IMP

Process View

Homo sapiens

30 genes annotated in human

negative regulation of protein import into nucleus

Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of protein import into nucleus"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of protein import into nucleus" (in gray)

Name	Description	Probability	Func Analog Organism
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.942
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.907
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.848
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.730
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.613
LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	0.600
GSK3B	glycogen synthase kinase 3 beta	0.547
BTRC	beta-transducin repeat containing	0.451	Fly
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.451
NFKBIB	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	0.394	Human Rat
FAS	Fas (TNF receptor superfamily, member 6)	0.348
TNFRSF6B	tumor necrosis factor receptor superfamily, member 6b, decoy	0.333
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.275
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.268
FBXW11	F-box and WD repeat domain containing 11	0.229	Mouse Fly
CHUK	conserved helix-loop-helix ubiquitous kinase	0.227
FADD	Fas (TNFRSF6)-associated via death domain	0.196
AXIN1	axin 1	0.176	Human
DTX3L	deltex 3-like (Drosophila)	0.142
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.140
CACNA1C	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.130
SKP1	S-phase kinase-associated protein 1	0.123
MAP3K8	mitogen-activated protein kinase kinase kinase 8	0.111
DDX58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	0.108
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.105
CREBBP	CREB binding protein	0.103
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.102
PKD2	polycystic kidney disease 2 (autosomal dominant)	0.100
PARP14	poly (ADP-ribose) polymerase family, member 14	0.089	Human
PSMC4	proteasome (prosome, macropain) 26S subunit, ATPase, 4	0.087
PML	promyelocytic leukemia	0.081
TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	0.078
PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	0.077
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.076
HIPK3	homeodomain interacting protein kinase 3	0.074
CFLAR	CASP8 and FADD-like apoptosis regulator	0.070
PKD1	polycystic kidney disease 1 (autosomal dominant)	0.062	Mouse
CUL1	cullin 1	0.061
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.060
ERBB2IP	erbb2 interacting protein	0.060
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.056
IGF1R	insulin-like growth factor 1 receptor	0.054	Worm
PARP9	poly (ADP-ribose) polymerase family, member 9	0.050	Human
PROX1	prospero homeobox 1	0.048
MAP2K5	mitogen-activated protein kinase kinase 5	0.047
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.047
PSMD7	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7	0.044
RARA	retinoic acid receptor, alpha	0.044
MAP3K3	mitogen-activated protein kinase kinase kinase 3	0.042
CKAP5	cytoskeleton associated protein 5	0.041
AXL	AXL receptor tyrosine kinase	0.040
TEK	TEK tyrosine kinase, endothelial	0.040
RANBP3	RAN binding protein 3	0.037
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.036	Human
MAPK3	mitogen-activated protein kinase 3	0.036
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.035
STRN3	striatin, calmodulin binding protein 3	0.034
TCF4	transcription factor 4	0.031
BCL3	B-cell CLL/lymphoma 3	0.031	Human
IRS1	insulin receptor substrate 1	0.030
RCN3	reticulocalbin 3, EF-hand calcium binding domain	0.030
CALD1	caldesmon 1	0.030
GLIS2	GLIS family zinc finger 2	0.030
LATS1	LATS, large tumor suppressor, homolog 1 (Drosophila)	0.029
DYRK4	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4	0.029	Human
RPTOR	regulatory associated protein of MTOR, complex 1	0.028
PSMD6	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	0.027
DDAH2	dimethylarginine dimethylaminohydrolase 2	0.027
SNAI1	snail homolog 1 (Drosophila)	0.026	Human
YAP1	Yes-associated protein 1	0.025	Human
IRS2	insulin receptor substrate 2	0.025
DYRK2	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2	0.024
PRKCZ	protein kinase C, zeta	0.024
LMO4	LIM domain only 4	0.024
SOCS1	suppressor of cytokine signaling 1	0.023
INSR	insulin receptor	0.022	Worm
C3orf15	chromosome 3 open reading frame 15	0.022
BBS10	Bardet-Biedl syndrome 10	0.022
ZNF260	zinc finger protein 260	0.021
GLI1	GLI family zinc finger 1	0.020
PSEN2	presenilin 2 (Alzheimer disease 4)	0.020
JUB	jub, ajuba homolog (Xenopus laevis)	0.020	Human
ZNF84	zinc finger protein 84	0.020
GRB10	growth factor receptor-bound protein 10	0.020
MAPK14	mitogen-activated protein kinase 14	0.020
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.020
C19orf46	chromosome 19 open reading frame 46	0.020
EMD	emerin	0.019
PSMD2	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2	0.019
AMMECR1	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1	0.019
PEX26	peroxisomal biogenesis factor 26	0.019
