IMP

Process View

Mus musculus

16 genes annotated in mouse

response to superoxide

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "response to superoxide"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "response to superoxide" (in gray)

Name	Description	Probability	Func Analog Organism
Mapk14	mitogen-activated protein kinase 14	0.999	Worm
Apoe	apolipoprotein E	0.705
Fbn1	fibrillin 1	0.669
Mapkapk2	MAP kinase-activated protein kinase 2	0.601
Tgfbr2	transforming growth factor, beta receptor II	0.454
Tgfbr1	transforming growth factor, beta receptor I	0.331
Fbln5	fibulin 5	0.327
Mmp2	matrix metallopeptidase 2	0.295
Ldlr	low density lipoprotein receptor	0.286
Mapk11	mitogen-activated protein kinase 11	0.286	Worm
Mknk2	MAP kinase-interacting serine/threonine kinase 2	0.282
Mt1	metallothionein 1	0.253
Steap3	STEAP family member 3	0.246
Slc39a4	solute carrier family 39 (zinc transporter), member 4	0.244
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.235
Atp7a	ATPase, Cu++ transporting, alpha polypeptide	0.227
Ltbp2	latent transforming growth factor beta binding protein 2	0.189	Mouse
Slc2a4	solute carrier family 2 (facilitated glucose transporter), member 4	0.188
Col6a1	collagen, type VI, alpha 1	0.185
Slc31a1	solute carrier family 31, member 1	0.143
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.118
Eln	elastin	0.116
Gcsh	glycine cleavage system protein H (aminomethyl carrier)	0.113
Htra3	HtrA serine peptidase 3	0.113
Slc9a3r2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.111
Mrpl16	mitochondrial ribosomal protein L16	0.104
Hbb-b1	hemoglobin, beta adult major chain	0.100
Mcl1	myeloid cell leukemia sequence 1	0.099
Duox2	dual oxidase 2	0.097
Psmb2	proteasome (prosome, macropain) subunit, beta type 2	0.097
Elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.090
Cul7	cullin 7	0.089
E2f1	E2F transcription factor 1	0.086
Slc12a6	solute carrier family 12, member 6	0.082
Lage3	L antigen family, member 3	0.075
Romo1	reactive oxygen species modulator 1	0.075
Lrp1	low density lipoprotein receptor-related protein 1	0.074
Idua	iduronidase, alpha-L-	0.074
Slc12a4	solute carrier family 12, member 4	0.073
Tgfb3	transforming growth factor, beta 3	0.068
Flna	filamin, alpha	0.065
Ndufa9	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9	0.063
Coq7	demethyl-Q 7	0.062
Smn1	survival motor neuron 1	0.059
Ngp	neutrophilic granule protein	0.057
Sp1	trans-acting transcription factor 1	0.056
Gja1	gap junction protein, alpha 1	0.056
Sorbs3	sorbin and SH3 domain containing 3	0.055
Gart	phosphoribosylglycinamide formyltransferase	0.055
Fam96a	family with sequence similarity 96, member A	0.054
Thbs3	thrombospondin 3	0.053
Mib1	mindbomb homolog 1 (Drosophila)	0.053
Tmed10	transmembrane emp24-like trafficking protein 10 (yeast)	0.053
Tlr4	toll-like receptor 4	0.052
Prnp	prion protein	0.052
Smad1	MAD homolog 1 (Drosophila)	0.050
Lox	lysyl oxidase	0.049
Stom	stomatin	0.047
Adsl	adenylosuccinate lyase	0.047
F2r	coagulation factor II (thrombin) receptor	0.046
Timm17a	translocase of inner mitochondrial membrane 17a	0.046
Tenc1	tensin like C1 domain-containing phosphatase	0.045
Cav1	caveolin 1, caveolae protein	0.045
