IMP

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Homo sapiens

4 genes annotated in human

semaphorin plexin signaling pathway

A series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "semaphorin plexin signaling pathway"

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Name	Description	Probability	Func Analog Organism
ARHGEF11	Rho guanine nucleotide exchange factor (GEF) 11	0.999
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.955
SEMA4A	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A	0.925	Human Mouse
VEGFA	vascular endothelial growth factor A	0.912
RND1	Rho family GTPase 1	0.868
GAS6	growth arrest-specific 6	0.855
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.755
PLXND1	plexin D1	0.625	Human Mouse
SORBS1	sorbin and SH3 domain containing 1	0.615
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.574
GAB1	GRB2-associated binding protein 1	0.560
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.538
PLXNB1	plexin B1	0.521
MST1R	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)	0.439	Human
SH3RF3	SH3 domain containing ring finger 3	0.391
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.377
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.355
RHOC	ras homolog gene family, member C	0.352
RANBP9	RAN binding protein 9	0.289
HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	0.286
RHOA	ras homolog gene family, member A	0.223
CHN2	chimerin (chimaerin) 2	0.215
EGFR	epidermal growth factor receptor	0.186
PAK2	p21 protein (Cdc42/Rac)-activated kinase 2	0.180
NCKAP1	NCK-associated protein 1	0.168
RAC3	ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)	0.162
OCRL	oculocerebrorenal syndrome of Lowe	0.162
HMOX2	heme oxygenase (decycling) 2	0.158
SEMA6D	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	0.152	Human Fly
EZR	ezrin	0.151
RHOG	ras homolog gene family, member G (rho G)	0.151
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.147
SEMA6A	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.104	Human Mouse Fly
LAT	linker for activation of T cells	0.101
BAK1	BCL2-antagonist/killer 1	0.089
FHOD1	formin homology 2 domain containing 1	0.077
UBE2R2	ubiquitin-conjugating enzyme E2R 2	0.076
PTPRC	protein tyrosine phosphatase, receptor type, C	0.074
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.073
PLXNB2	plexin B2	0.070	Human Mouse
JUP	junction plakoglobin	0.068
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.056
FGFR1	fibroblast growth factor receptor 1	0.055
IQGAP1	IQ motif containing GTPase activating protein 1	0.054
COL6A2	collagen, type VI, alpha 2	0.050
DOCK1	dedicator of cytokinesis 1	0.050
PLEC	plectin	0.049
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.048
PGF	placental growth factor	0.046
SORBS2	sorbin and SH3 domain containing 2	0.045
NRP2	neuropilin 2	0.044	Mouse
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.044
RDX	radixin	0.044
ARHGAP1	Rho GTPase activating protein 1	0.042
CD22	CD22 molecule	0.042
COL4A2	collagen, type IV, alpha 2	0.041
RBMS3	RNA binding motif, single stranded interacting protein 3	0.041
XIAP	X-linked inhibitor of apoptosis	0.040
SH3RF1	SH3 domain containing ring finger 1	0.039
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.038
STAU1	staufen, RNA binding protein, homolog 1 (Drosophila)	0.037
BAIAP2	BAI1-associated protein 2	0.037
PLXNB3	plexin B3	0.034
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.033
SEMA3E	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	0.032	Human
CDH5	cadherin 5, type 2 (vascular endothelium)	0.032
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.031
TGFB3	transforming growth factor, beta 3	0.031
LEPRE1	leucine proline-enriched proteoglycan (leprecan) 1	0.031
MSN	moesin	0.031
FLNB	filamin B, beta	0.031
SYNJ2	synaptojanin 2	0.030
MACF1	microtubule-actin crosslinking factor 1	0.030
TENC1	tensin like C1 domain containing phosphatase (tensin 2)	0.028
ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	0.028
IQGAP2	IQ motif containing GTPase activating protein 2	0.028
UNC119	unc-119 homolog (C. elegans)	0.027
NRP1	neuropilin 1	0.027	Mouse Rat
