IMP

Process View

Homo sapiens

24 genes annotated in human

regulation of extrinsic apoptotic signaling pathway via death domain receptors

GO:1902041

Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of extrinsic apoptotic signaling pathway via death domain receptors"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of extrinsic apoptotic signaling pathway via death domain receptors" (in gray)

Name	Description	Probability	Func Analog Organism
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.999
TEK	TEK tyrosine kinase, endothelial	0.969
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.748
FAS	Fas (TNF receptor superfamily, member 6)	0.712
TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	0.605
FGA	fibrinogen alpha chain	0.591
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.500
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.450
TGIF1	TGFB-induced factor homeobox 1	0.370
SNAP23	synaptosomal-associated protein, 23kDa	0.364
TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	0.330
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.328
PDPK1	3-phosphoinositide dependent protein kinase-1	0.305
PLAU	plasminogen activator, urokinase	0.289
FGB	fibrinogen beta chain	0.283
STK3	serine/threonine kinase 3	0.216	Mouse
STRN	striatin, calmodulin binding protein	0.182
VAMP3	vesicle-associated membrane protein 3 (cellubrevin)	0.167
ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	0.153
NAPA	N-ethylmaleimide-sensitive factor attachment protein, alpha	0.149
FTL	ferritin, light polypeptide	0.137
VIM	vimentin	0.135
FN1	fibronectin 1	0.123
SNAP25	synaptosomal-associated protein, 25kDa	0.120
CASP8AP2	caspase 8 associated protein 2	0.119
FGG	fibrinogen gamma chain	0.095
SP100	SP100 nuclear antigen	0.092
MAPK1	mitogen-activated protein kinase 1	0.088
LRP1	low density lipoprotein receptor-related protein 1	0.083
CALCOCO2	calcium binding and coiled-coil domain 2	0.074
PLAT	plasminogen activator, tissue	0.070
BCL2	B-cell CLL/lymphoma 2	0.070
MAP2K1	mitogen-activated protein kinase kinase 1	0.066
TRAF1	TNF receptor-associated factor 1	0.063
STK4	serine/threonine kinase 4	0.056	Mouse
PPM1F	protein phosphatase, Mg2+/Mn2+ dependent, 1F	0.055
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.055
CRADD	CASP2 and RIPK1 domain containing adaptor with death domain	0.055
PLAUR	plasminogen activator, urokinase receptor	0.054
FADD	Fas (TNFRSF6)-associated via death domain	0.051	Mouse
CA12	carbonic anhydrase XII	0.050
UROD	uroporphyrinogen decarboxylase	0.050
TP53BP2	tumor protein p53 binding protein, 2	0.050
BID	BH3 interacting domain death agonist	0.050
PTPRC	protein tyrosine phosphatase, receptor type, C	0.049
BAD	BCL2-associated agonist of cell death	0.046
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.045
FASLG	Fas ligand (TNF superfamily, member 6)	0.042
FHL2	four and a half LIM domains 2	0.041
FBN1	fibrillin 1	0.041
EMP3	epithelial membrane protein 3	0.040
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.039
PLEK	pleckstrin	0.038
MICA	MHC class I polypeptide-related sequence A	0.038
GBP1	guanylate binding protein 1, interferon-inducible	0.038
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.038
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.037
CRP	C-reactive protein, pentraxin-related	0.037
BIRC3	baculoviral IAP repeat containing 3	0.036
BCL2L1	BCL2-like 1	0.034
BAX	BCL2-associated X protein	0.034
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.034
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.033
S100A10	S100 calcium binding protein A10	0.033
ATXN3	ataxin 3	0.032
TNIP1	TNFAIP3 interacting protein 1	0.032
RASSF3	Ras association (RalGDS/AF-6) domain family member 3	0.032
SRI	sorcin	0.030
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.030
SAMD9	sterile alpha motif domain containing 9	0.029
CIB1	calcium and integrin binding 1 (calmyrin)	0.029
NMI	N-myc (and STAT) interactor	0.028
CASP2	caspase 2, apoptosis-related cysteine peptidase	0.025
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.025
GDF5	growth differentiation factor 5	0.024
CFLAR	CASP8 and FADD-like apoptosis regulator	0.024
PSEN1	presenilin 1	0.024
CASP4	caspase 4, apoptosis-related cysteine peptidase	0.023
TRIM38	tripartite motif containing 38	0.023
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.022
FAM190B	family with sequence similarity 190, member B	0.022
TMSB4X	thymosin beta 4, X-linked	0.021
TRAF6	TNF receptor-associated factor 6	0.021
BBC3	BCL2 binding component 3	0.019
COL6A2	collagen, type VI, alpha 2	0.019
CARD11	caspase recruitment domain family, member 11	0.019
RNF4	ring finger protein 4	0.019
BIK	BCL2-interacting killer (apoptosis-inducing)	0.019
COL4A1	collagen, type IV, alpha 1	0.018
