IMP

Process View

Homo sapiens

28 genes annotated in human

Multi-species View

smooth muscle cell proliferation

GO:0048659

The multiplication or reproduction of smooth muscle cells, resulting in the expansion of a cell population.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "smooth muscle cell proliferation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "smooth muscle cell proliferation" (in gray)

Name	Description	Probability	Func Analog Organism
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	1.000
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.997	Human
IL6	interleukin 6 (interferon, beta 2)	0.961
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.942	Human Rat
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.921
EGFR	epidermal growth factor receptor	0.898
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.891	Rat
JAG1	jagged 1	0.852
CCR5	chemokine (C-C motif) receptor 5	0.842
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.834	Human
C1QA	complement component 1, q subcomponent, A chain	0.805	Human
NCOR2	nuclear receptor corepressor 2	0.754
IRAK2	interleukin-1 receptor-associated kinase 2	0.709
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.675
PSEN1	presenilin 1	0.645
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.569
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.480
CCL4	chemokine (C-C motif) ligand 4	0.460	Human
IRS1	insulin receptor substrate 1	0.442
CXCL3	chemokine (C-X-C motif) ligand 3	0.428
FGF1	fibroblast growth factor 1 (acidic)	0.402
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.402	Rat
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.393
HIPK2	homeodomain interacting protein kinase 2	0.355
TRAF6	TNF receptor-associated factor 6	0.351	Rat
NCOR1	nuclear receptor corepressor 1	0.346
JUNB	jun B proto-oncogene	0.340
S100B	S100 calcium binding protein B	0.330
AR	androgen receptor	0.328
CCL2	chemokine (C-C motif) ligand 2	0.327	Human
BMPR1A	bone morphogenetic protein receptor, type IA	0.300
HNF4A	hepatocyte nuclear factor 4, alpha	0.289
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.280
CDH5	cadherin 5, type 2 (vascular endothelium)	0.279
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.269	Human
VEGFA	vascular endothelial growth factor A	0.267	Human Rat
IL8	interleukin 8	0.231
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.223
DSG2	desmoglein 2	0.216
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.216
PPARG	peroxisome proliferator-activated receptor gamma	0.215
NOSTRIN	nitric oxide synthase trafficker	0.210
C1QC	complement component 1, q subcomponent, C chain	0.197	Human
RALB	v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)	0.196
APC	adenomatous polyposis coli	0.193
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.192
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.189
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.186	Human
TBXA2R	thromboxane A2 receptor	0.185	Human
PDGFA	platelet-derived growth factor alpha polypeptide	0.182	Human
ESR1	estrogen receptor 1	0.153	Rat
RNASE4	ribonuclease, RNase A family, 4	0.147	Human
TGFB3	transforming growth factor, beta 3	0.142
ANG	angiogenin, ribonuclease, RNase A family, 5	0.138
BCAR1	breast cancer anti-estrogen resistance 1	0.133
PTGIR	prostaglandin I2 (prostacyclin) receptor (IP)	0.132
IGF1	insulin-like growth factor 1 (somatomedin C)	0.131
APOE	apolipoprotein E	0.128
FGF10	fibroblast growth factor 10	0.128
PGF	placental growth factor	0.124	Human
NRP1	neuropilin 1	0.122
CXCL9	chemokine (C-X-C motif) ligand 9	0.122
PELI3	pellino homolog 3 (Drosophila)	0.120
IRAK1	interleukin-1 receptor-associated kinase 1	0.118	Rat
IGF2	insulin-like growth factor 2 (somatomedin A)	0.118	Human
IGFBP5	insulin-like growth factor binding protein 5	0.117