TJP2	tight junction protein 2 (zona occludens 2)	0.019
APC	adenomatous polyposis coli	0.018	Human
AMOTL1	angiomotin like 1	0.018
SETD7	SET domain containing (lysine methyltransferase) 7	0.018
AMOTL2	angiomotin like 2	0.018
PRKCA	protein kinase C, alpha	0.018
LZTS2	leucine zipper, putative tumor suppressor 2	0.018
NOG	noggin	0.018
SMAD3	SMAD family member 3	0.018
ZNF432	zinc finger protein 432	0.017
TNIP1	TNFAIP3 interacting protein 1	0.017
MOBKL1A	MOB1, Mps One Binder kinase activator-like 1A (yeast)	0.017
TRPC1	transient receptor potential cation channel, subfamily C, member 1	0.017
DEPTOR	DEP domain containing MTOR-interacting protein	0.017
IFIH1	interferon induced with helicase C domain 1	0.016
ZNF585A	zinc finger protein 585A	0.016
RICTOR	RPTOR independent companion of MTOR, complex 2	0.016
UBR1	ubiquitin protein ligase E3 component n-recognin 1	0.016
CSNK1E	casein kinase 1, epsilon	0.016
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.015
SMAD2	SMAD family member 2	0.015
NCF1	neutrophil cytosolic factor 1	0.015
NLRC4	NLR family, CARD domain containing 4	0.015
TP73	tumor protein p73	0.015
HOXA9	homeobox A9	0.015
MAPK1	mitogen-activated protein kinase 1	0.015
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.015
SAMD9L	sterile alpha motif domain containing 9-like	0.015
USP14	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)	0.015
CDC34	cell division cycle 34 homolog (S. cerevisiae)	0.014
FBXO33	F-box protein 33	0.014
ZNF304	zinc finger protein 304	0.014
SREBF2	sterol regulatory element binding transcription factor 2	0.014
TNIP2	TNFAIP3 interacting protein 2	0.014
MAP3K2	mitogen-activated protein kinase kinase kinase 2	0.014
OPTN	optineurin	0.014
NCOA6	nuclear receptor coactivator 6	0.014
PDPK1	3-phosphoinositide dependent protein kinase-1	0.014
MED24	mediator complex subunit 24	0.014
ZNF571	zinc finger protein 571	0.013
GBP5	guanylate binding protein 5	0.013
NFE2L2	nuclear factor (erythroid-derived 2)-like 2	0.013
AXIN2	axin 2	0.013
ZNF512B	zinc finger protein 512B	0.013
DUSP3	dual specificity phosphatase 3	0.013
IFNAR1	interferon (alpha, beta and omega) receptor 1	0.013
RNF213	ring finger protein 213	0.013
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.013
SIRT6	sirtuin 6	0.013
IGF2	insulin-like growth factor 2 (somatomedin A)	0.013
FBXW7	F-box and WD repeat domain containing 7	0.012
PPM1G	protein phosphatase, Mg2+/Mn2+ dependent, 1G	0.012
CAPN1	calpain 1, (mu/I) large subunit	0.012
ZNF420	zinc finger protein 420	0.012
MAP2K1	mitogen-activated protein kinase kinase 1	0.012
KIAA1712	KIAA1712	0.012
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.012	Rat
MOBKL1B	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.012
FZD5	frizzled homolog 5 (Drosophila)	0.012
FLNB	filamin B, beta	0.012
ZNF180	zinc finger protein 180	0.012
TACC1	transforming, acidic coiled-coil containing protein 1	0.012
VASP	vasodilator-stimulated phosphoprotein	0.012
PEA15	phosphoprotein enriched in astrocytes 15	0.012
HMG20A	high mobility group 20A	0.012
QPRT	quinolinate phosphoribosyltransferase	0.012
STX8	syntaxin 8	0.012
RABAC1	Rab acceptor 1 (prenylated)	0.012
PACSIN2	protein kinase C and casein kinase substrate in neurons 2	0.012
AR	androgen receptor	0.012
MASP1	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	0.012
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.012
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.011
TNFRSF14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.011
ZRANB1	zinc finger, RAN-binding domain containing 1	0.011
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.011
PREX1	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	0.011
HDAC1	histone deacetylase 1	0.011
C10orf116	chromosome 10 open reading frame 116	0.011
PYDC2	pyrin domain containing 2	0.011
RHOG	ras homolog gene family, member G (rho G)	0.011
PIK3CA	phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.011
LTBP4	latent transforming growth factor beta binding protein 4	0.011
ITGB1BP1	integrin beta 1 binding protein 1	0.011
FGFR1	fibroblast growth factor receptor 1	0.011
PPM1A	protein phosphatase, Mg2+/Mn2+ dependent, 1A	0.011
AURKB	aurora kinase B	0.011
PAAF1	proteasomal ATPase-associated factor 1	0.011
APOL6	apolipoprotein L, 6	0.011
FHL3	four and a half LIM domains 3	0.011
PSMC1	proteasome (prosome, macropain) 26S subunit, ATPase, 1	0.011
AKAP8L	A kinase (PRKA) anchor protein 8-like	0.011
ARHGEF12	Rho guanine nucleotide exchange factor (GEF) 12	0.010
ZNF529	zinc finger protein 529	0.010
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.010
CAB39	calcium binding protein 39	0.010
C1orf93	chromosome 1 open reading frame 93	0.010
CDC20	cell division cycle 20 homolog (S. cerevisiae)	0.010
SLC9A3R2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.010
DEAF1	deformed epidermal autoregulatory factor 1 (Drosophila)	0.010
PXN	paxillin	0.010
ZFYVE9	zinc finger, FYVE domain containing 9	0.010
ZNF83	zinc finger protein 83	0.010
ZNF227	zinc finger protein 227	0.010
AKT1S1	AKT1 substrate 1 (proline-rich)	0.010
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.010