IMP

Process View

Mus musculus

14 genes annotated in mouse

positive regulation of cd4 positive alpha beta t cell differentiation

Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell differentiation.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of cd4 positive alpha beta t cell differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of cd4 positive alpha beta t cell differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.863
Ccl2	chemokine (C-C motif) ligand 2	0.737
Stat5a	signal transducer and activator of transcription 5A	0.657
Jak2	Janus kinase 2	0.614
Csf2rb2	colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)	0.491	Mouse
Cd28	CD28 antigen	0.482
Stat3	signal transducer and activator of transcription 3	0.458
Ccl7	chemokine (C-C motif) ligand 7	0.454	Mouse
Stat5b	signal transducer and activator of transcription 5B	0.443
Csf2rb	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.431	Mouse
Lepr	leptin receptor	0.428
Tnf	tumor necrosis factor	0.404
Gli2	GLI-Kruppel family member GLI2	0.261
Ccl3	chemokine (C-C motif) ligand 3	0.247	Mouse
Ifng	interferon gamma	0.225
Ccl8	chemokine (C-C motif) ligand 8	0.220
Foxp3	forkhead box P3	0.184
Cish	cytokine inducible SH2-containing protein	0.168	Mouse
Fas	Fas (TNF receptor superfamily member 6)	0.163
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.154
Gzma	granzyme A	0.153
Il6st	interleukin 6 signal transducer	0.146
Ccl12	chemokine (C-C motif) ligand 12	0.140	Mouse
Msr1	macrophage scavenger receptor 1	0.139
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.135
Ccr2	chemokine (C-C motif) receptor 2	0.133
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.121
Batf	basic leucine zipper transcription factor, ATF-like	0.115
Trp53	transformation related protein 53	0.108
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.108
Cd44	CD44 antigen	0.103
Mmp12	matrix metallopeptidase 12	0.098
Il1b	interleukin 1 beta	0.098
Socs1	suppressor of cytokine signaling 1	0.094	Mouse
Foxn1	forkhead box N1	0.091
Cxcl2	chemokine (C-X-C motif) ligand 2	0.089
Ccr1	chemokine (C-C motif) receptor 1	0.082
Il6	interleukin 6	0.074
Ldb3	LIM domain binding 3	0.070
C3ar1	complement component 3a receptor 1	0.065
Ch25h	cholesterol 25-hydroxylase	0.062
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.055
Ttc7	tetratricopeptide repeat domain 7	0.052
Cd86	CD86 antigen	0.051
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.048
Il1rn	interleukin 1 receptor antagonist	0.048
Rag1	recombination activating gene 1	0.048
Ccl22	chemokine (C-C motif) ligand 22	0.048
Batf3	basic leucine zipper transcription factor, ATF-like 3	0.047
Jak3	Janus kinase 3	0.047
Csf2	colony stimulating factor 2 (granulocyte-macrophage)	0.046
Nfkbie	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.046
Saa3	serum amyloid A 3	0.045
Cxcl1	chemokine (C-X-C motif) ligand 1	0.044
Cd40	CD40 antigen	0.044
Itgax	integrin alpha X	0.044
Akt1	thymoma viral proto-oncogene 1	0.042	Mouse
Cd4	CD4 antigen	0.042
Ccr7	chemokine (C-C motif) receptor 7	0.042
Bcl3	B-cell leukemia/lymphoma 3	0.041
Hhex	hematopoietically expressed homeobox	0.040
Cd14	CD14 antigen	0.040
Serpina3n	serine (or cysteine) peptidase inhibitor, clade A, member 3N	0.039
Creb1	cAMP responsive element binding protein 1	0.038
Plek	pleckstrin	0.037
Irg1	immunoresponsive gene 1	0.037
Egfr	epidermal growth factor receptor	0.037
Foxp2	forkhead box P2	0.034	Mouse
Il7r	interleukin 7 receptor	0.034
Casp8	caspase 8	0.033
Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.033
Socs2	suppressor of cytokine signaling 2	0.033	Mouse
Runx1	runt related transcription factor 1	0.033
Socs3	suppressor of cytokine signaling 3	0.033	Mouse
Fcer1g	Fc receptor, IgE, high affinity I, gamma polypeptide	0.032
Stat6	signal transducer and activator of transcription 6	0.031
9430031J16Rik	RIKEN cDNA 9430031J16 gene	0.030
Pard3	par-3 (partitioning defective 3) homolog (C. elegans)	0.030
Fcgr1	Fc receptor, IgG, high affinity I	0.030
Lag3	lymphocyte-activation gene 3	0.029
Traf6	TNF receptor-associated factor 6	0.029
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.028
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.028
Foxp1	forkhead box P1	0.027	Mouse
Bcl2	B-cell leukemia/lymphoma 2	0.027
Slc11a1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.026
Il1r1	interleukin 1 receptor, type I	0.025
Irf5	interferon regulatory factor 5	0.025
Clec4d	C-type lectin domain family 4, member d	0.024
Ccl9	chemokine (C-C motif) ligand 9	0.023	Mouse
