IMP

Process View

Homo sapiens

33 genes annotated in human

response to retinoic acid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "response to retinoic acid"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "response to retinoic acid" (in gray)

Name	Description	Probability	Func Analog Organism
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.955	Human
RXRA	retinoid X receptor, alpha	0.875
FYN	FYN oncogene related to SRC, FGR, YES	0.869	Human
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.462
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.403
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.394
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.310
MED25	mediator complex subunit 25	0.281
SYK	spleen tyrosine kinase	0.236
BCAR1	breast cancer anti-estrogen resistance 1	0.200
NCOA1	nuclear receptor coactivator 1	0.198
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.190
RARA	retinoic acid receptor, alpha	0.188
GRB10	growth factor receptor-bound protein 10	0.176
XIAP	X-linked inhibitor of apoptosis	0.161
NCOR2	nuclear receptor corepressor 2	0.154
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.146
MYD88	myeloid differentiation primary response gene (88)	0.124
HR	hairless homolog (mouse)	0.109
CDK6	cyclin-dependent kinase 6	0.101
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.096
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.091
PCGF2	polycomb group ring finger 2	0.089
FOXD3	forkhead box D3	0.080
CCND1	cyclin D1	0.077
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.077
PLCG1	phospholipase C, gamma 1	0.075
ANGPT2	angiopoietin 2	0.071
EGFR	epidermal growth factor receptor	0.071
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.070
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.064
HNF4A	hepatocyte nuclear factor 4, alpha	0.064	Human
CCND3	cyclin D3	0.062
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.062
SPRR2A	small proline-rich protein 2A	0.059
SNTB2	syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)	0.058
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.055
YAP1	Yes-associated protein 1	0.051	Mouse
CBX8	chromobox homolog 8	0.050
PVRL1	poliovirus receptor-related 1 (herpesvirus entry mediator C)	0.050
HIPK2	homeodomain interacting protein kinase 2	0.049
MDFI	MyoD family inhibitor	0.047
LGALS3	lectin, galactoside-binding, soluble, 3	0.043
SOX2	SRY (sex determining region Y)-box 2	0.041	Human Mouse
SMAD7	SMAD family member 7	0.040
APAF1	apoptotic peptidase activating factor 1	0.035
PPARG	peroxisome proliferator-activated receptor gamma	0.035
FAM46A	family with sequence similarity 46, member A	0.033
BMI1	BMI1 polycomb ring finger oncogene	0.032
EFNA1	ephrin-A1	0.032
INO80B	INO80 complex subunit B	0.031
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.030	Human
ESR1	estrogen receptor 1	0.028
COL6A1	collagen, type VI, alpha 1	0.028
BCR	breakpoint cluster region	0.028
GRB2	growth factor receptor-bound protein 2	0.028
PTPN23	protein tyrosine phosphatase, non-receptor type 23	0.027
TGFB1	transforming growth factor, beta 1	0.027
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.027
INSR	insulin receptor	0.027	Human
PTEN	phosphatase and tensin homolog	0.026
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.026
FGF18	fibroblast growth factor 18	0.026
CCND2	cyclin D2	0.026
EPHB2	EPH receptor B2	0.026	Human
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.026
PPARA	peroxisome proliferator-activated receptor alpha	0.026	Human
LOX	lysyl oxidase	0.026
BLNK	B-cell linker	0.026
EFNA5	ephrin-A5	0.025
ERBB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.025
EPOR	erythropoietin receptor	0.025
NCK1	NCK adaptor protein 1	0.025
CBX4	chromobox homolog 4	0.024
COL2A1	collagen, type II, alpha 1	0.024	Rat
SNX33	sorting nexin 33	0.024
SPOP	speckle-type POZ protein	0.024
POU3F2	POU class 3 homeobox 2	0.024
COL4A1	collagen, type IV, alpha 1	0.024
LPXN	leupaxin	0.024
SRCIN1	SRC kinase signaling inhibitor 1	0.024
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.023
FSTL1	follistatin-like 1	0.023
DNM1	dynamin 1	0.023
AMPH	amphiphysin	0.022
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.022	Rat
ANGPT1	angiopoietin 1	0.022
