IMP

Process View

Mus musculus

14 genes annotated in mouse

chromosome separation

The cell cycle process in which paired chromosomes are detached from each other. Chromosome separation begins with the release of cohesin complexes from chromosomes; in budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions. Chromosome separation also includes formation of chromatid axes mediated by condensins, and ends with the disentangling of inter-sister catenation catalyzed by topoisomerase II (topo II).

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "chromosome separation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "chromosome separation" (in gray)

Name	Description	Probability	Func Analog Organism
Trp53	transformation related protein 53	0.969
Ctnnb1	catenin (cadherin associated protein), beta 1	0.910
Cdc20	cell division cycle 20 homolog (S. cerevisiae)	0.902	Yeast Worm Fly
Brca2	breast cancer 2	0.588
Ccnb2	cyclin B2	0.492
Ccna2	cyclin A2	0.444
Cdk1	cyclin-dependent kinase 1	0.410
Ccnb1	cyclin B1	0.374
Asf1b	ASF1 anti-silencing function 1 homolog B (S. cerevisiae)	0.287
Mcm6	minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)	0.274
Tsc1	tuberous sclerosis 1	0.263
Cdca5	cell division cycle associated 5	0.237
Cdk2	cyclin-dependent kinase 2	0.183
Kif22	kinesin family member 22	0.181
Mki67	antigen identified by monoclonal antibody Ki 67	0.156
Cdca8	cell division cycle associated 8	0.152
Spag5	sperm associated antigen 5	0.142
Psen1	presenilin 1	0.141
Ccnf	cyclin F	0.141
C330027C09Rik	RIKEN cDNA C330027C09 gene	0.137
Nek2	NIMA (never in mitosis gene a)-related expressed kinase 2	0.134
Depdc1a	DEP domain containing 1a	0.131
Hmmr	hyaluronan mediated motility receptor (RHAMM)	0.127
Birc5	baculoviral IAP repeat-containing 5	0.113
Sgol1	shugoshin-like 1 (S. pombe)	0.113
Ooep	oocyte expressed protein homolog (dog)	0.111
Mastl	microtubule associated serine/threonine kinase-like	0.098
Melk	maternal embryonic leucine zipper kinase	0.098
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.096
Sgol2	shugoshin-like 2 (S. pombe)	0.089
Plk4	polo-like kinase 4 (Drosophila)	0.085
Kif20a	kinesin family member 20A	0.081
4632434I11Rik	RIKEN cDNA 4632434I11 gene	0.081
Kif4	kinesin family member 4	0.080
Prc1	protein regulator of cytokinesis 1	0.080
Cdc25c	cell division cycle 25 homolog C (S. pombe)	0.079
Mis18bp1	MIS18 binding protein 1	0.079
Stil	Scl/Tal1 interrupting locus	0.073
Cenpa	centromere protein A	0.073
Kif23	kinesin family member 23	0.072
Tcf19	transcription factor 19	0.071
Aurka	aurora kinase A	0.071
Ncapg	non-SMC condensin I complex, subunit G	0.071
Dlgap5	discs, large (Drosophila) homolog-associated protein 5	0.071
Bub1b	budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)	0.071
Ect2	ect2 oncogene	0.071
Ttk	Ttk protein kinase	0.066	Yeast Fly
Lin9	lin-9 homolog (C. elegans)	0.063
Cdkn3	cyclin-dependent kinase inhibitor 3	0.062
Rb1	retinoblastoma 1	0.059	Human
Rad51ap1	RAD51 associated protein 1	0.058
Fignl1	fidgetin-like 1	0.056
Prkar1a	protein kinase, cAMP dependent regulatory, type I, alpha	0.054
Mybl2	myeloblastosis oncogene-like 2	0.054
Ncapd2	non-SMC condensin I complex, subunit D2	0.050
Cbx1	chromobox homolog 1 (Drosophila HP1 beta)	0.050
Diap3	diaphanous homolog 3 (Drosophila)	0.050
