IMP

Process View

Mus musculus

14 genes annotated in mouse

regulation of phosphatidylinositol 3 kinase activity

Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an inositol lipid at the 3' position of the inositol ring.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of phosphatidylinositol 3 kinase activity"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of phosphatidylinositol 3 kinase activity" (in gray)

Name	Description	Probability	Func Analog Organism
Pik3r1	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)	0.978	Mouse Rat Fly
Klk1b8	kallikrein 1-related peptidase b8	0.944	Mouse
Klk1b26	kallikrein 1-related petidase b26	0.887	Mouse
Cbl	Casitas B-lineage lymphoma	0.874
Grb2	growth factor receptor bound protein 2	0.821
Klk1b5	kallikrein 1-related peptidase b5	0.770	Mouse
Klk1b1	kallikrein 1-related peptidase b1	0.744	Mouse
Klk1b11	kallikrein 1-related peptidase b11	0.736	Mouse
Klk1	kallikrein 1	0.679	Mouse
Pten	phosphatase and tensin homolog	0.669
Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.588
Ptprc	protein tyrosine phosphatase, receptor type, C	0.574
Grb10	growth factor receptor bound protein 10	0.503
Irs1	insulin receptor substrate 1	0.492
Cd19	CD19 antigen	0.459
Klk1b21	kallikrein 1-related peptidase b21	0.424	Mouse
Ephb2	Eph receptor B2	0.406	Mouse
Efnb2	ephrin B2	0.405
Dab1	disabled homolog 1 (Drosophila)	0.401
Ctnnb1	catenin (cadherin associated protein), beta 1	0.348
Ctrb1	chymotrypsinogen B1	0.335
Lepr	leptin receptor	0.332
Cela2a	chymotrypsin-like elastase family, member 2A	0.330
Ikzf1	IKAROS family zinc finger 1	0.316
Inpp5d	inositol polyphosphate-5-phosphatase D	0.314
Csf1	colony stimulating factor 1 (macrophage)	0.309
Klk1b27	kallikrein 1-related peptidase b27	0.249	Mouse
Src	Rous sarcoma oncogene	0.243	Mouse Rat
Klk1b9	kallikrein 1-related peptidase b9	0.236	Mouse
Klk1b24	kallikrein 1-related peptidase b24	0.229	Mouse
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.219
Ptk2	PTK2 protein tyrosine kinase 2	0.211	Mouse
Pik3ca	phosphatidylinositol 3-kinase, catalytic, alpha polypeptide	0.181
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.181
Vav2	vav 2 oncogene	0.176
Vav1	vav 1 oncogene	0.176	Mouse
Pak1	p21 protein (Cdc42/Rac)-activated kinase 1	0.172
Fyn	Fyn proto-oncogene	0.166	Mouse
Ins2	insulin II	0.155
2210010C04Rik	RIKEN cDNA 2210010C04 gene	0.136	Mouse
Epha4	Eph receptor A4	0.133	Mouse
Prkce	protein kinase C, epsilon	0.123
Ooep	oocyte expressed protein homolog (dog)	0.122
Prss2	protease, serine, 2	0.117	Mouse
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.117
Tgfb1	transforming growth factor, beta 1	0.115	Human
Blnk	B-cell linker	0.112
Nos3	nitric oxide synthase 3, endothelial cell	0.111
Pik3cb	phosphatidylinositol 3-kinase, catalytic, beta polypeptide	0.111
Ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.110
Klk1b16	kallikrein 1-related peptidase b16	0.107	Mouse
Gata5	GATA binding protein 5	0.105
Efnb1	ephrin B1	0.100
Notch2	Notch gene homolog 2 (Drosophila)	0.097
Cldn5	claudin 5	0.095
Psen1	presenilin 1	0.094
Bcar1	breast cancer anti-estrogen resistance 1	0.087
Prss3	protease, serine, 3	0.084	Mouse
