IMP

Process View

Mus musculus

22 genes annotated in mouse

Multi-species View

regulation of isotype switching

GO:0045191

Any process that modulates the frequency, rate or extent of isotype switching.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of isotype switching"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of isotype switching" (in gray)

Name	Description	Probability	Func Analog Organism
Foxp3	forkhead box P3	0.988
Ifng	interferon gamma	0.959
Il10	interleukin 10	0.922
Cd19	CD19 antigen	0.872
Tnf	tumor necrosis factor	0.800
Prf1	perforin 1 (pore forming protein)	0.678
Il2	interleukin 2	0.576
Fyn	Fyn proto-oncogene	0.557
Pitx1	paired-like homeodomain transcription factor 1	0.469
Il6	interleukin 6	0.410
Stat5b	signal transducer and activator of transcription 5B	0.400	Mouse
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.400
Tcra	T-cell receptor alpha chain	0.396
Ikzf1	IKAROS family zinc finger 1	0.339
Fas	Fas (TNF receptor superfamily member 6)	0.331
Rag1	recombination activating gene 1	0.324
Cd28	CD28 antigen	0.278
Lyz2	lysozyme 2	0.262
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.210
Stat5a	signal transducer and activator of transcription 5A	0.205	Mouse
Irf9	interferon regulatory factor 9	0.176
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.165
Rag2	recombination activating gene 2	0.153
Stat3	signal transducer and activator of transcription 3	0.152	Mouse
Cd40	CD40 antigen	0.141
Pitx2	paired-like homeodomain transcription factor 2	0.138
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.136
Socs1	suppressor of cytokine signaling 1	0.133
Inpp5d	inositol polyphosphate-5-phosphatase D	0.126
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.126
Il4	interleukin 4	0.120
Fasl	Fas ligand (TNF superfamily, member 6)	0.109
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.108
Tbx3	T-box 3	0.104	Mouse
Csf1	colony stimulating factor 1 (macrophage)	0.102
Lta	lymphotoxin A	0.093
Il4ra	interleukin 4 receptor, alpha	0.093
Ccl2	chemokine (C-C motif) ligand 2	0.087
Tlr4	toll-like receptor 4	0.087
Il6st	interleukin 6 signal transducer	0.086	Mouse
Ccr7	chemokine (C-C motif) receptor 7	0.081
Hcn4	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	0.075
Igh	immunoglobulin heavy chain complex	0.072
Pdcd1	programmed cell death 1	0.069
Chd7	chromodomain helicase DNA binding protein 7	0.067
Stat1	signal transducer and activator of transcription 1	0.062	Mouse
Smad3	MAD homolog 3 (Drosophila)	0.059
Il2rg	interleukin 2 receptor, gamma chain	0.057
Rc3h1	RING CCCH (C3H) domains 1	0.055
Tnfsf11	tumor necrosis factor (ligand) superfamily, member 11	0.052
Fgfr2	fibroblast growth factor receptor 2	0.051
Nos2	nitric oxide synthase 2, inducible	0.049
Tbx21	T-box 21	0.047
Stat6	signal transducer and activator of transcription 6	0.045
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.044
Il1r1	interleukin 1 receptor, type I	0.042
Pax2	paired box gene 2	0.042
Nlrp3	NLR family, pyrin domain containing 3	0.040
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.036
Cd40lg	CD40 ligand	0.036
Icos	inducible T-cell co-stimulator	0.036	Mouse
Spp1	secreted phosphoprotein 1	0.034
Apoe	apolipoprotein E	0.034
Mmp9	matrix metallopeptidase 9	0.033
H2-Ab1	histocompatibility 2, class II antigen A, beta 1	0.033
Myd88	myeloid differentiation primary response gene 88	0.033
Pou5f1	POU domain, class 5, transcription factor 1	0.032
Card11	caspase recruitment domain family, member 11	0.032
Tnfrsf4	tumor necrosis factor receptor superfamily, member 4	0.031
Spna1	spectrin alpha 1	0.030
Traf2	TNF receptor-associated factor 2	0.029
Zap70	zeta-chain (TCR) associated protein kinase	0.029
Lif	leukemia inhibitory factor	0.029
Itk	IL2-inducible T-cell kinase	0.029
Fgf10	fibroblast growth factor 10	0.028
Meox1	mesenchyme homeobox 1	0.028
Prrx1	paired related homeobox 1	0.028
Ccr6	chemokine (C-C motif) receptor 6	0.028
Il21r	interleukin 21 receptor	0.027
Lag3	lymphocyte-activation gene 3	0.025
Foxp2	forkhead box P2	0.025	Mouse
Dll4	delta-like 4 (Drosophila)	0.024
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.023
Hoxa13	homeobox A13	0.023
Rxra	retinoid X receptor alpha	0.023
Sh2d1a	SH2 domain protein 1A	0.023
Gpr132	G protein-coupled receptor 132	0.022
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.022
