 0.017
zfh2 Zn finger homeodomain 2 0.016
EloA Elongin A 0.016
wun wunen 0.015
btd buttonhead 0.015
Spn77Ba Serpin 77Ba 0.015
disp dispatched 0.015
ksr kinase suppressor of ras 0.015
kn knot 0.015
vvl ventral veins lacking 0.015
csw corkscrew 0.014
Mrtf Myocardin-related transcription factor 0.014
Dsor1 Downstream of raf1 0.014
Ras64B Ras oncogene at 64B 0.014
svp seven up 0.014
drk downstream of receptor kinase 0.013
CG9139 CG9139 gene product from transcript CG9139-RA 0.013
cnk connector enhancer of ksr 0.013
knk knickkopf 0.013
edl ETS-domain lacking 0.012
Ced-12 CG5336 gene product from transcript CG5336-RA 0.012
pyr pyramus 0.012
rl rolled 0.012
salm spalt major 0.012
mol moladietz 0.012
Cpsf160 Cleavage and polyadenylation specificity factor 160 0.012
conv convoluted 0.012
fz frizzled 0.012
Fas3 Fasciclin 3 0.012
Rac2 CG8556 gene product from transcript CG8556-RA 0.012
Spc105R Spc105-related 0.012
noc no ocelli 0.011
Klp64D Kinesin-like protein at 64D 0.011
Timp Tissue inhibitor of metalloproteases 0.011
robo roundabout 0.011
opa odd paired 0.010
esg escargot 0.010
egr eiger 0.010
tld tolloid 0.010
Rab5 Rab-protein 5 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
FGFR2 fibroblast growth factor receptor 2 1.000
FGF1 fibroblast growth factor 1 (acidic) 0.999
FGFR1 fibroblast growth factor receptor 1 0.997
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.996
STAMBP STAM binding protein 0.859
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.851
PLCG1 phospholipase C, gamma 1 0.700
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.571
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.549
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.539
FGF10 fibroblast growth factor 10 0.509
SH2D1A SH2 domain containing 1A 0.485
SH3KBP1 SH3-domain kinase binding protein 1 0.436
FGF2 fibroblast growth factor 2 (basic) 0.432
ZUFSP zinc finger with UFM1-specific peptidase domain 0.427
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.391
GRB2 growth factor receptor-bound protein 2 0.367
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.290
FRS2 fibroblast growth factor receptor substrate 2 0.285
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.272
HDAC7 histone deacetylase 7 0.243
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.239
TESK1 testis-specific kinase 1 0.155
CTGF connective tissue growth factor 0.149
SPRY2 sprouty homolog 2 (Drosophila) 0.142
TGFB1 transforming growth factor, beta 1 0.141
FGF8 fibroblast growth factor 8 (androgen-induced) 0.136
GLIS2 GLIS family zinc finger 2 0.135
CYR61 cysteine-rich, angiogenic inducer, 61 0.135
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.120
HIC1 hypermethylated in cancer 1 0.120
EGFR epidermal growth factor receptor 0.119
COL5A1 collagen, type V, alpha 1 0.118
FN1 fibronectin 1 0.114
EEA1 early endosome antigen 1 0.105
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.097
FGF7 fibroblast growth factor 7 0.095
STMN2 stathmin-like 2 0.093
LIN28B lin-28 homolog B (C. elegans) 0.081
ITSN1 intersectin 1 (SH3 domain protein) 0.080
APC adenomatous polyposis coli 0.080
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) 0.079
JAK1 Janus kinase 1 0.073
FERMT2 fermitin family member 2 0.068
ATF2 activating transcription factor 2 0.066
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.064
COL1A1 collagen, type I, alpha 1 0.064
TSG101 tumor susceptibility gene 101 0.064
MARCKS myristoylated alanine-rich protein kinase C substrate 0.062
KLB klotho beta 0.060
ERBB2IP erbb2 interacting protein 0.055
ABI1 abl-interactor 1 0.055
FYN FYN oncogene related to SRC, FGR, YES 0.051
FGFR3 fibroblast growth factor receptor 3 0.050
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.049
NCK1 NCK adaptor protein 1 0.049
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.047
GAB2 GRB2-associated binding protein 2 0.047
PDGFC platelet derived growth factor C 0.046
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.042
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.041
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.041
LAT linker for activation of T cells 0.041
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.039
SLAMF1 signaling lymphocytic activation molecule family member 1 0.039
THBS1 thrombospondin 1 0.038
UBR1 ubiquitin protein ligase E3 component n-recognin 1 0.038
BMP7 bone morphogenetic protein 7 0.035
FBLN1 fibulin 1 0.035
ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) 0.034
VCAN versican 0.034
PDGFA platelet-derived growth factor alpha polypeptide 0.034
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 0.034
NRP1 neuropilin 1 0.034
HSPG2 heparan sulfate proteoglycan 2 0.033
EGR1 early growth response 1 0.033
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.033
TIMP3 TIMP metallopeptidase inhibitor 3 0.032
ACTN4 actinin, alpha 4 0.031
GAB1 GRB2-associated binding protein 1 0.030
COL2A1 collagen, type II, alpha 1 0.030
COL4A1 collagen, type IV, alpha 1 0.030
PECAM1 platelet/endothelial cell adhesion molecule 0.030
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.029
COL6A1 collagen, type VI, alpha 1 0.029
TIMP2 TIMP metallopeptidase inhibitor 2 0.029
TGFB3 transforming growth factor, beta 3 0.028
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.027
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.027
CD33 CD33 molecule 0.026
EPS15 epidermal growth factor receptor pathway substrate 15 0.026
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 0.026
OCRL oculocerebrorenal syndrome of Lowe 0.026
SALL2 sal-like 2 (Drosophila) 0.025
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.025
RCC1 regulator of chromosome condensation 1 0.025
FZD1 frizzled homolog 1 (Drosophila) 0.024
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.024
NGF nerve growth factor (beta polypeptide) 0.024
IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) 0.024
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Rattus norvegicus
Name Description Probability Func Analog Organism
Gapdh glyceraldehyde-3-phosphate dehydrogenase 0.068
Gna12 guanine nucleotide binding protein (G protein) alpha 12 0.021
Fis1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 0.020
Erbb4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.018
Rcvrn recoverin 0.016
Rab7a RAB7A, member RAS oncogene family 0.016
Rab3il1 RAB3A interacting protein (rabin3)-like 1 0.016
Gpx4 glutathione peroxidase 4 0.015
Ucn2 urocortin 2 0.013
Unc5b unc-5 homolog B (C. elegans) 0.013
Cercam cerebral endothelial cell adhesion molecule 0.012
Cxxc4 CXXC finger 4 0.012
Gja3 gap junction protein, alpha 3 0.011
S100a7a S100 calcium binding protein A7A 0.011
Egfr epidermal growth factor receptor 0.011
Slc7a9 solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 0.010
Usf1 upstream transcription factor 1 0.010
Ndfip1 Nedd4 family interacting protein 1 0.010
Gper G protein-coupled estrogen receptor 1 0.010
Foxe3 forkhead box E3 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism