IMP

Process View

Homo sapiens

38 genes annotated in human

sphingolipid metabolic process

The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "sphingolipid metabolic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "sphingolipid metabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
LAMP1	lysosomal-associated membrane protein 1	0.587
PARD6A	par-6 partitioning defective 6 homolog alpha (C. elegans)	0.544
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.367
COTL1	coactosin-like 1 (Dictyostelium)	0.302
CTSA	cathepsin A	0.288
TMBIM6	transmembrane BAX inhibitor motif containing 6	0.275
SQLE	squalene epoxidase	0.258
CYP51A1	cytochrome P450, family 51, subfamily A, polypeptide 1	0.236
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.220
RPTOR	regulatory associated protein of MTOR, complex 1	0.185
NOXA1	NADPH oxidase activator 1	0.165
PDPK1	3-phosphoinositide dependent protein kinase-1	0.153
RTN4	reticulon 4	0.148
INSR	insulin receptor	0.128
CTGF	connective tissue growth factor	0.125
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.124
BCL2L1	BCL2-like 1	0.119
SURF4	surfeit 4	0.118
HMGCR	3-hydroxy-3-methylglutaryl-CoA reductase	0.106
SIGMAR1	sigma non-opioid intracellular receptor 1	0.103
USP22	ubiquitin specific peptidase 22	0.094
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.093
DUSP23	dual specificity phosphatase 23	0.087
ANXA4	annexin A4	0.081
CCDC115	coiled-coil domain containing 115	0.079
BAK1	BCL2-antagonist/killer 1	0.078
LAT	linker for activation of T cells	0.075
MFSD5	major facilitator superfamily domain containing 5	0.067
PRKCB	protein kinase C, beta	0.066
RNF144B	ring finger protein 144B	0.064
HMGCS1	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)	0.062
SLC39A1	solute carrier family 39 (zinc transporter), member 1	0.060
SC5DL	sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like	0.055
SH3RF1	SH3 domain containing ring finger 1	0.055
GNS	glucosamine (N-acetyl)-6-sulfatase	0.053
IDI1	isopentenyl-diphosphate delta isomerase 1	0.053
RNR2	l-rRNA	0.052
KITLG	KIT ligand	0.051
PREX1	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	0.051
MAPT	microtubule-associated protein tau	0.049
LAMP2	lysosomal-associated membrane protein 2	0.048
ELOVL1	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1	0.047
CCL14	chemokine (C-C motif) ligand 14	0.046
PICK1	protein interacting with PRKCA 1	0.045
NR1H2	nuclear receptor subfamily 1, group H, member 2	0.043
RICTOR	RPTOR independent companion of MTOR, complex 2	0.041
TM9SF1	transmembrane 9 superfamily member 1	0.041
ARF3	ADP-ribosylation factor 3	0.040
NUMB	numb homolog (Drosophila)	0.038
ASAH1	N-acylsphingosine amidohydrolase (acid ceramidase) 1	0.038
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.037
TMEM173	transmembrane protein 173	0.037
AKT1S1	AKT1 substrate 1 (proline-rich)	0.036
INSIG1	insulin induced gene 1	0.036
HEXA	hexosaminidase A (alpha polypeptide)	0.035	Mouse
DEPTOR	DEP domain containing MTOR-interacting protein	0.034
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.033	Yeast
LASS2	LAG1 homolog, ceramide synthase 2	0.032	Human Yeast Mouse
ZHX1	zinc fingers and homeoboxes 1	0.032
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.031
SNX9	sorting nexin 9	0.030
JAK2	Janus kinase 2	0.030
NMT2	N-myristoyltransferase 2	0.030
ALOX12B	arachidonate 12-lipoxygenase, 12R type	0.030
PRKCZ	protein kinase C, zeta	0.030	Human
CDCP1	CUB domain containing protein 1	0.030
NCF1	neutrophil cytosolic factor 1	0.030
ATXN1	ataxin 1	0.029
CD58	CD58 molecule	0.029
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.029
CTSL1	cathepsin L1	0.029
RNF13	ring finger protein 13	0.029