Ctla4	cytotoxic T-lymphocyte-associated protein 4	0.023
Ikzf1	IKAROS family zinc finger 1	0.023
Vhl	von Hippel-Lindau tumor suppressor	0.023
Ccl17	chemokine (C-C motif) ligand 17	0.023	Mouse
Pdcd1lg2	programmed cell death 1 ligand 2	0.022
Pdcd1	programmed cell death 1	0.022
Lat	linker for activation of T cells	0.022
Nlrp3	NLR family, pyrin domain containing 3	0.022
Il4	interleukin 4	0.022
Cxcl9	chemokine (C-X-C motif) ligand 9	0.022
Rag2	recombination activating gene 2	0.021
Selp	selectin, platelet	0.021
Twist2	twist homolog 2 (Drosophila)	0.021
Has1	hyaluronan synthase1	0.021
Lilrb4	leukocyte immunoglobulin-like receptor, subfamily B, member 4	0.020
Smad3	MAD homolog 3 (Drosophila)	0.020
Slc10a6	solute carrier family 10 (sodium/bile acid cotransporter family), member 6	0.020
Ctsw	cathepsin W	0.019
Clec7a	C-type lectin domain family 7, member a	0.019
Lcp2	lymphocyte cytosolic protein 2	0.019
Itgb2	integrin beta 2	0.019
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.019
Pfn2	profilin 2	0.018
Il4ra	interleukin 4 receptor, alpha	0.018
Il1r2	interleukin 1 receptor, type II	0.018
Olr1	oxidized low density lipoprotein (lectin-like) receptor 1	0.018
Spna1	spectrin alpha 1	0.017
Csf1	colony stimulating factor 1 (macrophage)	0.017
Clec4e	C-type lectin domain family 4, member e	0.017
Robo1	roundabout homolog 1 (Drosophila)	0.017
Actn2	actinin alpha 2	0.017
Tgfbr1	transforming growth factor, beta receptor I	0.017
Cxcl13	chemokine (C-X-C motif) ligand 13	0.017
Ccr5	chemokine (C-C motif) receptor 5	0.016
Spred1	sprouty protein with EVH-1 domain 1, related sequence	0.016
Lilrb3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.016
Sfn	stratifin	0.016
Rgs1	regulator of G-protein signaling 1	0.015
Il2rb	interleukin 2 receptor, beta chain	0.015
Timp1	tissue inhibitor of metalloproteinase 1	0.015
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.015
Prkce	protein kinase C, epsilon	0.015
Selplg	selectin, platelet (p-selectin) ligand	0.014
Slamf8	SLAM family member 8	0.014
Cybb	cytochrome b-245, beta polypeptide	0.014
Apc	adenomatosis polyposis coli	0.014
Arid5a	AT rich interactive domain 5A (MRF1-like)	0.014
Batf2	basic leucine zipper transcription factor, ATF-like 2	0.014
Emr1	EGF-like module containing, mucin-like, hormone receptor-like sequence 1	0.014
Cxcl10	chemokine (C-X-C motif) ligand 10	0.014
Foxo1	forkhead box O1	0.014
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.014
Gdf15	growth differentiation factor 15	0.014
Akt2	thymoma viral proto-oncogene 2	0.014	Mouse
Lep	leptin	0.014
Man1a2	mannosidase, alpha, class 1A, member 2	0.014
Lyz2	lysozyme 2	0.013
C5ar1	complement component 5a receptor 1	0.013
Rarg	retinoic acid receptor, gamma	0.013
St3gal1	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	0.013
Cul5	cullin 5	0.013
Prf1	perforin 1 (pore forming protein)	0.013
Prkcb	protein kinase C, beta	0.013
Mx2	myxovirus (influenza virus) resistance 2	0.013
Plekho2	pleckstrin homology domain containing, family O member 2	0.012
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.012
Fgf21	fibroblast growth factor 21	0.012
Egr2	early growth response 2	0.012
Mmp3	matrix metallopeptidase 3	0.012
Aire	autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)	0.012
Cd7	CD7 antigen	0.012
Rel	reticuloendotheliosis oncogene	0.012
Clec4n	C-type lectin domain family 4, member n	0.012
Tbxas1	thromboxane A synthase 1, platelet	0.012
Icam1	intercellular adhesion molecule 1	0.012
Gm11428	predicted gene 11428	0.012
Folr2	folate receptor 2 (fetal)	0.012
Lta	lymphotoxin A	0.012
F10	coagulation factor X	0.011
Adam8	a disintegrin and metallopeptidase domain 8	0.011
Cfb	complement factor B	0.011
H2-Ab1	histocompatibility 2, class II antigen A, beta 1	0.011
Kit	kit oncogene	0.011
Cd80	CD80 antigen	0.011
Il18rap	interleukin 18 receptor accessory protein	0.011
Ptprc	protein tyrosine phosphatase, receptor type, C	0.011
Il10ra	interleukin 10 receptor, alpha	0.011
Bcl2a1d	B-cell leukemia/lymphoma 2 related protein A1d	0.011
Gpr65	G-protein coupled receptor 65	0.011
Cxcl16	chemokine (C-X-C motif) ligand 16	0.010
Ubd	ubiquitin D	0.010
Rxra	retinoid X receptor alpha	0.010
Zap70	zeta-chain (TCR) associated protein kinase	0.010
Snx20	sorting nexin 20	0.010
Ikbkg	inhibitor of kappaB kinase gamma	0.010
Csf3	colony stimulating factor 3 (granulocyte)	0.010
Pou5f1	POU domain, class 5, transcription factor 1	0.010
Irf1	interferon regulatory factor 1	0.010
2310014H01Rik	RIKEN cDNA 2310014H01 gene	0.010
Gfpt2	glutamine fructose-6-phosphate transaminase 2	0.010