IMP

Process View

Homo sapiens

23 genes annotated in human

regulation of mitochondrial membrane potential

Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of mitochondrial membrane potential"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of mitochondrial membrane potential" (in gray)

Name	Description	Probability	Func Analog Organism
BCL2L1	BCL2-like 1	0.935
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.831	Human
BCL2	B-cell CLL/lymphoma 2	0.736	Human Mouse
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.700
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.629
PRDX4	peroxiredoxin 4	0.603	Human
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.458
DRD2	dopamine receptor D2	0.453
HCK	hemopoietic cell kinase	0.432	Human
PRDX1	peroxiredoxin 1	0.427	Human
TXN	thioredoxin	0.380
SYK	spleen tyrosine kinase	0.364
BAD	BCL2-associated agonist of cell death	0.353
GRB2	growth factor receptor-bound protein 2	0.272
VDAC1	voltage-dependent anion channel 1	0.260
GCLM	glutamate-cysteine ligase, modifier subunit	0.229	Mouse
LCK	lymphocyte-specific protein tyrosine kinase	0.228	Human
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.219
PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	0.211
GCLC	glutamate-cysteine ligase, catalytic subunit	0.208	Mouse
HSPA8	heat shock 70kDa protein 8	0.200
BLNK	B-cell linker	0.185
PDCD6	programmed cell death 6	0.165
SOD1	superoxide dismutase 1, soluble	0.161
BAK1	BCL2-antagonist/killer 1	0.153
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.147
PRDX3	peroxiredoxin 3	0.138
NLRC4	NLR family, CARD domain containing 4	0.128
FYN	FYN oncogene related to SRC, FGR, YES	0.118	Human
MPDZ	multiple PDZ domain protein	0.114
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.111
NAMPT	nicotinamide phosphoribosyltransferase	0.108
NCK1	NCK adaptor protein 1	0.101
BAX	BCL2-associated X protein	0.098
FADD	Fas (TNFRSF6)-associated via death domain	0.092
FBXO7	F-box protein 7	0.081
WIPF1	WAS/WASL interacting protein family, member 1	0.063
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.062	Mouse
IFITM3	interferon induced transmembrane protein 3 (1-8U)	0.060
SH3KBP1	SH3-domain kinase binding protein 1	0.060
BID	BH3 interacting domain death agonist	0.058
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.055
EIF6	eukaryotic translation initiation factor 6	0.054
HSPD1	heat shock 60kDa protein 1 (chaperonin)	0.047
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.046
SPRR2A	small proline-rich protein 2A	0.042
LRP6	low density lipoprotein receptor-related protein 6	0.042
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.040
LGALS1	lectin, galactoside-binding, soluble, 1	0.039
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.038	Human
CD320	CD320 molecule	0.038
GAS7	growth arrest-specific 7	0.037
MAP1LC3B	microtubule-associated protein 1 light chain 3 beta	0.037
SDHB	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)	0.037
AHSA1	AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)	0.037
NECAB2	N-terminal EF-hand calcium binding protein 2	0.036
CD2AP	CD2-associated protein	0.034
UBASH3B	ubiquitin associated and SH3 domain containing B	0.033
RNF144B	ring finger protein 144B	0.033
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.033
DAZAP2	DAZ associated protein 2	0.032
PRDX2	peroxiredoxin 2	0.032	Human
PRDX6	peroxiredoxin 6	0.032
RIPK2	receptor-interacting serine-threonine kinase 2	0.032
PTGES3	prostaglandin E synthase 3 (cytosolic)	0.031
HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1	0.031
SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.031
PPID	peptidylprolyl isomerase D	0.030	Rat
PARK2	parkinson protein 2, E3 ubiquitin protein ligase (parkin)	0.030
ITK	IL2-inducible T-cell kinase	0.030
RAB5B	RAB5B, member RAS oncogene family	0.030
OPTN	optineurin	0.028
IFI44	interferon-induced protein 44	0.028
STMN2	stathmin-like 2	0.028
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.027
MDH1	malate dehydrogenase 1, NAD (soluble)	0.027
PDHX	pyruvate dehydrogenase complex, component X	0.027
MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	0.026
TBXA2R	thromboxane A2 receptor	0.026
PYCARD	PYD and CARD domain containing	0.026
SERPINB1	serpin peptidase inhibitor, clade B (ovalbumin), member 1	0.025
RNF11	ring finger protein 11	0.025
DAPK1	death-associated protein kinase 1	0.025
DBN1	drebrin 1	0.024
CASP4	caspase 4, apoptosis-related cysteine peptidase	0.024
SQSTM1	sequestosome 1	0.024
IFI27	interferon, alpha-inducible protein 27	0.024	Human
PTEN	phosphatase and tensin homolog	0.024