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.045
Plcd1	phospholipase C, delta 1	0.044
Timm23	translocase of inner mitochondrial membrane 23 homolog (yeast)	0.043
Lamp2	lysosomal-associated membrane protein 2	0.043
Gp1ba	glycoprotein 1b, alpha polypeptide	0.041
Mafk	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)	0.040
Pax8	paired box gene 8	0.040
Sod3	superoxide dismutase 3, extracellular	0.040
Sulf1	sulfatase 1	0.039
Dbi	diazepam binding inhibitor	0.039
Hmbs	hydroxymethylbilane synthase	0.039
Prdx1	peroxiredoxin 1	0.037
Phb	prohibitin	0.036
Mmp11	matrix metallopeptidase 11	0.035
Ptrf	polymerase I and transcript release factor	0.035
Fabp4	fatty acid binding protein 4, adipocyte	0.035
Casp3	caspase 3	0.035
Leprel2	leprecan-like 2	0.034
Rhd	Rh blood group, D antigen	0.034
Prelp	proline arginine-rich end leucine-rich repeat	0.034
Nudt1	nudix (nucleoside diphosphate linked moiety X)-type motif 1	0.034
Ifngr1	interferon gamma receptor 1	0.033
H2afx	H2A histone family, member X	0.033
Atp5a1	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1	0.032
Figf	c-fos induced growth factor	0.032
Trp53	transformation related protein 53	0.032
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.031
Mknk1	MAP kinase-interacting serine/threonine kinase 1	0.031
Plin4	perilipin 4	0.031
Rhbdf1	rhomboid family 1 (Drosophila)	0.031
Gypa	glycophorin A	0.030
Pnpla2	patatin-like phospholipase domain containing 2	0.030
Scara3	scavenger receptor class A, member 3	0.030
Ndufb6	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6	0.030
Atp5b	ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit	0.029
Park2	Parkinson disease (autosomal recessive, juvenile) 2, parkin	0.029
Tshr	thyroid stimulating hormone receptor	0.029
Loxl1	lysyl oxidase-like 1	0.028
Aifm1	apoptosis-inducing factor, mitochondrion-associated 1	0.028
Agpat2	1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)	0.028
Stc2	stanniocalcin 2	0.027
Mrps28	mitochondrial ribosomal protein S28	0.027
1110008F13Rik	RIKEN cDNA 1110008F13 gene	0.026
Zyx	zyxin	0.026
Mrps17	mitochondrial ribosomal protein S17	0.026
Atr	ataxia telangiectasia and Rad3 related	0.026
Angptl2	angiopoietin-like 2	0.026
Tlr2	toll-like receptor 2	0.025
Scn9a	sodium channel, voltage-gated, type IX, alpha	0.025
Naa10	N(alpha)-acetyltransferase 10, NatA catalytic subunitNalpha acetyltransferase 10	0.025
Klf10	Kruppel-like factor 10	0.025
Ephb4	Eph receptor B4	0.025
Rcn3	reticulocalbin 3, EF-hand calcium binding domain	0.024
Smo	smoothened homolog (Drosophila)	0.024
Txnrd1	thioredoxin reductase 1	0.024
Mn1	meningioma 1	0.024
Cycs	cytochrome c, somatic	0.024
Ltbr	lymphotoxin B receptor	0.023
Mertk	c-mer proto-oncogene tyrosine kinase	0.023
Bcap31	B-cell receptor-associated protein 31	0.023
Hsd3b7	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	0.023
Ghr	growth hormone receptor	0.022
Txn1	thioredoxin 1	0.022
Mfge8	milk fat globule-EGF factor 8 protein	0.022
Efemp1	epidermal growth factor-containing fibulin-like extracellular matrix protein 1	0.022	Mouse
Pdgfb	platelet derived growth factor, B polypeptide	0.022
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.022