KLF6	Kruppel-like factor 6	0.022
LY96	lymphocyte antigen 96	0.022
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.022	Rat
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.021
PDCD6IP	programmed cell death 6 interacting protein	0.021
NCOA6	nuclear receptor coactivator 6	0.021
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.021
TJP1	tight junction protein 1 (zona occludens 1)	0.021
ALDH2	aldehyde dehydrogenase 2 family (mitochondrial)	0.021
ESRRG	estrogen-related receptor gamma	0.021
YES1	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	0.020	Human Mouse
PCOLCE	procollagen C-endopeptidase enhancer	0.020
THBS1	thrombospondin 1	0.020
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.020
USP11	ubiquitin specific peptidase 11	0.020
TBX5	T-box 5	0.020
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.020
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.020
RIN1	Ras and Rab interactor 1	0.020
LTK	leukocyte receptor tyrosine kinase	0.020
MAPK14	mitogen-activated protein kinase 14	0.019
EPHB3	EPH receptor B3	0.019	Human
RING1	ring finger protein 1	0.019
LAT	linker for activation of T cells	0.018
JAK2	Janus kinase 2	0.018
WNT1	wingless-type MMTV integration site family, member 1	0.018	Human
PTPN14	protein tyrosine phosphatase, non-receptor type 14	0.018
FNBP4	formin binding protein 4	0.018
COL4A2	collagen, type IV, alpha 2	0.018
SOS1	son of sevenless homolog 1 (Drosophila)	0.018
COL3A1	collagen, type III, alpha 1	0.018
ELN	elastin	0.018
BAP1	BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)	0.018
RARG	retinoic acid receptor, gamma	0.017
MMP11	matrix metallopeptidase 11 (stromelysin 3)	0.017
NDUFA11	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa	0.017
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.017
NCOA3	nuclear receptor coactivator 3	0.017
EFNB3	ephrin-B3	0.017
TICAM2	toll-like receptor adaptor molecule 2	0.017
HCK	hemopoietic cell kinase	0.016	Human
HCLS1	hematopoietic cell-specific Lyn substrate 1	0.016
PVRL3	poliovirus receptor-related 3	0.016
MARCKSL1	MARCKS-like 1	0.016
ADAM15	ADAM metallopeptidase domain 15	0.016
SFRP1	secreted frizzled-related protein 1	0.016
A2M	alpha-2-macroglobulin	0.016
FBXW11	F-box and WD repeat domain containing 11	0.016
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.016
COL5A1	collagen, type V, alpha 1	0.016
SLC9A3R2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.015
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.015
PDGFA	platelet-derived growth factor alpha polypeptide	0.015
CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	0.015
SALL2	sal-like 2 (Drosophila)	0.015
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.015
DIABLO	diablo, IAP-binding mitochondrial protein	0.015
CBX6	chromobox homolog 6	0.015
MLL3	myeloid/lymphoid or mixed-lineage leukemia 3	0.015
PVRL2	poliovirus receptor-related 2 (herpesvirus entry mediator B)	0.014
MED1	mediator complex subunit 1	0.014
THBS2	thrombospondin 2	0.014
MFAP2	microfibrillar-associated protein 2	0.014
WNT4	wingless-type MMTV integration site family, member 4	0.014	Human
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.014	Human
MGEA5	meningioma expressed antigen 5 (hyaluronidase)	0.014
IHH	Indian hedgehog	0.014
TGFB1I1	transforming growth factor beta 1 induced transcript 1	0.014
PAX3	paired box 3	0.014
MATK	megakaryocyte-associated tyrosine kinase	0.014
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.014
AMOTL1	angiomotin like 1	0.014
LCK	lymphocyte-specific protein tyrosine kinase	0.013	Human
SOX21	SRY (sex determining region Y)-box 21	0.013
NFATC4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	0.013
IRS1	insulin receptor substrate 1	0.013
MED28	mediator complex subunit 28	0.013
SULT2B1	sulfotransferase family, cytosolic, 2B, member 1	0.013
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.013
SNX9	sorting nexin 9	0.013
BMP7	bone morphogenetic protein 7	0.013
COL7A1	collagen, type VII, alpha 1	0.013
ZNF746	zinc finger protein 746	0.013
GUCA2A	guanylate cyclase activator 2A (guanylin)	0.013
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.013
CREBBP	CREB binding protein	0.013
PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	0.013
