IMP

Process View

Homo sapiens

19 genes annotated in human

response to ketone

GO:1901654

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "response to ketone"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "response to ketone" (in gray)

Name	Description	Probability	Func Analog Organism
EGFR	epidermal growth factor receptor	0.985
ESR1	estrogen receptor 1	0.984
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.953
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.730
NRP1	neuropilin 1	0.498
TGFB1	transforming growth factor, beta 1	0.395
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.372	Rat
CAV1	caveolin 1, caveolae protein, 22kDa	0.363
TGFB3	transforming growth factor, beta 3	0.278
GRB2	growth factor receptor-bound protein 2	0.277
CCR5	chemokine (C-C motif) receptor 5	0.267
HDAC1	histone deacetylase 1	0.259
JUN	jun proto-oncogene	0.224
ARRB1	arrestin, beta 1	0.219
JAK2	Janus kinase 2	0.212	Mouse
NCOA1	nuclear receptor coactivator 1	0.186
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.174
NOSTRIN	nitric oxide synthase trafficker	0.164
THBS1	thrombospondin 1	0.161
CREBBP	CREB binding protein	0.157
GSTM4	glutathione S-transferase mu 4	0.154
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.152
PLAU	plasminogen activator, urokinase	0.151
CCL2	chemokine (C-C motif) ligand 2	0.133	Human
PCGF2	polycomb group ring finger 2	0.128
AXL	AXL receptor tyrosine kinase	0.121
CXCL3	chemokine (C-X-C motif) ligand 3	0.105
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.104
XIAP	X-linked inhibitor of apoptosis	0.103
CCL4	chemokine (C-C motif) ligand 4	0.103	Human
APP	amyloid beta (A4) precursor protein	0.095
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.090
ENG	endoglin	0.086	Human
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.085	Rat
IL6	interleukin 6 (interferon, beta 2)	0.081
APAF1	apoptotic peptidase activating factor 1	0.077
CXCL9	chemokine (C-X-C motif) ligand 9	0.076
JUNB	jun B proto-oncogene	0.075
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.068
RARA	retinoic acid receptor, alpha	0.065
NRIP1	nuclear receptor interacting protein 1	0.063
EP300	E1A binding protein p300	0.059
PTEN	phosphatase and tensin homolog	0.059
DPP4	dipeptidyl-peptidase 4	0.057
GSTM2	glutathione S-transferase mu 2 (muscle)	0.056
LAT	linker for activation of T cells	0.053
ALDH1A1	aldehyde dehydrogenase 1 family, member A1	0.053
BCL3	B-cell CLL/lymphoma 3	0.049
IL1R1	interleukin 1 receptor, type I	0.047
CXCL10	chemokine (C-X-C motif) ligand 10	0.047
STAT5A	signal transducer and activator of transcription 5A	0.045
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.045
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.045
ATF3	activating transcription factor 3	0.044
ICAM1	intercellular adhesion molecule 1	0.043
IRS1	insulin receptor substrate 1	0.041
SOCS1	suppressor of cytokine signaling 1	0.040	Rat
DNMT3A	DNA (cytosine-5-)-methyltransferase 3 alpha	0.040
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.040
VEZF1	vascular endothelial zinc finger 1	0.039
TICAM2	toll-like receptor adaptor molecule 2	0.039
CDK2	cyclin-dependent kinase 2	0.038
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.038
RNF144B	ring finger protein 144B	0.038
MYD88	myeloid differentiation primary response gene (88)	0.037
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.037
CTTN	cortactin	0.036
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.035
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.033	Rat
PLAT	plasminogen activator, tissue	0.033	Rat
UHRF1	ubiquitin-like with PHD and ring finger domains 1	0.032
IGF1R	insulin-like growth factor 1 receptor	0.032
CCL19	chemokine (C-C motif) ligand 19	0.032
SPDEF	SAM pointed domain containing ets transcription factor	0.031
RNR2	l-rRNA	0.031
MAPK14	mitogen-activated protein kinase 14	0.031
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.031
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.030	Human
CDK6	cyclin-dependent kinase 6	0.030
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.030
CXCL11	chemokine (C-X-C motif) ligand 11	0.029
CSF1	colony stimulating factor 1 (macrophage)	0.029
SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal	0.029
BCAR1	breast cancer anti-estrogen resistance 1	0.029
BCL2L1	BCL2-like 1	0.029
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.029	Rat
EIF3F	eukaryotic translation initiation factor 3, subunit F	0.029
JDP2	Jun dimerization protein 2	0.028
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.027
EDF1	endothelial differentiation-related factor 1	0.027
CCL8	chemokine (C-C motif) ligand 8	0.026	Human
IER2	immediate early response 2	0.026
IL8	interleukin 8	0.025
CCR7	chemokine (C-C motif) receptor 7	0.025
IDE	insulin-degrading enzyme	0.024
EED	embryonic ectoderm development	0.024
MSTO1	misato homolog 1 (Drosophila)	0.024
DARC	Duffy blood group, chemokine receptor	0.023
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.022
FSTL1	follistatin-like 1	0.022
CCL13	chemokine (C-C motif) ligand 13	0.022	Human
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.022
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.022
RERE	arginine-glutamic acid dipeptide (RE) repeats	0.021
PHC1	polyhomeotic homolog 1 (Drosophila)	0.021	Fly
EGR1	early growth response 1	0.021