Cp	ceruloplasmin	0.021
Gpd2	glycerol phosphate dehydrogenase 2, mitochondrial	0.021
Cidec	cell death-inducing DFFA-like effector c	0.021
Mrpl13	mitochondrial ribosomal protein L13	0.021
Dctpp1	dCTP pyrophosphatase 1	0.021
Sepn1	selenoprotein N, 1	0.021
S1pr2	sphingosine-1-phosphate receptor 2	0.021
Lamb2	laminin, beta 2	0.021
Sdhd	succinate dehydrogenase complex, subunit D, integral membrane protein	0.021
Colec12	collectin sub-family member 12	0.021
Adipoq	adiponectin, C1Q and collagen domain containing	0.020
Hint1	histidine triad nucleotide binding protein 1	0.020
Adamts1	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1	0.020
Tal1	T-cell acute lymphocytic leukemia 1	0.020
Lpl	lipoprotein lipase	0.020
Sema4b	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B	0.019
Stat3	signal transducer and activator of transcription 3	0.019
Tnxb	tenascin XB	0.019
Fxyd1	FXYD domain-containing ion transport regulator 1	0.019
H6pd	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	0.019
Zfp503	zinc finger protein 503	0.019
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.019
Phlda3	pleckstrin homology-like domain, family A, member 3	0.018
Retn	resistin	0.018
Gata1	GATA binding protein 1	0.018
Mapk9	mitogen-activated protein kinase 9	0.018
Rnf128	ring finger protein 128	0.018
X99384	cDNA sequence X99384	0.018
Mmp9	matrix metallopeptidase 9	0.018
2310061C15Rik	RIKEN cDNA 2310061C15 gene	0.018
Lass2	LAG1 homolog, ceramide synthase 2	0.017
Txnip	thioredoxin interacting protein	0.017
Ep300	E1A binding protein p300	0.017
Urod	uroporphyrinogen decarboxylase	0.017
Hoxa1	homeobox A1	0.017
Abca1	ATP-binding cassette, sub-family A (ABC1), member 1	0.017
Agrp	agouti related protein	0.017
Egln1	EGL nine homolog 1 (C. elegans)	0.017
Huwe1	HECT, UBA and WWE domain containing 1	0.016
Pcolce	procollagen C-endopeptidase enhancer protein	0.016
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.016
Notch3	Notch gene homolog 3 (Drosophila)	0.016
Mrpl52	mitochondrial ribosomal protein L52	0.016
Ercc1	excision repair cross-complementing rodent repair deficiency, complementation group 1	0.016
Nampt	nicotinamide phosphoribosyltransferase	0.016
Ltc4s	leukotriene C4 synthase	0.016
Gclm	glutamate-cysteine ligase, modifier subunit	0.015
Hyal3	hyaluronoglucosaminidase 3	0.015
Thrb	thyroid hormone receptor beta	0.015
P2rx1	purinergic receptor P2X, ligand-gated ion channel, 1	0.015
St14	suppression of tumorigenicity 14 (colon carcinoma)	0.015
Nod2	nucleotide-binding oligomerization domain containing 2	0.015
Dusp1	dual specificity phosphatase 1	0.015
Mrpl2	mitochondrial ribosomal protein L2	0.015
Elane	elastase, neutrophil expressed	0.015
Alad	aminolevulinate, delta-, dehydratase	0.015
Rps6ka5	ribosomal protein S6 kinase, polypeptide 5	0.015
Pklr	pyruvate kinase liver and red blood cell	0.015
Gltp	glycolipid transfer protein	0.015
Mapk12	mitogen-activated protein kinase 12	0.015	Worm
Slc27a1	solute carrier family 27 (fatty acid transporter), member 1	0.015
Plod3	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3	0.015
Mus81	MUS81 endonuclease homolog (yeast)	0.015
Angptl4	angiopoietin-like 4	0.015
Ctdspl	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like	0.015