PDK1	pyruvate dehydrogenase kinase, isozyme 1	0.028
ZNF71	zinc finger protein 71	0.027
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.027
FDFT1	farnesyl-diphosphate farnesyltransferase 1	0.027
SOAT1	sterol O-acyltransferase 1	0.026
ACSL3	acyl-CoA synthetase long-chain family member 3	0.026
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.025
GLB1	galactosidase, beta 1	0.025
CARD11	caspase recruitment domain family, member 11	0.025
MAPKAP1	mitogen-activated protein kinase associated protein 1	0.025
ENPP5	ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)	0.024	Human
CYB561D2	cytochrome b-561 domain containing 2	0.024
RHOXF2	Rhox homeobox family, member 2	0.023
KRT5	keratin 5	0.023
RARA	retinoic acid receptor, alpha	0.023
BRF2	BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like	0.023
TMEM165	transmembrane protein 165	0.023
CPD	carboxypeptidase D	0.022
ASXL1	additional sex combs like 1 (Drosophila)	0.022
ATP6V0E1	ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1	0.022
TWF2	twinfilin, actin-binding protein, homolog 2 (Drosophila)	0.022
NSDHL	NAD(P) dependent steroid dehydrogenase-like	0.022
NPTN	neuroplastin	0.022
PARD6G	par-6 partitioning defective 6 homolog gamma (C. elegans)	0.022
C14orf1	chromosome 14 open reading frame 1	0.021
BAD	BCL2-associated agonist of cell death	0.021
MFSD1	major facilitator superfamily domain containing 1	0.021
GM2A	GM2 ganglioside activator	0.021	Mouse
ALOXE3	arachidonate lipoxygenase 3	0.021
DHCR24	24-dehydrocholesterol reductase	0.020
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.020
ENPP4	ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)	0.020	Human
TM9SF3	transmembrane 9 superfamily member 3	0.020
SCAMP2	secretory carrier membrane protein 2	0.020
PPP2R4	protein phosphatase 2A activator, regulatory subunit 4	0.019
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.019
PPT1	palmitoyl-protein thioesterase 1	0.019
ADAMTS1	ADAM metallopeptidase with thrombospondin type 1 motif, 1	0.019
PSENEN	presenilin enhancer 2 homolog (C. elegans)	0.019
RTN3	reticulon 3	0.019
BCL10	B-cell CLL/lymphoma 10	0.019
FUCA1	fucosidase, alpha-L- 1, tissue	0.019
TOR1B	torsin family 1, member B (torsin B)	0.018
RHEB	Ras homolog enriched in brain	0.018
DCTN1	dynactin 1	0.018
NEU1	sialidase 1 (lysosomal sialidase)	0.018
IDH1	isocitrate dehydrogenase 1 (NADP+), soluble	0.018
STK4	serine/threonine kinase 4	0.018
SH2B1	SH2B adaptor protein 1	0.018
SOCS6	suppressor of cytokine signaling 6	0.018
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.018
ARPC5	actin related protein 2/3 complex, subunit 5, 16kDa	0.018
CPEB4	cytoplasmic polyadenylation element binding protein 4	0.017
DAZAP2	DAZ associated protein 2	0.017
FKBP1A	FK506 binding protein 1A, 12kDa	0.017
SLC35B2	solute carrier family 35, member B2	0.017
PRR5	proline rich 5 (renal)	0.017
FYN	FYN oncogene related to SRC, FGR, YES	0.017
ADAM10	ADAM metallopeptidase domain 10	0.017
HEXB	hexosaminidase B (beta polypeptide)	0.017	Mouse
NFATC2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.017
F11R	F11 receptor	0.016
NAGA	N-acetylgalactosaminidase, alpha-	0.016
TMEM33	transmembrane protein 33	0.016
PRR13	proline rich 13	0.016
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.015
BCAP31	B-cell receptor-associated protein 31	0.015
GRB10	growth factor receptor-bound protein 10	0.015
AMOTL2	angiomotin like 2	0.015
DHCR7	7-dehydrocholesterol reductase	0.015
RHEBL1	Ras homolog enriched in brain like 1	0.015
RNPEP	arginyl aminopeptidase (aminopeptidase B)	0.015
UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	0.015
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.015
CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)	0.015
ROD1	ROD1 regulator of differentiation 1 (S. pombe)	0.015
ATG7	ATG7 autophagy related 7 homolog (S. cerevisiae)	0.015
SYNGR2	synaptogyrin 2	0.015
TRIM9	tripartite motif containing 9	0.015
MAGEA2	melanoma antigen family A, 2	0.015
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.015
AUP1	ancient ubiquitous protein 1	0.015
M6PR	mannose-6-phosphate receptor (cation dependent)	0.015
SFN	stratifin	0.014
SLC25A1	solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1	0.014
CTSB	cathepsin B	0.014
PNP	purine nucleoside phosphorylase	0.014
TMEM41B	transmembrane protein 41B	0.014
SPTLC2	serine palmitoyltransferase, long chain base subunit 2	0.014	Mouse
CD55	CD55 molecule, decay accelerating factor for complement (Cromer blood group)	0.014
P2RX4	purinergic receptor P2X, ligand-gated ion channel, 4	0.014
TMBIM1	transmembrane BAX inhibitor motif containing 1	0.014
UNC45A	unc-45 homolog A (C. elegans)	0.014
RBPMS	RNA binding protein with multiple splicing	0.014
IRS2	insulin receptor substrate 2	0.014
MANBA	mannosidase, beta A, lysosomal	0.014
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.014
CLIC1	chloride intracellular channel 1	0.014
KIAA0174	KIAA0174	0.014
DEGS1	degenerative spermatocyte homolog 1, lipid desaturase (Drosophila)	0.014	Mouse
LLGL1	lethal giant larvae homolog 1 (Drosophila)	0.014
SLC35B4	solute carrier family 35, member B4	0.014
NCSTN	nicastrin	0.014
IRS1	insulin receptor substrate 1	0.014
CMTM6	CKLF-like MARVEL transmembrane domain containing 6	0.014
ORMDL2	ORM1-like 2 (S. cerevisiae)	0.014
LARS	leucyl-tRNA synthetase	0.014
IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	0.014
ATP2C1	ATPase, Ca++ transporting, type 2C, member 1	0.013
STARD4	StAR-related lipid transfer (START) domain containing 4	0.013
KLF4	Kruppel-like factor 4 (gut)	0.013
AP1S1	adaptor-related protein complex 1, sigma 1 subunit	0.013
STK17A	serine/threonine kinase 17a	0.013
POFUT1	protein O-fucosyltransferase 1	0.013
FUCA2	fucosidase, alpha-L- 2, plasma	0.013
PLOD3	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3	0.013
RBM47	RNA binding motif protein 47	0.013
MGAT4B	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B	0.013
CBLC	Cas-Br-M (murine) ecotropic retroviral transforming sequence c	0.013
NPC1	Niemann-Pick disease, type C1	0.013
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.013
RER1	RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae)	0.013
SWAP70	SWAP switching B-cell complex 70kDa subunit	0.013
AKT3	v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)	0.013	Human
GUSB	glucuronidase, beta	0.013
PSEN1	presenilin 1	0.012
SORBS2	sorbin and SH3 domain containing 2	0.012
SLC30A1	solute carrier family 30 (zinc transporter), member 1	0.012
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.012
TUBB6	tubulin, beta 6	0.012
THEM4	thioesterase superfamily member 4	0.012
TIPARP	TCDD-inducible poly(ADP-ribose) polymerase	0.012
TSC22D1	TSC22 domain family, member 1	0.012
IFNGR1	interferon gamma receptor 1	0.012
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.012
MAP1LC3A	microtubule-associated protein 1 light chain 3 alpha	0.012
FHL2	four and a half LIM domains 2	0.012
CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	0.012
SCPEP1	serine carboxypeptidase 1	0.012
SPRR2A	small proline-rich protein 2A	0.012
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.012
ACVR1	activin A receptor, type I	0.012
PRDM8	PR domain containing 8	0.012
PCDHA4	protocadherin alpha 4	0.012
CTNS	cystinosis, nephropathic	0.012
LPCAT1	lysophosphatidylcholine acyltransferase 1	0.012