Ncf1	neutrophil cytosolic factor 1	0.082
Rnase1	ribonuclease, RNase A family, 1 (pancreatic)	0.079
Pycard	PYD and CARD domain containing	0.079
Cd44	CD44 antigen	0.079
Rac1	RAS-related C3 botulinum substrate 1	0.078
Dok1	docking protein 1	0.075
Klk1b3	kallikrein 1-related peptidase b3	0.075	Mouse
Nf1	neurofibromatosis 1	0.072
Ghr	growth hormone receptor	0.069
Lce1h	late cornified envelope 1H	0.069
Jag1	jagged 1	0.065
Ephb3	Eph receptor B3	0.065	Mouse
Cd247	CD247 antigen	0.064
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.064
Lyz2	lysozyme 2	0.064
Was	Wiskott-Aldrich syndrome homolog (human)	0.064
Hcls1	hematopoietic cell specific Lyn substrate 1	0.063
Card11	caspase recruitment domain family, member 11	0.061
Kit	kit oncogene	0.059
Apoe	apolipoprotein E	0.059
Plcg2	phospholipase C, gamma 2	0.059
5430421N21Rik	RIKEN cDNA 5430421N21 gene	0.059
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.058	Human
Shank3	SH3/ankyrin domain gene 3	0.057
Nphp3	nephronophthisis 3 (adolescent)	0.057
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.056
Krt14	keratin 14	0.055
Pdgfb	platelet derived growth factor, B polypeptide	0.054	Human
Ptprb	protein tyrosine phosphatase, receptor type, B	0.053
Cd79a	CD79A antigen (immunoglobulin-associated alpha)	0.052
Klk1b4	kallikrein 1-related pepidase b4	0.052
Krt17	keratin 17	0.051
Emx1	empty spiracles homolog 1 (Drosophila)	0.050
Pxn	paxillin	0.047
Foxn1	forkhead box N1	0.046
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.046	Human
Plcg1	phospholipase C, gamma 1	0.045
Cuzd1	CUB and zona pellucida-like domains 1	0.043
Itgb2	integrin beta 2	0.043
Sema3f	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	0.042
Mdfi	MyoD family inhibitor	0.041
Zg16	zymogen granule protein 16	0.041
Sykb	spleen tyrosine kinase	0.041
Ptpre	protein tyrosine phosphatase, receptor type, E	0.040
Apc	adenomatosis polyposis coli	0.040
Il2rg	interleukin 2 receptor, gamma chain	0.039
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.038
Try10	trypsin 10	0.038
Reg2	regenerating islet-derived 2	0.038
Cela3b	chymotrypsin-like elastase family, member 3B	0.037
Arhgef15	Rho guanine nucleotide exchange factor (GEF) 15	0.036
Ednrb	endothelin receptor type B	0.035
Crk	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.035
Cdkn1c	cyclin-dependent kinase inhibitor 1C (P57)	0.035
Emcn	endomucin	0.034
Rasip1	Ras interacting protein 1	0.034
Il1r1	interleukin 1 receptor, type I	0.034
Klk7	kallikrein related-peptidase 7 (chymotryptic, stratum corneum)	0.033	Mouse
Egfr	epidermal growth factor receptor	0.033
Gab1	growth factor receptor bound protein 2-associated protein 1	0.033
Arhgap1	Rho GTPase activating protein 1	0.032
Gm10334	predicted gene 10334	0.031	Mouse
Vdr	vitamin D receptor	0.030
Clnk	cytokine-dependent hematopoietic cell linker	0.030
Cwh43	cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)	0.030
Unc93b1	unc-93 homolog B1 (C. elegans)	0.030
Cdc42	cell division cycle 42 homolog (S. cerevisiae)	0.030
Arhgdia	Rho GDP dissociation inhibitor (GDI) alpha	0.029
Krt2	keratin 2	0.029
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.029
Cckar	cholecystokinin A receptor	0.028