Hic1	hypermethylated in cancer 1	0.015
Gpc1	glypican 1	0.015
Slc40a1	solute carrier family 40 (iron-regulated transporter), member 1	0.015
Gas1	growth arrest specific 1	0.015
Tiparp	TCDD-inducible poly(ADP-ribose) polymerase	0.014
Cd34	CD34 antigen	0.014
Akap13	A kinase (PRKA) anchor protein 13	0.014
Qdpr	quinoid dihydropteridine reductase	0.014
Itgb5	integrin beta 5	0.014
Pfn1	profilin 1	0.014
Cisd2	CDGSH iron sulfur domain 2	0.014
Stoml2	stomatin (Epb7.2)-like 2	0.014
Slc29a1	solute carrier family 29 (nucleoside transporters), member 1	0.014
Sp7	Sp7 transcription factor 7	0.014
Tgfb1i1	transforming growth factor beta 1 induced transcript 1	0.014
Timp2	tissue inhibitor of metalloproteinase 2	0.014
Il1r2	interleukin 1 receptor, type II	0.014
Btg1	B-cell translocation gene 1, anti-proliferative	0.014
Chad	chondroadherin	0.014
Stk40	serine/threonine kinase 40	0.014
Smyd1	SET and MYND domain containing 1	0.013
Trip10	thyroid hormone receptor interactor 10	0.013
Fam136a	family with sequence similarity 136, member A	0.013
Smoc2	SPARC related modular calcium binding 2	0.013
Ccr9	chemokine (C-C motif) receptor 9	0.013
Htra1	HtrA serine peptidase 1	0.013
Slc1a5	solute carrier family 1 (neutral amino acid transporter), member 5	0.013
Ifrd2	interferon-related developmental regulator 2	0.013
Aqp1	aquaporin 1	0.013
Dpep1	dipeptidase 1 (renal)	0.013
Camp	cathelicidin antimicrobial peptide	0.013
Wwox	WW domain-containing oxidoreductase	0.013
Xpa	xeroderma pigmentosum, complementation group A	0.013
Smtn	smoothelin	0.013
Klk1b21	kallikrein 1-related peptidase b21	0.013
Dmpk	dystrophia myotonica-protein kinase	0.013
Lactb2	lactamase, beta 2	0.013
Esd	esterase D/formylglutathione hydrolase	0.013
Capn1	calpain 1	0.013
Gigyf1	GRB10 interacting GYF protein 1	0.013
Spna1	spectrin alpha 1	0.013
Fh1	fumarate hydratase 1	0.013
Mmp8	matrix metallopeptidase 8	0.013
Aoc3	amine oxidase, copper containing 3	0.013
Gadd45a	growth arrest and DNA-damage-inducible 45 alpha	0.013
Wasf2	WAS protein family, member 2	0.013
Gm3150	predicted gene 3150	0.013
Map3k6	mitogen-activated protein kinase kinase kinase 6	0.013
Sykb	spleen tyrosine kinase	0.013
Soat2	sterol O-acyltransferase 2	0.013
L3mbtl2	l(3)mbt-like 2 (Drosophila)	0.012
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.012
Lmna	lamin A	0.012
Mkl2	MKL/myocardin-like 2	0.012
Tmem40	transmembrane protein 40	0.012
Bag3	BCL2-associated athanogene 3	0.012
Sqstm1	sequestosome 1	0.012
Nit2	nitrilase family, member 2	0.012
Ltb4r1	leukotriene B4 receptor 1	0.012
Hps1	Hermansky-Pudlak syndrome 1 homolog (human)	0.012
Aco1	aconitase 1	0.012
Alox12	arachidonate 12-lipoxygenase	0.012
Psmb7	proteasome (prosome, macropain) subunit, beta type 7	0.012
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.012
Igfbp4	insulin-like growth factor binding protein 4	0.012
Bmx	BMX non-receptor tyrosine kinase	0.012
Thbd	thrombomodulin	0.012
Mocs1	molybdenum cofactor synthesis 1	0.012
Klf6	Kruppel-like factor 6	0.012
Gpd1	glycerol-3-phosphate dehydrogenase 1 (soluble)	0.012
Asprv1	aspartic peptidase, retroviral-like 1	0.012
Scarb1	scavenger receptor class B, member 1	0.012	Mouse