CTNNBIP1	catenin, beta interacting protein 1	0.117
FCER1G	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	0.115
RUNX1	runt-related transcription factor 1	0.112
EDN1	endothelin 1	0.111
KITLG	KIT ligand	0.111
IL6R	interleukin 6 receptor	0.111
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.107
DCN	decorin	0.098
IL23A	interleukin 23, alpha subunit p19	0.097
CCL8	chemokine (C-C motif) ligand 8	0.094	Human
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.092
IL1B	interleukin 1, beta	0.091
CXCL2	chemokine (C-X-C motif) ligand 2	0.085
C3	complement component 3	0.083
CREBBP	CREB binding protein	0.077
EPAS1	endothelial PAS domain protein 1	0.077
ZC3H12A	zinc finger CCCH-type containing 12A	0.076
IL2RB	interleukin 2 receptor, beta	0.075
RARA	retinoic acid receptor, alpha	0.074
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.071
A2M	alpha-2-macroglobulin	0.066
DDIT3	DNA-damage-inducible transcript 3	0.065
ATF5	activating transcription factor 5	0.064
CXCL12	chemokine (C-X-C motif) ligand 12	0.064
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.063
ITGB1BP3	integrin beta 1 binding protein 3	0.059
FGFR1	fibroblast growth factor receptor 1	0.058
PTPRB	protein tyrosine phosphatase, receptor type, B	0.057
IGF2R	insulin-like growth factor 2 receptor	0.057
HR	hairless homolog (mouse)	0.056
JAK1	Janus kinase 1	0.055
PLCG1	phospholipase C, gamma 1	0.055
IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	0.054
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.054
MARCO	macrophage receptor with collagenous structure	0.053
MPO	myeloperoxidase	0.052
FGF7	fibroblast growth factor 7	0.052
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.051
TCF4	transcription factor 4	0.051
DDR2	discoidin domain receptor tyrosine kinase 2	0.050
PRTN3	proteinase 3	0.048	Human
MEF2C	myocyte enhancer factor 2C	0.048
PPP5C	protein phosphatase 5, catalytic subunit	0.046
MEF2A	myocyte enhancer factor 2A	0.044
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.044
INO80B	INO80 complex subunit B	0.043
IDE	insulin-degrading enzyme	0.043
LDLR	low density lipoprotein receptor	0.043
CCR1	chemokine (C-C motif) receptor 1	0.042
C1QB	complement component 1, q subcomponent, B chain	0.042	Human
IL12A	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	0.042
IL10	interleukin 10	0.042
TF	transferrin	0.041
TLE1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	0.041
FGFR1OP2	FGFR1 oncogene partner 2	0.040
CCL13	chemokine (C-C motif) ligand 13	0.040	Human
HSPG2	heparan sulfate proteoglycan 2	0.039
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.038
CCL3	chemokine (C-C motif) ligand 3	0.038	Human
PRMT2	protein arginine methyltransferase 2	0.038
KLF6	Kruppel-like factor 6	0.038
DARC	Duffy blood group, chemokine receptor	0.037
FBLN1	fibulin 1	0.037
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.036
CD34	CD34 molecule	0.036
IRAK3	interleukin-1 receptor-associated kinase 3	0.036
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.036
VEGFC	vascular endothelial growth factor C	0.036	Human
COL1A1	collagen, type I, alpha 1	0.035
SOCS3	suppressor of cytokine signaling 3	0.035
ZFYVE9	zinc finger, FYVE domain containing 9	0.034
SELE	selectin E	0.033
ESRRG	estrogen-related receptor gamma	0.033
DUSP23	dual specificity phosphatase 23	0.033
GLIS2	GLIS family zinc finger 2	0.033
JUP	junction plakoglobin	0.033	Human
CTNND1	catenin (cadherin-associated protein), delta 1	0.033
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.032
SLAMF8	SLAM family member 8	0.032
EP300	E1A binding protein p300	0.032
FLT4	fms-related tyrosine kinase 4	0.031	Human
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.030
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.030
MYD88	myeloid differentiation primary response gene (88)	0.030	Rat
