IMP

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Homo sapiens

4 genes annotated in human

mast cell degranulation

The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "mast cell degranulation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "mast cell degranulation" (in gray)

Name	Description	Probability	Func Analog Organism
SYK	spleen tyrosine kinase	0.991	Mouse Rat
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.982
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.960	Human
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.956
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.946	Mouse
BLNK	B-cell linker	0.931
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.913
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.813
PLCG1	phospholipase C, gamma 1	0.793
LAT	linker for activation of T cells	0.758
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.737
GRB2	growth factor receptor-bound protein 2	0.666
C19orf50	chromosome 19 open reading frame 50	0.592
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.480
IL4R	interleukin 4 receptor	0.465	Mouse
FYN	FYN oncogene related to SRC, FGR, YES	0.451
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.426
UBASH3B	ubiquitin associated and SH3 domain containing B	0.405
LCK	lymphocyte-specific protein tyrosine kinase	0.383
VAV1	vav 1 guanine nucleotide exchange factor	0.363
NRP1	neuropilin 1	0.339
FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	0.337
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.335
PDGFA	platelet-derived growth factor alpha polypeptide	0.212
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.212
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.209
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.207
GAB1	GRB2-associated binding protein 1	0.198
TFF1	trefoil factor 1	0.196
SLA	Src-like-adaptor	0.187
IL4	interleukin 4	0.187	Mouse
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.171
FGFR1	fibroblast growth factor receptor 1	0.165
FCER1G	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	0.151	Mouse
BTK	Bruton agammaglobulinemia tyrosine kinase	0.144	Rat
SOS1	son of sevenless homolog 1 (Drosophila)	0.142
VEGFA	vascular endothelial growth factor A	0.136
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.134
IL2RG	interleukin 2 receptor, gamma	0.128
CARD11	caspase recruitment domain family, member 11	0.121
HCK	hemopoietic cell kinase	0.113
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.108	Human
PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	0.105
CRH	corticotropin releasing hormone	0.101
NCK1	NCK adaptor protein 1	0.100
CDH5	cadherin 5, type 2 (vascular endothelium)	0.100
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.087
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.080
ZNF746	zinc finger protein 746	0.078
BAI1	brain-specific angiogenesis inhibitor 1	0.074
HCLS1	hematopoietic cell-specific Lyn substrate 1	0.068
PECAM1	platelet/endothelial cell adhesion molecule	0.068
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.067
WIPF1	WAS/WASL interacting protein family, member 1	0.064
SOS2	son of sevenless homolog 2 (Drosophila)	0.056
FYB	FYN binding protein	0.048
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.046
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.045
ZNF775	zinc finger protein 775	0.044
PGF	placental growth factor	0.043
ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	0.042
GAS7	growth arrest-specific 7	0.042
PDGFC	platelet derived growth factor C	0.042
FASLG	Fas ligand (TNF superfamily, member 6)	0.042
FCGR3B	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	0.040
CMIP	c-Maf-inducing protein	0.040
AXL	AXL receptor tyrosine kinase	0.039
IBTK	inhibitor of Bruton agammaglobulinemia tyrosine kinase	0.038
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.037
HK3	hexokinase 3 (white cell)	0.036
IRS1	insulin receptor substrate 1	0.035
SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.035
CSF3R	colony stimulating factor 3 receptor (granulocyte)	0.034
KITLG	KIT ligand	0.034
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.033	Human
PARK2	parkinson protein 2, E3 ubiquitin protein ligase (parkin)	0.033
SH2B2	SH2B adaptor protein 2	0.032
KRT81	keratin 81	0.032
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.031
PRKCQ	protein kinase C, theta	0.031
PIK3CB	phosphoinositide-3-kinase, catalytic, beta polypeptide	0.031
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.030
CD33	CD33 molecule	0.029
ABI3	ABI family, member 3	0.027
CPA3	carboxypeptidase A3 (mast cell)	0.024
EPOR	erythropoietin receptor	0.023
JAK2	Janus kinase 2	0.022
PTEN	phosphatase and tensin homolog	0.022
C1orf93	chromosome 1 open reading frame 93	0.022
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.022	Human
CAV1	caveolin 1, caveolae protein, 22kDa	0.021
MPEG1	macrophage expressed 1	0.021
HPGDS	hematopoietic prostaglandin D synthase	0.021
FLT4	fms-related tyrosine kinase 4	0.021	Human
HDC	histidine decarboxylase	0.020
CYTH4	cytohesin 4	0.020
INSR	insulin receptor	0.019
FRS2	fibroblast growth factor receptor substrate 2	0.019
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.019
FCGR2B	Fc fragment of IgG, low affinity IIb, receptor (CD32)	0.019
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.018
ILK	integrin-linked kinase	0.017
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.017
