IMP

Process View

Mus musculus

4 genes annotated in mouse

positive regulation of steroid biosynthetic process

Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of steroid biosynthetic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of steroid biosynthetic process" (in gray)

Name	Description	Probability	Func Analog Organism
Rarg	retinoic acid receptor, gamma	0.999	Mouse
Rarb	retinoic acid receptor, beta	0.961	Mouse
Thra	thyroid hormone receptor alpha	0.942	Mouse
Rxra	retinoid X receptor alpha	0.917
Rara	retinoic acid receptor, alpha	0.812	Mouse
Pax8	paired box gene 8	0.798
Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	0.692
Thrb	thyroid hormone receptor beta	0.657	Mouse
Hoxa3	homeobox A3	0.626
Ece1	endothelin converting enzyme 1	0.549
Ghr	growth hormone receptor	0.546
Fgfr2	fibroblast growth factor receptor 2	0.452
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.366
Egfr	epidermal growth factor receptor	0.341
Fgfr1	fibroblast growth factor receptor 1	0.329
Pax2	paired box gene 2	0.293
Vegfa	vascular endothelial growth factor A	0.279
Ednra	endothelin receptor type A	0.278
Grb10	growth factor receptor bound protein 10	0.277
Foxc1	forkhead box C1	0.265
Bmp4	bone morphogenetic protein 4	0.255
Igf2r	insulin-like growth factor 2 receptor	0.245
Npc1	Niemann Pick type C1	0.199
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.197
Lhx1	LIM homeobox protein 1	0.186
Eya1	eyes absent 1 homolog (Drosophila)	0.175
Dbp	D site albumin promoter binding protein	0.143
Acvr1	activin A receptor, type 1	0.140
Emx2	empty spiracles homolog 2 (Drosophila)	0.136
Esr1	estrogen receptor 1 (alpha)	0.126
Pitx2	paired-like homeodomain transcription factor 2	0.125
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.124
Lhx3	LIM homeobox protein 3	0.124
Agrp	agouti related protein	0.123
Abca1	ATP-binding cassette, sub-family A (ABC1), member 1	0.120
Duox2	dual oxidase 2	0.120
Sox4	SRY-box containing gene 4	0.107
Tef	thyrotroph embryonic factor	0.101
Foxc2	forkhead box C2	0.098
Lyz2	lysozyme 2	0.097
Bmper	BMP-binding endothelial regulator	0.096
Cdkn1c	cyclin-dependent kinase inhibitor 1C (P57)	0.095
Il1a	interleukin 1 alpha	0.094
Tgfb2	transforming growth factor, beta 2	0.094
Sox9	SRY-box containing gene 9	0.093
Nostrin	nitric oxide synthase trafficker	0.087
Apoe	apolipoprotein E	0.080
Wnt9b	wingless-type MMTV integration site 9B	0.080
Ncoa1	nuclear receptor coactivator 1	0.073
Igf1	insulin-like growth factor 1	0.069	Rat
Dhcr7	7-dehydrocholesterol reductase	0.067
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.067
Tshr	thyroid stimulating hormone receptor	0.067
Pbx1	pre B-cell leukemia transcription factor 1	0.057
Idua	iduronidase, alpha-L-	0.055
Plxnd1	plexin D1	0.055
Csf1	colony stimulating factor 1 (macrophage)	0.054
Fasn	fatty acid synthase	0.052
Nr1d1	nuclear receptor subfamily 1, group D, member 1	0.051
Slc16a2	solute carrier family 16 (monocarboxylic acid transporters), member 2	0.051
Prdm16	PR domain containing 16	0.050