Foxp1	forkhead box P1	0.022	Mouse
Wt1	Wilms tumor 1 homolog	0.021
Bcl6	B-cell leukemia/lymphoma 6	0.021
Sox7	SRY-box containing gene 7	0.021
B2m	beta-2 microglobulin	0.020
Prkcd	protein kinase C, delta	0.020
Cd4	CD4 antigen	0.020
Foxn1	forkhead box N1	0.019
Traf6	TNF receptor-associated factor 6	0.019
Agap2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	0.019
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.019
Lat	linker for activation of T cells	0.018
Aire	autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)	0.018
Vangl2	vang-like 2 (van gogh, Drosophila)	0.017
Kit	kit oncogene	0.017
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.017
Noto	notochord homolog (Xenopus laevis)	0.017
Pag1	phosphoprotein associated with glycosphingolipid microdomains 1	0.017
Otx2	orthodenticle homolog 2 (Drosophila)	0.017
Ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.016
Trim21	tripartite motif-containing 21	0.016
Ncoa3	nuclear receptor coactivator 3	0.016
Pten	phosphatase and tensin homolog	0.016
Cd5	CD5 antigen	0.016
Il12rb1	interleukin 12 receptor, beta 1	0.016
Cd247	CD247 antigen	0.016
Ighmbp2	immunoglobulin mu binding protein 2	0.016
Zeb1	zinc finger E-box binding homeobox 1	0.015
Mefv	Mediterranean fever	0.015
Pou2af1	POU domain, class 2, associating factor 1	0.015
Gata3	GATA binding protein 3	0.015
Lef1	lymphoid enhancer binding factor 1	0.015
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.014
Slamf1	signaling lymphocytic activation molecule family member 1	0.014
Prdm1	PR domain containing 1, with ZNF domain	0.014
Cd22	CD22 antigen	0.014
Ptgs2	prostaglandin-endoperoxide synthase 2	0.014
Ccr1	chemokine (C-C motif) receptor 1	0.014
Ctla4	cytotoxic T-lymphocyte-associated protein 4	0.014	Mouse
Ifnar2	interferon (alpha and beta) receptor 2	0.014
Adam17	a disintegrin and metallopeptidase domain 17	0.014
Zic3	zinc finger protein of the cerebellum 3	0.013
Trp63	transformation related protein 63	0.013
Lmx1a	LIM homeobox transcription factor 1 alpha	0.013
Nfil3	nuclear factor, interleukin 3, regulated	0.013
Irf1	interferon regulatory factor 1	0.013
Myod1	myogenic differentiation 1	0.013
Ifnar1	interferon (alpha and beta) receptor 1	0.013
Sykb	spleen tyrosine kinase	0.013
Jak1	Janus kinase 1	0.013
Batf	basic leucine zipper transcription factor, ATF-like	0.013
Gja5	gap junction protein, alpha 5	0.013
Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.013
Gli2	GLI-Kruppel family member GLI2	0.013
Scn5a	sodium channel, voltage-gated, type V, alpha	0.013
Irx3	Iroquois related homeobox 3 (Drosophila)	0.013
Runx3	runt related transcription factor 3	0.013
Cd44	CD44 antigen	0.012
Tcfap2a	transcription factor AP-2, alpha	0.012
Alx4	aristaless-like homeobox 4	0.012
Tapbp	TAP binding protein	0.012
Chl1	cell adhesion molecule with homology to L1CAM	0.012
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.012
Gata4	GATA binding protein 4	0.012
Gdf3	growth differentiation factor 3	0.012
Cd47	CD47 antigen (Rh-related antigen, integrin-associated signal transducer)	0.012
Sorbs3	sorbin and SH3 domain containing 3	0.012
Il22	interleukin 22	0.012
Capn6	calpain 6	0.012
Pgrmc1	progesterone receptor membrane component 1	0.012
Cd160	CD160 antigen	0.012
Bcl3	B-cell leukemia/lymphoma 3	0.012
Stx11	syntaxin 11	0.012
Btk	Bruton agammaglobulinemia tyrosine kinase	0.011
Trp53	transformation related protein 53	0.011
Col13a1	collagen, type XIII, alpha 1	0.011
Htt	huntingtin	0.011
Cd96	CD96 antigen	0.011
Apc	adenomatosis polyposis coli	0.011
Tcf21	transcription factor 21	0.011
Meox2	mesenchyme homeobox 2	0.011
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.011
Cd6	CD6 antigen	0.011
Pdcd1lg2	programmed cell death 1 ligand 2	0.011
Tbx5	T-box 5	0.010	Mouse
Mx2	myxovirus (influenza virus) resistance 2	0.010
Lrp5	low density lipoprotein receptor-related protein 5	0.010
Stat2	signal transducer and activator of transcription 2	0.010	Mouse
Itgal	integrin alpha L	0.010
Hoxa1	homeobox A1	0.010
Cox4i2	cytochrome c oxidase subunit IV isoform 2	0.010
Gak	cyclin G associated kinase	0.010
S1pr4	sphingosine-1-phosphate receptor 4	0.010
Osr1	odd-skipped related 1 (Drosophila)	0.010
Alx1	ALX homeobox 1	0.010
Ciita	class II transactivator	0.010
Ikbkg	inhibitor of kappaB kinase gamma	0.010