IMP

Process View

Homo sapiens

36 genes annotated in human

primary immunodeficiency disease

DOID:612

An immune system disease that results when one or more essential parts of the immune system is missing or not working properly at birth due to a genetic mutation.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "primary immunodeficiency disease"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "primary immunodeficiency disease" (in gray)

Name	Description	Probability	Func Analog Organism
NCF1	neutrophil cytosolic factor 1	1.000
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	1.000	Human
NCF4	neutrophil cytosolic factor 4, 40kDa	1.000
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.999	Human
TAP2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	0.988
CYBA	cytochrome b-245, alpha polypeptide	0.987
TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.984
NCF2	neutrophil cytosolic factor 2	0.971
TAPBP	TAP binding protein (tapasin)	0.968
CD79A	CD79a molecule, immunoglobulin-associated alpha	0.964
BLNK	B-cell linker	0.933
BTK	Bruton agammaglobulinemia tyrosine kinase	0.931
APLF	aprataxin and PNKP like factor	0.902
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.877	Human
CD19	CD19 molecule	0.792
BCL3	B-cell CLL/lymphoma 3	0.791
PRKCB	protein kinase C, beta	0.769
PSMB9	proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)	0.760
CD22	CD22 molecule	0.608
TRIM9	tripartite motif containing 9	0.562
CD79B	CD79b molecule, immunoglobulin-associated beta	0.534
PSMB8	proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)	0.522
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.472
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.468
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.432	Human
SYK	spleen tyrosine kinase	0.364
TNIP2	TNFAIP3 interacting protein 2	0.313
PRKCA	protein kinase C, alpha	0.259
CD40	CD40 molecule, TNF receptor superfamily member 5	0.225
ACTB	actin, beta	0.220
IBTK	inhibitor of Bruton agammaglobulinemia tyrosine kinase	0.188
RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	0.187
HLA-A	major histocompatibility complex, class I, A	0.184
GNAI2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	0.178
XRCC4	X-ray repair complementing defective repair in Chinese hamster cells 4	0.151
MAP3K8	mitogen-activated protein kinase kinase kinase 8	0.148
CDCP1	CUB domain containing protein 1	0.146
PRKCD	protein kinase C, delta	0.127
BLK	B lymphoid tyrosine kinase	0.119	Human
HLA-F	major histocompatibility complex, class I, F	0.113
TSPAN4	tetraspanin 4	0.099
NFKBIB	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	0.096
MZB1	marginal zone B and B1 cell-specific protein	0.096
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.093
INO80B	INO80 complex subunit B	0.090
FCER2	Fc fragment of IgE, low affinity II, receptor for (CD23)	0.089
HLA-G	major histocompatibility complex, class I, G	0.079
PDIA3	protein disulfide isomerase family A, member 3	0.079
NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.078
IL4R	interleukin 4 receptor	0.076
CAPN1	calpain 1, (mu/I) large subunit	0.076
B2M	beta-2-microglobulin	0.075
TNFSF13B	tumor necrosis factor (ligand) superfamily, member 13b	0.074
CD9	CD9 molecule	0.073	Human
SPIB	Spi-B transcription factor (Spi-1/PU.1 related)	0.073
TCL1A	T-cell leukemia/lymphoma 1A	0.070
POU2AF1	POU class 2 associating factor 1	0.067
MS4A1	membrane-spanning 4-domains, subfamily A, member 1	0.057
CXCR5	chemokine (C-X-C motif) receptor 5	0.053
FAIM3	Fas apoptotic inhibitory molecule 3	0.051
TNIP1	TNFAIP3 interacting protein 1	0.043
VPREB3	pre-B lymphocyte 3	0.043
HLA-C	major histocompatibility complex, class I, C	0.040