CRHR1	corticotropin releasing hormone receptor 1	0.021
PRMT2	protein arginine methyltransferase 2	0.021
EPOR	erythropoietin receptor	0.021
NIPBL	Nipped-B homolog (Drosophila)	0.021
SCMH1	sex comb on midleg homolog 1 (Drosophila)	0.021
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.021
IFNG	interferon, gamma	0.020
ABCC8	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	0.020
MAPK3	mitogen-activated protein kinase 3	0.020
CBX4	chromobox homolog 4	0.020
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.020
CUEDC2	CUE domain containing 2	0.020
S100B	S100 calcium binding protein B	0.020
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.020
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.019
BAZ1B	bromodomain adjacent to zinc finger domain, 1B	0.019
GABRA3	gamma-aminobutyric acid (GABA) A receptor, alpha 3	0.019
RSF1	remodeling and spacing factor 1	0.019
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.019
SMAD4	SMAD family member 4	0.018
RING1	ring finger protein 1	0.018
CCL3	chemokine (C-C motif) ligand 3	0.018	Human
SOCS3	suppressor of cytokine signaling 3	0.018	Rat
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.017
CXCL2	chemokine (C-X-C motif) ligand 2	0.017
H3F3C	H3 histone, family 3C	0.017
RANBP2	RAN binding protein 2	0.017
HSD11B1	hydroxysteroid (11-beta) dehydrogenase 1	0.017
CCL11	chemokine (C-C motif) ligand 11	0.017	Human
CCL7	chemokine (C-C motif) ligand 7	0.017	Human
VCAM1	vascular cell adhesion molecule 1	0.016
CLNS1A	chloride channel, nucleotide-sensitive, 1A	0.016
CXCL13	chemokine (C-X-C motif) ligand 13	0.016
NBN	nibrin	0.016
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.016
CCND3	cyclin D3	0.016
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.016
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.016
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.016
TIMP3	TIMP metallopeptidase inhibitor 3	0.016
CCL22	chemokine (C-C motif) ligand 22	0.016	Human
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.016
CBX8	chromobox homolog 8	0.015
IL1RAP	interleukin 1 receptor accessory protein	0.015
ANKS1B	ankyrin repeat and sterile alpha motif domain containing 1B	0.015
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.015
PPP5C	protein phosphatase 5, catalytic subunit	0.015
ADH1C	alcohol dehydrogenase 1C (class I), gamma polypeptide	0.015
PRKCA	protein kinase C, alpha	0.014
TGFBR3	transforming growth factor, beta receptor III	0.014
PRMT6	protein arginine methyltransferase 6	0.014
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.014	Rat
PRRC2B	proline-rich coiled-coil 2B	0.014
MYLK2	myosin light chain kinase 2	0.014
FOSB	FBJ murine osteosarcoma viral oncogene homolog B	0.014	Rat
IL1RN	interleukin 1 receptor antagonist	0.014
SELE	selectin E	0.014
CXCL12	chemokine (C-X-C motif) ligand 12	0.014
STAT5B	signal transducer and activator of transcription 5B	0.014
RB1	retinoblastoma 1	0.014
WNT2	wingless-type MMTV integration site family member 2	0.013
CCL20	chemokine (C-C motif) ligand 20	0.013	Human
NTRK2	neurotrophic tyrosine kinase, receptor, type 2	0.013
BIRC3	baculoviral IAP repeat containing 3	0.013
BBS10	Bardet-Biedl syndrome 10	0.013
CCND1	cyclin D1	0.013	Rat
EIF4E	eukaryotic translation initiation factor 4E	0.013
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.013
CXCL5	chemokine (C-X-C motif) ligand 5	0.013
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.012
PLCG1	phospholipase C, gamma 1	0.012
SPSB1	splA/ryanodine receptor domain and SOCS box containing 1	0.012
GHR	growth hormone receptor	0.012
GPC3	glypican 3	0.012
MED13	mediator complex subunit 13	0.012
NCOR2	nuclear receptor corepressor 2	0.012
RPS6KA5	ribosomal protein S6 kinase, 90kDa, polypeptide 5	0.012
NCF1	neutrophil cytosolic factor 1	0.012
IQGAP1	IQ motif containing GTPase activating protein 1	0.012
CD83	CD83 molecule	0.012
CCR4	chemokine (C-C motif) receptor 4	0.012
NCOA3	nuclear receptor coactivator 3	0.012
F3	coagulation factor III (thromboplastin, tissue factor)	0.012
INSR	insulin receptor	0.012	Rat
MED15	mediator complex subunit 15	0.012
KCTD17	potassium channel tetramerisation domain containing 17	0.012
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.011
IL1B	interleukin 1, beta	0.011	Rat
HBEGF	heparin-binding EGF-like growth factor	0.011
CHD1	chromodomain helicase DNA binding protein 1	0.011
ARRDC3	arrestin domain containing 3	0.011
CD40	CD40 molecule, TNF receptor superfamily member 5	0.011
SFRP1	secreted frizzled-related protein 1	0.011
SOD1	superoxide dismutase 1, soluble	0.011
DDIT3	DNA-damage-inducible transcript 3	0.011
SMAD3	SMAD family member 3	0.011
BCL2A1	BCL2-related protein A1	0.011
ATF2	activating transcription factor 2	0.011
DCN	decorin	0.011
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.011
USP11	ubiquitin specific peptidase 11	0.011
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.010
ADRBK1	adrenergic, beta, receptor kinase 1	0.010
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.010
CLU	clusterin	0.010
LEPR	leptin receptor	0.010
DES	desmin	0.010
PAK3	p21 protein (Cdc42/Rac)-activated kinase 3	0.010
FHL3	four and a half LIM domains 3	0.010
COMMD1	copper metabolism (Murr1) domain containing 1	0.010
LY96	lymphocyte antigen 96	0.010
UBD	ubiquitin D	0.010
STC1	stanniocalcin 1	0.010
FKBP1A	FK506 binding protein 1A, 12kDa	0.010