Igf1r	insulin-like growth factor I receptor	0.049	Rat
Chrd	chordin	0.049
Chd7	chromodomain helicase DNA binding protein 7	0.049
Cav1	caveolin 1, caveolae protein	0.048
Gata3	GATA binding protein 3	0.048
Adam17	a disintegrin and metallopeptidase domain 17	0.044
Irs2	insulin receptor substrate 2	0.044
Srf	serum response factor	0.042
Fgfrl1	fibroblast growth factor receptor-like 1	0.041
Nlrp3	NLR family, pyrin domain containing 3	0.040
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.039
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.039
Insr	insulin receptor	0.038
Vangl2	vang-like 2 (van gogh, Drosophila)	0.038
Casp1	caspase 1	0.038
Gna11	guanine nucleotide binding protein, alpha 11	0.037
Smo	smoothened homolog (Drosophila)	0.036
Smpd3	sphingomyelin phosphodiesterase 3, neutral	0.036
Mvd	mevalonate (diphospho) decarboxylase	0.036
Tbx1	T-box 1	0.036
Cat	catalase	0.035
Gpc3	glypican 3	0.033
Jag1	jagged 1	0.032
Lepr	leptin receptor	0.029
Rxrb	retinoid X receptor beta	0.029
Scd1	stearoyl-Coenzyme A desaturase 1	0.028
Dhcr24	24-dehydrocholesterol reductase	0.027
Hsd3b7	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	0.027
Hoxa5	homeobox A5	0.027
Ret	ret proto-oncogene	0.027
Mrc1	mannose receptor, C type 1	0.026
Nrp1	neuropilin 1	0.026
Islr	immunoglobulin superfamily containing leucine-rich repeat	0.026
Reep6	receptor accessory protein 6	0.025
Slc25a1	solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1	0.025
Scd2	stearoyl-Coenzyme A desaturase 2	0.024
Hr	hairless	0.024
Cacna1d	calcium channel, voltage-dependent, L type, alpha 1D subunit	0.024
Clip2	CAP-GLY domain containing linker protein 2	0.023
Aldh1a1	aldehyde dehydrogenase family 1, subfamily A1	0.023
Pparg	peroxisome proliferator activated receptor gamma	0.023
Il18	interleukin 18	0.023
Atp2b2	ATPase, Ca++ transporting, plasma membrane 2	0.022
Lamc1	laminin, gamma 1	0.022
Igf2	insulin-like growth factor 2	0.022	Rat
C3ar1	complement component 3a receptor 1	0.022
Pklr	pyruvate kinase liver and red blood cell	0.021
Jup	junction plakoglobin	0.021
Osr1	odd-skipped related 1 (Drosophila)	0.021
Adipor2	adiponectin receptor 2	0.021
Klf9	Kruppel-like factor 9	0.021
Csf1r	colony stimulating factor 1 receptor	0.021
Rdh10	retinol dehydrogenase 10 (all-trans)	0.021
Ldlr	low density lipoprotein receptor	0.021
Efnb2	ephrin B2	0.021
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.020
Cfh	complement component factor h	0.020
Gli2	GLI-Kruppel family member GLI2	0.020
Ptgds	prostaglandin D2 synthase (brain)	0.020
Ache	acetylcholinesterase	0.020
Ptms	parathymosin	0.020
Ppap2b	phosphatidic acid phosphatase type 2B	0.020
Meox2	mesenchyme homeobox 2	0.020
Asprv1	aspartic peptidase, retroviral-like 1	0.020
Lum	lumican	0.019
Ccl12	chemokine (C-C motif) ligand 12	0.019
Fgf8	fibroblast growth factor 8	0.019
Fcgr2b	Fc receptor, IgG, low affinity IIb	0.019
Fads2	fatty acid desaturase 2	0.019
Nfic	nuclear factor I/C	0.019
Lpin1	lipin 1	0.019
Abcg8	ATP-binding cassette, sub-family G (WHITE), member 8	0.019