KIAA1199	KIAA1199	0.027
ARHGEF12	Rho guanine nucleotide exchange factor (GEF) 12	0.026
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.026
PTPRA	protein tyrosine phosphatase, receptor type, A	0.025
CBFA2T3	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	0.025
COL5A1	collagen, type V, alpha 1	0.025
BMP1	bone morphogenetic protein 1	0.025
TGFBR1	transforming growth factor, beta receptor 1	0.024
CUL7	cullin 7	0.024
ADAM15	ADAM metallopeptidase domain 15	0.023
LIMK1	LIM domain kinase 1	0.023
MAP1A	microtubule-associated protein 1A	0.023
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.023
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.023
PARD6G	par-6 partitioning defective 6 homolog gamma (C. elegans)	0.023
ADCY6	adenylate cyclase 6	0.023
RIPK2	receptor-interacting serine-threonine kinase 2	0.022
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.022
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.022
RHOU	ras homolog gene family, member U	0.022
ENG	endoglin	0.022
ARHGEF4	Rho guanine nucleotide exchange factor (GEF) 4	0.022
EWSR1	Ewing sarcoma breakpoint region 1	0.022
STC1	stanniocalcin 1	0.021
SPRY4	sprouty homolog 4 (Drosophila)	0.021
PTMA	prothymosin, alpha	0.021
DCBLD2	discoidin, CUB and LCCL domain containing 2	0.021
PFDN1	prefoldin subunit 1	0.021
MAPK8IP2	mitogen-activated protein kinase 8 interacting protein 2	0.020
UNKL	unkempt homolog (Drosophila)-like	0.020
RTKN	rhotekin	0.020
CTNNBIP1	catenin, beta interacting protein 1	0.020
WASF2	WAS protein family, member 2	0.020
PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.020
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.020
DLGAP4	discs, large (Drosophila) homolog-associated protein 4	0.020
GAB2	GRB2-associated binding protein 2	0.020
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.020
DOCK2	dedicator of cytokinesis 2	0.019
IRS1	insulin receptor substrate 1	0.019
NCKIPSD	NCK interacting protein with SH3 domain	0.019
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	0.019
PTPN21	protein tyrosine phosphatase, non-receptor type 21	0.019
CMIP	c-Maf-inducing protein	0.019
FGD1	FYVE, RhoGEF and PH domain containing 1	0.019
TGFB1	transforming growth factor, beta 1	0.019
CRIP2	cysteine-rich protein 2	0.018
BNC2	basonuclin 2	0.018
PPAP2B	phosphatidic acid phosphatase type 2B	0.018
CD276	CD276 molecule	0.017
PCDH17	protocadherin 17	0.017
LARGE	like-glycosyltransferase	0.017
FURIN	furin (paired basic amino acid cleaving enzyme)	0.017
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.017
ARL2BP	ADP-ribosylation factor-like 2 binding protein	0.017
RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	0.017
CTNND1	catenin (cadherin-associated protein), delta 1	0.017
CACNB3	calcium channel, voltage-dependent, beta 3 subunit	0.017
GIT1	G protein-coupled receptor kinase interacting ArfGAP 1	0.016
INSR	insulin receptor	0.016
RAMP2	receptor (G protein-coupled) activity modifying protein 2	0.016
PVR	poliovirus receptor	0.016
TGFA	transforming growth factor, alpha	0.016
AGAP1	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	0.016
RARG	retinoic acid receptor, gamma	0.016
PAK7	p21 protein (Cdc42/Rac)-activated kinase 7	0.016
TIMP3	TIMP metallopeptidase inhibitor 3	0.016
ARHGAP31	Rho GTPase activating protein 31	0.016
ANGPTL2	angiopoietin-like 2	0.016
RPS6KA2	ribosomal protein S6 kinase, 90kDa, polypeptide 2	0.016
RAB11B	RAB11B, member RAS oncogene family	0.016
NFASC	neurofascin	0.016
SPRY2	sprouty homolog 2 (Drosophila)	0.015
IL1RAPL1	interleukin 1 receptor accessory protein-like 1	0.015
MCC	mutated in colorectal cancers	0.015
PLVAP	plasmalemma vesicle associated protein	0.015
NCF2	neutrophil cytosolic factor 2	0.015
JAK2	Janus kinase 2	0.015
EPHB4	EPH receptor B4	0.015
SLC4A4	solute carrier family 4, sodium bicarbonate cotransporter, member 4	0.015
SEMA5B	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	0.015
DIAPH1	diaphanous homolog 1 (Drosophila)	0.015
REPS2	RALBP1 associated Eps domain containing 2	0.015
SERPINH1	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)	0.015
HMGXB3	HMG box domain containing 3	0.015