NR1I2	nuclear receptor subfamily 1, group I, member 2	0.013	Human
RAMP2	receptor (G protein-coupled) activity modifying protein 2	0.013
IGFBP3	insulin-like growth factor binding protein 3	0.013
BBS1	Bardet-Biedl syndrome 1	0.013
EFEMP2	EGF containing fibulin-like extracellular matrix protein 2	0.013
CD34	CD34 molecule	0.013
CACNA1G	calcium channel, voltage-dependent, T type, alpha 1G subunit	0.013
TEK	TEK tyrosine kinase, endothelial	0.013	Mouse
COL18A1	collagen, type XVIII, alpha 1	0.013
TIE1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.013	Mouse
BMP2	bone morphogenetic protein 2	0.013	Rat
RXRG	retinoid X receptor, gamma	0.013	Human Rat
HOXA9	homeobox A9	0.012
SFTPD	surfactant protein D	0.012
KCTD17	potassium channel tetramerisation domain containing 17	0.012
MEN1	multiple endocrine neoplasia I	0.012
AQP5	aquaporin 5	0.012
FOXG1	forkhead box G1	0.012
EDN3	endothelin 3	0.012
TTR	transthyretin	0.012
ETS1	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)	0.012
NOTCH3	notch 3	0.012
SMO	smoothened homolog (Drosophila)	0.012
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.012
JUN	jun proto-oncogene	0.012
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.012
ADAMTSL4	ADAMTS-like 4	0.012
MYB	v-myb myeloblastosis viral oncogene homolog (avian)	0.012
TIMP3	TIMP metallopeptidase inhibitor 3	0.012
HYAL1	hyaluronoglucosaminidase 1	0.012
HOXD13	homeobox D13	0.012
NR2F2	nuclear receptor subfamily 2, group F, member 2	0.012	Human
IBTK	inhibitor of Bruton agammaglobulinemia tyrosine kinase	0.012
WIPF1	WAS/WASL interacting protein family, member 1	0.012
FGF4	fibroblast growth factor 4	0.012
GAS6	growth arrest-specific 6	0.012
SREBF2	sterol regulatory element binding transcription factor 2	0.012
BGN	biglycan	0.012
MMP16	matrix metallopeptidase 16 (membrane-inserted)	0.012
ITGB1BP2	integrin beta 1 binding protein (melusin) 2	0.011
RHOB	ras homolog gene family, member B	0.011
NDUFA3	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa	0.011
COL1A1	collagen, type I, alpha 1	0.011	Rat
BCL11A	B-cell CLL/lymphoma 11A (zinc finger protein)	0.011
CBLC	Cas-Br-M (murine) ecotropic retroviral transforming sequence c	0.011
SLC9A1	solute carrier family 9 (sodium/hydrogen exchanger), member 1	0.011
AMOTL2	angiomotin like 2	0.011
FGFR4	fibroblast growth factor receptor 4	0.011
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.011
HDAC3	histone deacetylase 3	0.011
SAMD9	sterile alpha motif domain containing 9	0.011
PROX1	prospero homeobox 1	0.011
SIRT1	sirtuin 1	0.011
OTP	orthopedia homeobox	0.011
EPHA7	EPH receptor A7	0.011	Human
PARVA	parvin, alpha	0.011
LMO2	LIM domain only 2 (rhombotin-like 1)	0.011
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.011
PTK2	PTK2 protein tyrosine kinase 2	0.011	Human
PDCD6	programmed cell death 6	0.011
CXXC5	CXXC finger protein 5	0.011
TBX2	T-box 2	0.011
COL6A2	collagen, type VI, alpha 2	0.011
TRIM29	tripartite motif containing 29	0.011
EFNB2	ephrin-B2	0.011
FOXE1	forkhead box E1 (thyroid transcription factor 2)	0.011
CD22	CD22 molecule	0.011
PGR	progesterone receptor	0.011
IFI16	interferon, gamma-inducible protein 16	0.011
SLC6A2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	0.011
BCOR	BCL6 corepressor	0.011
KLF13	Kruppel-like factor 13	0.011
HES2	hairy and enhancer of split 2 (Drosophila)	0.011
CBX2	chromobox homolog 2	0.010
BCAM	basal cell adhesion molecule (Lutheran blood group)	0.010
DUSP9	dual specificity phosphatase 9	0.010
GAS7	growth arrest-specific 7	0.010
SNRNP70	small nuclear ribonucleoprotein 70kDa (U1)	0.010
CCKBR	cholecystokinin B receptor	0.010
AFF2	AF4/FMR2 family, member 2	0.010
WIF1	WNT inhibitory factor 1	0.010
MRC2	mannose receptor, C type 2	0.010
TCF4	transcription factor 4	0.010
HOXD9	homeobox D9	0.010
TFAP2C	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	0.010
SRF	serum response factor (c-fos serum response element-binding transcription factor)	0.010
POU5F1	POU class 5 homeobox 1	0.010	Mouse
NKD2	naked cuticle homolog 2 (Drosophila)	0.010
ZFYVE9	zinc finger, FYVE domain containing 9	0.010
CBX7	chromobox homolog 7	0.010
FAM107A	family with sequence similarity 107, member A	0.010
IGFBP5	insulin-like growth factor binding protein 5	0.010
SRSF5	serine/arginine-rich splicing factor 5	0.010