Nos3	nitric oxide synthase 3, endothelial cell	0.019
Tgfbr3	transforming growth factor, beta receptor III	0.019
Sts	steroid sulfatase	0.019
Sqle	squalene epoxidase	0.018
Aacs	acetoacetyl-CoA synthetase	0.018
Bmp7	bone morphogenetic protein 7	0.018
Acadm	acyl-Coenzyme A dehydrogenase, medium chain	0.018
Slc27a1	solute carrier family 27 (fatty acid transporter), member 1	0.018
Aldh6a1	aldehyde dehydrogenase family 6, subfamily A1	0.018
Fzd4	frizzled homolog 4 (Drosophila)	0.018
Pcx	pyruvate carboxylase	0.018
Cxcl2	chemokine (C-X-C motif) ligand 2	0.018
Lrp5	low density lipoprotein receptor-related protein 5	0.018
Cd14	CD14 antigen	0.017
Idh1	isocitrate dehydrogenase 1 (NADP+), soluble	0.017
Med25	mediator of RNA polymerase II transcription, subunit 25 homolog (yeast)	0.017
Dag1	dystroglycan 1	0.017
Sepp1	selenoprotein P, plasma, 1	0.017
Nkx2-1	NK2 homeobox 1	0.017
Kcnh1	potassium voltage-gated channel, subfamily H (eag-related), member 1	0.017
Serpind1	serine (or cysteine) peptidase inhibitor, clade D, member 1	0.016
4931406C07Rik	RIKEN cDNA 4931406C07 gene	0.016
Mesp1	mesoderm posterior 1	0.016
Car5a	carbonic anhydrase 5a, mitochondrial	0.016
Lcat	lecithin cholesterol acyltransferase	0.016
Pten	phosphatase and tensin homolog	0.016
Acox1	acyl-Coenzyme A oxidase 1, palmitoyl	0.016
Pcyt2	phosphate cytidylyltransferase 2, ethanolamine	0.016
Ogn	osteoglycin	0.016
Sec14l2	SEC14-like 2 (S. cerevisiae)	0.016	Rat
Twist2	twist homolog 2 (Drosophila)	0.015
Plaur	plasminogen activator, urokinase receptor	0.015
AI464131	expressed sequence AI464131	0.015
Tgfbr2	transforming growth factor, beta receptor II	0.015
Ednrb	endothelin receptor type B	0.015
Hamp	hepcidin antimicrobial peptide	0.015
Hpn	hepsin	0.015
Fuz	fuzzy homolog (Drosophila)	0.015
Clec4n	C-type lectin domain family 4, member n	0.015
Timp1	tissue inhibitor of metalloproteinase 1	0.015
Yap1	yes-associated protein 1	0.015
Faah	fatty acid amide hydrolase	0.015
F10	coagulation factor X	0.015
Lims2	LIM and senescent cell antigen like domains 2	0.014
1500003O03Rik	RIKEN cDNA 1500003O03 gene	0.014
Dbi	diazepam binding inhibitor	0.014
Bhlhe40	basic helix-loop-helix family, member e40	0.014
Btd	biotinidase	0.014
Gli3	GLI-Kruppel family member GLI3	0.014
Traf4	TNF receptor associated factor 4	0.014
Hlf	hepatic leukemia factor	0.014
Bcl2	B-cell leukemia/lymphoma 2	0.014
Nf1	neurofibromatosis 1	0.014
Ar	androgen receptor	0.014
Hsd17b4	hydroxysteroid (17-beta) dehydrogenase 4	0.014
Emr1	EGF-like module containing, mucin-like, hormone receptor-like sequence 1	0.014
Marveld2	MARVEL (membrane-associating) domain containing 2	0.014
Gjb6	gap junction protein, beta 6	0.014
Cpne6	copine VI	0.014
Phyh	phytanoyl-CoA hydroxylase	0.014
Gdf11	growth differentiation factor 11	0.014
Tpo	thyroid peroxidase	0.014
Lipc	lipase, hepatic	0.013
Slc9a3r1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.013
Mmp9	matrix metallopeptidase 9	0.013
Nr1d2	nuclear receptor subfamily 1, group D, member 2	0.013	Mouse