TMC6	transmembrane channel-like 6	0.018	Human
DOCK7	dedicator of cytokinesis 7	0.018
BECN1	beclin 1, autophagy related	0.018
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.018
ORM1	orosomucoid 1	0.018
BAK1	BCL2-antagonist/killer 1	0.018
USP15	ubiquitin specific peptidase 15	0.018
TRADD	TNFRSF1A-associated via death domain	0.018
ETS1	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)	0.017
LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	0.017
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.017
IFI16	interferon, gamma-inducible protein 16	0.017
OSMR	oncostatin M receptor	0.017
MAPK3	mitogen-activated protein kinase 3	0.017
ITGB1BP1	integrin beta 1 binding protein 1	0.016
TUBB6	tubulin, beta 6	0.016
IL8	interleukin 8	0.016
TMC8	transmembrane channel-like 8	0.016
VPS13D	vacuolar protein sorting 13 homolog D (S. cerevisiae)	0.016
SOD1	superoxide dismutase 1, soluble	0.016
HSD3B7	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	0.016
DUSP3	dual specificity phosphatase 3	0.016
CD44	CD44 molecule (Indian blood group)	0.016
RARRES2	retinoic acid receptor responder (tazarotene induced) 2	0.016
F2	coagulation factor II (thrombin)	0.016
S100A11	S100 calcium binding protein A11	0.015
TMSB10	thymosin beta 10	0.015
MYD88	myeloid differentiation primary response gene (88)	0.015
PPP1R14A	protein phosphatase 1, regulatory (inhibitor) subunit 14A	0.015
C1orf38	chromosome 1 open reading frame 38	0.015
PEBP4	phosphatidylethanolamine-binding protein 4	0.015
XAF1	XIAP associated factor 1	0.015
SAV1	salvador homolog 1 (Drosophila)	0.015
SPSB1	splA/ryanodine receptor domain and SOCS box containing 1	0.015
ANXA1	annexin A1	0.015
TNFRSF12A	tumor necrosis factor receptor superfamily, member 12A	0.015
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.014
SP140L	SP140 nuclear body protein-like	0.014	Human
SFRP4	secreted frizzled-related protein 4	0.014
SQSTM1	sequestosome 1	0.014
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.014
FLNB	filamin B, beta	0.014
TSPO	translocator protein (18kDa)	0.014
AEBP1	AE binding protein 1	0.014
CSNK1A1	casein kinase 1, alpha 1	0.014
PECAM1	platelet/endothelial cell adhesion molecule	0.014
OAZ1	ornithine decarboxylase antizyme 1	0.013
RRAS	related RAS viral (r-ras) oncogene homolog	0.013
TGFB1	transforming growth factor, beta 1	0.013
ITGB5	integrin, beta 5	0.013
EFEMP2	EGF containing fibulin-like extracellular matrix protein 2	0.013
RASSF2	Ras association (RalGDS/AF-6) domain family member 2	0.013
IRF1	interferon regulatory factor 1	0.013
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	0.013
APOA1	apolipoprotein A-I	0.013
HMGN2	high mobility group nucleosomal binding domain 2	0.013
TNFAIP2	tumor necrosis factor, alpha-induced protein 2	0.013
WIPI1	WD repeat domain, phosphoinositide interacting 1	0.013
TNF	tumor necrosis factor	0.013
DDB2	damage-specific DNA binding protein 2, 48kDa	0.013
USP4	ubiquitin specific peptidase 4 (proto-oncogene)	0.012
ADAR	adenosine deaminase, RNA-specific	0.012
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.012
TIMP1	TIMP metallopeptidase inhibitor 1	0.012
TNIP2	TNFAIP3 interacting protein 2	0.012
CCND2	cyclin D2	0.012
ENG	endoglin	0.012
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.012
MSN	moesin	0.012
RHEB	Ras homolog enriched in brain	0.012
SPHK1	sphingosine kinase 1	0.012
ASPN	asporin	0.012
STAM	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	0.012
IER3	immediate early response 3	0.012
DUSP5	dual specificity phosphatase 5	0.012
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.011
CCND1	cyclin D1	0.011
THY1	Thy-1 cell surface antigen	0.011
VAMP8	vesicle-associated membrane protein 8 (endobrevin)	0.011
PHLDA1	pleckstrin homology-like domain, family A, member 1	0.011
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.011
VHL	von Hippel-Lindau tumor suppressor	0.011
LAPTM5	lysosomal protein transmembrane 5	0.011
TUBA1A	tubulin, alpha 1a	0.011
HMHA1	histocompatibility (minor) HA-1	0.011
ZC3H12A	zinc finger CCCH-type containing 12A	0.011
SOCS3	suppressor of cytokine signaling 3	0.011
MBD1	methyl-CpG binding domain protein 1	0.011
ISG20	interferon stimulated exonuclease gene 20kDa	0.011
EXT2	exostosin 2	0.011
ANKRD28	ankyrin repeat domain 28	0.011
HRK	harakiri, BCL2 interacting protein (contains only BH3 domain)	0.011
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.010
MARCO	macrophage receptor with collagenous structure	0.010
GPX4	glutathione peroxidase 4 (phospholipid hydroperoxidase)	0.010
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.010
FBLN1	fibulin 1	0.010
BCL10	B-cell CLL/lymphoma 10	0.010
DPT	dermatopontin	0.010
LGALS1	lectin, galactoside-binding, soluble, 1	0.010	Human