IMP

Process View

Homo sapiens

27 genes annotated in human

Multi-species View

regulation of erbb signaling pathway

GO:1901184

Any process that modulates the frequency, rate or extent of ERBB signaling pathway.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of erbb signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of erbb signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
EGFR	epidermal growth factor receptor	0.986
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.977
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.950	Human
GHR	growth hormone receptor	0.892
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.765
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.531
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.499
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.474	Human Fly
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.461	Human
PSEN1	presenilin 1	0.452	Mouse
NCK1	NCK adaptor protein 1	0.282
ESR1	estrogen receptor 1	0.215	Rat
ERBB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.213
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.188
ABI2	abl-interactor 2	0.187
GAB1	GRB2-associated binding protein 1	0.183
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.162
APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	0.147
CTNND1	catenin (cadherin-associated protein), delta 1	0.141
UCHL1	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)	0.140
SOCS1	suppressor of cytokine signaling 1	0.137	Human
PLCG1	phospholipase C, gamma 1	0.136	Fly
DLG1	discs, large homolog 1 (Drosophila)	0.126	Fly
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.124
SH3GL2	SH3-domain GRB2-like 2	0.108
YES1	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	0.099
SNX9	sorting nexin 9	0.098
GRAP2	GRB2-related adaptor protein 2	0.086	Fly
GDA	guanine deaminase	0.079
PTPRA	protein tyrosine phosphatase, receptor type, A	0.077
STAMBP	STAM binding protein	0.062
VAV1	vav 1 guanine nucleotide exchange factor	0.062
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.062
PTPN23	protein tyrosine phosphatase, non-receptor type 23	0.061	Fly
APBB2	amyloid beta (A4) precursor protein-binding, family B, member 2	0.061
PBRM1	polybromo 1	0.060
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.060
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.059
ADRM1	adhesion regulating molecule 1	0.058
MPDZ	multiple PDZ domain protein	0.054
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.051
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.051
PXN	paxillin	0.050
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.050
APP	amyloid beta (A4) precursor protein	0.049	Mouse
PTK2	PTK2 protein tyrosine kinase 2	0.048	Fly
MUC1	mucin 1, cell surface associated	0.048
ZAP70	zeta-chain (TCR) associated protein kinase 70kDa	0.047
GRB10	growth factor receptor-bound protein 10	0.046
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.044
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.044
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.043
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.043
SPRR2A	small proline-rich protein 2A	0.042
EPOR	erythropoietin receptor	0.041
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.041
GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	0.041
ARID1A	AT rich interactive domain 1A (SWI-like)	0.040
MAP3K11	mitogen-activated protein kinase kinase kinase 11	0.039
CUL2	cullin 2	0.039
GRB2	growth factor receptor-bound protein 2	0.037	Fly
PDCD6IP	programmed cell death 6 interacting protein	0.036
MAD2L2	MAD2 mitotic arrest deficient-like 2 (yeast)	0.035
ARID1B	AT rich interactive domain 1B (SWI1-like)	0.034
PTEN	phosphatase and tensin homolog	0.034
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.034
FASLG	Fas ligand (TNF superfamily, member 6)	0.034
SH3KBP1	SH3-domain kinase binding protein 1	0.033
CD2AP	CD2-associated protein	0.033
ZNF746	zinc finger protein 746	0.032
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.032
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.032
BLNK	B-cell linker	0.030
PPP5C	protein phosphatase 5, catalytic subunit	0.030
ARHGAP5	Rho GTPase activating protein 5	0.029
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.029
TOM1L1	target of myb1 (chicken)-like 1	0.029
NCOR1	nuclear receptor corepressor 1	0.029
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.027
DSG2	desmoglein 2	0.026
SH2D3A	SH2 domain containing 3A	0.026
CD28	CD28 molecule	0.025
IRS1	insulin receptor substrate 1	0.025
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.025
PRKCA	protein kinase C, alpha	0.024
FYN	FYN oncogene related to SRC, FGR, YES	0.023
RASA1	RAS p21 protein activator (GTPase activating protein) 1	0.022
CAV1	caveolin 1, caveolae protein, 22kDa	0.022
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.022
ANKS1B	ankyrin repeat and sterile alpha motif domain containing 1B	0.022
TNK2	tyrosine kinase, non-receptor, 2	0.021
SOCS2	suppressor of cytokine signaling 2	0.021	Human
EGF	epidermal growth factor	0.021
CSK	c-src tyrosine kinase	0.021
LAT	linker for activation of T cells	0.020
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.020
TCEB2	transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)	0.020
UBR5	ubiquitin protein ligase E3 component n-recognin 5	0.020
CAV2	caveolin 2	0.020
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.020
SOCS5	suppressor of cytokine signaling 5	0.019