NR0B2	nuclear receptor subfamily 0, group B, member 2	0.030
FOSB	FBJ murine osteosarcoma viral oncogene homolog B	0.029
TEK	TEK tyrosine kinase, endothelial	0.029
SLMAP	sarcolemma associated protein	0.029
STRN3	striatin, calmodulin binding protein 3	0.029
KLF5	Kruppel-like factor 5 (intestinal)	0.029
WDYHV1	WDYHV motif containing 1	0.028
STC1	stanniocalcin 1	0.028
CCL7	chemokine (C-C motif) ligand 7	0.028	Human
C2	complement component 2	0.027
EGLN3	egl nine homolog 3 (C. elegans)	0.026
ORC2	origin recognition complex, subunit 2	0.026
SIRT1	sirtuin 1	0.026
CCL19	chemokine (C-C motif) ligand 19	0.026	Human
PRKCA	protein kinase C, alpha	0.025
MS4A4A	membrane-spanning 4-domains, subfamily A, member 4	0.025
PDGFC	platelet derived growth factor C	0.025
PARVB	parvin, beta	0.025
CTBP1	C-terminal binding protein 1	0.025
ELANE	elastase, neutrophil expressed	0.024
RHOB	ras homolog gene family, member B	0.024
AZU1	azurocidin 1	0.024	Human
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.023
SRGN	serglycin	0.023
PARVA	parvin, alpha	0.023
HP	haptoglobin	0.023
PLAT	plasminogen activator, tissue	0.023
CD163	CD163 molecule	0.023
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.023
TDGF1	teratocarcinoma-derived growth factor 1	0.022
TAX1BP1	Tax1 (human T-cell leukemia virus type I) binding protein 1	0.022
NCOA6	nuclear receptor coactivator 6	0.022
VSIG4	V-set and immunoglobulin domain containing 4	0.022
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.022
JUN	jun proto-oncogene	0.022	Rat
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.021	Rat
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.021
RAMP2	receptor (G protein-coupled) activity modifying protein 2	0.021
SP1	Sp1 transcription factor	0.021
SLA	Src-like-adaptor	0.021
EEA1	early endosome antigen 1	0.020
RABEP1	rabaptin, RAB GTPase binding effector protein 1	0.020
GAB2	GRB2-associated binding protein 2	0.020
DSP	desmoplakin	0.020
IER3	immediate early response 3	0.020
CEBPG	CCAAT/enhancer binding protein (C/EBP), gamma	0.019
CCL11	chemokine (C-C motif) ligand 11	0.019	Human
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.019
CH25H	cholesterol 25-hydroxylase	0.019
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.019
NOV	nephroblastoma overexpressed gene	0.019
SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	0.019
IGFBP3	insulin-like growth factor binding protein 3	0.019
PLAUR	plasminogen activator, urokinase receptor	0.018
RGS1	regulator of G-protein signaling 1	0.018
GPX3	glutathione peroxidase 3 (plasma)	0.018
WISP2	WNT1 inducible signaling pathway protein 2	0.018
INHBA	inhibin, beta A	0.018
STAB1	stabilin 1	0.018
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.018
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	0.017
CFD	complement factor D (adipsin)	0.017
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.017
BMP2	bone morphogenetic protein 2	0.017	Human
THBS1	thrombospondin 1	0.017
YAP1	Yes-associated protein 1	0.017
EGLN1	egl nine homolog 1 (C. elegans)	0.017
RGS16	regulator of G-protein signaling 16	0.017
CSNK1E	casein kinase 1, epsilon	0.017
TNF	tumor necrosis factor	0.017
CTSG	cathepsin G	0.016
GRB7	growth factor receptor-bound protein 7	0.016
GNLY	granulysin	0.016
INSR	insulin receptor	0.016
RNH1	ribonuclease/angiogenin inhibitor 1	0.016
G0S2	G0/G1switch 2	0.016
FBXW11	F-box and WD repeat domain containing 11	0.016
PLG	plasminogen	0.016
LEP	leptin	0.016
CTTNBP2NL	CTTNBP2 N-terminal like	0.016
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.016
CD68	CD68 molecule	0.016
PTPN23	protein tyrosine phosphatase, non-receptor type 23	0.015
FSTL1	follistatin-like 1	0.015
TMEM176B	transmembrane protein 176B	0.015
RICTOR	RPTOR independent companion of MTOR, complex 2	0.015
CXCL14	chemokine (C-X-C motif) ligand 14	0.015