ZFYVE9	zinc finger, FYVE domain containing 9	0.023
SSTR2	somatostatin receptor 2	0.023	Human
DLD	dihydrolipoamide dehydrogenase	0.023
MAD2L2	MAD2 mitotic arrest deficient-like 2 (yeast)	0.023
DUSP23	dual specificity phosphatase 23	0.022
FCER1G	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	0.022
GABARAPL2	GABA(A) receptor-associated protein-like 2	0.022
VAV1	vav 1 guanine nucleotide exchange factor	0.022
IFI44L	interferon-induced protein 44-like	0.021
RPL10	ribosomal protein L10	0.020
BTK	Bruton agammaglobulinemia tyrosine kinase	0.019	Human
RNR2	l-rRNA	0.019
SSTR3	somatostatin receptor 3	0.019	Human
CDK2AP2	cyclin-dependent kinase 2 associated protein 2	0.019
PARK7	Parkinson disease (autosomal recessive, early onset) 7	0.019
HSD17B10	hydroxysteroid (17-beta) dehydrogenase 10	0.018
AIFM1	apoptosis-inducing factor, mitochondrion-associated, 1	0.018
CD79A	CD79a molecule, immunoglobulin-associated alpha	0.018
KRT5	keratin 5	0.018
DAD1	defender against cell death 1	0.018
MAP2K6	mitogen-activated protein kinase kinase 6	0.017
ADORA1	adenosine A1 receptor	0.017
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.017
ARPC1B	actin related protein 2/3 complex, subunit 1B, 41kDa	0.017
EIF3I	eukaryotic translation initiation factor 3, subunit I	0.017
CCKBR	cholecystokinin B receptor	0.017
DYNLL1	dynein, light chain, LC8-type 1	0.017
IFRD1	interferon-related developmental regulator 1	0.017
CYCS	cytochrome c, somatic	0.017
PDCD6IP	programmed cell death 6 interacting protein	0.017
ARID3A	AT rich interactive domain 3A (BRIGHT-like)	0.016
WWP1	WW domain containing E3 ubiquitin protein ligase 1	0.016
FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	0.016
MKRN1	makorin ring finger protein 1	0.016
HSPE1	heat shock 10kDa protein 1 (chaperonin 10)	0.015
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	0.015
SNX9	sorting nexin 9	0.015
IARS2	isoleucyl-tRNA synthetase 2, mitochondrial	0.015
PPP1R9B	protein phosphatase 1, regulatory (inhibitor) subunit 9B	0.015
PLP2	proteolipid protein 2 (colonic epithelium-enriched)	0.014
HCLS1	hematopoietic cell-specific Lyn substrate 1	0.014
CLTC	clathrin, heavy chain (Hc)	0.014
UQCRC2	ubiquinol-cytochrome c reductase core protein II	0.014
DOK1	docking protein 1, 62kDa (downstream of tyrosine kinase 1)	0.014
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.014
HUWE1	HECT, UBA and WWE domain containing 1	0.014
SQRDL	sulfide quinone reductase-like (yeast)	0.014
ALOX5	arachidonate 5-lipoxygenase	0.014
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.014
TOMM22	translocase of outer mitochondrial membrane 22 homolog (yeast)	0.014
GCH1	GTP cyclohydrolase 1	0.013
USP4	ubiquitin specific peptidase 4 (proto-oncogene)	0.013
CTTN	cortactin	0.013
HRSP12	heat-responsive protein 12	0.013
SDF2L1	stromal cell-derived factor 2-like 1	0.013
RSAD2	radical S-adenosyl methionine domain containing 2	0.013
BIK	BCL2-interacting killer (apoptosis-inducing)	0.013
OAS1	2',5'-oligoadenylate synthetase 1, 40/46kDa	0.013
RHOA	ras homolog gene family, member A	0.013
TXNDC5	thioredoxin domain containing 5 (endoplasmic reticulum)	0.012
PDIA6	protein disulfide isomerase family A, member 6	0.012
NFATC2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.012
RGS14	regulator of G-protein signaling 14	0.012
APOO	apolipoprotein O	0.012
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.012
PRKCQ	protein kinase C, theta	0.012
IMMT	inner membrane protein, mitochondrial	0.012
C4orf14	chromosome 4 open reading frame 14	0.012
EIF4A1	eukaryotic translation initiation factor 4A1	0.012
SLC25A5	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5	0.012
NGF	nerve growth factor (beta polypeptide)	0.012
PLSCR1	phospholipid scramblase 1	0.011
BCL2A1	BCL2-related protein A1	0.011
PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)	0.011
SALL2	sal-like 2 (Drosophila)	0.011
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.011
PNOC	prepronociceptin	0.011
GSTO1	glutathione S-transferase omega 1	0.011
MAPT	microtubule-associated protein tau	0.011
MX1	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	0.011
HTR2C	5-hydroxytryptamine (serotonin) receptor 2C	0.011
TMSB10	thymosin beta 10	0.011
HSPA9	heat shock 70kDa protein 9 (mortalin)	0.011
SH2D1A	SH2 domain containing 1A	0.011
SH3BP5	SH3-domain binding protein 5 (BTK-associated)	0.010
KCNF1	potassium voltage-gated channel, subfamily F, member 1	0.010
ARPC2	actin related protein 2/3 complex, subunit 2, 34kDa	0.010
TALDO1	transaldolase 1	0.010
TUBA1A	tubulin, alpha 1a	0.010
AMBRA1	autophagy/beclin-1 regulator 1	0.010
GTF2I	general transcription factor IIi	0.010