Mcm3	minichromosome maintenance deficient 3 (S. cerevisiae)	0.048
Anln	anillin, actin binding protein	0.048
Wdhd1	WD repeat and HMG-box DNA binding protein 1	0.046
Ncapd3	non-SMC condensin II complex, subunit D3	0.045
Nuf2	NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.045
Incenp	inner centromere protein	0.044
6720463M24Rik	RIKEN cDNA 6720463M24 gene	0.044
Ncapg2	non-SMC condensin II complex, subunit G2	0.044
Aurkb	aurora kinase B	0.043
Dbf4	DBF4 homolog (S. cerevisiae)	0.043
Kif2c	kinesin family member 2C	0.043
Kntc1	kinetochore associated 1	0.042
Uhrf1	ubiquitin-like, containing PHD and RING finger domains, 1	0.042
Cenpp	centromere protein P	0.042
Vasp	vasodilator-stimulated phosphoprotein	0.041
Blm	Bloom syndrome, RecQ helicase-like	0.041	Worm
Nbn	nibrin	0.041
Stag1	stromal antigen 1	0.040
Chek1	checkpoint kinase 1 homolog (S. pombe)	0.039
Shcbp1	Shc SH2-domain binding protein 1	0.038
Plk1	polo-like kinase 1 (Drosophila)	0.038	Human Yeast
Esco2	establishment of cohesion 1 homolog 2 (S. cerevisiae)	0.038
Rrm2	ribonucleotide reductase M2	0.036
Ptprq	protein tyrosine phosphatase, receptor type, Q	0.036
Cenpe	centromere protein E	0.035
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.035
Ckap2	cytoskeleton associated protein 2	0.035
Chek2	CHK2 checkpoint homolog (S. pombe)	0.034
Axin1	axin 1	0.034
Ccne1	cyclin E1	0.034	Fly
Usp9x	ubiquitin specific peptidase 9, X chromosome	0.034
Cpsf3l	cleavage and polyadenylation specific factor 3-like	0.033
Cul4a	cullin 4A	0.033
Dna2	DNA replication helicase 2 homolog (yeast)	0.031
Ckap2l	cytoskeleton associated protein 2-like	0.031
Lig4	ligase IV, DNA, ATP-dependent	0.031
Gsg2	germ cell-specific gene 2	0.031
Cep55	centrosomal protein 55	0.031
Kif20b	kinesin family member 20B	0.030
E2f1	E2F transcription factor 1	0.030
Cenpn	centromere protein N	0.030
Dtl	denticleless homolog (Drosophila)	0.030
Ush1g	Usher syndrome 1G homolog (human)	0.030
Bub1	budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)	0.029	Fly
Arl6ip6	ADP-ribosylation factor-like 6 interacting protein 6	0.029
E2f8	E2F transcription factor 8	0.028
Acd	adrenocortical dysplasia	0.028
Rac1	RAS-related C3 botulinum substrate 1	0.027
Apc	adenomatosis polyposis coli	0.027
Nlrp5	NLR family, pyrin domain containing 5	0.027
Nxf2	nuclear RNA export factor 2	0.027
Mybl1	myeloblastosis oncogene-like 1	0.027
Racgap1	Rac GTPase-activating protein 1	0.027
Ccdc99	coiled-coil domain containing 99	0.026
E2f7	E2F transcription factor 7	0.026
Kif11	kinesin family member 11	0.026
Ube2t	ubiquitin-conjugating enzyme E2T (putative)	0.026
Brca1	breast cancer 1	0.025
Hist1h2bm	histone cluster 1, H2bm	0.025
Stat3	signal transducer and activator of transcription 3	0.025
Mcm4	minichromosome maintenance deficient 4 homolog (S. cerevisiae)	0.025
Prr11	proline rich 11	0.025
Htt	huntingtin	0.025
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.024
Ywhaz	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.024
Kars	lysyl-tRNA synthetase	0.023
Mns1	meiosis-specific nuclear structural protein 1	0.023
Ccnd1	cyclin D1	0.022
Rrm1	ribonucleotide reductase M1	0.022
Gsk3b	glycogen synthase kinase 3 beta	0.022	Fly
Gtse1	G two S phase expressed protein 1	0.022
Pot1a	protection of telomeres 1A	0.022