SHC3	SHC (Src homology 2 domain containing) transforming protein 3	0.019
TGFA	transforming growth factor, alpha	0.019
SNF8	SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)	0.019
GAB2	GRB2-associated binding protein 2	0.019
CCDC6	coiled-coil domain containing 6	0.019
NUP54	nucleoporin 54kDa	0.019
TCEB1	transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)	0.019
NCSTN	nicastrin	0.018
DSP	desmoplakin	0.018
MAP4K3	mitogen-activated protein kinase kinase kinase kinase 3	0.018	Fly
NCOR2	nuclear receptor corepressor 2	0.018
EIF1B	eukaryotic translation initiation factor 1B	0.018
BLK	B lymphoid tyrosine kinase	0.018
SH3D19	SH3 domain containing 19	0.018
SOS1	son of sevenless homolog 1 (Drosophila)	0.017
COMMD1	copper metabolism (Murr1) domain containing 1	0.017
RHOXF2	Rhox homeobox family, member 2	0.017
NOTCH1	notch 1	0.017
GRIN2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	0.016
XPO6	exportin 6	0.016
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.016
ABL2	v-abl Abelson murine leukemia viral oncogene homolog 2	0.016
MAPK8IP2	mitogen-activated protein kinase 8 interacting protein 2	0.016
CHMP4B	chromatin modifying protein 4B	0.016
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.016
DLG4	discs, large homolog 4 (Drosophila)	0.016	Fly
VPS24	vacuolar protein sorting 24 homolog (S. cerevisiae)	0.016
FLNB	filamin B, beta	0.016
MATK	megakaryocyte-associated tyrosine kinase	0.015
PTPRF	protein tyrosine phosphatase, receptor type, F	0.015	Rat
SH3GL3	SH3-domain GRB2-like 3	0.015
DNM2	dynamin 2	0.015
SOCS3	suppressor of cytokine signaling 3	0.015	Human
SMAD2	SMAD family member 2	0.015
DOK4	docking protein 4	0.015
ADRBK1	adrenergic, beta, receptor kinase 1	0.015
EZR	ezrin	0.014
FEM1B	fem-1 homolog b (C. elegans)	0.014
SOS2	son of sevenless homolog 2 (Drosophila)	0.014
AXIN1	axin 1	0.014
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.014
BTRC	beta-transducin repeat containing	0.014
TNS4	tensin 4	0.014
KCTD1	potassium channel tetramerisation domain containing 1	0.014
MECP2	methyl CpG binding protein 2 (Rett syndrome)	0.014
UBE2M	ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)	0.014
MED28	mediator complex subunit 28	0.014
RNF38	ring finger protein 38	0.014
PLEKHA1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1	0.014
ADAM17	ADAM metallopeptidase domain 17	0.013
SH3BP2	SH3-domain binding protein 2	0.013
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.013
ZNF512B	zinc finger protein 512B	0.013
DAZ1	deleted in azoospermia 1	0.013
CMTM8	CKLF-like MARVEL transmembrane domain containing 8	0.013
ELL	elongation factor RNA polymerase II	0.013
USP8	ubiquitin specific peptidase 8	0.013
MAP1S	microtubule-associated protein 1S	0.013
PSEN2	presenilin 2 (Alzheimer disease 4)	0.013	Mouse
PTPN12	protein tyrosine phosphatase, non-receptor type 12	0.013
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.013
JUP	junction plakoglobin	0.013
PAK2	p21 protein (Cdc42/Rac)-activated kinase 2	0.013
STAM2	signal transducing adaptor molecule (SH3 domain and ITAM motif) 2	0.013	Fly
BCAR1	breast cancer anti-estrogen resistance 1	0.013
PRPF6	PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)	0.013
UBE3A	ubiquitin protein ligase E3A	0.013
LCK	lymphocyte-specific protein tyrosine kinase	0.012
ATXN1L	ataxin 1-like	0.012
IGFBP3	insulin-like growth factor binding protein 3	0.012
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.012
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.012	Fly
SIRT1	sirtuin 1	0.012
SRCIN1	SRC kinase signaling inhibitor 1	0.012
VAV2	vav 2 guanine nucleotide exchange factor	0.012
SEC61A1	Sec61 alpha 1 subunit (S. cerevisiae)	0.012
CISH	cytokine inducible SH2-containing protein	0.012	Human
TMEM173	transmembrane protein 173	0.012
HPS6	Hermansky-Pudlak syndrome 6	0.012
CIB1	calcium and integrin binding 1 (calmyrin)	0.012
FYB	FYN binding protein	0.012
ATP2B2	ATPase, Ca++ transporting, plasma membrane 2	0.012
RYK	RYK receptor-like tyrosine kinase	0.012
PIK3R3	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)	0.012
SOCS4	suppressor of cytokine signaling 4	0.012
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.011
PKP3	plakophilin 3	0.011
IRS4	insulin receptor substrate 4	0.011
DEGS1	degenerative spermatocyte homolog 1, lipid desaturase (Drosophila)	0.011
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.011
APH1A	anterior pharynx defective 1 homolog A (C. elegans)	0.011
DOK6	docking protein 6	0.011
ADNP	activity-dependent neuroprotector homeobox	0.011
STAM	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	0.011	Fly
DPYSL4	dihydropyrimidinase-like 4	0.011
DKK1	dickkopf homolog 1 (Xenopus laevis)	0.011
UBQLN1	ubiquilin 1	0.011
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.011
VAV3	vav 3 guanine nucleotide exchange factor	0.011
DAZAP2	DAZ associated protein 2	0.011
NACAD	NAC alpha domain containing	0.011
PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)	0.010	Fly
RNF11	ring finger protein 11	0.010
DDR2	discoidin domain receptor tyrosine kinase 2	0.010
EEA1	early endosome antigen 1	0.010
SH2D1A	SH2 domain containing 1A	0.010
SMARCC2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	0.010
FNBP1L	formin binding protein 1-like	0.010
ZNF775	zinc finger protein 775	0.010
CAPRIN2	caprin family member 2	0.010
UBASH3B	ubiquitin associated and SH3 domain containing B	0.010
TBL1X	transducin (beta)-like 1X-linked	0.010	Fly
ARRDC3	arrestin domain containing 3	0.010