ST8SIA4	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	0.015
ARFIP2	ADP-ribosylation factor interacting protein 2	0.015
GHR	growth hormone receptor	0.015
OSTF1	osteoclast stimulating factor 1	0.015
ABCA2	ATP-binding cassette, sub-family A (ABC1), member 2	0.015
TAF1C	TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa	0.014
ZXDC	ZXD family zinc finger C	0.014
GRB2	growth factor receptor-bound protein 2	0.014
NOVA1	neuro-oncological ventral antigen 1	0.014
HAAO	3-hydroxyanthranilate 3,4-dioxygenase	0.014
MPP1	membrane protein, palmitoylated 1, 55kDa	0.014
UNC5B	unc-5 homolog B (C. elegans)	0.014
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.014
RND2	Rho family GTPase 2	0.014
EFS	embryonal Fyn-associated substrate	0.014
PTPRB	protein tyrosine phosphatase, receptor type, B	0.014
ITGA10	integrin, alpha 10	0.014
SLIT2	slit homolog 2 (Drosophila)	0.014
RHOD	ras homolog gene family, member D	0.014
RAB35	RAB35, member RAS oncogene family	0.014
PTBP1	polypyrimidine tract binding protein 1	0.014
NGEF	neuronal guanine nucleotide exchange factor	0.014
MAST2	microtubule associated serine/threonine kinase 2	0.014
ITGB4	integrin, beta 4	0.014
FRS3	fibroblast growth factor receptor substrate 3	0.013
IGF2BP1	insulin-like growth factor 2 mRNA binding protein 1	0.013
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.013
APLNR	apelin receptor	0.013
AGRN	agrin	0.013
MAPK8IP3	mitogen-activated protein kinase 8 interacting protein 3	0.013
PLXNA2	plexin A2	0.013	Human Mouse Fly
APLP1	amyloid beta (A4) precursor-like protein 1	0.013
ARHGAP15	Rho GTPase activating protein 15	0.013
CELSR2	cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)	0.013
TWF2	twinfilin, actin-binding protein, homolog 2 (Drosophila)	0.013
ACCN2	amiloride-sensitive cation channel 2, neuronal	0.013
PLCG1	phospholipase C, gamma 1	0.013
MMRN2	multimerin 2	0.013
EDIL3	EGF-like repeats and discoidin I-like domains 3	0.013
COL4A5	collagen, type IV, alpha 5	0.013
PTPRD	protein tyrosine phosphatase, receptor type, D	0.013
PLD2	phospholipase D2	0.013
CST1	cystatin SN	0.013
UTRN	utrophin	0.013
TUBB3	tubulin, beta 3	0.013
NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	0.013
ABL2	v-abl Abelson murine leukemia viral oncogene homolog 2	0.013
TAF1B	TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa	0.013
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.013
PARM1	prostate androgen-regulated mucin-like protein 1	0.012
KLHL5	kelch-like 5 (Drosophila)	0.012
OSMR	oncostatin M receptor	0.012
GLI3	GLI family zinc finger 3	0.012
ARHGEF17	Rho guanine nucleotide exchange factor (GEF) 17	0.012
CALR	calreticulin	0.012
WDR73	WD repeat domain 73	0.012
PHLDB1	pleckstrin homology-like domain, family B, member 1	0.012
PTPRF	protein tyrosine phosphatase, receptor type, F	0.012
PPP1R1A	protein phosphatase 1, regulatory (inhibitor) subunit 1A	0.012
NCS1	neuronal calcium sensor 1	0.012
IGF1R	insulin-like growth factor 1 receptor	0.012
PTPRU	protein tyrosine phosphatase, receptor type, U	0.012
SORBS3	sorbin and SH3 domain containing 3	0.012
VEGFC	vascular endothelial growth factor C	0.012
SH2B2	SH2B adaptor protein 2	0.012
EFNB1	ephrin-B1	0.012
KPNA6	karyopherin alpha 6 (importin alpha 7)	0.012
KIAA0284	KIAA0284	0.012
RIPK4	receptor-interacting serine-threonine kinase 4	0.012
ACVRL1	activin A receptor type II-like 1	0.012
ZFP28	zinc finger protein 28 homolog (mouse)	0.012
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.012
SLC6A8	solute carrier family 6 (neurotransmitter transporter, creatine), member 8	0.012
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.012
MAP3K2	mitogen-activated protein kinase kinase kinase 2	0.012
ELK3	ELK3, ETS-domain protein (SRF accessory protein 2)	0.012
SOX13	SRY (sex determining region Y)-box 13	0.012
FAM189A2	family with sequence similarity 189, member A2	0.012
ATP1B2	ATPase, Na+/K+ transporting, beta 2 polypeptide	0.012
COL18A1	collagen, type XVIII, alpha 1	0.012
LHX1	LIM homeobox 1	0.012
VAV1	vav 1 guanine nucleotide exchange factor	0.012
RNF122	ring finger protein 122	0.012
LENG8	leukocyte receptor cluster (LRC) member 8	0.012