Zfp101	zinc finger protein 101	0.022
Pten	phosphatase and tensin homolog	0.022
Eri2	exoribonuclease 2	0.021
Psmd4	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4	0.021
Hist1h2aa	histone cluster 1, H2aa	0.021
Pkn2	protein kinase N2	0.020
Lig1	ligase I, DNA, ATP-dependent	0.020
Cdca4	cell division cycle associated 4	0.020
Ppp1cc	protein phosphatase 1, catalytic subunit, gamma isoform	0.020	Yeast
Trim59	tripartite motif-containing 59	0.020
Trp73	transformation related protein 73	0.019
Tpm4	tropomyosin 4	0.019
Ndc80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	0.019
Cenpi	centromere protein I	0.019
Tacc3	transforming, acidic coiled-coil containing protein 3	0.019
Cenpk	centromere protein K	0.019
Pms2	postmeiotic segregation increased 2 (S. cerevisiae)	0.018
Ppp1ca	protein phosphatase 1, catalytic subunit, alpha isoform	0.018
Eif4g2	eukaryotic translation initiation factor 4, gamma 2	0.018
Mynn	myoneurin	0.018
Skp2	S-phase kinase-associated protein 2 (p45)	0.018
Cdkn2c	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.018
Espl1	extra spindle poles-like 1 (S. cerevisiae)	0.018
Kif18a	kinesin family member 18A	0.018
Traf7	TNF receptor-associated factor 7	0.018
Chtf18	CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)	0.018
Haus5	HAUS augmin-like complex, subunit 5	0.017
Braf	Braf transforming gene	0.017
Top2a	topoisomerase (DNA) II alpha	0.017
Cops7b	COP9 (constitutive photomorphogenic) homolog, subunit 7b (Arabidopsis thaliana)	0.017
Usp42	ubiquitin specific peptidase 42	0.017
Mapk8	mitogen-activated protein kinase 8	0.017
Smc2	structural maintenance of chromosomes 2	0.016
Wdr26	WD repeat domain 26	0.016
Hist2h4	histone cluster 2, H4	0.016
Suv39h2	suppressor of variegation 3-9 homolog 2 (Drosophila)	0.016
Dmtf1	cyclin D binding myb-like transcription factor 1	0.016
Pole2	polymerase (DNA directed), epsilon 2 (p59 subunit)	0.016
H2afx	H2A histone family, member X	0.016
Prkdc	protein kinase, DNA activated, catalytic polypeptide	0.016
Actr3	ARP3 actin-related protein 3 homolog (yeast)	0.016
Cenpf	centromere protein F	0.016
Cenph	centromere protein H	0.016
Tmpo	thymopoietin	0.016
Gsk3a	glycogen synthase kinase 3 alpha	0.015	Fly
Thbs1	thrombospondin 1	0.015
Exosc8	exosome component 8	0.015
Depdc1b	DEP domain containing 1B	0.015
Fkbp4	FK506 binding protein 4	0.015
Cdca2	cell division cycle associated 2	0.015
Ttf2	transcription termination factor, RNA polymerase II	0.015
Wdr1	WD repeat domain 1	0.015
Mapk14	mitogen-activated protein kinase 14	0.014
Qk	quaking	0.014
Trip13	thyroid hormone receptor interactor 13	0.014
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.014
Myo6	myosin VI	0.014
Arhgap11a	Rho GTPase activating protein 11A	0.014
Ube2c	ubiquitin-conjugating enzyme E2C	0.014	Fly
Zbtb25	zinc finger and BTB domain containing 25	0.014
Slmap	sarcolemma associated protein	0.014
Nf1	neurofibromatosis 1	0.014
Mre11a	meiotic recombination 11 homolog A (S. cerevisiae)	0.014
Skil	SKI-like	0.014
Fbxo43	F-box protein 43	0.014
Rad51	RAD51 homolog (S. cerevisiae)	0.014
Fbxo5	F-box protein 5	0.013	Human Fly
Dsn1	DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)	0.013
4930547N16Rik	RIKEN cDNA 4930547N16 gene	0.013
Mxd3	Max dimerization protein 3	0.013