IL13RA1	interleukin 13 receptor, alpha 1	0.012
SEPT11	septin 11	0.012
TIMP2	TIMP metallopeptidase inhibitor 2	0.011
ATXN7L3	ataxin 7-like 3	0.011
PEBP4	phosphatidylethanolamine-binding protein 4	0.011
GSK3B	glycogen synthase kinase 3 beta	0.011
TMEM50A	transmembrane protein 50A	0.011
SESN2	sestrin 2	0.011
GLA	galactosidase, alpha	0.011	Mouse
OSTM1	osteopetrosis associated transmembrane protein 1	0.011
IL10RB	interleukin 10 receptor, beta	0.011
CTSC	cathepsin C	0.011
DLG1	discs, large homolog 1 (Drosophila)	0.011
CD164	CD164 molecule, sialomucin	0.011
ELOVL6	ELOVL family member 6, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)	0.011
ETS1	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)	0.011
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.011
RHOB	ras homolog gene family, member B	0.011
SPRED1	sprouty-related, EVH1 domain containing 1	0.011
SLC4A2	solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)	0.011
CTSH	cathepsin H	0.011
TM9SF4	transmembrane 9 superfamily protein member 4	0.011
MAP2K3	mitogen-activated protein kinase kinase 3	0.011
TOR1A	torsin family 1, member A (torsin A)	0.011
CREG1	cellular repressor of E1A-stimulated genes 1	0.011
PTTG1IP	pituitary tumor-transforming 1 interacting protein	0.011
ANXA5	annexin A5	0.011
GLT25D1	glycosyltransferase 25 domain containing 1	0.011
SCD	stearoyl-CoA desaturase (delta-9-desaturase)	0.011
DCTD	dCMP deaminase	0.011
SNX18	sorting nexin 18	0.011
SH2D2A	SH2 domain containing 2A	0.011
DNAJC3	DnaJ (Hsp40) homolog, subfamily C, member 3	0.011
SCARB2	scavenger receptor class B, member 2	0.011
C7orf42	chromosome 7 open reading frame 42	0.011
BID	BH3 interacting domain death agonist	0.011
SH2D1A	SH2 domain containing 1A	0.011
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.011
GNPDA1	glucosamine-6-phosphate deaminase 1	0.011
RETSAT	retinol saturase (all-trans-retinol 13,14-reductase)	0.011
SLC31A1	solute carrier family 31 (copper transporters), member 1	0.011
RRAGD	Ras-related GTP binding D	0.011
DTX1	deltex homolog 1 (Drosophila)	0.010
GPR137B	G protein-coupled receptor 137B	0.010
PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	0.010
DPYSL2	dihydropyrimidinase-like 2	0.010
TM9SF2	transmembrane 9 superfamily member 2	0.010
GANAB	glucosidase, alpha; neutral AB	0.010
ZBTB43	zinc finger and BTB domain containing 43	0.010
VIM	vimentin	0.010
RNF149	ring finger protein 149	0.010
LRRK2	leucine-rich repeat kinase 2	0.010
FUT8	fucosyltransferase 8 (alpha (1,6) fucosyltransferase)	0.010
TGM1	transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)	0.010
MPDU1	mannose-P-dolichol utilization defect 1	0.010
LIPA	lipase A, lysosomal acid, cholesterol esterase	0.010
INO80B	INO80 complex subunit B	0.010
ARF5	ADP-ribosylation factor 5	0.010
KIAA1598	KIAA1598	0.010
DENND5A	DENN/MADD domain containing 5A	0.010
PIGO	phosphatidylinositol glycan anchor biosynthesis, class O	0.010
TMBIM4	transmembrane BAX inhibitor motif containing 4	0.010
PTPLB	protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b	0.010
PLP2	proteolipid protein 2 (colonic epithelium-enriched)	0.010
C1orf93	chromosome 1 open reading frame 93	0.010
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.010
GNG10	guanine nucleotide binding protein (G protein), gamma 10	0.010
SGPP1	sphingosine-1-phosphate phosphatase 1	0.010
ALG2	asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae)	0.010
ALCAM	activated leukocyte cell adhesion molecule	0.010
DNASE2	deoxyribonuclease II, lysosomal	0.010
ITM2A	integral membrane protein 2A	0.010
SLC25A22	solute carrier family 25 (mitochondrial carrier: glutamate), member 22	0.010
TPM4	tropomyosin 4	0.010