CD300C	CD300c molecule	0.017	Human
TNFSF11	tumor necrosis factor (ligand) superfamily, member 11	0.017
FNBP1	formin binding protein 1	0.017
NSF	N-ethylmaleimide-sensitive factor	0.017
RET	ret proto-oncogene	0.017
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.017
TBXAS1	thromboxane A synthase 1 (platelet)	0.017
ZC3HC1	zinc finger, C3HC-type containing 1	0.016
CTSG	cathepsin G	0.016
EPHA8	EPH receptor A8	0.016
CD93	CD93 molecule	0.016
IGF1R	insulin-like growth factor 1 receptor	0.016
MAP2	microtubule-associated protein 2	0.016
ARID3A	AT rich interactive domain 3A (BRIGHT-like)	0.016
TGFB3	transforming growth factor, beta 3	0.016
SH3BP5	SH3-domain binding protein 5 (BTK-associated)	0.016
GAB2	GRB2-associated binding protein 2	0.016	Mouse
SIRPB1	signal-regulatory protein beta 1	0.016
SPRY4	sprouty homolog 4 (Drosophila)	0.015
EGFR	epidermal growth factor receptor	0.015
SBF1	SET binding factor 1	0.015
PIK3CD	phosphoinositide-3-kinase, catalytic, delta polypeptide	0.015
C5AR1	complement component 5a receptor 1	0.015
TEC	tec protein tyrosine kinase	0.015	Human
DOK1	docking protein 1, 62kDa (downstream of tyrosine kinase 1)	0.015
DOK3	docking protein 3	0.015
TREM2	triggering receptor expressed on myeloid cells 2	0.014
AKAP2	A kinase (PRKA) anchor protein 2	0.014
KIR2DL1	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1	0.014
PRKCB	protein kinase C, beta	0.014
ROBO4	roundabout homolog 4, magic roundabout (Drosophila)	0.014
CD300A	CD300a molecule	0.014
FLT3	fms-related tyrosine kinase 3	0.014	Human
LDLR	low density lipoprotein receptor	0.014
CR1	complement component (3b/4b) receptor 1 (Knops blood group)	0.014
NCKAP1L	NCK-associated protein 1-like	0.014
ERBB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.014
SNX33	sorting nexin 33	0.014
PACSIN1	protein kinase C and casein kinase substrate in neurons 1	0.014
FOXF2	forkhead box F2	0.014
TYROBP	TYRO protein tyrosine kinase binding protein	0.014
PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)	0.013
ALOX5	arachidonate 5-lipoxygenase	0.013
SASH3	SAM and SH3 domain containing 3	0.013
LRRC25	leucine rich repeat containing 25	0.013
GPSM3	G-protein signaling modulator 3	0.013
CSF1R	colony stimulating factor 1 receptor	0.013	Human
EZR	ezrin	0.013
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.013
SPI1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.013
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.013
CD1C	CD1c molecule	0.012
PAX2	paired box 2	0.012
ITGAM	integrin, alpha M (complement component 3 receptor 3 subunit)	0.012
HSH2D	hematopoietic SH2 domain containing	0.012
PIK3AP1	phosphoinositide-3-kinase adaptor protein 1	0.012
CEACAM4	carcinoembryonic antigen-related cell adhesion molecule 4	0.012
OSCAR	osteoclast associated, immunoglobulin-like receptor	0.012
MYO1F	myosin IF	0.012
FES	feline sarcoma oncogene	0.012
ERG	v-ets erythroblastosis virus E26 oncogene homolog (avian)	0.012
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.012
MS4A2	membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)	0.012	Rat
PIM1	pim-1 oncogene	0.012
ID4	inhibitor of DNA binding 4, dominant negative helix-loop-helix protein	0.012
CD37	CD37 molecule	0.012
TLR3	toll-like receptor 3	0.012
BCR	breakpoint cluster region	0.012
DMBT1	deleted in malignant brain tumors 1	0.012
APOBR	apolipoprotein B receptor	0.011
P2RX1	purinergic receptor P2X, ligand-gated ion channel, 1	0.011
RHOU	ras homolog gene family, member U	0.011
IL18RAP	interleukin 18 receptor accessory protein	0.011
TCAP	titin-cap (telethonin)	0.011
EMR1	egf-like module containing, mucin-like, hormone receptor-like 1	0.011
FPR1	formyl peptide receptor 1	0.011
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.011
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.011
GREM1	gremlin 1	0.011
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.011
VEGFC	vascular endothelial growth factor C	0.011
CNR2	cannabinoid receptor 2 (macrophage)	0.011
SELL	selectin L	0.011
SH3KBP1	SH3-domain kinase binding protein 1	0.011
STK4	serine/threonine kinase 4	0.011
RGS14	regulator of G-protein signaling 14	0.011
CD34	CD34 molecule	0.011
SIGLEC9	sialic acid binding Ig-like lectin 9	0.011
GRB7	growth factor receptor-bound protein 7	0.011
SOCS6	suppressor of cytokine signaling 6	0.011
LTK	leukocyte receptor tyrosine kinase	0.011
DYSF	dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)	0.011
ACVRL1	activin A receptor type II-like 1	0.010
LRMP	lymphoid-restricted membrane protein	0.010
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.010
CLEC4A	C-type lectin domain family 4, member A	0.010
SIGLEC5	sialic acid binding Ig-like lectin 5	0.010
PLEKHO2	pleckstrin homology domain containing, family O member 2	0.010
NFAM1	NFAT activating protein with ITAM motif 1	0.010
SH3BP2	SH3-domain binding protein 2	0.010
ALOX5AP	arachidonate 5-lipoxygenase-activating protein	0.010
P2RY14	purinergic receptor P2Y, G-protein coupled, 14	0.010
FCN1	ficolin (collagen/fibrinogen domain containing) 1	0.010
PDE4DIP	phosphodiesterase 4D interacting protein	0.010
LRRC33	leucine rich repeat containing 33	0.010
PIK3CG	phosphoinositide-3-kinase, catalytic, gamma polypeptide	0.010
ABL2	v-abl Abelson murine leukemia viral oncogene homolog 2	0.010
SLAMF1	signaling lymphocytic activation molecule family member 1	0.010
SOCS1	suppressor of cytokine signaling 1	0.010
PROM1	prominin 1	0.010