Stk11	serine/threonine kinase 11	0.013
Xrn1	5'-3' exoribonuclease 1	0.013
Pask	PAS domain containing serine/threonine kinase	0.013
Lmnb1	lamin B1	0.013
Pbk	PDZ binding kinase	0.013
Polr3c	polymerase (RNA) III (DNA directed) polypeptide C	0.013
Sass6	spindle assembly 6 homolog (C. elegans)	0.013
Haus4	HAUS augmin-like complex, subunit 4	0.013
Csnk2b	casein kinase 2, beta polypeptide	0.013
Fbxo15	F-box protein 15	0.013
Rps6ka3	ribosomal protein S6 kinase polypeptide 3	0.013
Psmc2	proteasome (prosome, macropain) 26S subunit, ATPase 2	0.013
Msh2	mutS homolog 2 (E. coli)	0.012
Recql	RecQ protein-like	0.012
Kit	kit oncogene	0.012
Foxm1	forkhead box M1	0.012
Hus1	Hus1 homolog (S. pombe)	0.012
Ints7	integrator complex subunit 7	0.012
Bmi1	Bmi1 polycomb ring finger oncogene	0.012
Mdm2	transformed mouse 3T3 cell double minute 2	0.012
Rbbp7	retinoblastoma binding protein 7	0.012
Polr1a	polymerase (RNA) I polypeptide A	0.012
Whrn	whirlin	0.012
Hist2h3c2-ps	histone cluster 2, H3c2, pseudogene	0.012
Carm1	coactivator-associated arginine methyltransferase 1	0.011
Cdc25b	cell division cycle 25 homolog B (S. pombe)	0.011
Usp15	ubiquitin specific peptidase 15	0.011
Tgfb1	transforming growth factor, beta 1	0.011
Myh9	myosin, heavy polypeptide 9, non-muscle	0.011
Dazap1	DAZ associated protein 1	0.011
4930579G24Rik	RIKEN cDNA 4930579G24 gene	0.011
Tdp1	tyrosyl-DNA phosphodiesterase 1	0.011
Dlgap1	discs, large (Drosophila) homolog-associated protein 1	0.011
Creb1	cAMP responsive element binding protein 1	0.011
Psmd11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	0.011
Prmt5	protein arginine N-methyltransferase 5	0.011
Clgn	calmegin	0.011
Mcph1	microcephaly, primary autosomal recessive 1	0.011
Cdk4	cyclin-dependent kinase 4	0.011
Polh	polymerase (DNA directed), eta (RAD 30 related)	0.011
Atad2	ATPase family, AAA domain containing 2	0.011
Atf2	activating transcription factor 2	0.011
D2Ertd750e	DNA segment, Chr 2, ERATO Doi 750, expressed	0.011
Cenpl	centromere protein L	0.011
Exosc7	exosome component 7	0.011
Spc25	SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.011
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.011
Cltc	clathrin, heavy polypeptide (Hc)	0.010
Pold1	polymerase (DNA directed), delta 1, catalytic subunit	0.010
Dppa3	developmental pluripotency-associated 3	0.010
Cdc34	cell division cycle 34 homolog (S. cerevisiae)	0.010
Mcf2	mcf.2 transforming sequence	0.010
Dnajc9	DnaJ (Hsp40) homolog, subfamily C, member 9	0.010
Lrp6	low density lipoprotein receptor-related protein 6	0.010
Aspm	asp (abnormal spindle)-like, microcephaly associated (Drosophila)	0.010
Prpf19	PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)	0.010
Ercc6l	excision repair cross-complementing rodent repair deficiency complementation group 6 - like	0.010
Caprin1	cell cycle associated protein 1	0.010
Cd44	CD44 antigen	0.010
Palb2	partner and localizer of BRCA2	0.010
Rqcd1	rcd1 (required for cell differentiation) homolog 1 (S. pombe)	0.010
Spnb2	spectrin beta 2	0.010
Psmc3	proteasome (prosome, macropain) 26S subunit, ATPase 3	0.010
Dlg1	discs, large homolog 1 (Drosophila)	0.010
Atad5	ATPase family, AAA domain containing 5	0.010
Nsf	N-ethylmaleimide sensitive fusion protein	0.010
Hist2h2ab	histone cluster 2, H2ab	0.010