Mfn2	mitofusin 2	0.012
Fbxo47	F-box protein 47	0.012
Slc4a1	solute carrier family 4 (anion exchanger), member 1	0.012
Kcnj10	potassium inwardly-rectifying channel, subfamily J, member 10	0.012
Creg1	cellular repressor of E1A-stimulated genes 1	0.012
Mstn	myostatin	0.012
Cbr2	carbonyl reductase 2	0.012
Nudt19	nudix (nucleoside diphosphate linked moiety X)-type motif 19	0.012
Pltp	phospholipid transfer protein	0.012
Ebf1	early B-cell factor 1	0.012
Rdh10	retinol dehydrogenase 10 (all-trans)	0.012
Cyb5	cytochrome b-5	0.012
Trabd	TraB domain containing	0.012
Ghitm	growth hormone inducible transmembrane protein	0.011
Gsta4	glutathione S-transferase, alpha 4	0.011
Glis2	GLIS family zinc finger 2	0.011
Chd2	chromodomain helicase DNA binding protein 2	0.011
Soat1	sterol O-acyltransferase 1	0.011
Mrps25	mitochondrial ribosomal protein S25	0.011
Impa2	inositol (myo)-1(or 4)-monophosphatase 2	0.011
Sulf2	sulfatase 2	0.011
Upk3b	uroplakin 3B	0.011
Tgfb1	transforming growth factor, beta 1	0.011
Trip6	thyroid hormone receptor interactor 6	0.011
Cfd	complement factor D (adipsin)	0.011
Col1a2	collagen, type I, alpha 2	0.011
Ltf	lactotransferrin	0.011
Gp5	glycoprotein 5 (platelet)	0.011
Mrpl23	mitochondrial ribosomal protein L23	0.011
Tsc1	tuberous sclerosis 1	0.011
Sod1	superoxide dismutase 1, soluble	0.011
Islr	immunoglobulin superfamily containing leucine-rich repeat	0.011
Cdh1	cadherin 1	0.011
Bcl2l1	BCL2-like 1	0.011
Pfkfb1	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	0.011
Cfh	complement component factor h	0.011
Rbm38	RNA binding motif protein 38	0.011
Sfrp4	secreted frizzled-related protein 4	0.011
Gpx1	glutathione peroxidase 1	0.011
Fzd2	frizzled homolog 2 (Drosophila)	0.011
Cat	catalase	0.011
Slc35a4	solute carrier family 35, member A4	0.011
Mfap4	microfibrillar-associated protein 4	0.011
Gfm1	G elongation factor, mitochondrial 1	0.011
Met	met proto-oncogene	0.011
Ndufab1	NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1	0.011
Mrpl35	mitochondrial ribosomal protein L35	0.011
Pim1	proviral integration site 1	0.011
Klf1	Kruppel-like factor 1 (erythroid)	0.011
Cidea	cell death-inducing DNA fragmentation factor, alpha subunit-like effector A	0.011
Ppp3r1	protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)	0.011
Igfbp6	insulin-like growth factor binding protein 6	0.011
Cops6	COP9 (constitutive photomorphogenic) homolog, subunit 6 (Arabidopsis thaliana)	0.011
Crat	carnitine acetyltransferase	0.011
Per3	period homolog 3 (Drosophila)	0.011
2010106G01Rik	RIKEN cDNA 2010106G01 gene	0.011
Inppl1	inositol polyphosphate phosphatase-like 1	0.010
Xylt2	xylosyltransferase II	0.010
Atp7b	ATPase, Cu++ transporting, beta polypeptide	0.010	Mouse
Stim2	stromal interaction molecule 2	0.010
Mitf	microphthalmia-associated transcription factor	0.010
Fkbp10	FK506 binding protein 10	0.010
Ms4a3	membrane-spanning 4-domains, subfamily A, member 3	0.010
Fmod	fibromodulin	0.010
Nfatc3	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	0.010
Phb2	prohibitin 2	0.010
Fkbp4	FK506 binding protein 4	0.010
Fzd4	frizzled homolog 4 (Drosophila)	0.010
Ifnar1	interferon (alpha and beta) receptor 1	0.010
Myo10	myosin X	0.010