LPAR1	lysophosphatidic acid receptor 1	0.012
ETV1	ets variant 1	0.012
DMPK	dystrophia myotonica-protein kinase	0.012
RHOB	ras homolog gene family, member B	0.011
CASKIN2	CASK interacting protein 2	0.011
GPD1	glycerol-3-phosphate dehydrogenase 1 (soluble)	0.011
TRIO	triple functional domain (PTPRF interacting)	0.011
ADCY3	adenylate cyclase 3	0.011
PHF17	PHD finger protein 17	0.011
ARHGEF6	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6	0.011
NEO1	neogenin 1	0.011
SLCO2A1	solute carrier organic anion transporter family, member 2A1	0.011
POU3F1	POU class 3 homeobox 1	0.011
CDC42SE1	CDC42 small effector 1	0.011
SEMA3A	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	0.011	Human Mouse
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.011
RAB5C	RAB5C, member RAS oncogene family	0.011
TLR3	toll-like receptor 3	0.011
RAP1GDS1	RAP1, GTP-GDP dissociation stimulator 1	0.011
ADAMTSL2	ADAMTS-like 2	0.011
SYNPO	synaptopodin	0.011
SRGAP3	SLIT-ROBO Rho GTPase activating protein 3	0.011
PODXL	podocalyxin-like	0.011
WDYHV1	WDYHV motif containing 1	0.011
FRMD4A	FERM domain containing 4A	0.011
PIK3CB	phosphoinositide-3-kinase, catalytic, beta polypeptide	0.011
KIF5A	kinesin family member 5A	0.011
MC1R	melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)	0.011
NRN1	neuritin 1	0.011
TNKS1BP1	tankyrase 1 binding protein 1, 182kDa	0.011
APOBEC2	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2	0.011
MUS81	MUS81 endonuclease homolog (S. cerevisiae)	0.011
DOCK3	dedicator of cytokinesis 3	0.011
TRPV4	transient receptor potential cation channel, subfamily V, member 4	0.011
NDP	Norrie disease (pseudoglioma)	0.011
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.011
GATA4	GATA binding protein 4	0.011
HSF4	heat shock transcription factor 4	0.011
VWF	von Willebrand factor	0.011
FSCN1	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)	0.011
HDAC11	histone deacetylase 11	0.011
NPAS2	neuronal PAS domain protein 2	0.011
SGK2	serum/glucocorticoid regulated kinase 2	0.011
RGL1	ral guanine nucleotide dissociation stimulator-like 1	0.011
GPC1	glypican 1	0.011
GABRE	gamma-aminobutyric acid (GABA) A receptor, epsilon	0.011
UBE2D3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.011
GFPT2	glutamine-fructose-6-phosphate transaminase 2	0.011
NRSN2	neurensin 2	0.011
A4GALT	alpha 1,4-galactosyltransferase	0.011
GLB1L	galactosidase, beta 1-like	0.011
DSP	desmoplakin	0.010
TNMD	tenomodulin	0.010
PLAT	plasminogen activator, tissue	0.010
NEIL1	nei endonuclease VIII-like 1 (E. coli)	0.010
HSD11B2	hydroxysteroid (11-beta) dehydrogenase 2	0.010
TMEM22	transmembrane protein 22	0.010
ELMO1	engulfment and cell motility 1	0.010
TGFBR3	transforming growth factor, beta receptor III	0.010
FZD4	frizzled homolog 4 (Drosophila)	0.010
EXT2	exostosin 2	0.010
MMP15	matrix metallopeptidase 15 (membrane-inserted)	0.010
TP53I11	tumor protein p53 inducible protein 11	0.010
SPOCK2	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2	0.010
KCNJ2	potassium inwardly-rectifying channel, subfamily J, member 2	0.010
ABCB9	ATP-binding cassette, sub-family B (MDR/TAP), member 9	0.010
NGFR	nerve growth factor receptor	0.010
BFSP1	beaded filament structural protein 1, filensin	0.010
PDE3A	phosphodiesterase 3A, cGMP-inhibited	0.010
SH3D19	SH3 domain containing 19	0.010
RGS12	regulator of G-protein signaling 12	0.010
KDM5C	lysine (K)-specific demethylase 5C	0.010
CREB5	cAMP responsive element binding protein 5	0.010
LOXL2	lysyl oxidase-like 2	0.010
PLEKHA4	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4	0.010
ADAM12	ADAM metallopeptidase domain 12	0.010
DAGLA	diacylglycerol lipase, alpha	0.010
PAK3	p21 protein (Cdc42/Rac)-activated kinase 3	0.010
TSPAN15	tetraspanin 15	0.010
GPR161	G protein-coupled receptor 161	0.010
ITGA9	integrin, alpha 9	0.010
GEMIN8	gem (nuclear organelle) associated protein 8	0.010
PMEL	premelanosome protein	0.010
PTCH1	patched 1	0.010
PTPRM	protein tyrosine phosphatase, receptor type, M	0.010
KIRREL	kin of IRRE like (Drosophila)	0.010
GJA4	gap junction protein, alpha 4, 37kDa	0.010
VAV2	vav 2 guanine nucleotide exchange factor	0.010