Grin2b	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	0.028
Pkp1	plakophilin 1	0.028
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.028
Fgfr2	fibroblast growth factor receptor 2	0.027
Tie1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.027
2310014H01Rik	RIKEN cDNA 2310014H01 gene	0.027
Jup	junction plakoglobin	0.026
Dmbt1	deleted in malignant brain tumors 1	0.026
Nphp4	nephronophthisis 4 (juvenile) homolog (human)	0.026
Tnf	tumor necrosis factor	0.026
Cdh5	cadherin 5	0.025
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.025
Il2rb	interleukin 2 receptor, beta chain	0.023
Socs1	suppressor of cytokine signaling 1	0.023
Cpa1	carboxypeptidase A1	0.023
2310002J15Rik	RIKEN cDNA 2310002J15 gene	0.022
Adam17	a disintegrin and metallopeptidase domain 17	0.022
Dsc3	desmocollin 3	0.022
Kdr	kinase insert domain protein receptor	0.022
Spry4	sprouty homolog 4 (Drosophila)	0.022
Tcra	T-cell receptor alpha chain	0.022
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.021
Fas	Fas (TNF receptor superfamily member 6)	0.021
Sycn	syncollin	0.021
Egfbp2	epidermal growth factor binding protein type B	0.021
Clps	colipase, pancreatic	0.021
Pax9	paired box gene 9	0.020
Braf	Braf transforming gene	0.020
Tgfbr2	transforming growth factor, beta receptor II	0.020
Krt78	keratin 78	0.020
Nrp1	neuropilin 1	0.020
Ptf1a	pancreas specific transcription factor, 1a	0.019
Bhlha15	basic helix-loop-helix family, member a15	0.019
Tff2	trefoil factor 2 (spasmolytic protein 1)	0.019
Asap1	ArfGAP with SH# domain, ankyrin repeat and PH domain1	0.019
Cd160	CD160 antigen	0.019
Cd37	CD37 antigen	0.019
Rag2	recombination activating gene 2	0.018
Agap3	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3	0.018
Try5	trypsin 5	0.018	Mouse
Ldlr	low density lipoprotein receptor	0.017
Rnd3	Rho family GTPase 3	0.017
Ppy	pancreatic polypeptide	0.017
Smr3a	submaxillary gland androgen regulated protein 3A	0.017
Pcdh12	protocadherin 12	0.017
Sox18	SRY-box containing gene 18	0.017
Tyro3	TYRO3 protein tyrosine kinase 3	0.017
Gcgr	glucagon receptor	0.016
Lat	linker for activation of T cells	0.016
Cd7	CD7 antigen	0.016
Khdrbs1	KH domain containing, RNA binding, signal transduction associated 1	0.016
Arpc4	actin related protein 2/3 complex, subunit 4	0.016
Ret	ret proto-oncogene	0.016
Ets1	E26 avian leukemia oncogene 1, 5' domain	0.016
Gif	gastric intrinsic factor	0.016
Acap1	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	0.016
Slc6a2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	0.016
Vegfa	vascular endothelial growth factor A	0.016
Itga8	integrin alpha 8	0.015
Cd8b1	CD8 antigen, beta chain 1	0.015
Reg1	regenerating islet-derived 1	0.015
Klk1b22	kallikrein 1-related peptidase b22	0.015	Mouse
Tek	endothelial-specific receptor tyrosine kinase	0.015	Human
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.015
Pnliprp1	pancreatic lipase related protein 1	0.015
Kiss1	KiSS-1 metastasis-suppressor	0.014
Prkcd	protein kinase C, delta	0.014
Lif	leukemia inhibitory factor	0.014
Cdc42ep1	CDC42 effector protein (Rho GTPase binding) 1	0.014
Plxna4	plexin A4	0.014
Cdh11	cadherin 11	0.014
Smurf2	SMAD specific E3 ubiquitin protein ligase 2	0.014
