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Process View

Mus musculus

11 genes annotated in mouse

negative regulation of necrotic cell death

Any process that decreases the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of necrotic cell death"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of necrotic cell death" (in gray)

Name	Description	Probability	Func Analog Organism
Ikbkg	inhibitor of kappaB kinase gamma	1.000
Tnf	tumor necrosis factor	0.987
Gbp5	guanylate binding protein 5	0.983
Pycard	PYD and CARD domain containing	0.968
Sharpin	SHANK-associated RH domain interacting protein	0.947	Mouse
Ikbkb	inhibitor of kappaB kinase beta	0.934
Traf2	TNF receptor-associated factor 2	0.933
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.932
Aim2	absent in melanoma 2	0.919
Tlr4	toll-like receptor 4	0.907
Casp8	caspase 8	0.871
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.715
Il18	interleukin 18	0.683
Rnf31	ring finger protein 31	0.612
Nlrp3	NLR family, pyrin domain containing 3	0.564
Hif1a	hypoxia inducible factor 1, alpha subunit	0.536
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.515
Traf6	TNF receptor-associated factor 6	0.493
Myd88	myeloid differentiation primary response gene 88	0.427
Fadd	Fas (TNFRSF6)-associated via death domain	0.386
Itch	itchy, E3 ubiquitin protein ligase	0.360
Ctsl	cathepsin L	0.222
Cyld	cylindromatosis (turban tumor syndrome)	0.212
Arnt	aryl hydrocarbon receptor nuclear translocator	0.175
Birc3	baculoviral IAP repeat-containing 3	0.172
Smad5	MAD homolog 5 (Drosophila)	0.164
Il1b	interleukin 1 beta	0.128
Fas	Fas (TNF receptor superfamily member 6)	0.113
Bub1b	budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)	0.112
Foxp3	forkhead box P3	0.111
Rbck1	RanBP-type and C3HC4-type zinc finger containing 1	0.109
Diablo	diablo homolog (Drosophila)	0.093
Stat3	signal transducer and activator of transcription 3	0.088
Eif2ak2	eukaryotic translation initiation factor 2-alpha kinase 2	0.088
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.082	Mouse
Il1r1	interleukin 1 receptor, type I	0.072
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.067
Ripk3	receptor-interacting serine-threonine kinase 3	0.065
Cd14	CD14 antigen	0.062
Ccnb2	cyclin B2	0.062
Gja1	gap junction protein, alpha 1	0.060
Naip2	NLR family, apoptosis inhibitory protein 2	0.052
Ahr	aryl-hydrocarbon receptor	0.052
Tgfbr1	transforming growth factor, beta receptor I	0.051
Gbp7	guanylate binding protein 7	0.044
Map3k1	mitogen-activated protein kinase kinase kinase 1	0.042
Ghr	growth hormone receptor	0.040
Hccs	holocytochrome c synthetase	0.040
Tab1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.036
Abca1	ATP-binding cassette, sub-family A (ABC1), member 1	0.035
Eya2	eyes absent 2 homolog (Drosophila)	0.034
Ttc7	tetratricopeptide repeat domain 7	0.031
Map3k2	mitogen-activated protein kinase kinase kinase 2	0.030
Cflar	CASP8 and FADD-like apoptosis regulator	0.030
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.030
Casp7	caspase 7	0.028	Mouse
Ly96	lymphocyte antigen 96	0.027
Elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.026
Cd40	CD40 antigen	0.024
Tnfsf10	tumor necrosis factor (ligand) superfamily, member 10	0.023
Cdk1	cyclin-dependent kinase 1	0.022
Gbp3	guanylate binding protein 3	0.021
Nmi	N-myc (and STAT) interactor	0.021
Smad1	MAD homolog 1 (Drosophila)	0.020
Naip5	NLR family, apoptosis inhibitory protein 5	0.020	Mouse
Tnfrsf11a	tumor necrosis factor receptor superfamily, member 11a	0.018
Zufsp	zinc finger with UFM1-specific peptidase domain	0.016
Hmgb1	high mobility group box 1	0.016
Lyz2	lysozyme 2	0.015
Stk3	serine/threonine kinase 3 (Ste20, yeast homolog)	0.015
Cdca8	cell division cycle associated 8	0.015
Map2k4	mitogen-activated protein kinase kinase 4	0.015
Pml	promyelocytic leukemia	0.015
Pik3c2a	phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide	0.015
Hgf	hepatocyte growth factor	0.014
Fgl2	fibrinogen-like protein 2	0.014
Zfp26	zinc finger protein 26	0.014
Il13ra1	interleukin 13 receptor, alpha 1	0.014
Plscr1	phospholipid scramblase 1	0.013
Trim30d	tripartite motif-containing 30D	0.013
Nat2	N-acetyltransferase 2 (arylamine N-acetyltransferase)	0.013
Ube2n	ubiquitin-conjugating enzyme E2N	0.013
Stat6	signal transducer and activator of transcription 6	0.012
Card11	caspase recruitment domain family, member 11	0.012
Malt1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.012
Ccna2	cyclin A2	0.011
C1ra	complement component 1, r subcomponent A	0.011
Nlrp6	NLR family, pyrin domain containing 6	0.011
Xiap	X-linked inhibitor of apoptosis	0.011	Mouse
Skil	SKI-like	0.011
Hdgf	hepatoma-derived growth factor	0.011
Cycs	cytochrome c, somatic	0.011
Racgap1	Rac GTPase-activating protein 1	0.011
Nfkbiz	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.011
Htt	huntingtin	0.011
H2afx	H2A histone family, member X	0.011
Sirt7	sirtuin 7 (silent mating type information regulation 2, homolog) 7 (S. cerevisiae)	0.011
Ms4a4d	membrane-spanning 4-domains, subfamily A, member 4D	0.011
Irak3	interleukin-1 receptor-associated kinase 3	0.010
Ticam1	toll-like receptor adaptor molecule 1	0.010