IRF1	interferon regulatory factor 1	0.040
IL32	interleukin 32	0.038
ARID3A	AT rich interactive domain 3A (BRIGHT-like)	0.037
FCER1G	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	0.037
PPIF	peptidylprolyl isomerase F	0.035
PNOC	prepronociceptin	0.034
LY86	lymphocyte antigen 86	0.034
C3	complement component 3	0.033	Human
CD1C	CD1c molecule	0.031
CD27	CD27 molecule	0.031
PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)	0.031
HLA-E	major histocompatibility complex, class I, E	0.029
SETD7	SET domain containing (lysine methyltransferase) 7	0.029
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.029
TNFRSF17	tumor necrosis factor receptor superfamily, member 17	0.028
ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	0.028
IL7R	interleukin 7 receptor	0.028
IGL@	immunoglobulin lambda locus	0.027
CD99	CD99 molecule	0.026
IRF8	interferon regulatory factor 8	0.026
LTB	lymphotoxin beta (TNF superfamily, member 3)	0.026
SELL	selectin L	0.025
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.024	Human
MSN	moesin	0.024
HLA-DOB	major histocompatibility complex, class II, DO beta	0.024
PSME1	proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)	0.024
TAGLN2	transgelin 2	0.024
CD72	CD72 molecule	0.023
MAP4K1	mitogen-activated protein kinase kinase kinase kinase 1	0.023
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.023
RFX5	regulatory factor X, 5 (influences HLA class II expression)	0.023
STAP1	signal transducing adaptor family member 1	0.022
IGJ	immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides	0.022
CD180	CD180 molecule	0.022
PASK	PAS domain containing serine/threonine kinase	0.022
IRF4	interferon regulatory factor 4	0.022
TRAF5	TNF receptor-associated factor 5	0.021
PSME2	proteasome (prosome, macropain) activator subunit 2 (PA28 beta)	0.021
ZC3H12A	zinc finger CCCH-type containing 12A	0.021
RHOH	ras homolog gene family, member H	0.021
SH3BP5	SH3-domain binding protein 5 (BTK-associated)	0.021
STK10	serine/threonine kinase 10	0.021
NHEJ1	nonhomologous end-joining factor 1	0.021
GLA	galactosidase, alpha	0.020
CCR2	chemokine (C-C motif) receptor 2	0.020
GFI1	growth factor independent 1 transcription repressor	0.020
HLA-B	major histocompatibility complex, class I, B	0.019
CALR	calreticulin	0.019
HLA-DOA	major histocompatibility complex, class II, DO alpha	0.019
FLNA	filamin A, alpha	0.018
SOCS1	suppressor of cytokine signaling 1	0.018
CD86	CD86 molecule	0.018
HLA-DMA	major histocompatibility complex, class II, DM alpha	0.018
TRAF3	TNF receptor-associated factor 3	0.018
UBASH3B	ubiquitin associated and SH3 domain containing B	0.018
PAX5	paired box 5	0.017
CBLB	Cas-Br-M (murine) ecotropic retroviral transforming sequence b	0.017
PIM2	pim-2 oncogene	0.017
GPR18	G protein-coupled receptor 18	0.017
THOC5	THO complex 5	0.017
GRPEL1	GrpE-like 1, mitochondrial (E. coli)	0.016
CR2	complement component (3d/Epstein Barr virus) receptor 2	0.016
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.015
CD52	CD52 molecule	0.015
LRMP	lymphoid-restricted membrane protein	0.015
CXCL13	chemokine (C-X-C motif) ligand 13	0.015
ZNF259	zinc finger protein 259	0.015
DLG5	discs, large homolog 5 (Drosophila)	0.014
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.014
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.014
CSF2RA	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	0.014
HLA-DMB	major histocompatibility complex, class II, DM beta	0.014
SASH3	SAM and SH3 domain containing 3	0.014
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.014
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.014
CCR7	chemokine (C-C motif) receptor 7	0.014