Ccl17	chemokine (C-C motif) ligand 17	0.013
Cyp51	cytochrome P450, family 51	0.013
Aldh4a1	aldehyde dehydrogenase 4 family, member A1	0.013
Fgfr3	fibroblast growth factor receptor 3	0.013
Tppp3	tubulin polymerization-promoting protein family member 3	0.013
Selp	selectin, platelet	0.013
Gjb2	gap junction protein, beta 2	0.013
Jag2	jagged 2	0.013
Phc2	polyhomeotic-like 2 (Drosophila)	0.013
Tcf21	transcription factor 21	0.013
Chi3l1	chitinase 3-like 1	0.013
Por	P450 (cytochrome) oxidoreductase	0.013	Rat
Ccl9	chemokine (C-C motif) ligand 9	0.013
Adra1b	adrenergic receptor, alpha 1b	0.013
Ctdsp2	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2	0.013
Gstm1	glutathione S-transferase, mu 1	0.013
Fcgrt	Fc receptor, IgG, alpha chain transporter	0.013
Fpr1	formyl peptide receptor 1	0.013
Abcb4	ATP-binding cassette, sub-family B (MDR/TAP), member 4	0.013
Sirpa	signal-regulatory protein alpha	0.013
Car11	carbonic anhydrase 11	0.013
Slc25a10	solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10	0.013
Pcsk6	proprotein convertase subtilisin/kexin type 6	0.013
Tst	thiosulfate sulfurtransferase, mitochondrial	0.013
Dgat2	diacylglycerol O-acyltransferase 2	0.013
Sorbs3	sorbin and SH3 domain containing 3	0.013
Trim8	tripartite motif-containing 8	0.013
Lss	lanosterol synthase	0.013
Gnmt	glycine N-methyltransferase	0.013
Apoa1	apolipoprotein A-I	0.013
S100a9	S100 calcium binding protein A9 (calgranulin B)	0.013
Ctsk	cathepsin K	0.013
Stard10	START domain containing 10	0.013
Rin2	Ras and Rab interactor 2	0.012
Csf2rb	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.012
Hmgcs1	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1	0.012
Scn1b	sodium channel, voltage-gated, type I, beta	0.012
Isl1	ISL1 transcription factor, LIM/homeodomain	0.012
Abhd14b	abhydrolase domain containing 14b	0.012
Ccl7	chemokine (C-C motif) ligand 7	0.012
Cyp2d22	cytochrome P450, family 2, subfamily d, polypeptide 22	0.012
Pcbd1	pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1	0.012
Hadh	hydroxyacyl-Coenzyme A dehydrogenase	0.012
Fgf10	fibroblast growth factor 10	0.012
Enpep	glutamyl aminopeptidase	0.012
Il1rn	interleukin 1 receptor antagonist	0.012
Clstn3	calsyntenin 3	0.012
Sod3	superoxide dismutase 3, extracellular	0.012
Herpud1	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1	0.012
Shh	sonic hedgehog	0.012
Cyp4v3	cytochrome P450, family 4, subfamily v, polypeptide 3	0.012
Glg1	golgi apparatus protein 1	0.012
Lrp1	low density lipoprotein receptor-related protein 1	0.012
Ctnnb1	catenin (cadherin associated protein), beta 1	0.012
Klf15	Kruppel-like factor 15	0.012
Rap1gap	Rap1 GTPase-activating protein	0.012
Mertk	c-mer proto-oncogene tyrosine kinase	0.011
Elovl6	ELOVL family member 6, elongation of long chain fatty acids (yeast)	0.011
Ogfod2	2-oxoglutarate and iron-dependent oxygenase domain containing 2	0.011
Ngef	neuronal guanine nucleotide exchange factor	0.011
Drd2	dopamine receptor D2	0.011
Bmp5	bone morphogenetic protein 5	0.011