CD14	CD14 molecule	0.015
CDH2	cadherin 2, type 1, N-cadherin (neuronal)	0.015	Human
EMD	emerin	0.015
FOXO1	forkhead box O1	0.014
SKP1	S-phase kinase-associated protein 1	0.014
PXN	paxillin	0.014
TLR4	toll-like receptor 4	0.014
IGFBP2	insulin-like growth factor binding protein 2, 36kDa	0.014	Human
VHL	von Hippel-Lindau tumor suppressor	0.014
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.014
MIF4GD	MIF4G domain containing	0.014
FHL2	four and a half LIM domains 2	0.014
GHRL	ghrelin/obestatin prepropeptide	0.013
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.013
DUSP5	dual specificity phosphatase 5	0.013
SFRP1	secreted frizzled-related protein 1	0.013
NCOA1	nuclear receptor coactivator 1	0.013
ENG	endoglin	0.013
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.013
BMP4	bone morphogenetic protein 4	0.013
DPT	dermatopontin	0.013
KRT5	keratin 5	0.013
NDRG1	N-myc downstream regulated 1	0.013
PLA2G7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	0.013
ICAM1	intercellular adhesion molecule 1	0.013
C3AR1	complement component 3a receptor 1	0.013	Rat
EMR1	egf-like module containing, mucin-like, hormone receptor-like 1	0.013
BTRC	beta-transducin repeat containing	0.012
ITGA6	integrin, alpha 6	0.012
EIF4EBP1	eukaryotic translation initiation factor 4E binding protein 1	0.012
APPL1	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	0.012
CXCL13	chemokine (C-X-C motif) ligand 13	0.012
VCAM1	vascular cell adhesion molecule 1	0.012
ATF3	activating transcription factor 3	0.012
ADRB2	adrenergic, beta-2-, receptor, surface	0.012
PDZD3	PDZ domain containing 3	0.012
THBD	thrombomodulin	0.012
SLC2A5	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	0.012
PIK3CB	phosphoinositide-3-kinase, catalytic, beta polypeptide	0.012
CFH	complement factor H	0.012
S100A9	S100 calcium binding protein A9	0.012
FTL	ferritin, light polypeptide	0.012
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.012
CXCL5	chemokine (C-X-C motif) ligand 5	0.012
ENPEP	glutamyl aminopeptidase (aminopeptidase A)	0.012
CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	0.012
ADAM12	ADAM metallopeptidase domain 12	0.012
CCL3L3	chemokine (C-C motif) ligand 3-like 3	0.012
ADM	adrenomedullin	0.012
MYLK2	myosin light chain kinase 2	0.012
CCR7	chemokine (C-C motif) receptor 7	0.012
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.012
RUNX3	runt-related transcription factor 3	0.012
GGT5	gamma-glutamyltransferase 5	0.011
MGP	matrix Gla protein	0.011
OMD	osteomodulin	0.011
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.011	Rat
BCL2A1	BCL2-related protein A1	0.011
PLA2G2A	phospholipase A2, group IIA (platelets, synovial fluid)	0.011
HK3	hexokinase 3 (white cell)	0.011
RAMP3	receptor (G protein-coupled) activity modifying protein 3	0.011
PCK2	phosphoenolpyruvate carboxykinase 2 (mitochondrial)	0.011
TERF2	telomeric repeat binding factor 2	0.011
TGFB2	transforming growth factor, beta 2	0.011
SGK1	serum/glucocorticoid regulated kinase 1	0.011
RNASE3	ribonuclease, RNase A family, 3	0.011	Human
COL4A3	collagen, type IV, alpha 3 (Goodpasture antigen)	0.011
PTGDS	prostaglandin D2 synthase 21kDa (brain)	0.011
CTSL1	cathepsin L1	0.011
CCL22	chemokine (C-C motif) ligand 22	0.011
CCL23	chemokine (C-C motif) ligand 23	0.011	Human
CAV1	caveolin 1, caveolae protein, 22kDa	0.010
GADD45B	growth arrest and DNA-damage-inducible, beta	0.010
FAF1	Fas (TNFRSF6) associated factor 1	0.010
MS4A3	membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)	0.010
CAMP	cathelicidin antimicrobial peptide	0.010
C10orf54	chromosome 10 open reading frame 54	0.010
TGFBR3	transforming growth factor, beta receptor III	0.010
ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	0.010
MDFI	MyoD family inhibitor	0.010
FN1	fibronectin 1	0.010