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.014
FASLG	Fas ligand (TNF superfamily, member 6)	0.013
ITK	IL2-inducible T-cell kinase	0.013
MATK	megakaryocyte-associated tyrosine kinase	0.013
P2RX5	purinergic receptor P2X, ligand-gated ion channel, 5	0.013
ADAMDEC1	ADAM-like, decysin 1	0.013
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.013	Human
SIT1	signaling threshold regulating transmembrane adaptor 1	0.013
IL2RA	interleukin 2 receptor, alpha	0.012
IKZF1	IKAROS family zinc finger 1 (Ikaros)	0.012
FAS	Fas (TNF receptor superfamily, member 6)	0.012
GNB1	guanine nucleotide binding protein (G protein), beta polypeptide 1	0.012
CD37	CD37 molecule	0.012
PSMB10	proteasome (prosome, macropain) subunit, beta type, 10	0.012
TRAF3IP3	TRAF3 interacting protein 3	0.012
CD2AP	CD2-associated protein	0.012
ACTN4	actinin, alpha 4	0.012
CD38	CD38 molecule	0.012
GTF2I	general transcription factor IIi	0.012
FAM65B	family with sequence similarity 65, member B	0.012
CCR6	chemokine (C-C motif) receptor 6	0.012
TRAF4	TNF receptor-associated factor 4	0.012
LAT2	linker for activation of T cells family, member 2	0.012
DDOST	dolichyl-diphosphooligosaccharide--protein glycosyltransferase	0.012
CHUK	conserved helix-loop-helix ubiquitous kinase	0.012
FCRLA	Fc receptor-like A	0.012
VPREB1	pre-B lymphocyte 1	0.012
ZHX1	zinc fingers and homeoboxes 1	0.011
IKZF3	IKAROS family zinc finger 3 (Aiolos)	0.011
HCP5	HLA complex P5	0.011
TIFA	TRAF-interacting protein with forkhead-associated domain	0.011
CUTA	cutA divalent cation tolerance homolog (E. coli)	0.011
BANK1	B-cell scaffold protein with ankyrin repeats 1	0.011
IKBKE	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	0.011
MAPKAPK3	mitogen-activated protein kinase-activated protein kinase 3	0.011
ERMP1	endoplasmic reticulum metallopeptidase 1	0.011
TNFSF13	tumor necrosis factor (ligand) superfamily, member 13	0.011
CPT1A	carnitine palmitoyltransferase 1A (liver)	0.011
SIRT6	sirtuin 6	0.011
FCRL2	Fc receptor-like 2	0.011
IL7	interleukin 7	0.011
GP1BB	glycoprotein Ib (platelet), beta polypeptide	0.011
SBNO2	strawberry notch homolog 2 (Drosophila)	0.011
LMO2	LIM domain only 2 (rhombotin-like 1)	0.011
HK2	hexokinase 2	0.011
RGS14	regulator of G-protein signaling 14	0.011
PLXND1	plexin D1	0.011
CD2	CD2 molecule	0.011
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.011
CD151	CD151 molecule (Raph blood group)	0.010
GADD45GIP1	growth arrest and DNA-damage-inducible, gamma interacting protein 1	0.010
HP	haptoglobin	0.010
HLA-DRB4	major histocompatibility complex, class II, DR beta 4	0.010
HCK	hemopoietic cell kinase	0.010	Human
LCP1	lymphocyte cytosolic protein 1 (L-plastin)	0.010
IL2RG	interleukin 2 receptor, gamma	0.009
RFXAP	regulatory factor X-associated protein	0.008
IGLL1	immunoglobulin lambda-like polypeptide 1	0.008
ADA	adenosine deaminase	0.007
CIITA	class II, major histocompatibility complex, transactivator	0.007
CYBB	cytochrome b-245, beta polypeptide	0.007
C5	complement component 5	0.006
ICOS	inducible T-cell co-stimulator	0.005
TNFRSF13B	tumor necrosis factor receptor superfamily, member 13B	0.005
RFXANK	regulatory factor X-associated ankyrin-containing protein	0.005
CFI	complement factor I	0.004
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.004
LRRC8A	leucine rich repeat containing 8 family, member A	0.003
TNFRSF13C	tumor necrosis factor receptor superfamily, member 13C	0.003
LIG4	ligase IV, DNA, ATP-dependent	0.003
LRBA	LPS-responsive vesicle trafficking, beach and anchor containing	0.003
CD81	CD81 molecule	0.002
TBX1	T-box 1	0.001
PNP	purine nucleoside phosphorylase	0.001
AK2	adenylate kinase 2	0.001