Rgs14	regulator of G-protein signaling 14	0.014
Fbn1	fibrillin 1	0.014
L1cam	L1 cell adhesion molecule	0.014
Vasp	vasodilator-stimulated phosphoprotein	0.014
Prom2	prominin 2	0.014
Esam	endothelial cell-specific adhesion molecule	0.014
Gprc5d	G protein-coupled receptor, family C, group 5, member D	0.014
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.013
Vav3	vav 3 oncogene	0.013
Pnlip	pancreatic lipase	0.013
Lgals7	lectin, galactose binding, soluble 7	0.013
Gpr87	G protein-coupled receptor 87	0.013
Fgfr1	fibroblast growth factor receptor 1	0.013
Yap1	yes-associated protein 1	0.013
Wnt7a	wingless-related MMTV integration site 7A	0.013
Cd6	CD6 antigen	0.013
Fgf21	fibroblast growth factor 21	0.013
Fjx1	four jointed box 1 (Drosophila)	0.013
Krtdap	keratinocyte differentiation associated protein	0.013
Ebi3	Epstein-Barr virus induced gene 3	0.013
Itk	IL2-inducible T-cell kinase	0.013
Sprr1b	small proline-rich protein 1B	0.013
Cd40	CD40 antigen	0.013
Fzd4	frizzled homolog 4 (Drosophila)	0.012
Cmklr1	chemokine-like receptor 1	0.012
Efs	embryonal Fyn-associated substrate	0.012
Pou2af1	POU domain, class 2, associating factor 1	0.012
Iapp	islet amyloid polypeptide	0.012
Ptcra	pre T-cell antigen receptor alpha	0.012
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.012
Tcf7l2	transcription factor 7-like 2, T-cell specific, HMG-box	0.012
Crhr1	corticotropin releasing hormone receptor 1	0.012
Plekhg5	pleckstrin homology domain containing, family G (with RhoGef domain) member 5	0.012
Serpinb5	serine (or cysteine) peptidase inhibitor, clade B, member 5	0.012
Trp53	transformation related protein 53	0.012	Fly
Wfdc5	WAP four-disulfide core domain 5	0.012
Irf1	interferon regulatory factor 1	0.012
Tnip1	TNFAIP3 interacting protein 1	0.011
Expi	extracellular proteinase inhibitor	0.011
Tmed11	transmembrane emp24 protein transport domain containing	0.011
Xcl1	chemokine (C motif) ligand 1	0.011
Cd79b	CD79B antigen	0.011
G6pc2	glucose-6-phosphatase, catalytic, 2	0.011
Gna11	guanine nucleotide binding protein, alpha 11	0.011
Ptk2b	PTK2 protein tyrosine kinase 2 beta	0.011
Csk	c-src tyrosine kinase	0.011
Necap2	NECAP endocytosis associated 2	0.011
Mdm4	transformed mouse 3T3 cell double minute 4	0.011
Bcr	breakpoint cluster region	0.011
Irs2	insulin receptor substrate 2	0.011	Mouse
Itga1	integrin alpha 1	0.011
Wnt5a	wingless-related MMTV integration site 5A	0.011
Adam11	a disintegrin and metallopeptidase domain 11	0.011
4933421I07Rik	RIKEN cDNA 4933421I07 gene	0.011
Lst1	leukocyte specific transcript 1	0.011
Zbtb7b	zinc finger and BTB domain containing 7B	0.011
Pbsn	probasin	0.011
Ltb	lymphotoxin B	0.011
Kl	klotho	0.011
Cel	carboxyl ester lipase	0.011
Igf1r	insulin-like growth factor I receptor	0.010
Sox9	SRY-box containing gene 9	0.010
Madcam1	mucosal vascular addressin cell adhesion molecule 1	0.010
BC013712	cDNA sequence BC013712	0.010
She	src homology 2 domain-containing transforming protein E	0.010
Ptpra	protein tyrosine phosphatase, receptor type, A	0.010
Serpinb6c	serine (or cysteine) peptidase inhibitor, clade B, member 6c	0.010
Mucl1	mucin-like 1	0.010
Cd3d	CD3 antigen, delta polypeptide	0.010