Il1r1	interleukin 1 receptor, type I	0.011
Scarb1	scavenger receptor class B, member 1	0.011
Lpcat3	lysophosphatidylcholine acyltransferase 3	0.011
Aldh1b1	aldehyde dehydrogenase 1 family, member B1	0.011
Ptprf	protein tyrosine phosphatase, receptor type, F	0.011
Lrp4	low density lipoprotein receptor-related protein 4	0.011
Tmbim6	transmembrane BAX inhibitor motif containing 6	0.011
Pltp	phospholipid transfer protein	0.011
Fads1	fatty acid desaturase 1	0.011
Expi	extracellular proteinase inhibitor	0.011
Adcyap1r1	adenylate cyclase activating polypeptide 1 receptor 1	0.011
Arhgef10	Rho guanine nucleotide exchange factor (GEF) 10	0.011
Hand2	heart and neural crest derivatives expressed transcript 2	0.011
Atg2a	ATG2 autophagy related 2 homolog A (S. cerevisiae)	0.011
Tnks1bp1	tankyrase 1 binding protein 1	0.011
Pde1b	phosphodiesterase 1B, Ca2+-calmodulin dependent	0.011
Lzts2	leucine zipper, putative tumor suppressor 2	0.011
Cdh23	cadherin 23 (otocadherin)	0.011
Mknk2	MAP kinase-interacting serine/threonine kinase 2	0.011
Cpt1a	carnitine palmitoyltransferase 1a, liver	0.011
Stard4	StAR-related lipid transfer (START) domain containing 4	0.011
Spns1	spinster homolog 1 (Drosophila)	0.011
Ppara	peroxisome proliferator activated receptor alpha	0.011
Hoxb3	homeobox B3	0.011
Cideb	cell death-inducing DNA fragmentation factor, alpha subunit-like effector B	0.011
Nr1h3	nuclear receptor subfamily 1, group H, member 3	0.011
Cxcl5	chemokine (C-X-C motif) ligand 5	0.011
Ephx1	epoxide hydrolase 1, microsomal	0.011
F7	coagulation factor VII	0.011
Ninj1	ninjurin 1	0.011
Gpt	glutamic pyruvic transaminase, soluble	0.011
Mme	membrane metallo endopeptidase	0.011
Gpld1	glycosylphosphatidylinositol specific phospholipase D1	0.011
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.011
Tkt	transketolase	0.010
Fmnl1	formin-like 1	0.010
Ccl3	chemokine (C-C motif) ligand 3	0.010
Nos1	nitric oxide synthase 1, neuronal	0.010
Hsdl2	hydroxysteroid dehydrogenase like 2	0.010
Cish	cytokine inducible SH2-containing protein	0.010
Slc27a4	solute carrier family 27 (fatty acid transporter), member 4	0.010
Cd36	CD36 antigen	0.010
Aoah	acyloxyacyl hydrolase	0.010
Alas1	aminolevulinic acid synthase 1	0.010
Fxyd6	FXYD domain-containing ion transport regulator 6	0.010
Ext1	exostoses (multiple) 1	0.010
Eef1a2	eukaryotic translation elongation factor 1 alpha 2	0.010
Tek	endothelial-specific receptor tyrosine kinase	0.010
Plekhh3	pleckstrin homology domain containing, family H (with MyTH4 domain) member 3	0.010
Slc6a6	solute carrier family 6 (neurotransmitter transporter, taurine), member 6	0.010
Mark4	MAP/microtubule affinity-regulating kinase 4	0.010
Hrsp12	heat-responsive protein 12	0.010
Pex5	peroxisomal biogenesis factor 5	0.010
Axin1	axin 1	0.010
Asb13	ankyrin repeat and SOCS box-containing 13	0.010
Timp3	tissue inhibitor of metalloproteinase 3	0.010
Cdk5r2	cyclin-dependent kinase 5, regulatory subunit 2 (p39)	0.010
Wnt4	wingless-related MMTV integration site 4	0.010